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Q6ZT21 (TMPPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein with metallophosphoesterase domain

EC=3.1.-.-
Gene names
Name:TMPPE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

Binds 2 divalent metal cations By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the metallophosphoesterase superfamily. LOC643853 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandMetal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZT21-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZT21-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 453453Transmembrane protein with metallophosphoesterase domain
PRO_0000322116

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane114 – 13421Helical; Potential
Transmembrane162 – 18221Helical; Potential

Sites

Metal binding2141Divalent metal cation 1 By similarity
Metal binding2161Divalent metal cation 1 By similarity
Metal binding2461Divalent metal cation 1 By similarity
Metal binding2461Divalent metal cation 2 By similarity
Metal binding2771Divalent metal cation 2 By similarity
Metal binding3911Divalent metal cation 2 By similarity
Metal binding3931Divalent metal cation 1 By similarity

Natural variations

Alternative sequence1 – 137137Missing in isoform 2.
VSP_031858

Experimental info

Sequence conflict2091I → V in BAC86774. Ref.1
Sequence conflict2661H → R in BAC86774. Ref.1
Sequence conflict3471H → R in BAC87349. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: F5455B6801793D68

FASTA45349,453
        10         20         30         40         50         60 
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL FVNSLLLIGS 

        70         80         90        100        110        120 
LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF FTMFFLVAEE PYLFSLAAYS 

       130        140        150        160        170        180 
CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG RVVGSLEKTR KLVLRPALAV GVTAVLSVAG 

       190        200        210        220        230        240 
ILNAAQPPAV KTVEVPIHQL PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI 

       250        260        270        280        290        300 
TVIVGDLSDS EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL 

       310        320        330        340        350        360 
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD LDKALEGCSP 

       370        380        390        400        410        420 
DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL NVAAYLLNPF FAGLYQVAQA 

       430        440        450 
TFVYVSPGTA YYGIPMRLGS RAEITELILQ RSP 

« Hide

Isoform 2 [UniParc].

Checksum: 1226BF591D3C3E44
Show »

FASTA31634,078

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK126979 mRNA. Translation: BAC86774.1.
AK128242 mRNA. Translation: BAC87349.1.
BC136872 mRNA. Translation: AAI36873.1.
BC136873 mRNA. Translation: AAI36874.1.
CCDSCCDS33732.1. [Q6ZT21-1]
CCDS46786.1. [Q6ZT21-2]
RefSeqNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
UniGeneHs.443031.

3D structure databases

ProteinModelPortalQ6ZT21.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6ZT21.

Polymorphism databases

DMDM190359341.

Proteomic databases

MaxQBQ6ZT21.
PaxDbQ6ZT21.
PRIDEQ6ZT21.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
GeneID643853.
KEGGhsa:643853.
UCSCuc003cfk.2. human. [Q6ZT21-1]

Organism-specific databases

CTD643853.
GeneCardsGC03M033108.
HGNCHGNC:33865. TMPPE.
HPAHPA027019.
neXtProtNX_Q6ZT21.
PharmGKBPA164726564.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1408.
HOGENOMHOG000207216.
InParanoidQ6ZT21.
OMAHEYYTSD.
OrthoDBEOG78SQHW.
PhylomeDBQ6ZT21.
TreeFamTF315106.

Gene expression databases

BgeeQ6ZT21.
GenevestigatorQ6ZT21.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi643853.
NextBio115481.
PROQ6ZT21.

Entry information

Entry nameTMPPE_HUMAN
AccessionPrimary (citable) accession number: Q6ZT21
Secondary accession number(s): B2RNG5, Q6ZRG1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM