Q6ZT21 (TMPPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein with metallophosphoesterase domain
EC=3.1.-.-

Gene names

Name:

TMPPE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Binds 2 divalent metal cations By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the metallophosphoesterase superfamily. LOC643853 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZT21-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZT21-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Transmembrane protein with metallophosphoesterase domain		PRO_0000322116
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
Sites
	Metal binding	214	1	Divalent metal cation 1 By similarity
	Metal binding	216	1	Divalent metal cation 1 By similarity
	Metal binding	246	1	Divalent metal cation 1 By similarity
	Metal binding	246	1	Divalent metal cation 2 By similarity
	Metal binding	277	1	Divalent metal cation 2 By similarity
	Metal binding	391	1	Divalent metal cation 2 By similarity
	Metal binding	393	1	Divalent metal cation 1 By similarity
Natural variations
	Alternative sequence	1 – 137	137	Missing in isoform 2.		VSP_031858
Experimental info
	Sequence conflict	209	1	I → V in BAC86774. Ref.1
	Sequence conflict	266	1	H → R in BAC86774. Ref.1
	Sequence conflict	347	1	H → R in BAC87349. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: F5455B6801793D68	FASTA	453	49,453
	10 20 30 40 50 60 MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL FVNSLLLIGS 70 80 90 100 110 120 LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF FTMFFLVAEE PYLFSLAAYS 130 140 150 160 170 180 CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG RVVGSLEKTR KLVLRPALAV GVTAVLSVAG 190 200 210 220 230 240 ILNAAQPPAV KTVEVPIHQL PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI 250 260 270 280 290 300 TVIVGDLSDS EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL 310 320 330 340 350 360 HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD LDKALEGCSP 370 380 390 400 410 420 DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL NVAAYLLNPF FAGLYQVAQA 430 440 450 TFVYVSPGTA YYGIPMRLGS RAEITELILQ RSP
	Isoform 2 [UniParc]. Checksum: 1226BF591D3C3E44	FASTA	316	34,078
	10 20 30 40 50 60 MEQAYQLLAW RSGRVVGSLE KTRKLVLRPA LAVGVTAVLS VAGILNAAQP PAVKTVEVPI 70 80 90 100 110 120 HQLPASMNNL KIVLLSDIHL GPTVGRTKME MFVRMVNVLE PDITVIVGDL SDSEASVLRT 130 140 150 160 170 180 AVAPLGQLHS HLGAYFVTGN HEYYTSDVSN WFALLESLHV QPLHNENVKI SATRAQRGGG 190 200 210 220 230 240 GSGSGSEDED WICLAGVDDI EADILHYSGH GMDLDKALEG CSPDHTIILL AHQPLAAKRA 250 260 270 280 290 300 LQARPDINLI LSGHTHAGQI FPLNVAAYLL NPFFAGLYQV AQATFVYVSP GTAYYGIPMR 310 LGSRAEITEL ILQRSP

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Testis.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK126979 mRNA. Translation: BAC86774.1. AK128242 mRNA. Translation: BAC87349.1. BC136872 mRNA. Translation: AAI36873.1. BC136873 mRNA. Translation: AAI36874.1.
IPI	IPI00418754. IPI00885142.
RefSeq	NP_001034859.2. NM_001039770.2. NP_001129710.1. NM_001136238.1.
UniGene	Hs.443031.
3D structure databases
ProteinModelPortal	Q6ZT21.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000343398.
PTM databases
PhosphoSite	Q6ZT21.
Polymorphism databases
DMDM	190359341.
Proteomic databases
PaxDb	Q6ZT21.
PRIDE	Q6ZT21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342462; ENSP00000343398; ENSG00000188167. ENST00000416695; ENSP00000400715; ENSG00000188167.
GeneID	643853.
KEGG	hsa:643853.
UCSC	uc003cfk.2. human.
Organism-specific databases
CTD	643853.
GeneCards	GC03M033108.
HGNC	HGNC:33865. TMPPE.
HPA	HPA027019.
neXtProt	NX_Q6ZT21.
PharmGKB	PA164726564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1408.
HOGENOM	HOG000207216.
InParanoid	Q6ZT21.
OMA	HEYYTSD.
PhylomeDB	Q6ZT21.
Gene expression databases
Bgee	Q6ZT21.
Genevestigator	Q6ZT21.
Family and domain databases
InterPro	IPR004843. Metallo_PEstase_dom. [Graphical view]
Pfam	PF00149. Metallophos. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	643853.
NextBio	115481.

Entry information

Entry name

TMPPE_HUMAN

Accession

Primary (citable) accession number: Q6ZT21
Secondary accession number(s): B2RNG5, Q6ZRG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.