Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6ZTA4 (TRI67_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 67
Alternative name(s):
TRIM9-like protein
Gene names
Name:TRIM67
Synonyms:TNL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length783 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity. Note: Microtubule-associated By similarity.

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 2 B box-type zinc fingers.

Contains 1 B30.2/SPRY domain.

Contains 1 COS domain.

Contains 1 fibronectin type-III domain.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence BAC86689.1 differs from that shown. Reason: Probable cloning artifact.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZTA4-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Gene prediction based on EST data.
Isoform 2 (identifier: Q6ZTA4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     42-81: Missing.
     251-272: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 783783Tripartite motif-containing protein 67
PRO_0000256864

Regions

Domain448 – 50659COS
Domain513 – 60795Fibronectin type-III
Domain589 – 780192B30.2/SPRY
Zinc finger7 – 4236RING-type; degenerate
Zinc finger206 – 25348B box-type 1; degenerate
Zinc finger298 – 34043B box-type 2
Coiled coil345 – 38238 Potential
Compositional bias59 – 657Poly-Ala
Compositional bias74 – 9623Gly-rich
Compositional bias139 – 1424Poly-Ala
Compositional bias148 – 1569Poly-Ser
Compositional bias201 – 2066Poly-Ala
Compositional bias277 – 2804Poly-Gly

Natural variations

Alternative sequence42 – 8140Missing in isoform 2.
VSP_021359
Alternative sequence251 – 27222Missing in isoform 2.
VSP_021360

Experimental info

Sequence conflict221C → R in BAC86689. Ref.3
Sequence conflict6791M → V in BAC86689. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 10, 2010. Version 3.
Checksum: FC07A0E0B576D821

FASTA78383,823
        10         20         30         40         50         60 
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG 

        70         80         90        100        110        120 
AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK 

       130        140        150        160        170        180 
SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR 

       190        200        210        220        230        240 
LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP 

       250        260        270        280        290        300 
SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF 

       310        320        330        340        350        360 
PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD 

       370        380        390        400        410        420 
KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL 

       430        440        450        460        470        480 
KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE 

       490        500        510        520        530        540 
PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT 

       550        560        570        580        590        600 
HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV 

       610        620        630        640        650        660 
VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY 

       670        680        690        700        710        720 
DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG 

       730        740        750        760        770        780 
VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL 


SGN 

« Hide

Isoform 2 [UniParc].

Checksum: D999202C92BF23DE
Show »

FASTA72178,073

References

« Hide 'large scale' references
[1]"Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding."
Short K.M., Cox T.C.
J. Biol. Chem. 281:8970-8980(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
Tissue: Cerebellum.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY253917 mRNA. Translation: AAP69949.1.
AL109810 Genomic DNA. Translation: CAI19160.1.
AL109810 Genomic DNA. Translation: CAI19161.1.
AL109810 Genomic DNA. Translation: CAI19162.1.
AK126782 mRNA. Translation: BAC86689.1. Sequence problems.
CCDSCCDS44333.1. [Q6ZTA4-3]
RefSeqNP_001004342.3. NM_001004342.3. [Q6ZTA4-3]
XP_005273195.1. XM_005273138.1. [Q6ZTA4-2]
UniGeneHs.655089.

3D structure databases

ProteinModelPortalQ6ZTA4.
SMRQ6ZTA4. Positions 1-36, 199-340, 393-450, 512-606.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000412124.

PTM databases

PhosphoSiteQ6ZTA4.

Polymorphism databases

DMDM302393802.

Proteomic databases

PaxDbQ6ZTA4.
PRIDEQ6ZTA4.

Protocols and materials databases

DNASU440730.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
GeneID440730.
KEGGhsa:440730.
UCSCuc009xfn.1. human. [Q6ZTA4-3]

Organism-specific databases

CTD440730.
GeneCardsGC01P231298.
H-InvDBHIX0001690.
HGNCHGNC:31859. TRIM67.
HPAHPA034776.
MIM610584. gene.
neXtProtNX_Q6ZTA4.
PharmGKBPA134947738.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260378.
HOGENOMHOG000007387.
HOVERGENHBG062305.
InParanoidQ6ZTA4.
KOK10649.
OMALPCARTI.
PhylomeDBQ6ZTA4.
TreeFamTF315216.

Gene expression databases

ArrayExpressQ6ZTA4.
BgeeQ6ZTA4.
CleanExHS_TRIM67.
GenevestigatorQ6ZTA4.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.40.10. 2 hits.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003649. Bbox_C.
IPR008985. ConA-like_lec_gl_sf.
IPR017903. COS_domain.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTSM00502. BBC. 1 hit.
SM00336. BBOX. 2 hits.
SM00060. FN3. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS51262. COS. 1 hit.
PS50853. FN3. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi440730.
NextBio109477.
PROQ6ZTA4.
SOURCESearch...

Entry information

Entry nameTRI67_HUMAN
AccessionPrimary (citable) accession number: Q6ZTA4
Secondary accession number(s): Q5TER7, Q5TER8, Q7Z4K7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: August 10, 2010
Last modified: July 9, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM