ID   TMPPE_HUMAN             Reviewed;         453 AA.
AC   Q6ZT21; B2RNG5; Q6ZRG1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   27-MAR-2024, entry version 129.
DE   RecName: Full=Transmembrane protein with metallophosphoesterase domain;
DE            EC=3.1.-.-;
GN   Name=TMPPE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- INTERACTION:
CC       Q6ZT21; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-11724433, EBI-11522760;
CC       Q6ZT21; P07307-3: ASGR2; NbExp=3; IntAct=EBI-11724433, EBI-12808270;
CC       Q6ZT21; P11912: CD79A; NbExp=3; IntAct=EBI-11724433, EBI-7797864;
CC       Q6ZT21; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-11724433, EBI-11959453;
CC       Q6ZT21; P58418: CLRN1; NbExp=3; IntAct=EBI-11724433, EBI-17274839;
CC       Q6ZT21; P34972: CNR2; NbExp=3; IntAct=EBI-11724433, EBI-2835940;
CC       Q6ZT21; P49447: CYB561; NbExp=3; IntAct=EBI-11724433, EBI-8646596;
CC       Q6ZT21; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-11724433, EBI-3385283;
CC       Q6ZT21; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-11724433, EBI-713304;
CC       Q6ZT21; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11724433, EBI-13345167;
CC       Q6ZT21; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-11724433, EBI-725665;
CC       Q6ZT21; P48051: KCNJ6; NbExp=3; IntAct=EBI-11724433, EBI-12017638;
CC       Q6ZT21; P26715: KLRC1; NbExp=3; IntAct=EBI-11724433, EBI-9018187;
CC       Q6ZT21; Q68G75: LEMD1; NbExp=3; IntAct=EBI-11724433, EBI-12268900;
CC       Q6ZT21; P11836: MS4A1; NbExp=3; IntAct=EBI-11724433, EBI-2808234;
CC       Q6ZT21; Q9Y342: PLLP; NbExp=3; IntAct=EBI-11724433, EBI-3919291;
CC       Q6ZT21; Q8TBJ4: PLPPR1; NbExp=3; IntAct=EBI-11724433, EBI-18063495;
CC       Q6ZT21; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-11724433, EBI-8652812;
CC       Q6ZT21; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-11724433, EBI-7545592;
CC       Q6ZT21; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-11724433, EBI-14065960;
CC       Q6ZT21; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-11724433, EBI-10192441;
CC       Q6ZT21; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-11724433, EBI-10244780;
CC       Q6ZT21; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-11724433, EBI-17247926;
CC       Q6ZT21; Q8TD22: SFXN5; NbExp=3; IntAct=EBI-11724433, EBI-17274136;
CC       Q6ZT21; Q96DU3: SLAMF6; NbExp=3; IntAct=EBI-11724433, EBI-14058448;
CC       Q6ZT21; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-11724433, EBI-9978441;
CC       Q6ZT21; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-11724433, EBI-10226799;
CC       Q6ZT21; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-11724433, EBI-17280858;
CC       Q6ZT21; Q13277: STX3; NbExp=3; IntAct=EBI-11724433, EBI-1394295;
CC       Q6ZT21; Q9UNK0: STX8; NbExp=3; IntAct=EBI-11724433, EBI-727240;
CC       Q6ZT21; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-11724433, EBI-2852148;
CC       Q6ZT21; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-11724433, EBI-11988865;
CC       Q6ZT21; Q15836: VAMP3; NbExp=3; IntAct=EBI-11724433, EBI-722343;
CC       Q6ZT21; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-11724433, EBI-7850136;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZT21-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZT21-2; Sequence=VSP_031858;
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       LOC643853 family. {ECO:0000305}.
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DR   EMBL; AK126979; BAC86774.1; -; mRNA.
DR   EMBL; AK128242; BAC87349.1; -; mRNA.
DR   EMBL; BC136872; AAI36873.1; -; mRNA.
DR   EMBL; BC136873; AAI36874.1; -; mRNA.
DR   CCDS; CCDS33732.1; -. [Q6ZT21-1]
DR   CCDS; CCDS46786.1; -. [Q6ZT21-2]
DR   RefSeq; NP_001034859.2; NM_001039770.2. [Q6ZT21-1]
DR   RefSeq; NP_001129710.1; NM_001136238.1. [Q6ZT21-2]
DR   AlphaFoldDB; Q6ZT21; -.
DR   BioGRID; 569104; 73.
DR   IntAct; Q6ZT21; 58.
DR   MINT; Q6ZT21; -.
DR   STRING; 9606.ENSP00000343398; -.
DR   iPTMnet; Q6ZT21; -.
DR   PhosphoSitePlus; Q6ZT21; -.
DR   SwissPalm; Q6ZT21; -.
DR   BioMuta; TMPPE; -.
DR   DMDM; 190359341; -.
DR   EPD; Q6ZT21; -.
DR   jPOST; Q6ZT21; -.
DR   MassIVE; Q6ZT21; -.
DR   MaxQB; Q6ZT21; -.
DR   PaxDb; 9606-ENSP00000343398; -.
DR   PeptideAtlas; Q6ZT21; -.
DR   ProteomicsDB; 68256; -. [Q6ZT21-1]
DR   ProteomicsDB; 68257; -. [Q6ZT21-2]
DR   Pumba; Q6ZT21; -.
DR   Antibodypedia; 11672; 81 antibodies from 17 providers.
DR   DNASU; 643853; -.
DR   Ensembl; ENST00000342462.5; ENSP00000343398.4; ENSG00000188167.9. [Q6ZT21-1]
DR   Ensembl; ENST00000416695.6; ENSP00000400715.2; ENSG00000188167.9. [Q6ZT21-2]
DR   GeneID; 643853; -.
DR   KEGG; hsa:643853; -.
DR   MANE-Select; ENST00000342462.5; ENSP00000343398.4; NM_001039770.3; NP_001034859.2.
DR   UCSC; uc003cfk.3; human. [Q6ZT21-1]
DR   AGR; HGNC:33865; -.
DR   CTD; 643853; -.
DR   DisGeNET; 643853; -.
DR   GeneCards; TMPPE; -.
DR   HGNC; HGNC:33865; TMPPE.
DR   HPA; ENSG00000188167; Tissue enhanced (bone).
DR   MalaCards; TMPPE; -.
DR   neXtProt; NX_Q6ZT21; -.
DR   OpenTargets; ENSG00000188167; -.
DR   PharmGKB; PA164726564; -.
DR   VEuPathDB; HostDB:ENSG00000188167; -.
DR   eggNOG; ENOG502QRHG; Eukaryota.
DR   GeneTree; ENSGT00390000010260; -.
DR   HOGENOM; CLU_025443_6_0_1; -.
DR   InParanoid; Q6ZT21; -.
DR   OMA; DTHYGPI; -.
DR   OrthoDB; 24482at2759; -.
DR   PhylomeDB; Q6ZT21; -.
DR   TreeFam; TF315106; -.
DR   PathwayCommons; Q6ZT21; -.
DR   SignaLink; Q6ZT21; -.
DR   BioGRID-ORCS; 643853; 12 hits in 1149 CRISPR screens.
DR   GenomeRNAi; 643853; -.
DR   Pharos; Q6ZT21; Tdark.
DR   PRO; PR:Q6ZT21; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q6ZT21; Protein.
DR   Bgee; ENSG00000188167; Expressed in primordial germ cell in gonad and 110 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd07385; MPP_YkuE_C; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR31302:SF0; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN; 1.
DR   PANTHER; PTHR31302; TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Hydrolase; Membrane; Metal-binding;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..453
FT                   /note="Transmembrane protein with metallophosphoesterase
FT                   domain"
FT                   /id="PRO_0000322116"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         214
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         216
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         246
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         246
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         277
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         391
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         393
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         1..137
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_031858"
FT   CONFLICT        209
FT                   /note="I -> V (in Ref. 1; BAC86774)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="H -> R (in Ref. 1; BAC86774)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        347
FT                   /note="H -> R (in Ref. 1; BAC87349)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   453 AA;  49453 MW;  F5455B6801793D68 CRC64;
     MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL FVNSLLLIGS
     LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF FTMFFLVAEE PYLFSLAAYS
     CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG RVVGSLEKTR KLVLRPALAV GVTAVLSVAG
     ILNAAQPPAV KTVEVPIHQL PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI
     TVIVGDLSDS EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
     HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD LDKALEGCSP
     DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL NVAAYLLNPF FAGLYQVAQA
     TFVYVSPGTA YYGIPMRLGS RAEITELILQ RSP
//