Q6ZTA4 (TRI67_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 67

Alternative name(s):
TRIM9-like protein

Gene names

Name:	TRIM67
Synonyms:	TNL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	783 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity. Cytoplasm › cytoskeleton By similarity. Note: Microtubule-associated By similarity.
Sequence similarities	Belongs to the TRIM/RBCC family. Contains 2 B box-type zinc fingers. Contains 1 B30.2/SPRY domain. Contains 1 COS domain. Contains 1 fibronectin type-III domain. Contains 1 RING-type zinc finger.
Sequence caution	The sequence BAC86689.1 differs from that shown. Reason: Probable cloning artifact.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara positive regulation of neuron projection development Inferred from electronic annotation. Source: Compara positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZTA4-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 (identifier: Q6ZTA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     42-81: Missing.
     251-272: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 783	783	Tripartite motif-containing protein 67		PRO_0000256864
Regions
	Domain	448 – 506	59	COS
	Domain	513 – 604	92	Fibronectin type-III
	Domain	589 – 780	192	B30.2/SPRY
	Zinc finger	7 – 42	36	RING-type; degenerate
	Zinc finger	206 – 253	48	B box-type 1; degenerate
	Zinc finger	298 – 340	43	B box-type 2
	Coiled coil	345 – 382	38	Potential
	Compositional bias	59 – 65	7	Poly-Ala
	Compositional bias	74 – 96	23	Gly-rich
	Compositional bias	139 – 142	4	Poly-Ala
	Compositional bias	148 – 156	9	Poly-Ser
	Compositional bias	201 – 206	6	Poly-Ala
	Compositional bias	277 – 280	4	Poly-Gly
Natural variations
	Alternative sequence	42 – 81	40	Missing in isoform 2.		VSP_021359
	Alternative sequence	251 – 272	22	Missing in isoform 2.		VSP_021360
Experimental info
	Sequence conflict	22	1	C → R in BAC86689. Ref.3
	Sequence conflict	679	1	M → V in BAC86689. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 10, 2010. Version 3. Checksum: FC07A0E0B576D821	FASTA	783	83,823
	10 20 30 40 50 60 MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG 70 80 90 100 110 120 AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK 130 140 150 160 170 180 SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR 190 200 210 220 230 240 LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP 250 260 270 280 290 300 SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF 310 320 330 340 350 360 PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD 370 380 390 400 410 420 KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL 430 440 450 460 470 480 KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE 490 500 510 520 530 540 PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT 550 560 570 580 590 600 HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV 610 620 630 640 650 660 VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY 670 680 690 700 710 720 DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG 730 740 750 760 770 780 VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL SGN
	Isoform 2 [UniParc]. Checksum: D999202C92BF23DE	FASTA	721	78,073
	10 20 30 40 50 60 MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GGSAAGGLGG GAGGGGDHAD 70 80 90 100 110 120 KLSLYSETDS GYGSYTPSLK SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP 130 140 150 160 170 180 QCHRSASLDH RGLRGFQRNR LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA 190 200 210 220 230 240 TLCEQCDVLY CSACQLKCHP SRGPFAKHRL GAPSGGGGCK SPGGAGAGAT GGSTARKFPT 250 260 270 280 290 300 CPEHEMENYS MYCVSCRTPV CYLCLEEGRH AKHEVKPLGA MWKQHKAQLS QALNGVSDKA 310 320 330 340 350 360 KEAKEFLVQL KNILQQIQEN GLDYEACLVA QCDALVDALT RQKAKLLTKV TKEREHKLKM 370 380 390 400 410 420 VWDQINHCTL KLRQSTGLME YCLEVIKEND PSGFLQISDA LIKRVQVSQE QWVKGALEPK 430 440 450 460 470 480 VSAEFDLTLD SEPLLQAIHQ LDFIQMKCRV PPVPLLQLEK CCTRNNSVTL AWRMPPFTHS 490 500 510 520 530 540 PVDGYILELD DGAGGQFREV YVGKETLCTI DGLHFNSTYN ARVKAFNSSG VGPYSKTVVL 550 560 570 580 590 600 QTSDVAWFTF DPNSGHRDII LSNDNQTATC SSYDDRVVLG TAAFSKGVHY WELHVDRYDN 610 620 630 640 650 660 HPDPAFGVAR ASVVKDMMLG KDDKAWAMYV DNNRSWFMHC NSHTNRTEGG VCKGATVGVL 670 680 690 700 710 720 LDLNKHTLTF FINGQQQGPT AFSHVDGVFM PALSLNRNVQ VTLHTGLEVP TNLGRPKLSG N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding." Short K.M., Cox T.C. J. Biol. Chem. 281:8970-8980(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1). Tissue: Cerebellum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY253917 mRNA. Translation: AAP69949.1. AL109810 Genomic DNA. Translation: CAI19160.1. AL109810 Genomic DNA. Translation: CAI19161.1. AL109810 Genomic DNA. Translation: CAI19162.1. AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
IPI	IPI00455477. IPI00641288.
RefSeq	NP_001004342.3. NM_001004342.3.
UniGene	Hs.655089.
3D structure databases
HSSP	HSSP built from PDB template 2DB8 based on UniProtKB Q9C026.
ProteinModelPortal	Q6ZTA4.
SMR	Q6ZTA4. Positions 1-36, 199-340, 512-606.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000412124.
PTM databases
PhosphoSite	Q6ZTA4.
Polymorphism databases
DMDM	302393802.
Proteomic databases
PaxDb	Q6ZTA4.
PRIDE	Q6ZTA4.
Protocols and materials databases
DNASU	440730.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366653; ENSP00000355613; ENSG00000119283. ENST00000449018; ENSP00000400163; ENSG00000119283.
GeneID	440730.
KEGG	hsa:440730.
UCSC	uc009xfn.1. human.
Organism-specific databases
CTD	440730.
GeneCards	GC01P231298.
H-InvDB	HIX0001690.
HGNC	HGNC:31859. TRIM67.
HPA	HPA034776.
MIM	610584. gene.
neXtProt	NX_Q6ZTA4.
PharmGKB	PA134947738.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260378.
HOGENOM	HOG000007387.
HOVERGEN	HBG062305.
InParanoid	Q6ZTA4.
KO	K10649.
OMA	LPCSHNV.
Gene expression databases
ArrayExpress	Q6ZTA4.
Bgee	Q6ZTA4.
CleanEx	HS_TRIM67.
Genevestigator	Q6ZTA4.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.40.10. 2 hits.
InterPro	IPR001870. B30.2/SPRY. IPR003649. Bbox_C. IPR008985. ConA-like_lec_gl_sf. IPR017903. COS_domain. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00041. fn3. 1 hit. PF00622. SPRY. 1 hit. PF00643. zf-B_box. 1 hit. [Graphical view]
SMART	SM00502. BBC. 1 hit. SM00336. BBOX. 2 hits. SM00060. FN3. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS51262. COS. 1 hit. PS50853. FN3. 1 hit. PS50119. ZF_BBOX. 2 hits. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	440730.
NextBio	109477.
SOURCE	Search...

Entry information

Entry name

TRI67_HUMAN

Accession

Primary (citable) accession number: Q6ZTA4
Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	August 10, 2010
Last modified:	May 1, 2013
This is version 76 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.