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Q6ZTA4

- TRI67_HUMAN

UniProt

Q6ZTA4 - TRI67_HUMAN

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Protein

Tripartite motif-containing protein 67

Gene
TRIM67, TNL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 4236RING-type; degenerateAdd
BLAST
Zinc fingeri206 – 25348B box-type 1; degenerateAdd
BLAST
Zinc fingeri298 – 34043B box-type 2Add
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of Ras protein signal transduction Source: Ensembl
  2. positive regulation of neuron projection development Source: Ensembl
  3. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 67
Alternative name(s):
TRIM9-like protein
Gene namesi
Name:TRIM67
Synonyms:TNL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:31859. TRIM67.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: Microtubule-associated By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134947738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 783783Tripartite motif-containing protein 67PRO_0000256864Add
BLAST

Proteomic databases

PaxDbiQ6ZTA4.
PRIDEiQ6ZTA4.

PTM databases

PhosphoSiteiQ6ZTA4.

Expressioni

Gene expression databases

ArrayExpressiQ6ZTA4.
BgeeiQ6ZTA4.
CleanExiHS_TRIM67.
GenevestigatoriQ6ZTA4.

Organism-specific databases

HPAiHPA034776.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000412124.

Structurei

3D structure databases

ProteinModelPortaliQ6ZTA4.
SMRiQ6ZTA4. Positions 1-36, 199-340, 393-450, 512-606.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini448 – 50659COSAdd
BLAST
Domaini513 – 60795Fibronectin type-IIIAdd
BLAST
Domaini589 – 780192B30.2/SPRYAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili345 – 38238 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 657Poly-Ala
Compositional biasi74 – 9623Gly-richAdd
BLAST
Compositional biasi139 – 1424Poly-Ala
Compositional biasi148 – 1569Poly-Ser
Compositional biasi201 – 2066Poly-Ala
Compositional biasi277 – 2804Poly-Gly

Sequence similaritiesi

Belongs to the TRIM/RBCC family.
Contains 1 B30.2/SPRY domain.
Contains 1 COS domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri7 – 4236RING-type; degenerateAdd
BLAST
Zinc fingeri206 – 25348B box-type 1; degenerateAdd
BLAST
Zinc fingeri298 – 34043B box-type 2Add
BLAST

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG260378.
HOGENOMiHOG000007387.
HOVERGENiHBG062305.
InParanoidiQ6ZTA4.
KOiK10649.
OMAiLPCARTI.
PhylomeDBiQ6ZTA4.
TreeFamiTF315216.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZTA4-3) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL    50
LSRGSGLQAG AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD 100
KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL 150
SSSSSSITCP QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS 200
AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP SRGPFAKHRL 250
VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF 300
PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ 350
LSQALNGVSD KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA 400
LTRQKAKLLT KVTKEREHKL KMVWDQINHC TLKLRQSTGL MEYCLEVIKE 450
NDPSGFLQIS DALIKRVQVS QEQWVKGALE PKVSAEFDLT LDSEPLLQAI 500
HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT HSPVDGYILE 550
LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV 600
VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV 650
HYWELHVDRY DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM 700
HCNSHTNRTE GGVCKGATVG VLLDLNKHTL TFFINGQQQG PTAFSHVDGV 750
FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN 783

Note: Gene prediction based on EST data.

Length:783
Mass (Da):83,823
Last modified:August 10, 2010 - v3
Checksum:iFC07A0E0B576D821
GO
Isoform 2 (identifier: Q6ZTA4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-81: Missing.
     251-272: Missing.

Show »
Length:721
Mass (Da):78,073
Checksum:iD999202C92BF23DE
GO

Sequence cautioni

The sequence BAC86689.1 differs from that shown. Reason: Probable cloning artifact.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei42 – 8140Missing in isoform 2. VSP_021359Add
BLAST
Alternative sequencei251 – 27222Missing in isoform 2. VSP_021360Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221C → R in BAC86689. 1 Publication
Sequence conflicti679 – 6791M → V in BAC86689. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY253917 mRNA. Translation: AAP69949.1.
AL109810 Genomic DNA. Translation: CAI19160.1.
AL109810 Genomic DNA. Translation: CAI19161.1.
AL109810 Genomic DNA. Translation: CAI19162.1.
AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
CCDSiCCDS44333.1. [Q6ZTA4-3]
RefSeqiNP_001004342.3. NM_001004342.3. [Q6ZTA4-3]
XP_005273195.1. XM_005273138.1. [Q6ZTA4-2]
UniGeneiHs.655089.

Genome annotation databases

EnsembliENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
GeneIDi440730.
KEGGihsa:440730.
UCSCiuc009xfn.1. human. [Q6ZTA4-3]

Polymorphism databases

DMDMi302393802.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY253917 mRNA. Translation: AAP69949.1 .
AL109810 Genomic DNA. Translation: CAI19160.1 .
AL109810 Genomic DNA. Translation: CAI19161.1 .
AL109810 Genomic DNA. Translation: CAI19162.1 .
AK126782 mRNA. Translation: BAC86689.1 . Sequence problems.
CCDSi CCDS44333.1. [Q6ZTA4-3 ]
RefSeqi NP_001004342.3. NM_001004342.3. [Q6ZTA4-3 ]
XP_005273195.1. XM_005273138.1. [Q6ZTA4-2 ]
UniGenei Hs.655089.

3D structure databases

ProteinModelPortali Q6ZTA4.
SMRi Q6ZTA4. Positions 1-36, 199-340, 393-450, 512-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000412124.

PTM databases

PhosphoSitei Q6ZTA4.

Polymorphism databases

DMDMi 302393802.

Proteomic databases

PaxDbi Q6ZTA4.
PRIDEi Q6ZTA4.

Protocols and materials databases

DNASUi 440730.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366653 ; ENSP00000355613 ; ENSG00000119283 . [Q6ZTA4-3 ]
ENST00000449018 ; ENSP00000400163 ; ENSG00000119283 . [Q6ZTA4-2 ]
GeneIDi 440730.
KEGGi hsa:440730.
UCSCi uc009xfn.1. human. [Q6ZTA4-3 ]

Organism-specific databases

CTDi 440730.
GeneCardsi GC01P231298.
H-InvDB HIX0001690.
HGNCi HGNC:31859. TRIM67.
HPAi HPA034776.
MIMi 610584. gene.
neXtProti NX_Q6ZTA4.
PharmGKBi PA134947738.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG260378.
HOGENOMi HOG000007387.
HOVERGENi HBG062305.
InParanoidi Q6ZTA4.
KOi K10649.
OMAi LPCARTI.
PhylomeDBi Q6ZTA4.
TreeFami TF315216.

Miscellaneous databases

GenomeRNAii 440730.
NextBioi 109477.
PROi Q6ZTA4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZTA4.
Bgeei Q6ZTA4.
CleanExi HS_TRIM67.
Genevestigatori Q6ZTA4.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view ]
SMARTi SM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding."
    Short K.M., Cox T.C.
    J. Biol. Chem. 281:8970-8980(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
    Tissue: Cerebellum.

Entry informationi

Entry nameiTRI67_HUMAN
AccessioniPrimary (citable) accession number: Q6ZTA4
Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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