Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Filamin-interacting protein FAM101A

Gene

FAM101A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Filamin-interacting protein FAM101ACurated
Alternative name(s):
Regulator of filamin protein A
Short name:
RefilinA
Gene namesi
Name:FAM101A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27051. FAM101A.

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity

  • Note: Colocalizes with FLNA along actin bundle-like structures.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Filamin-interacting protein FAM101APRO_0000274331Add
BLAST

Proteomic databases

EPDiQ6ZTI6.
PaxDbiQ6ZTI6.
PeptideAtlasiQ6ZTI6.
PRIDEiQ6ZTI6.

PTM databases

PhosphoSiteiQ6ZTI6.

Expressioni

Gene expression databases

BgeeiENSG00000178882.
CleanExiHS_FAM101A.
GenevisibleiQ6ZTI6. HS.

Organism-specific databases

HPAiCAB020717.

Interactioni

Subunit structurei

Interacts with FLNA and FLNB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP21333-23EBI-10200920,EBI-9641086

Protein-protein interaction databases

BioGridi126843. 1 interaction.
IntActiQ6ZTI6. 1 interaction.
STRINGi9606.ENSP00000315626.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM101 family.Curated

Phylogenomic databases

eggNOGiENOG410IVW8. Eukaryota.
ENOG410ZX5R. LUCA.
GeneTreeiENSGT00390000016836.
HOGENOMiHOG000112422.
HOVERGENiHBG107859.
InParanoidiQ6ZTI6.
OMAiQARSSFR.
OrthoDBiEOG091G13B3.
PhylomeDBiQ6ZTI6.
TreeFamiTF332387.

Family and domain databases

InterProiIPR028215. FAM101.
[Graphical view]
PfamiPF15068. FAM101. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVGHLHLQGM EDSLKEQGRE GLLDSPDSGL PPSPSPSPPF YSLAPGILDA
60 70 80 90 100
RAGGAGASSE PPGPSEARAP PSQLPNPPAS EMRPRMLPVF FGESIKVNPE
110 120 130 140 150
PTHEIRCNSE VKYASEKHFQ DKVFYAPVPT VTAYSETIVA APNCTWRNYR
160 170 180 190 200
SQLTLEPRPR ALRFRSTTII FPKHARSTFR TTLHCSLGRP SRWFTASVQL
210
QLCQDPAPSL LGPATL
Length:216
Mass (Da):23,610
Last modified:November 4, 2008 - v3
Checksum:i6679E5A4CB3485E8
GO
Isoform 2 (identifier: Q6ZTI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.
Show »
Length:135
Mass (Da):15,464
Checksum:i6A9F4247F5D551B1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti98 – 981N → S in BAC86601 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_022713Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073916 Genomic DNA. No translation available.
AK126577 mRNA. Translation: BAC86601.1.
BC141805 mRNA. Translation: AAI41806.1.
CCDSiCCDS9258.1. [Q6ZTI6-2]
RefSeqiNP_001191228.1. NM_001204299.1. [Q6ZTI6-2]
NP_859060.3. NM_181709.4. [Q6ZTI6-2]
UniGeneiHs.432901.
Hs.524828.

Genome annotation databases

EnsembliENST00000324038; ENSP00000315626; ENSG00000178882. [Q6ZTI6-2]
ENST00000338359; ENSP00000345898; ENSG00000178882. [Q6ZTI6-2]
ENST00000389727; ENSP00000374377; ENSG00000178882. [Q6ZTI6-2]
ENST00000546355; ENSP00000444080; ENSG00000178882. [Q6ZTI6-1]
GeneIDi100533183.
144347.
KEGGihsa:100533183.
hsa:144347.
UCSCiuc001ugd.3. human. [Q6ZTI6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073916 Genomic DNA. No translation available.
AK126577 mRNA. Translation: BAC86601.1.
BC141805 mRNA. Translation: AAI41806.1.
CCDSiCCDS9258.1. [Q6ZTI6-2]
RefSeqiNP_001191228.1. NM_001204299.1. [Q6ZTI6-2]
NP_859060.3. NM_181709.4. [Q6ZTI6-2]
UniGeneiHs.432901.
Hs.524828.

3D structure databases

ProteinModelPortaliQ6ZTI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126843. 1 interaction.
IntActiQ6ZTI6. 1 interaction.
STRINGi9606.ENSP00000315626.

PTM databases

PhosphoSiteiQ6ZTI6.

Proteomic databases

EPDiQ6ZTI6.
PaxDbiQ6ZTI6.
PeptideAtlasiQ6ZTI6.
PRIDEiQ6ZTI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324038; ENSP00000315626; ENSG00000178882. [Q6ZTI6-2]
ENST00000338359; ENSP00000345898; ENSG00000178882. [Q6ZTI6-2]
ENST00000389727; ENSP00000374377; ENSG00000178882. [Q6ZTI6-2]
ENST00000546355; ENSP00000444080; ENSG00000178882. [Q6ZTI6-1]
GeneIDi100533183.
144347.
KEGGihsa:100533183.
hsa:144347.
UCSCiuc001ugd.3. human. [Q6ZTI6-1]

Organism-specific databases

CTDi100533183.
144347.
GeneCardsiFAM101A.
ZNF664-FAM101A.
HGNCiHGNC:27051. FAM101A.
HPAiCAB020717.
MIMi615927. gene.
neXtProtiNX_Q6ZTI6.
PharmGKBiPA143485462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVW8. Eukaryota.
ENOG410ZX5R. LUCA.
GeneTreeiENSGT00390000016836.
HOGENOMiHOG000112422.
HOVERGENiHBG107859.
InParanoidiQ6ZTI6.
OMAiQARSSFR.
OrthoDBiEOG091G13B3.
PhylomeDBiQ6ZTI6.
TreeFamiTF332387.

Miscellaneous databases

PROiQ6ZTI6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178882.
CleanExiHS_FAM101A.
GenevisibleiQ6ZTI6. HS.

Family and domain databases

InterProiIPR028215. FAM101.
[Graphical view]
PfamiPF15068. FAM101. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF101A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTI6
Secondary accession number(s): A5D8T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 4, 2008
Last modified: September 7, 2016
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.