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Q6ZTA4

- TRI67_HUMAN

UniProt

Q6ZTA4 - TRI67_HUMAN

Protein

Tripartite motif-containing protein 67

Gene

TRIM67

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 3 (10 Aug 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 4236RING-type; degenerateAdd
    BLAST
    Zinc fingeri206 – 25348B box-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 34043B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of Ras protein signal transduction Source: Ensembl
    2. positive regulation of neuron projection development Source: Ensembl
    3. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 67
    Alternative name(s):
    TRIM9-like protein
    Gene namesi
    Name:TRIM67
    Synonyms:TNL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:31859. TRIM67.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: Microtubule-associated.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134947738.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 783783Tripartite motif-containing protein 67PRO_0000256864Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZTA4.
    PRIDEiQ6ZTA4.

    PTM databases

    PhosphoSiteiQ6ZTA4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZTA4.
    BgeeiQ6ZTA4.
    CleanExiHS_TRIM67.
    GenevestigatoriQ6ZTA4.

    Organism-specific databases

    HPAiHPA034776.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000412124.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZTA4.
    SMRiQ6ZTA4. Positions 1-36, 199-340, 393-450, 512-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini448 – 50659COSPROSITE-ProRule annotationAdd
    BLAST
    Domaini513 – 60795Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST
    Domaini589 – 780192B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili345 – 38238Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 657Poly-Ala
    Compositional biasi74 – 9623Gly-richAdd
    BLAST
    Compositional biasi139 – 1424Poly-Ala
    Compositional biasi148 – 1569Poly-Ser
    Compositional biasi201 – 2066Poly-Ala
    Compositional biasi277 – 2804Poly-Gly

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 COS domain.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri7 – 4236RING-type; degenerateAdd
    BLAST
    Zinc fingeri206 – 25348B box-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri298 – 34043B box-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG260378.
    HOGENOMiHOG000007387.
    HOVERGENiHBG062305.
    InParanoidiQ6ZTA4.
    KOiK10649.
    OMAiLPCARTI.
    PhylomeDBiQ6ZTA4.
    TreeFamiTF315216.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.40.10. 2 hits.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003649. Bbox_C.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view]
    SMARTiSM00502. BBC. 1 hit.
    SM00336. BBOX. 2 hits.
    SM00060. FN3. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS00518. ZF_RING_1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZTA4-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL    50
    LSRGSGLQAG AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD 100
    KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL 150
    SSSSSSITCP QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS 200
    AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP SRGPFAKHRL 250
    VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF 300
    PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ 350
    LSQALNGVSD KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA 400
    LTRQKAKLLT KVTKEREHKL KMVWDQINHC TLKLRQSTGL MEYCLEVIKE 450
    NDPSGFLQIS DALIKRVQVS QEQWVKGALE PKVSAEFDLT LDSEPLLQAI 500
    HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT HSPVDGYILE 550
    LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV 600
    VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV 650
    HYWELHVDRY DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM 700
    HCNSHTNRTE GGVCKGATVG VLLDLNKHTL TFFINGQQQG PTAFSHVDGV 750
    FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN 783

    Note: Gene prediction based on EST data.

    Length:783
    Mass (Da):83,823
    Last modified:August 10, 2010 - v3
    Checksum:iFC07A0E0B576D821
    GO
    Isoform 2 (identifier: Q6ZTA4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         42-81: Missing.
         251-272: Missing.

    Show »
    Length:721
    Mass (Da):78,073
    Checksum:iD999202C92BF23DE
    GO

    Sequence cautioni

    The sequence BAC86689.1 differs from that shown. Reason: Probable cloning artifact.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221C → R in BAC86689. (PubMed:14702039)Curated
    Sequence conflicti679 – 6791M → V in BAC86689. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei42 – 8140Missing in isoform 2. 1 PublicationVSP_021359Add
    BLAST
    Alternative sequencei251 – 27222Missing in isoform 2. 1 PublicationVSP_021360Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY253917 mRNA. Translation: AAP69949.1.
    AL109810 Genomic DNA. Translation: CAI19160.1.
    AL109810 Genomic DNA. Translation: CAI19161.1.
    AL109810 Genomic DNA. Translation: CAI19162.1.
    AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
    CCDSiCCDS44333.1. [Q6ZTA4-3]
    RefSeqiNP_001004342.3. NM_001004342.3. [Q6ZTA4-3]
    XP_005273195.1. XM_005273138.1. [Q6ZTA4-2]
    UniGeneiHs.655089.

    Genome annotation databases

    EnsembliENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
    ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
    GeneIDi440730.
    KEGGihsa:440730.
    UCSCiuc009xfn.1. human. [Q6ZTA4-3]

    Polymorphism databases

    DMDMi302393802.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY253917 mRNA. Translation: AAP69949.1 .
    AL109810 Genomic DNA. Translation: CAI19160.1 .
    AL109810 Genomic DNA. Translation: CAI19161.1 .
    AL109810 Genomic DNA. Translation: CAI19162.1 .
    AK126782 mRNA. Translation: BAC86689.1 . Sequence problems.
    CCDSi CCDS44333.1. [Q6ZTA4-3 ]
    RefSeqi NP_001004342.3. NM_001004342.3. [Q6ZTA4-3 ]
    XP_005273195.1. XM_005273138.1. [Q6ZTA4-2 ]
    UniGenei Hs.655089.

    3D structure databases

    ProteinModelPortali Q6ZTA4.
    SMRi Q6ZTA4. Positions 1-36, 199-340, 393-450, 512-606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000412124.

    PTM databases

    PhosphoSitei Q6ZTA4.

    Polymorphism databases

    DMDMi 302393802.

    Proteomic databases

    PaxDbi Q6ZTA4.
    PRIDEi Q6ZTA4.

    Protocols and materials databases

    DNASUi 440730.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366653 ; ENSP00000355613 ; ENSG00000119283 . [Q6ZTA4-3 ]
    ENST00000449018 ; ENSP00000400163 ; ENSG00000119283 . [Q6ZTA4-2 ]
    GeneIDi 440730.
    KEGGi hsa:440730.
    UCSCi uc009xfn.1. human. [Q6ZTA4-3 ]

    Organism-specific databases

    CTDi 440730.
    GeneCardsi GC01P231298.
    H-InvDB HIX0001690.
    HGNCi HGNC:31859. TRIM67.
    HPAi HPA034776.
    MIMi 610584. gene.
    neXtProti NX_Q6ZTA4.
    PharmGKBi PA134947738.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260378.
    HOGENOMi HOG000007387.
    HOVERGENi HBG062305.
    InParanoidi Q6ZTA4.
    KOi K10649.
    OMAi LPCARTI.
    PhylomeDBi Q6ZTA4.
    TreeFami TF315216.

    Miscellaneous databases

    GenomeRNAii 440730.
    NextBioi 109477.
    PROi Q6ZTA4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZTA4.
    Bgeei Q6ZTA4.
    CleanExi HS_TRIM67.
    Genevestigatori Q6ZTA4.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.40.10. 2 hits.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003649. Bbox_C.
    IPR008985. ConA-like_lec_gl_sf.
    IPR017903. COS_domain.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR018957. Znf_C3HC4_RING-type.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    PF00622. SPRY. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00097. zf-C3HC4. 1 hit.
    [Graphical view ]
    SMARTi SM00502. BBC. 1 hit.
    SM00336. BBOX. 2 hits.
    SM00060. FN3. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS51262. COS. 1 hit.
    PS50853. FN3. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS00518. ZF_RING_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding."
      Short K.M., Cox T.C.
      J. Biol. Chem. 281:8970-8980(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiTRI67_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZTA4
    Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: August 10, 2010
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3