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Protein

Transmembrane protein with metallophosphoesterase domain

Gene

TMPPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi214Divalent metal cation 1By similarity1
Metal bindingi216Divalent metal cation 1By similarity1
Metal bindingi246Divalent metal cation 1By similarity1
Metal bindingi246Divalent metal cation 2By similarity1
Metal bindingi277Divalent metal cation 2By similarity1
Metal bindingi391Divalent metal cation 2By similarity1
Metal bindingi393Divalent metal cation 1By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein with metallophosphoesterase domain (EC:3.1.-.-)
Gene namesi
Name:TMPPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:33865. TMPPE.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188167.
PharmGKBiPA164726564.

Polymorphism and mutation databases

BioMutaiTMPPE.
DMDMi190359341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003221161 – 453Transmembrane protein with metallophosphoesterase domainAdd BLAST453

Proteomic databases

EPDiQ6ZT21.
MaxQBiQ6ZT21.
PaxDbiQ6ZT21.
PeptideAtlasiQ6ZT21.
PRIDEiQ6ZT21.

PTM databases

iPTMnetiQ6ZT21.
PhosphoSitePlusiQ6ZT21.
SwissPalmiQ6ZT21.

Expressioni

Gene expression databases

BgeeiENSG00000188167.

Organism-specific databases

HPAiHPA027019.

Interactioni

Protein-protein interaction databases

BioGridi569104. 26 interactors.
IntActiQ6ZT21. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6ZT21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFRM. Eukaryota.
COG1408. LUCA.
GeneTreeiENSGT00390000010260.
HOGENOMiHOG000207216.
InParanoidiQ6ZT21.
OMAiHEYYTSD.
OrthoDBiEOG091G07LC.
PhylomeDBiQ6ZT21.
TreeFamiTF315106.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZT21-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL
60 70 80 90 100
FVNSLLLIGS LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF
110 120 130 140 150
FTMFFLVAEE PYLFSLAAYS CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG
160 170 180 190 200
RVVGSLEKTR KLVLRPALAV GVTAVLSVAG ILNAAQPPAV KTVEVPIHQL
210 220 230 240 250
PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI TVIVGDLSDS
260 270 280 290 300
EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
310 320 330 340 350
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD
360 370 380 390 400
LDKALEGCSP DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL
410 420 430 440 450
NVAAYLLNPF FAGLYQVAQA TFVYVSPGTA YYGIPMRLGS RAEITELILQ

RSP
Length:453
Mass (Da):49,453
Last modified:February 26, 2008 - v2
Checksum:iF5455B6801793D68
GO
Isoform 2 (identifier: Q6ZT21-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):34,078
Checksum:i1226BF591D3C3E44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209I → V in BAC86774 (PubMed:14702039).Curated1
Sequence conflicti266H → R in BAC86774 (PubMed:14702039).Curated1
Sequence conflicti347H → R in BAC87349 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0318581 – 137Missing in isoform 2. 1 PublicationAdd BLAST137

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126979 mRNA. Translation: BAC86774.1.
AK128242 mRNA. Translation: BAC87349.1.
BC136872 mRNA. Translation: AAI36873.1.
BC136873 mRNA. Translation: AAI36874.1.
CCDSiCCDS33732.1. [Q6ZT21-1]
CCDS46786.1. [Q6ZT21-2]
RefSeqiNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
UniGeneiHs.443031.

Genome annotation databases

EnsembliENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
GeneIDi643853.
KEGGihsa:643853.
UCSCiuc003cfk.3. human. [Q6ZT21-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126979 mRNA. Translation: BAC86774.1.
AK128242 mRNA. Translation: BAC87349.1.
BC136872 mRNA. Translation: AAI36873.1.
BC136873 mRNA. Translation: AAI36874.1.
CCDSiCCDS33732.1. [Q6ZT21-1]
CCDS46786.1. [Q6ZT21-2]
RefSeqiNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
UniGeneiHs.443031.

3D structure databases

ProteinModelPortaliQ6ZT21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569104. 26 interactors.
IntActiQ6ZT21. 1 interactor.

PTM databases

iPTMnetiQ6ZT21.
PhosphoSitePlusiQ6ZT21.
SwissPalmiQ6ZT21.

Polymorphism and mutation databases

BioMutaiTMPPE.
DMDMi190359341.

Proteomic databases

EPDiQ6ZT21.
MaxQBiQ6ZT21.
PaxDbiQ6ZT21.
PeptideAtlasiQ6ZT21.
PRIDEiQ6ZT21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
GeneIDi643853.
KEGGihsa:643853.
UCSCiuc003cfk.3. human. [Q6ZT21-1]

Organism-specific databases

CTDi643853.
GeneCardsiTMPPE.
HGNCiHGNC:33865. TMPPE.
HPAiHPA027019.
neXtProtiNX_Q6ZT21.
OpenTargetsiENSG00000188167.
PharmGKBiPA164726564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFRM. Eukaryota.
COG1408. LUCA.
GeneTreeiENSGT00390000010260.
HOGENOMiHOG000207216.
InParanoidiQ6ZT21.
OMAiHEYYTSD.
OrthoDBiEOG091G07LC.
PhylomeDBiQ6ZT21.
TreeFamiTF315106.

Miscellaneous databases

GenomeRNAii643853.
PROiQ6ZT21.

Gene expression databases

BgeeiENSG00000188167.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTMPPE_HUMAN
AccessioniPrimary (citable) accession number: Q6ZT21
Secondary accession number(s): B2RNG5, Q6ZRG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.