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Protein

Transmembrane protein with metallophosphoesterase domain

Gene

TMPPE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi214 – 2141Divalent metal cation 1By similarity
Metal bindingi216 – 2161Divalent metal cation 1By similarity
Metal bindingi246 – 2461Divalent metal cation 1By similarity
Metal bindingi246 – 2461Divalent metal cation 2By similarity
Metal bindingi277 – 2771Divalent metal cation 2By similarity
Metal bindingi391 – 3911Divalent metal cation 2By similarity
Metal bindingi393 – 3931Divalent metal cation 1By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein with metallophosphoesterase domain (EC:3.1.-.-)
Gene namesi
Name:TMPPE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:33865. TMPPE.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Transmembrane protein with metallophosphoesterase domainPRO_0000322116Add
BLAST

Proteomic databases

MaxQBiQ6ZT21.
PaxDbiQ6ZT21.
PRIDEiQ6ZT21.

PTM databases

PhosphoSiteiQ6ZT21.

Expressioni

Gene expression databases

BgeeiQ6ZT21.
GenevestigatoriQ6ZT21.

Organism-specific databases

HPAiHPA027019.

Interactioni

Protein-protein interaction databases

BioGridi569104. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZT21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1408.
GeneTreeiENSGT00390000010260.
HOGENOMiHOG000207216.
InParanoidiQ6ZT21.
OMAiHEYYTSD.
OrthoDBiEOG78SQHW.
PhylomeDBiQ6ZT21.
TreeFamiTF315106.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZT21-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL
60 70 80 90 100
FVNSLLLIGS LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF
110 120 130 140 150
FTMFFLVAEE PYLFSLAAYS CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG
160 170 180 190 200
RVVGSLEKTR KLVLRPALAV GVTAVLSVAG ILNAAQPPAV KTVEVPIHQL
210 220 230 240 250
PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI TVIVGDLSDS
260 270 280 290 300
EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
310 320 330 340 350
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD
360 370 380 390 400
LDKALEGCSP DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL
410 420 430 440 450
NVAAYLLNPF FAGLYQVAQA TFVYVSPGTA YYGIPMRLGS RAEITELILQ

RSP
Length:453
Mass (Da):49,453
Last modified:February 26, 2008 - v2
Checksum:iF5455B6801793D68
GO
Isoform 2 (identifier: Q6ZT21-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Note: No experimental confirmation available.

Show »
Length:316
Mass (Da):34,078
Checksum:i1226BF591D3C3E44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091I → V in BAC86774. (PubMed:14702039)Curated
Sequence conflicti266 – 2661H → R in BAC86774. (PubMed:14702039)Curated
Sequence conflicti347 – 3471H → R in BAC87349. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 137137Missing in isoform 2. 1 PublicationVSP_031858Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126979 mRNA. Translation: BAC86774.1.
AK128242 mRNA. Translation: BAC87349.1.
BC136872 mRNA. Translation: AAI36873.1.
BC136873 mRNA. Translation: AAI36874.1.
CCDSiCCDS33732.1. [Q6ZT21-1]
CCDS46786.1. [Q6ZT21-2]
RefSeqiNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
UniGeneiHs.443031.

Genome annotation databases

EnsembliENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
GeneIDi643853.
KEGGihsa:643853.
UCSCiuc003cfk.2. human. [Q6ZT21-1]

Polymorphism databases

DMDMi190359341.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126979 mRNA. Translation: BAC86774.1.
AK128242 mRNA. Translation: BAC87349.1.
BC136872 mRNA. Translation: AAI36873.1.
BC136873 mRNA. Translation: AAI36874.1.
CCDSiCCDS33732.1. [Q6ZT21-1]
CCDS46786.1. [Q6ZT21-2]
RefSeqiNP_001034859.2. NM_001039770.2. [Q6ZT21-1]
NP_001129710.1. NM_001136238.1. [Q6ZT21-2]
UniGeneiHs.443031.

3D structure databases

ProteinModelPortaliQ6ZT21.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569104. 10 interactions.

PTM databases

PhosphoSiteiQ6ZT21.

Polymorphism databases

DMDMi190359341.

Proteomic databases

MaxQBiQ6ZT21.
PaxDbiQ6ZT21.
PRIDEiQ6ZT21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342462; ENSP00000343398; ENSG00000188167. [Q6ZT21-1]
ENST00000416695; ENSP00000400715; ENSG00000188167. [Q6ZT21-2]
GeneIDi643853.
KEGGihsa:643853.
UCSCiuc003cfk.2. human. [Q6ZT21-1]

Organism-specific databases

CTDi643853.
GeneCardsiGC03M033108.
HGNCiHGNC:33865. TMPPE.
HPAiHPA027019.
neXtProtiNX_Q6ZT21.
PharmGKBiPA164726564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1408.
GeneTreeiENSGT00390000010260.
HOGENOMiHOG000207216.
InParanoidiQ6ZT21.
OMAiHEYYTSD.
OrthoDBiEOG78SQHW.
PhylomeDBiQ6ZT21.
TreeFamiTF315106.

Miscellaneous databases

GenomeRNAii643853.
NextBioi115481.
PROiQ6ZT21.

Gene expression databases

BgeeiQ6ZT21.
GenevestigatoriQ6ZT21.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Entry informationi

Entry nameiTMPPE_HUMAN
AccessioniPrimary (citable) accession number: Q6ZT21
Secondary accession number(s): B2RNG5, Q6ZRG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.