Q6ZTN6 (AN13D_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ankyrin repeat domain-containing protein 13D

Gene names

Name:

ANKRD13D

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 3 UIM (ubiquitin-interacting motif) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZTN6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZTN6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     264-270: EMSSKVQ → MSCGRLG

Note: No experimental confirmation available.

Isoform 3 (identifier: Q6ZTN6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAGPGPTFPL...EAVSTGDPEM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Ankyrin repeat domain-containing protein 13D		PRO_0000240651
Regions
	Repeat	395 – 414	20	UIM 1
	Repeat	441 – 460	20	UIM 2
	Repeat	477 – 496	20	UIM 3
Amino acid modifications
	Modified residue	465	1	Phosphoserine Ref.4 Ref.5 Ref.6
	Modified residue	469	1	Phosphothreonine Ref.4 Ref.5 Ref.6
Natural variations
	Alternative sequence	1 – 263	263	Missing in isoform 2.		VSP_019411
	Alternative sequence	1	1	M → MAGPGPTFPLHRLVWANRHR ELEAALHSHQHDIEQEDPRG RTPLELAVSLGNLESVRVLL RHNANVGKENRQGWAVLQEA VSTGDPEM in isoform 3.		VSP_042047
	Alternative sequence	264 – 270	7	EMSSKVQ → MSCGRLG in isoform 2.		VSP_019412
Experimental info
	Sequence conflict	79	1	M → V in BAC85932. Ref.1
	Sequence conflict	96	1	G → R in BAC86550. Ref.1
	Sequence conflict	365	1	P → S in BAC86550. Ref.1
	Sequence conflict	488	1	L → F in AAI10420. Ref.3
	Sequence conflict	506	1	D → Y in BAC86550. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 1DF1E1801A455144	FASTA	518	58,476
	10 20 30 40 50 60 MVQLVLQYRD YQRATQRLAG IPELLNKLRQ APDFYVEMKW EFTSWVPLVS KMCPSDVYRV 70 80 90 100 110 120 WKRGESLRVD TSLLGFEHMT WQRGRRSFIF KGQEAGALVM EVDHDRQVVH VETLGLTLQE 130 140 150 160 170 180 PETLLAAMRP SEEHVASRLT SPIVSTHLDT RNVAFERNKC GIWGWRSEKM ETVSGYEAKV 190 200 210 220 230 240 YSATNVELVT RTRTEHLSDQ DKSRSKAGKT PFQSFLGMAQ QHSSHTGAPV QQAASPTNPT 250 260 270 280 290 300 AISPEEYFDP NFSLESRNIG RPIEMSSKVQ RFKATLWLSE EHPLSLGDQV TPIIDLMAIS 310 320 330 340 350 360 NAHFAKLRDF ITLRLPPGFP VKIEIPLFHV LNARITFSNL CGCDEPLSSV WVPAPSSAVA 370 380 390 400 410 420 ASGNPFPCEV DPTVFEVPNG YSVLGMERNE PLRDEDDDLL QFAIQQSLLE AGTEAEQVTV 430 440 450 460 470 480 WEALTNTRPG ARPPPQATVY EEQLQLERAL QESLQLSTEP RGPGSPPRTP PAPGPPSFEE 490 500 510 QLRLALELSS REQEERERRG QQEEEDLQRI LQLSLTEH
	Isoform 2 [UniParc]. Checksum: 083383F3F65F1755	FASTA	255	28,380
	10 20 30 40 50 60 MSCGRLGRFK ATLWLSEEHP LSLGDQVTPI IDLMAISNAH FAKLRDFITL RLPPGFPVKI 70 80 90 100 110 120 EIPLFHVLNA RITFSNLCGC DEPLSSVWVP APSSAVAASG NPFPCEVDPT VFEVPNGYSV 130 140 150 160 170 180 LGMERNEPLR DEDDDLLQFA IQQSLLEAGT EAEQVTVWEA LTNTRPGARP PPQATVYEEQ 190 200 210 220 230 240 LQLERALQES LQLSTEPRGP GSPPRTPPAP GPPSFEEQLR LALELSSREQ EERERRGQQE 250 EEDLQRILQL SLTEH
	Isoform 3 [UniParc]. Checksum: 27F91C1518642550	FASTA	605	68,172
	10 20 30 40 50 60 MAGPGPTFPL HRLVWANRHR ELEAALHSHQ HDIEQEDPRG RTPLELAVSL GNLESVRVLL 70 80 90 100 110 120 RHNANVGKEN RQGWAVLQEA VSTGDPEMVQ LVLQYRDYQR ATQRLAGIPE LLNKLRQAPD 130 140 150 160 170 180 FYVEMKWEFT SWVPLVSKMC PSDVYRVWKR GESLRVDTSL LGFEHMTWQR GRRSFIFKGQ 190 200 210 220 230 240 EAGALVMEVD HDRQVVHVET LGLTLQEPET LLAAMRPSEE HVASRLTSPI VSTHLDTRNV 250 260 270 280 290 300 AFERNKCGIW GWRSEKMETV SGYEAKVYSA TNVELVTRTR TEHLSDQDKS RSKAGKTPFQ 310 320 330 340 350 360 SFLGMAQQHS SHTGAPVQQA ASPTNPTAIS PEEYFDPNFS LESRNIGRPI EMSSKVQRFK 370 380 390 400 410 420 ATLWLSEEHP LSLGDQVTPI IDLMAISNAH FAKLRDFITL RLPPGFPVKI EIPLFHVLNA 430 440 450 460 470 480 RITFSNLCGC DEPLSSVWVP APSSAVAASG NPFPCEVDPT VFEVPNGYSV LGMERNEPLR 490 500 510 520 530 540 DEDDDLLQFA IQQSLLEAGT EAEQVTVWEA LTNTRPGARP PPQATVYEEQ LQLERALQES 550 560 570 580 590 600 LQLSTEPRGP GSPPRTPPAP GPPSFEEQLR LALELSSREQ EERERRGQQE EEDLQRILQL SLTEH

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Blood and Lung.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND THR-469, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK124721 mRNA. Translation: BAC85932.1. AK126438 mRNA. Translation: BAC86550.1. AP001885 Genomic DNA. No translation available. BC044239 mRNA. Translation: AAH44239.1. BC110419 mRNA. Translation: AAI10420.1. BC121024 mRNA. Translation: AAI21025.1. BC121025 mRNA. Translation: AAI21026.1.
IPI	IPI00784159. IPI00941092.
RefSeq	NP_997237.2. NM_207354.2.
UniGene	Hs.438673.
3D structure databases
ProteinModelPortal	Q6ZTN6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZTN6. 5 interactions.
MINT	MINT-2879348.
PTM databases
PhosphoSite	Q6ZTN6.
Polymorphism databases
DMDM	109940208.
Proteomic databases
PRIDE	Q6ZTN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000308440; ENSP00000310874; ENSG00000172932. ENST00000447274; ENSP00000402616; ENSG00000172932.
GeneID	338692.
KEGG	hsa:338692.
UCSC	uc001okc.1. human. uc001okg.1. human.
Organism-specific databases
CTD	338692.
GeneCards	GC11P067056.
H-InvDB	HIX0013674. HIX0021990.
HGNC	HGNC:27880. ANKRD13D.
HPA	HPA039950.
neXtProt	NX_Q6ZTN6.
PharmGKB	PA142672618.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09732.
GeneTree	ENSGT00410000025381.
HOVERGEN	HBG059287.
InParanoid	Q6ZTN6.
OrthoDB	EOG4K0QN1.
PhylomeDB	Q6ZTN6.
Gene expression databases
ArrayExpress	Q6ZTN6.
Bgee	Q6ZTN6.
CleanEx	HS_ANKRD13D.
Genevestigator	Q6ZTN6.
GermOnline	ENSG00000172932. Homo sapiens.
Family and domain databases
InterPro	IPR021832. DUF3424. IPR003903. Ubiquitin-int_motif. [Graphical view]
Pfam	PF11904. DUF3424. 1 hit. [Graphical view]
SMART	SM00726. UIM. 4 hits. [Graphical view]
PROSITE	PS50330. UIM. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	97103.

Entry information

Entry name

AN13D_HUMAN

Accession

Primary (citable) accession number: Q6ZTN6
Secondary accession number(s): D6RCN6 , Q0VAK0, Q0VGC3, Q6ZVD0, Q86SU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	January 25, 2012
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.