Q6ZTN6 (AN13D_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ankyrin repeat domain-containing protein 13D | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 518 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Contains 3 UIM (ubiquitin-interacting motif) repeats. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q6ZTN6-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q6ZTN6-2) The sequence of this isoform differs from the canonical sequence as follows: 1-263: Missing. 264-270: EMSSKVQ → MSCGRLG | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q6ZTN6-3) The sequence of this isoform differs from the canonical sequence as follows: 1-1: M → MAGPGPTFPL...EAVSTGDPEM | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 518 | 518 | Ankyrin repeat domain-containing protein 13D | PRO_0000240651 | |||||
Regions | |||||||||
| Repeat | 395 – 414 | 20 | UIM 1 | ||||||
| Repeat | 441 – 460 | 20 | UIM 2 | ||||||
| Repeat | 477 – 496 | 20 | UIM 3 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 465 | 1 | Phosphoserine Ref.4 Ref.5 Ref.6 | ||||||
| Modified residue | 469 | 1 | Phosphothreonine Ref.4 Ref.5 Ref.6 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 263 | 263 | Missing in isoform 2. | VSP_019411 | |||||
| Alternative sequence | 1 | 1 | M → MAGPGPTFPLHRLVWANRHR ELEAALHSHQHDIEQEDPRG RTPLELAVSLGNLESVRVLL RHNANVGKENRQGWAVLQEA VSTGDPEM in isoform 3. | VSP_042047 | |||||
| Alternative sequence | 264 – 270 | 7 | EMSSKVQ → MSCGRLG in isoform 2. | VSP_019412 | |||||
Experimental info | |||||||||
| Sequence conflict | 79 | 1 | M → V in BAC85932. Ref.1 | ||||||
| Sequence conflict | 96 | 1 | G → R in BAC86550. Ref.1 | ||||||
| Sequence conflict | 365 | 1 | P → S in BAC86550. Ref.1 | ||||||
| Sequence conflict | 488 | 1 | L → F in AAI10420. Ref.3 | ||||||
| Sequence conflict | 506 | 1 | D → Y in BAC86550. Ref.1 | ||||||
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus. |
| [2] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Blood and Lung. |
| [4] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [6] | "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Leukemic T-cell. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK124721 mRNA. Translation: BAC85932.1. AK126438 mRNA. Translation: BAC86550.1. AP001885 Genomic DNA. No translation available. BC044239 mRNA. Translation: AAH44239.1. BC110419 mRNA. Translation: AAI10420.1. BC121024 mRNA. Translation: AAI21025.1. BC121025 mRNA. Translation: AAI21026.1. |
| IPI | IPI00784159. IPI00941092. |
| RefSeq | NP_997237.2. NM_207354.2. |
| UniGene | Hs.438673. |
3D structure databases | |
| ProteinModelPortal | Q6ZTN6. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q6ZTN6. 5 interactions. |
| MINT | MINT-2879348. |
PTM databases | |
| PhosphoSite | Q6ZTN6. |
Polymorphism databases | |
| DMDM | 109940208. |
Proteomic databases | |
| PRIDE | Q6ZTN6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000308440; ENSP00000310874; ENSG00000172932. ENST00000447274; ENSP00000402616; ENSG00000172932. |
| GeneID | 338692. |
| KEGG | hsa:338692. |
| UCSC | uc001okc.1. human. uc001okg.1. human. |
Organism-specific databases | |
| CTD | 338692. |
| GeneCards | GC11P067056. |
| H-InvDB | HIX0013674. HIX0021990. |
| HGNC | HGNC:27880. ANKRD13D. |
| HPA | HPA039950. |
| neXtProt | NX_Q6ZTN6. |
| PharmGKB | PA142672618. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG09732. |
| GeneTree | ENSGT00410000025381. |
| HOVERGEN | HBG059287. |
| InParanoid | Q6ZTN6. |
| OrthoDB | EOG4K0QN1. |
| PhylomeDB | Q6ZTN6. |
Gene expression databases | |
| ArrayExpress | Q6ZTN6. |
| Bgee | Q6ZTN6. |
| CleanEx | HS_ANKRD13D. |
| Genevestigator | Q6ZTN6. |
| GermOnline | ENSG00000172932. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR021832. DUF3424. IPR003903. Ubiquitin-int_motif. [Graphical view] |
| Pfam | PF11904. DUF3424. 1 hit. [Graphical view] |
| SMART | SM00726. UIM. 4 hits. [Graphical view] |
| PROSITE | PS50330. UIM. 3 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 97103. |
Entry information
| Entry name | AN13D_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q6ZTN6 Secondary accession number(s): D6RCN6 Q86SU1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with