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Q6ZT21

- TMPPE_HUMAN

UniProt

Q6ZT21 - TMPPE_HUMAN

Protein

Transmembrane protein with metallophosphoesterase domain

Gene

TMPPE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 2 divalent metal cations.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi214 – 2141Divalent metal cation 1By similarity
    Metal bindingi216 – 2161Divalent metal cation 1By similarity
    Metal bindingi246 – 2461Divalent metal cation 1By similarity
    Metal bindingi246 – 2461Divalent metal cation 2By similarity
    Metal bindingi277 – 2771Divalent metal cation 2By similarity
    Metal bindingi391 – 3911Divalent metal cation 2By similarity
    Metal bindingi393 – 3931Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein with metallophosphoesterase domain (EC:3.1.-.-)
    Gene namesi
    Name:TMPPE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:33865. TMPPE.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164726564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 453453Transmembrane protein with metallophosphoesterase domainPRO_0000322116Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZT21.
    PaxDbiQ6ZT21.
    PRIDEiQ6ZT21.

    PTM databases

    PhosphoSiteiQ6ZT21.

    Expressioni

    Gene expression databases

    BgeeiQ6ZT21.
    GenevestigatoriQ6ZT21.

    Organism-specific databases

    HPAiHPA027019.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZT21.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1408.
    HOGENOMiHOG000207216.
    InParanoidiQ6ZT21.
    OMAiHEYYTSD.
    OrthoDBiEOG78SQHW.
    PhylomeDBiQ6ZT21.
    TreeFamiTF315106.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZT21-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL    50
    FVNSLLLIGS LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF 100
    FTMFFLVAEE PYLFSLAAYS CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG 150
    RVVGSLEKTR KLVLRPALAV GVTAVLSVAG ILNAAQPPAV KTVEVPIHQL 200
    PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI TVIVGDLSDS 250
    EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL 300
    HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD 350
    LDKALEGCSP DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL 400
    NVAAYLLNPF FAGLYQVAQA TFVYVSPGTA YYGIPMRLGS RAEITELILQ 450
    RSP 453
    Length:453
    Mass (Da):49,453
    Last modified:February 26, 2008 - v2
    Checksum:iF5455B6801793D68
    GO
    Isoform 2 (identifier: Q6ZT21-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-137: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:316
    Mass (Da):34,078
    Checksum:i1226BF591D3C3E44
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti209 – 2091I → V in BAC86774. (PubMed:14702039)Curated
    Sequence conflicti266 – 2661H → R in BAC86774. (PubMed:14702039)Curated
    Sequence conflicti347 – 3471H → R in BAC87349. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_031858Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126979 mRNA. Translation: BAC86774.1.
    AK128242 mRNA. Translation: BAC87349.1.
    BC136872 mRNA. Translation: AAI36873.1.
    BC136873 mRNA. Translation: AAI36874.1.
    CCDSiCCDS33732.1. [Q6ZT21-1]
    CCDS46786.1. [Q6ZT21-2]
    RefSeqiNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
    NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
    UniGeneiHs.443031.

    Genome annotation databases

    EnsembliENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
    ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
    GeneIDi643853.
    KEGGihsa:643853.
    UCSCiuc003cfk.2. human. [Q6ZT21-1]

    Polymorphism databases

    DMDMi190359341.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK126979 mRNA. Translation: BAC86774.1 .
    AK128242 mRNA. Translation: BAC87349.1 .
    BC136872 mRNA. Translation: AAI36873.1 .
    BC136873 mRNA. Translation: AAI36874.1 .
    CCDSi CCDS33732.1. [Q6ZT21-1 ]
    CCDS46786.1. [Q6ZT21-2 ]
    RefSeqi NP_001034859.2. NM_001039770.2. [Q6ZT21-1 ]
    NP_001129710.1. NM_001136238.1. [Q6ZT21-2 ]
    UniGenei Hs.443031.

    3D structure databases

    ProteinModelPortali Q6ZT21.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6ZT21.

    Polymorphism databases

    DMDMi 190359341.

    Proteomic databases

    MaxQBi Q6ZT21.
    PaxDbi Q6ZT21.
    PRIDEi Q6ZT21.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342462 ; ENSP00000343398 ; ENSG00000188167 . [Q6ZT21-1 ]
    ENST00000416695 ; ENSP00000400715 ; ENSG00000188167 . [Q6ZT21-2 ]
    GeneIDi 643853.
    KEGGi hsa:643853.
    UCSCi uc003cfk.2. human. [Q6ZT21-1 ]

    Organism-specific databases

    CTDi 643853.
    GeneCardsi GC03M033108.
    HGNCi HGNC:33865. TMPPE.
    HPAi HPA027019.
    neXtProti NX_Q6ZT21.
    PharmGKBi PA164726564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1408.
    HOGENOMi HOG000207216.
    InParanoidi Q6ZT21.
    OMAi HEYYTSD.
    OrthoDBi EOG78SQHW.
    PhylomeDBi Q6ZT21.
    TreeFami TF315106.

    Miscellaneous databases

    GenomeRNAii 643853.
    NextBioi 115481.
    PROi Q6ZT21.

    Gene expression databases

    Bgeei Q6ZT21.
    Genevestigatori Q6ZT21.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

    Entry informationi

    Entry nameiTMPPE_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZT21
    Secondary accession number(s): B2RNG5, Q6ZRG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3