Reviewed, UniProtKB/Swiss-Prot Q6ZTN6 (AN13D_HUMAN)

Names and origin

Protein names

Recommended name:
    Ankyrin repeat domain-containing protein 13D

Gene names

Name:

ANKRD13D

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZTN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZTN6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     264-270: EMSSKVQ → MSCGRLG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Ankyrin repeat domain-containing protein 13D		PRO_0000240651
Regions
	Repeat	395 – 414	20	UIM 1
	Repeat	441 – 460	20	UIM 2
	Repeat	477 – 496	20	UIM 3
Amino acid modifications
	Modified residue	465	1	Phosphoserine Ref.3 Ref.4
	Modified residue	469	1	Phosphothreonine Ref.3 Ref.4
Natural variations
	Alternative sequence	1 – 263	263	Missing in isoform 2.		VSP_019411
	Alternative sequence	264 – 270	7	EMSSKVQ → MSCGRLG in isoform 2.		VSP_019412
Experimental info
	Sequence conflict	79	1	M → V in BAC85932. Ref.1
	Sequence conflict	96	1	G → R in BAC86550. Ref.1
	Sequence conflict	365	1	P → S in BAC86550. Ref.1
	Sequence conflict	506	1	D → Y in BAC86550. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 1DF1E1801A455144	FASTA	518	58,476
	10 20 30 40 50 60 MVQLVLQYRD YQRATQRLAG IPELLNKLRQ APDFYVEMKW EFTSWVPLVS KMCPSDVYRV 70 80 90 100 110 120 WKRGESLRVD TSLLGFEHMT WQRGRRSFIF KGQEAGALVM EVDHDRQVVH VETLGLTLQE 130 140 150 160 170 180 PETLLAAMRP SEEHVASRLT SPIVSTHLDT RNVAFERNKC GIWGWRSEKM ETVSGYEAKV 190 200 210 220 230 240 YSATNVELVT RTRTEHLSDQ DKSRSKAGKT PFQSFLGMAQ QHSSHTGAPV QQAASPTNPT 250 260 270 280 290 300 AISPEEYFDP NFSLESRNIG RPIEMSSKVQ RFKATLWLSE EHPLSLGDQV TPIIDLMAIS 310 320 330 340 350 360 NAHFAKLRDF ITLRLPPGFP VKIEIPLFHV LNARITFSNL CGCDEPLSSV WVPAPSSAVA 370 380 390 400 410 420 ASGNPFPCEV DPTVFEVPNG YSVLGMERNE PLRDEDDDLL QFAIQQSLLE AGTEAEQVTV 430 440 450 460 470 480 WEALTNTRPG ARPPPQATVY EEQLQLERAL QESLQLSTEP RGPGSPPRTP PAPGPPSFEE 490 500 510 QLRLALELSS REQEERERRG QQEEEDLQRI LQLSLTEH
	Isoform 2. Checksum: 083383F3F65F1755	FASTA	255	28,380
	10 20 30 40 50 60 MSCGRLGRFK ATLWLSEEHP LSLGDQVTPI IDLMAISNAH FAKLRDFITL RLPPGFPVKI 70 80 90 100 110 120 EIPLFHVLNA RITFSNLCGC DEPLSSVWVP APSSAVAASG NPFPCEVDPT VFEVPNGYSV 130 140 150 160 170 180 LGMERNEPLR DEDDDLLQFA IQQSLLEAGT EAEQVTVWEA LTNTRPGARP PPQATVYEEQ 190 200 210 220 230 240 LQLERALQES LQLSTEPRGP GSPPRTPPAP GPPSFEEQLR LALELSSREQ EERERRGQQE 250 EEDLQRILQL SLTEH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Lung.
[3]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY.
[5]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: T-cell.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK124721 mRNA. Translation: BAC85932.1. AK126438 mRNA. Translation: BAC86550.1. BC044239 mRNA. Translation: AAH44239.1. BC121024 mRNA. Translation: AAI21025.1. BC121025 mRNA. Translation: AAI21026.1.
IPI	IPI00784159. IPI00941092.
RefSeq	NP_997237.1.
UniGene	Hs.438673
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZTN6. 1 interaction.
PTM databases
PhosphoSite	Q6ZTN6.
Genome annotation databases
Ensembl	ENST00000308440; ENSP00000310874; ENSG00000172932; Homo sapiens. [Genome view] ENST00000447274; ENSP00000402616; ENSG00000172932; Homo sapiens. [Genome view]
GeneID	338692.
KEGG	hsa:338692.
UCSC	uc001okc.1. human. uc001okg.1. human.
Organism-specific databases
CTD	338692.
GeneCards	GC11P066814.
HGNC	HGNC:27880. ANKRD13D.
PharmGKB	PA142672618.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q6ZTN6.
Gene expression databases
ArrayExpress	Q6ZTN6.
Bgee	Q6ZTN6.
CleanEx	HS_ANKRD13D.
Genevestigator	Q6ZTN6.
GermOnline	ENSG00000172932. Homo sapiens.
Family and domain databases
InterPro	IPR003903. Ubiquitin-int_motif. [Graphical view]
Pfam	PF02809. UIM. 3 hits. [Graphical view]
SMART	SM00726. UIM. 4 hits. [Graphical view]
PROSITE	PS50330. UIM. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	97103.

Entry information

Entry name

AN13D_HUMAN

Accession

Primary (citable) accession number: Q6ZTN6
Secondary accession number(s): Q0VAK0, Q6ZVD0, Q86SU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	November 24, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.