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Protein

Ankyrin repeat domain-containing protein 13D

Gene

ANKRD13D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13D
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:27880. ANKRD13D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672618.

Polymorphism and mutation databases

BioMutaiANKRD13D.
DMDMi109940208.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Ankyrin repeat domain-containing protein 13DPRO_0000240651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei465 – 4651PhosphoserineCombined sources
Modified residuei469 – 4691PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZTN6.
MaxQBiQ6ZTN6.
PaxDbiQ6ZTN6.
PRIDEiQ6ZTN6.

PTM databases

iPTMnetiQ6ZTN6.
PhosphoSiteiQ6ZTN6.

Expressioni

Gene expression databases

BgeeiQ6ZTN6.
CleanExiHS_ANKRD13D.
ExpressionAtlasiQ6ZTN6. baseline and differential.
GenevisibleiQ6ZTN6. HS.

Organism-specific databases

HPAiHPA039950.

Interactioni

Subunit structurei

Interacts with EGFR (ubiquitinated); the interaction is direct and may regulate EGFR internalization.1 Publication

Protein-protein interaction databases

BioGridi130781. 20 interactions.
IntActiQ6ZTN6. 8 interactions.
MINTiMINT-2879348.
STRINGi9606.ENSP00000427130.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini395 – 41420UIM 1PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 46020UIM 2PROSITE-ProRule annotationAdd
BLAST
Domaini477 – 49620UIM 3PROSITE-ProRule annotationAdd
BLAST
Domaini502 – 51817UIM 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 UIM (ubiquitin-interacting motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0522. Eukaryota.
ENOG410XNMS. LUCA.
GeneTreeiENSGT00410000025381.
HOGENOMiHOG000230821.
HOVERGENiHBG059287.
InParanoidiQ6ZTN6.
OMAiHRLVWAN.
OrthoDBiEOG76QFGX.
PhylomeDBiQ6ZTN6.
TreeFamiTF314176.

Family and domain databases

InterProiIPR021832. ANKRD13.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR12447. PTHR12447. 1 hit.
PfamiPF11904. GPCR_chapero_1. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 4 hits.
[Graphical view]
PROSITEiPS50330. UIM. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVQLVLQYRD YQRATQRLAG IPELLNKLRQ APDFYVEMKW EFTSWVPLVS
60 70 80 90 100
KMCPSDVYRV WKRGESLRVD TSLLGFEHMT WQRGRRSFIF KGQEAGALVM
110 120 130 140 150
EVDHDRQVVH VETLGLTLQE PETLLAAMRP SEEHVASRLT SPIVSTHLDT
160 170 180 190 200
RNVAFERNKC GIWGWRSEKM ETVSGYEAKV YSATNVELVT RTRTEHLSDQ
210 220 230 240 250
DKSRSKAGKT PFQSFLGMAQ QHSSHTGAPV QQAASPTNPT AISPEEYFDP
260 270 280 290 300
NFSLESRNIG RPIEMSSKVQ RFKATLWLSE EHPLSLGDQV TPIIDLMAIS
310 320 330 340 350
NAHFAKLRDF ITLRLPPGFP VKIEIPLFHV LNARITFSNL CGCDEPLSSV
360 370 380 390 400
WVPAPSSAVA ASGNPFPCEV DPTVFEVPNG YSVLGMERNE PLRDEDDDLL
410 420 430 440 450
QFAIQQSLLE AGTEAEQVTV WEALTNTRPG ARPPPQATVY EEQLQLERAL
460 470 480 490 500
QESLQLSTEP RGPGSPPRTP PAPGPPSFEE QLRLALELSS REQEERERRG
510
QQEEEDLQRI LQLSLTEH
Length:518
Mass (Da):58,476
Last modified:June 27, 2006 - v2
Checksum:i1DF1E1801A455144
GO
Isoform 2 (identifier: Q6ZTN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     264-270: EMSSKVQ → MSCGRLG

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):28,380
Checksum:i083383F3F65F1755
GO
Isoform 3 (identifier: Q6ZTN6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPGPTFPL...EAVSTGDPEM

Note: No experimental confirmation available.
Show »
Length:605
Mass (Da):68,172
Checksum:i27F91C1518642550
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti79 – 791M → V in BAC85932 (PubMed:14702039).Curated
Sequence conflicti96 – 961G → R in BAC86550 (PubMed:14702039).Curated
Sequence conflicti365 – 3651P → S in BAC86550 (PubMed:14702039).Curated
Sequence conflicti488 – 4881L → F in AAI10420 (PubMed:15489334).Curated
Sequence conflicti506 – 5061D → Y in BAC86550 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 263263Missing in isoform 2. 1 PublicationVSP_019411Add
BLAST
Alternative sequencei1 – 11M → MAGPGPTFPLHRLVWANRHR ELEAALHSHQHDIEQEDPRG RTPLELAVSLGNLESVRVLL RHNANVGKENRQGWAVLQEA VSTGDPEM in isoform 3. 1 PublicationVSP_042047
Alternative sequencei264 – 2707EMSSKVQ → MSCGRLG in isoform 2. 1 PublicationVSP_019412

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124721 mRNA. Translation: BAC85932.1.
AK126438 mRNA. Translation: BAC86550.1.
AP001885 Genomic DNA. No translation available.
BC044239 mRNA. Translation: AAH44239.1.
BC110419 mRNA. Translation: AAI10420.1.
BC121024 mRNA. Translation: AAI21025.1.
BC121025 mRNA. Translation: AAI21026.1.
CCDSiCCDS31616.2. [Q6ZTN6-3]
RefSeqiNP_997237.2. NM_207354.2. [Q6ZTN6-3]
UniGeneiHs.438673.

Genome annotation databases

EnsembliENST00000308440; ENSP00000310874; ENSG00000172932. [Q6ZTN6-1]
ENST00000447274; ENSP00000402616; ENSG00000172932. [Q6ZTN6-1]
ENST00000511455; ENSP00000427130; ENSG00000172932. [Q6ZTN6-3]
ENST00000514166; ENSP00000444404; ENSG00000172932. [Q6ZTN6-1]
ENST00000515828; ENSP00000443977; ENSG00000172932. [Q6ZTN6-2]
GeneIDi338692.
KEGGihsa:338692.
UCSCiuc001okc.3. human. [Q6ZTN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK124721 mRNA. Translation: BAC85932.1.
AK126438 mRNA. Translation: BAC86550.1.
AP001885 Genomic DNA. No translation available.
BC044239 mRNA. Translation: AAH44239.1.
BC110419 mRNA. Translation: AAI10420.1.
BC121024 mRNA. Translation: AAI21025.1.
BC121025 mRNA. Translation: AAI21026.1.
CCDSiCCDS31616.2. [Q6ZTN6-3]
RefSeqiNP_997237.2. NM_207354.2. [Q6ZTN6-3]
UniGeneiHs.438673.

3D structure databases

ProteinModelPortaliQ6ZTN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130781. 20 interactions.
IntActiQ6ZTN6. 8 interactions.
MINTiMINT-2879348.
STRINGi9606.ENSP00000427130.

PTM databases

iPTMnetiQ6ZTN6.
PhosphoSiteiQ6ZTN6.

Polymorphism and mutation databases

BioMutaiANKRD13D.
DMDMi109940208.

Proteomic databases

EPDiQ6ZTN6.
MaxQBiQ6ZTN6.
PaxDbiQ6ZTN6.
PRIDEiQ6ZTN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308440; ENSP00000310874; ENSG00000172932. [Q6ZTN6-1]
ENST00000447274; ENSP00000402616; ENSG00000172932. [Q6ZTN6-1]
ENST00000511455; ENSP00000427130; ENSG00000172932. [Q6ZTN6-3]
ENST00000514166; ENSP00000444404; ENSG00000172932. [Q6ZTN6-1]
ENST00000515828; ENSP00000443977; ENSG00000172932. [Q6ZTN6-2]
GeneIDi338692.
KEGGihsa:338692.
UCSCiuc001okc.3. human. [Q6ZTN6-1]

Organism-specific databases

CTDi338692.
GeneCardsiANKRD13D.
HGNCiHGNC:27880. ANKRD13D.
HPAiHPA039950.
MIMi615126. gene.
neXtProtiNX_Q6ZTN6.
PharmGKBiPA142672618.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0522. Eukaryota.
ENOG410XNMS. LUCA.
GeneTreeiENSGT00410000025381.
HOGENOMiHOG000230821.
HOVERGENiHBG059287.
InParanoidiQ6ZTN6.
OMAiHRLVWAN.
OrthoDBiEOG76QFGX.
PhylomeDBiQ6ZTN6.
TreeFamiTF314176.

Miscellaneous databases

ChiTaRSiANKRD13D. human.
GenomeRNAii338692.
PROiQ6ZTN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZTN6.
CleanExiHS_ANKRD13D.
ExpressionAtlasiQ6ZTN6. baseline and differential.
GenevisibleiQ6ZTN6. HS.

Family and domain databases

InterProiIPR021832. ANKRD13.
IPR003903. UIM_dom.
[Graphical view]
PANTHERiPTHR12447. PTHR12447. 1 hit.
PfamiPF11904. GPCR_chapero_1. 1 hit.
[Graphical view]
SMARTiSM00726. UIM. 4 hits.
[Graphical view]
PROSITEiPS50330. UIM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Uterus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Blood and Lung.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. "The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane."
    Tanno H., Yamaguchi T., Goto E., Ishido S., Komada M.
    Mol. Biol. Cell 23:1343-1353(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EGFR, UBIQUITIN-BINDING, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiAN13D_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTN6
Secondary accession number(s): D6RCN6
, Q0VAK0, Q0VGC3, Q6ZVD0, Q86SU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.