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Protein

TBC1 domain family member 9

Gene

TBC1D9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei562 – 5621Arginine fingerBy similarity
Sitei601 – 6011Glutamine fingerBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 9
Alternative name(s):
TBC1 domain family member 9A
Gene namesi
Name:TBC1D9
Synonyms:KIAA0882, TBC1D9A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:21710. TBC1D9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394607.

Polymorphism and mutation databases

BioMutaiTBC1D9.
DMDMi148887054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12661266TBC1 domain family member 9PRO_0000288499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021PhosphothreonineBy similarity
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei441 – 4411PhosphoserineBy similarity
Modified residuei471 – 4711PhosphoserineBy similarity
Modified residuei1257 – 12571PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZT07.
MaxQBiQ6ZT07.
PaxDbiQ6ZT07.
PeptideAtlasiQ6ZT07.
PRIDEiQ6ZT07.

PTM databases

iPTMnetiQ6ZT07.
PhosphoSiteiQ6ZT07.

Expressioni

Gene expression databases

BgeeiENSG00000109436.
CleanExiHS_TBC1D9.
GenevisibleiQ6ZT07. HS.

Organism-specific databases

HPAiHPA000262.
HPA006503.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116771. 19 interactions.
IntActiQ6ZT07. 7 interactions.
STRINGi9606.ENSP00000411197.

Structurei

3D structure databases

ProteinModelPortaliQ6ZT07.
SMRiQ6ZT07. Positions 473-731, 812-936.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 21368GRAM 1Add
BLAST
Domaini293 – 36169GRAM 2Add
BLAST
Domaini515 – 702188Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST
Domaini886 – 92136EF-handPROSITE-ProRule annotationAdd
BLAST

Domaini

The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site.By similarity

Sequence similaritiesi

Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 2 GRAM domains.Curated
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000276905.
HOVERGENiHBG054142.
InParanoidiQ6ZT07.
KOiK19951.
OMAiFQTPIQI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ6ZT07.
TreeFamiTF313145.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZT07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWVNPEEVLL ANALWITERA NPYFILQRRK GHAGDGGGGG GLAGLLVGTL
60 70 80 90 100
DVVLDSSARV APYRILYQTP DSLVYWTIAC GGSRKEITEH WEWLEQNLLQ
110 120 130 140 150
TLSIFENEND ITTFVRGKIQ GIIAEYNKIN DVKEDDDTEK FKEAIVKFHR
160 170 180 190 200
LFGMPEEEKL VNYYSCSYWK GKVPRQGWMY LSINHLCFYS FLMGREAKLV
210 220 230 240 250
IRWVDITQLE KNATLLLPDV IKVSTRSSEH FFSVFLNINE TFKLMEQLAN
260 270 280 290 300
IAMRQLLDNE GFEQDRSLPK LKRKSPKKVS ALKRDLDARA KSERYRALFR
310 320 330 340 350
LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP
360 370 380 390 400
LREVTIVEKA DSSSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ
410 420 430 440 450
QTTSKIYSDK EFAGSYNSSD DEVYSRPSSL VSSSPQRSTS SDADGERQFN
460 470 480 490 500
LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA KEFLKEQAWK IHFAEYGQGI
510 520 530 540 550
CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG YYEDLVEKSM
560 570 580 590 600
GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
610 620 630 640 650
QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE
660 670 680 690 700
ELARDYVPQL YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY
710 720 730 740 750
EGIKVIFQLA LAVLDANVDK LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP
760 770 780 790 800
IPHLHSLLSD DVEPYPEVDI FRLIRTSYEK FGTIRADLIE QMRFKQRLKV
810 820 830 840 850
IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT SCYWGGSSNA
860 870 880 890 900
LDRHDPSLPY LEQYRIDFEQ FKGMFALLFP WACGTHSDVL ASRLFQLLDE
910 920 930 940 950
NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS SDQDEPDSAF
960 970 980 990 1000
EATQYFFEDI TPECTHVVGL DSRSKQGADD GFVTVSLKPD KGKRANSQEN
1010 1020 1030 1040 1050
RNYLRLWTPE NKSKSKNAKD LPKLNQGQFI ELCKTMYNMF SEDPNEQELY
1060 1070 1080 1090 1100
HATAAVTSLL LEIGEVGKLF VAQPAKEGGS GGSGPSCHQG IPGVLFPKKG
1110 1120 1130 1140 1150
PGQPYVVESV EPLPASLAPD SEEHSLGGQM EDIKLEDSSP RDNGACSSML
1160 1170 1180 1190 1200
ISDDDTKDDS SMSSYSVLSA GSHEEDKLHC EDIGEDTVLV RSGQGTAALP
1210 1220 1230 1240 1250
RSTSLDRDWA ITFEQFLASL LTEPALVKYF DKPVCMMARI TSAKNIRMMG
1260
KPLTSASDYE ISAMSG
Length:1,266
Mass (Da):143,229
Last modified:May 29, 2007 - v2
Checksum:i4A300EE192685088
GO

Sequence cautioni

The sequence BAA74905 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC86789 differs from that shown.Aberrant splicing.Curated
The sequence BAC86789 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1204 – 12041S → G in BAC86789 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71E → K.
Corresponds to variant rs13108827 [ dbSNP | Ensembl ].
VAR_052539
Natural varianti779 – 7791E → K.
Corresponds to variant rs13118702 [ dbSNP | Ensembl ].
VAR_052540

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449892 mRNA. Translation: BAH16635.1.
AB020689 mRNA. Translation: BAA74905.2. Different initiation.
CH471056 Genomic DNA. Translation: EAX05092.1.
CH471056 Genomic DNA. Translation: EAX05094.1.
BC146758 mRNA. Translation: AAI46759.1.
AK127020 mRNA. Translation: BAC86789.1. Sequence problems.
CCDSiCCDS47136.1.
RefSeqiNP_055945.2. NM_015130.2.
UniGeneiHs.480819.
Hs.595450.

Genome annotation databases

EnsembliENST00000442267; ENSP00000411197; ENSG00000109436.
GeneIDi23158.
KEGGihsa:23158.
UCSCiuc010ioj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449892 mRNA. Translation: BAH16635.1.
AB020689 mRNA. Translation: BAA74905.2. Different initiation.
CH471056 Genomic DNA. Translation: EAX05092.1.
CH471056 Genomic DNA. Translation: EAX05094.1.
BC146758 mRNA. Translation: AAI46759.1.
AK127020 mRNA. Translation: BAC86789.1. Sequence problems.
CCDSiCCDS47136.1.
RefSeqiNP_055945.2. NM_015130.2.
UniGeneiHs.480819.
Hs.595450.

3D structure databases

ProteinModelPortaliQ6ZT07.
SMRiQ6ZT07. Positions 473-731, 812-936.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116771. 19 interactions.
IntActiQ6ZT07. 7 interactions.
STRINGi9606.ENSP00000411197.

PTM databases

iPTMnetiQ6ZT07.
PhosphoSiteiQ6ZT07.

Polymorphism and mutation databases

BioMutaiTBC1D9.
DMDMi148887054.

Proteomic databases

EPDiQ6ZT07.
MaxQBiQ6ZT07.
PaxDbiQ6ZT07.
PeptideAtlasiQ6ZT07.
PRIDEiQ6ZT07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442267; ENSP00000411197; ENSG00000109436.
GeneIDi23158.
KEGGihsa:23158.
UCSCiuc010ioj.4. human.

Organism-specific databases

CTDi23158.
GeneCardsiTBC1D9.
HGNCiHGNC:21710. TBC1D9.
HPAiHPA000262.
HPA006503.
neXtProtiNX_Q6ZT07.
PharmGKBiPA128394607.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4347. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000276905.
HOVERGENiHBG054142.
InParanoidiQ6ZT07.
KOiK19951.
OMAiFQTPIQI.
OrthoDBiEOG091G00RI.
PhylomeDBiQ6ZT07.
TreeFamiTF313145.

Miscellaneous databases

ChiTaRSiTBC1D9. human.
GeneWikiiTBC1D9.
GenomeRNAii23158.
PROiQ6ZT07.

Gene expression databases

BgeeiENSG00000109436.
CleanExiHS_TBC1D9.
GenevisibleiQ6ZT07. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR004182. GRAM.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF02893. GRAM. 2 hits.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF47923. SSF47923. 2 hits.
PROSITEiPS50222. EF_HAND_2. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBCD9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZT07
Secondary accession number(s): A6H8U8, D3DNZ1, O94958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.