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Protein

Solute carrier family 25 member 48

Gene

SLC25A48

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.8.8 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 48
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145832.12
HGNCiHGNC:30451 SLC25A48
MIMi616150 gene
neXtProtiNX_Q6ZT89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei189 – 209Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei277 – 295Helical; Name=6Sequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145832
PharmGKBiPA165660536

Polymorphism and mutation databases

BioMutaiSLC25A48

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003257681 – 311Solute carrier family 25 member 48Add BLAST311

Proteomic databases

PaxDbiQ6ZT89
PeptideAtlasiQ6ZT89
PRIDEiQ6ZT89

PTM databases

iPTMnetiQ6ZT89
PhosphoSitePlusiQ6ZT89

Expressioni

Gene expression databases

BgeeiENSG00000145832
ExpressionAtlasiQ6ZT89 baseline and differential
GenevisibleiQ6ZT89 HS

Organism-specific databases

HPAiHPA014674

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi127489, 11 interactors
IntActiQ6ZT89, 13 interactors
STRINGi9606.ENSP00000413049

Structurei

3D structure databases

ProteinModelPortaliQ6ZT89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 86Solcar 1Add BLAST84
Repeati101 – 205Solcar 2Add BLAST105
Repeati214 – 301Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0758 Eukaryota
ENOG410XS86 LUCA
GeneTreeiENSGT00700000104295
HOVERGENiHBG003500
InParanoidiQ6ZT89
KOiK15124
OrthoDBiEOG091G0HVE
PhylomeDBiQ6ZT89
TreeFamiTF351739

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZT89-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSFQLEDFA AGWIGGAASV IVGHPLDTVK TRLQAGVGYG NTLSCIRVVY
60 70 80 90 100
RRESMFGFFK GMSFPLASIA VYNSVVFGVF SNTQRFLSQH RCGEPEASPP
110 120 130 140 150
RTLSDLLLAS MVAGVVSVGL GGPVDLIKIR LQMQTQPFRD ANLGLKSRAV
160 170 180 190 200
APAEQPAYQG PVHCITTIVR NEGLAGLYRG ASAMLLRDVP GYCLYFIPYV
210 220 230 240 250
FLSEWITPEA CTGPSPCAVW LAGGMAGAIS WGTATPMDVV KSRLQADGVY
260 270 280 290 300
LNKYKGVLDC ISQSYQKEGL KVFFRGITVN AVRGFPMSAA MFLGYELSLQ
310
AIRGDHAVTS P
Note: Gene prediction based on similarity to bovine ortholog.
Length:311
Mass (Da):33,440
Last modified:March 18, 2008 - v2
Checksum:iC29F5D3437D267FC
GO
Isoform 2 (identifier: Q6ZT89-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-311: AISWGTATPM...IRGDHAVTSP → KGSSSWSRTP...PQSHPFPMQL

Show »
Length:291
Mass (Da):30,961
Checksum:iB7AC17643A430664
GO
Isoform 3 (identifier: Q6ZT89-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-157: ANLGLKSRAVAPAEQPA → GGEHRMTTVFPGPHLCM
     158-311: Missing.

Show »
Length:157
Mass (Da):16,955
Checksum:i7441D2FF63F03F56
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032397141 – 157ANLGL…AEQPA → GGEHRMTTVFPGPHLCM in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_032398158 – 311Missing in isoform 3. 1 PublicationAdd BLAST154
Alternative sequenceiVSP_032399228 – 311AISWG…AVTSP → KGSSSWSRTPVQATAVGQLG NCHALLSPGGGQDTFRYSPN NSLLGTYSVPGPLPPQSHPF PMQL in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126812 mRNA Translation: BAC86705.1
AC011427 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62205.1
BC025747 mRNA Translation: AAH25747.1
CCDSiCCDS43366.2 [Q6ZT89-3]
RefSeqiNP_660325.4, NM_145282.4 [Q6ZT89-3]
XP_006714609.1, XM_006714546.1 [Q6ZT89-1]
XP_016864575.1, XM_017009086.1
XP_016864576.1, XM_017009087.1 [Q6ZT89-1]
XP_016864577.1, XM_017009088.1 [Q6ZT89-1]
UniGeneiHs.412418
Hs.720329

Genome annotation databases

EnsembliENST00000274513; ENSP00000274513; ENSG00000145832 [Q6ZT89-2]
ENST00000412661; ENSP00000413049; ENSG00000145832 [Q6ZT89-3]
GeneIDi153328
KEGGihsa:153328
UCSCiuc003laz.1 human [Q6ZT89-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS2548_HUMAN
AccessioniPrimary (citable) accession number: Q6ZT89
Secondary accession number(s): Q8TAV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: January 31, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health