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Protein

Tripartite motif-containing protein 67

Gene

TRIM67

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 42RING-type; degenerateAdd BLAST36
Zinc fingeri206 – 253B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri298 – 340B box-type 2PROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 67
Alternative name(s):
TRIM9-like protein
Gene namesi
Name:TRIM67
Synonyms:TNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31859. TRIM67.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119283.
PharmGKBiPA134947738.

Polymorphism and mutation databases

BioMutaiTRIM67.
DMDMi302393802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002568641 – 783Tripartite motif-containing protein 67Add BLAST783

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZTA4.
PeptideAtlasiQ6ZTA4.
PRIDEiQ6ZTA4.

PTM databases

iPTMnetiQ6ZTA4.
PhosphoSitePlusiQ6ZTA4.

Expressioni

Gene expression databases

BgeeiENSG00000119283.
CleanExiHS_TRIM67.
ExpressionAtlasiQ6ZTA4. baseline and differential.

Organism-specific databases

HPAiHPA034776.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355613.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTA4.
SMRiQ6ZTA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini448 – 506COSPROSITE-ProRule annotationAdd BLAST59
Domaini513 – 607Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST95
Domaini589 – 780B30.2/SPRYPROSITE-ProRule annotationAdd BLAST192

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili345 – 382Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 65Poly-Ala7
Compositional biasi74 – 96Gly-richAdd BLAST23
Compositional biasi139 – 142Poly-Ala4
Compositional biasi148 – 156Poly-Ser9
Compositional biasi201 – 206Poly-Ala6
Compositional biasi277 – 280Poly-Gly4

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 2 B box-type zinc fingers.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 COS domain.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 42RING-type; degenerateAdd BLAST36
Zinc fingeri206 – 253B box-type 1; degeneratePROSITE-ProRule annotationAdd BLAST48
Zinc fingeri298 – 340B box-type 2PROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4367. Eukaryota.
ENOG410XQMV. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000007387.
HOVERGENiHBG062305.
InParanoidiQ6ZTA4.
KOiK10649.
OMAiLPCARTI.
OrthoDBiEOG091G0PBB.
PhylomeDBiQ6ZTA4.
TreeFamiTF315216.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZTA4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL
60 70 80 90 100
LSRGSGLQAG AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD
110 120 130 140 150
KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL
160 170 180 190 200
SSSSSSITCP QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS
210 220 230 240 250
AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP SRGPFAKHRL
260 270 280 290 300
VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF
310 320 330 340 350
PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ
360 370 380 390 400
LSQALNGVSD KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA
410 420 430 440 450
LTRQKAKLLT KVTKEREHKL KMVWDQINHC TLKLRQSTGL MEYCLEVIKE
460 470 480 490 500
NDPSGFLQIS DALIKRVQVS QEQWVKGALE PKVSAEFDLT LDSEPLLQAI
510 520 530 540 550
HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT HSPVDGYILE
560 570 580 590 600
LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV
610 620 630 640 650
VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV
660 670 680 690 700
HYWELHVDRY DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM
710 720 730 740 750
HCNSHTNRTE GGVCKGATVG VLLDLNKHTL TFFINGQQQG PTAFSHVDGV
760 770 780
FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN
Note: Gene prediction based on EST data.
Length:783
Mass (Da):83,823
Last modified:August 10, 2010 - v3
Checksum:iFC07A0E0B576D821
GO
Isoform 2 (identifier: Q6ZTA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-81: Missing.
     251-272: Missing.

Show »
Length:721
Mass (Da):78,073
Checksum:iD999202C92BF23DE
GO

Sequence cautioni

The sequence BAC86689 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22C → R in BAC86689 (PubMed:14702039).Curated1
Sequence conflicti679M → V in BAC86689 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02135942 – 81Missing in isoform 2. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_021360251 – 272Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253917 mRNA. Translation: AAP69949.1.
AL109810 Genomic DNA. Translation: CAI19160.1.
AL109810 Genomic DNA. Translation: CAI19161.1.
AL109810 Genomic DNA. Translation: CAI19162.1.
AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
CCDSiCCDS44333.1. [Q6ZTA4-3]
CCDS73048.1. [Q6ZTA4-2]
RefSeqiNP_001004342.3. NM_001004342.3. [Q6ZTA4-3]
NP_001287818.1. NM_001300889.1. [Q6ZTA4-2]
UniGeneiHs.655089.

Genome annotation databases

EnsembliENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
GeneIDi440730.
KEGGihsa:440730.
UCSCiuc009xfn.2. human. [Q6ZTA4-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY253917 mRNA. Translation: AAP69949.1.
AL109810 Genomic DNA. Translation: CAI19160.1.
AL109810 Genomic DNA. Translation: CAI19161.1.
AL109810 Genomic DNA. Translation: CAI19162.1.
AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
CCDSiCCDS44333.1. [Q6ZTA4-3]
CCDS73048.1. [Q6ZTA4-2]
RefSeqiNP_001004342.3. NM_001004342.3. [Q6ZTA4-3]
NP_001287818.1. NM_001300889.1. [Q6ZTA4-2]
UniGeneiHs.655089.

3D structure databases

ProteinModelPortaliQ6ZTA4.
SMRiQ6ZTA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355613.

PTM databases

iPTMnetiQ6ZTA4.
PhosphoSitePlusiQ6ZTA4.

Polymorphism and mutation databases

BioMutaiTRIM67.
DMDMi302393802.

Proteomic databases

PaxDbiQ6ZTA4.
PeptideAtlasiQ6ZTA4.
PRIDEiQ6ZTA4.

Protocols and materials databases

DNASUi440730.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
GeneIDi440730.
KEGGihsa:440730.
UCSCiuc009xfn.2. human. [Q6ZTA4-3]

Organism-specific databases

CTDi440730.
GeneCardsiTRIM67.
H-InvDBHIX0001690.
HGNCiHGNC:31859. TRIM67.
HPAiHPA034776.
MIMi610584. gene.
neXtProtiNX_Q6ZTA4.
OpenTargetsiENSG00000119283.
PharmGKBiPA134947738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4367. Eukaryota.
ENOG410XQMV. LUCA.
GeneTreeiENSGT00760000118878.
HOGENOMiHOG000007387.
HOVERGENiHBG062305.
InParanoidiQ6ZTA4.
KOiK10649.
OMAiLPCARTI.
OrthoDBiEOG091G0PBB.
PhylomeDBiQ6ZTA4.
TreeFamiTF315216.

Miscellaneous databases

GenomeRNAii440730.
PROiQ6ZTA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119283.
CleanExiHS_TRIM67.
ExpressionAtlasiQ6ZTA4. baseline and differential.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR013320. ConA-like_dom.
IPR017903. COS_domain.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI67_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTA4
Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 10, 2010
Last modified: November 30, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.