Reviewed, UniProtKB/Swiss-Prot Q6ZSZ5 (ARHGI_HUMAN)

Names and origin

Protein names

Recommended name:
    Rho guanine nucleotide exchange factor 18
Alternative name(s):
    114 kDa Rho-specific guanine nucleotide exchange factor
    p114-Rho-GEF
      Short name=p114RhoGEF
    Septin-associated RhoGEF
      Short name=SA-RhoGEF

Gene names

Name:	ARHGEF18
Synonyms:	KIAA0521

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Ref.4 Ref.6 Ref.7
Subunit structure	Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2. Ref.6 Ref.7
Subcellular location	Cytoplasm. Note: Colocalizes with actin stress fibers. Ref.7
Tissue specificity	Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis. Ref.4 Ref.6 Ref.7
Sequence similarities	Contains 1 DH (DBL-homology) domain. Contains 1 PH domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Guanine-nucleotide releasing factor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Ref.6 Inferred from direct assay. Source: MGI apoptosis Inferred from Experiment. Source: Reactome induction of apoptosis by extracellular signals Inferred from Experiment. Source: Reactome regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro regulation of cell shape Ref.6 Inferred from direct assay. Source: MGI small GTPase mediated signal transduction Ref.6 Inferred from direct assay. Source: MGI
Cellular component	cytosol Inferred from Experiment. Source: Reactome
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZSZ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZSZ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.

Isoform 3 (identifier: Q6ZSZ5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.
     1157-1173: TPLSAKEDASKEDVIFF → RWRRQHLSPESGRIHFPNRAPRRFTMNLRVRE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1173	1173	Rho guanine nucleotide exchange factor 18		PRO_0000341415
Regions
	Domain	259 – 456	198	DH
	Domain	496 – 598	103	PH
	Coiled coil	799 – 819	21	Potential
	Coiled coil	850 – 960	111	Potential
	Compositional bias	1104 – 1158	55	Pro-rich
Amino acid modifications
	Modified residue	209	1	Phosphoserine Ref.9
	Modified residue	212	1	Phosphothreonine Ref.9
	Modified residue	733	1	Phosphoserine Ref.9
	Modified residue	1101	1	Phosphoserine Ref.9
	Modified residue	1103	1	Phosphoserine Ref.9 Ref.8
	Modified residue	1124	1	Phosphoserine Ref.9
	Modified residue	1130	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 158	158	Missing in isoform 2 and isoform 3.		VSP_034315
	Alternative sequence	1157 – 1173	17	TPLSA…DVIFF → RWRRQHLSPESGRIHFPNRA PRRFTMNLRVRE in isoform 3.		VSP_034316
	Natural variant	701	1	R → Q: dbSNP rs2287918. Ref.2		VAR_044066
	Natural variant	752	1	R → Q: dbSNP rs2287920.		VAR_044067
Experimental info
	Sequence conflict	183	1	I → V in BAC86801. Ref.2
	Sequence conflict	1019	1	S → N in BAC86801. Ref.2
	Sequence conflict	1107	1	P → S in BAC86801. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: E8AEE8754577655E	FASTA	1,173	130,814
	10 20 30 40 50 60 MVTVGTNILP SRPAASANTA REDAALFSRR IPPRHKNGAA QPGAAPGPGA PGANMGNAHS 70 80 90 100 110 120 KSGDRHSALP GRPELSFYGS FPRKWSENVF LDNELLTSKI LSMLRPQSER GFRAGDLRYP 130 140 150 160 170 180 THFLSTNSVL ASVTASLKEH PRGTLLSDGS PALSRNVGMT VSQKGGPQPT PSPAGPGTQL 190 200 210 220 230 240 GPITGEMDEA DSAFLKFKQT ADDSLSLTSP NTESIFVEDP YTASLRSEIE SDGHEFEAES 250 260 270 280 290 300 WSLAVDAAYA KKQKREVVKR QDVLYELMQT EVHHVRTLKI MLKVYSRALQ EELQFSSKAI 310 320 330 340 350 360 GRLFPCADDL LETHSHFLAR LKERRQESLE EGSDRNYVIQ KIGDLLVQQF SGENGERMKE 370 380 390 400 410 420 KYGVFCSGHN EAVSHYKLLL QQNKKFQNLI KKIGNFSIVR RLGVQECILL VTQRITKYPV 430 440 450 460 470 480 LVERIIQNTE AGTEDYEDLT QALNLIKDII SQVDAKVSEC EKGQRLREIA GKMDLKSSSK 490 500 510 520 530 540 LKNGLTFRKE DMLQRQLHLE GMLCWKTTSG RLKDILAILL TDVLLLLQEK DQKYVFASVD 550 560 570 580 590 600 SKPPVISLQK LIVREVANEE KAMFLISASL QGPEMYEIYT SSKEDRNAWM AHIQRAVESC 610 620 630 640 650 660 PDEEEGPFSL PEEERKVVEA RATRLRDFQE RLSMKDQLIA QSLLEKQQIY LEMAEMGGLE 670 680 690 700 710 720 DLPQPRGLFR GGDPSETLQG ELILKSAMSE IEGIQSLICR RLGSANGQAE DGGSSTGPPR 730 740 750 760 770 780 RAETFAGYDC TNSPTKNGSF KKKVSSTDPR PRDWRGPPNS PDLKLSDSDI PGSSEESPQV 790 800 810 820 830 840 VEAPGTESDP RLPTVLESEL VQRIQTLSQL LLNLQAVIAH QDSYVETQRA AIQEREKQFR 850 860 870 880 890 900 LQSTRGNLLL EQERQRNFEK QREERAALEK LQSQLRHEQQ RWERERQWQH QELERAGARL 910 920 930 940 950 960 QEREGEARQL RERLEQERAE LERQRQAYQH DLERLREAQR AVERERERLE LLRRLKKQNT 970 980 990 1000 1010 1020 APGALPPDTL AEAQPPSHPP SFNGEGLEGP RVSMLPSGVG PEYAERPEVA RRDSAPTESR 1030 1040 1050 1060 1070 1080 LAKSDVPIQL LSATNQFQRQ AAVQQQIPTK LAASTKGGKD KGGKSRGSQR WESSASFDLK 1090 1100 1110 1120 1130 1140 QQLLLNKLMG KDESTSRNRR SLSPILPGRH SPAPPPDPGF PAPSPPPADS PSEGFSLKAG 1150 1160 1170 GTALLPGPPA PSPLPATPLS AKEDASKEDV IFF
	Isoform 2. Checksum: 7785510A2D8BB86B	FASTA	1,015	114,078
	10 20 30 40 50 60 MTVSQKGGPQ PTPSPAGPGT QLGPITGEMD EADSAFLKFK QTADDSLSLT SPNTESIFVE 70 80 90 100 110 120 DPYTASLRSE IESDGHEFEA ESWSLAVDAA YAKKQKREVV KRQDVLYELM QTEVHHVRTL 130 140 150 160 170 180 KIMLKVYSRA LQEELQFSSK AIGRLFPCAD DLLETHSHFL ARLKERRQES LEEGSDRNYV 190 200 210 220 230 240 IQKIGDLLVQ QFSGENGERM KEKYGVFCSG HNEAVSHYKL LLQQNKKFQN LIKKIGNFSI 250 260 270 280 290 300 VRRLGVQECI LLVTQRITKY PVLVERIIQN TEAGTEDYED LTQALNLIKD IISQVDAKVS 310 320 330 340 350 360 ECEKGQRLRE IAGKMDLKSS SKLKNGLTFR KEDMLQRQLH LEGMLCWKTT SGRLKDILAI 370 380 390 400 410 420 LLTDVLLLLQ EKDQKYVFAS VDSKPPVISL QKLIVREVAN EEKAMFLISA SLQGPEMYEI 430 440 450 460 470 480 YTSSKEDRNA WMAHIQRAVE SCPDEEEGPF SLPEEERKVV EARATRLRDF QERLSMKDQL 490 500 510 520 530 540 IAQSLLEKQQ IYLEMAEMGG LEDLPQPRGL FRGGDPSETL QGELILKSAM SEIEGIQSLI 550 560 570 580 590 600 CRRLGSANGQ AEDGGSSTGP PRRAETFAGY DCTNSPTKNG SFKKKVSSTD PRPRDWRGPP 610 620 630 640 650 660 NSPDLKLSDS DIPGSSEESP QVVEAPGTES DPRLPTVLES ELVQRIQTLS QLLLNLQAVI 670 680 690 700 710 720 AHQDSYVETQ RAAIQEREKQ FRLQSTRGNL LLEQERQRNF EKQREERAAL EKLQSQLRHE 730 740 750 760 770 780 QQRWERERQW QHQELERAGA RLQEREGEAR QLRERLEQER AELERQRQAY QHDLERLREA 790 800 810 820 830 840 QRAVERERER LELLRRLKKQ NTAPGALPPD TLAEAQPPSH PPSFNGEGLE GPRVSMLPSG 850 860 870 880 890 900 VGPEYAERPE VARRDSAPTE SRLAKSDVPI QLLSATNQFQ RQAAVQQQIP TKLAASTKGG 910 920 930 940 950 960 KDKGGKSRGS QRWESSASFD LKQQLLLNKL MGKDESTSRN RRSLSPILPG RHSPAPPPDP 970 980 990 1000 1010 GFPAPSPPPA DSPSEGFSLK AGGTALLPGP PAPSPLPATP LSAKEDASKE DVIFF
	Isoform 3. Checksum: E61F0B32B90FCA5E	FASTA	1,030	116,238
	10 20 30 40 50 60 MTVSQKGGPQ PTPSPAGPGT QLGPITGEMD EADSAFLKFK QTADDSLSLT SPNTESIFVE 70 80 90 100 110 120 DPYTASLRSE IESDGHEFEA ESWSLAVDAA YAKKQKREVV KRQDVLYELM QTEVHHVRTL 130 140 150 160 170 180 KIMLKVYSRA LQEELQFSSK AIGRLFPCAD DLLETHSHFL ARLKERRQES LEEGSDRNYV 190 200 210 220 230 240 IQKIGDLLVQ QFSGENGERM KEKYGVFCSG HNEAVSHYKL LLQQNKKFQN LIKKIGNFSI 250 260 270 280 290 300 VRRLGVQECI LLVTQRITKY PVLVERIIQN TEAGTEDYED LTQALNLIKD IISQVDAKVS 310 320 330 340 350 360 ECEKGQRLRE IAGKMDLKSS SKLKNGLTFR KEDMLQRQLH LEGMLCWKTT SGRLKDILAI 370 380 390 400 410 420 LLTDVLLLLQ EKDQKYVFAS VDSKPPVISL QKLIVREVAN EEKAMFLISA SLQGPEMYEI 430 440 450 460 470 480 YTSSKEDRNA WMAHIQRAVE SCPDEEEGPF SLPEEERKVV EARATRLRDF QERLSMKDQL 490 500 510 520 530 540 IAQSLLEKQQ IYLEMAEMGG LEDLPQPRGL FRGGDPSETL QGELILKSAM SEIEGIQSLI 550 560 570 580 590 600 CRRLGSANGQ AEDGGSSTGP PRRAETFAGY DCTNSPTKNG SFKKKVSSTD PRPRDWRGPP 610 620 630 640 650 660 NSPDLKLSDS DIPGSSEESP QVVEAPGTES DPRLPTVLES ELVQRIQTLS QLLLNLQAVI 670 680 690 700 710 720 AHQDSYVETQ RAAIQEREKQ FRLQSTRGNL LLEQERQRNF EKQREERAAL EKLQSQLRHE 730 740 750 760 770 780 QQRWERERQW QHQELERAGA RLQEREGEAR QLRERLEQER AELERQRQAY QHDLERLREA 790 800 810 820 830 840 QRAVERERER LELLRRLKKQ NTAPGALPPD TLAEAQPPSH PPSFNGEGLE GPRVSMLPSG 850 860 870 880 890 900 VGPEYAERPE VARRDSAPTE SRLAKSDVPI QLLSATNQFQ RQAAVQQQIP TKLAASTKGG 910 920 930 940 950 960 KDKGGKSRGS QRWESSASFD LKQQLLLNKL MGKDESTSRN RRSLSPILPG RHSPAPPPDP 970 980 990 1000 1010 1020 GFPAPSPPPA DSPSEGFSLK AGGTALLPGP PAPSPLPARW RRQHLSPESG RIHFPNRAPR 1030 RFTMNLRVRE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed: 9628581] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-701. Tissue: Brain.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Lymph.
[4]	"Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor." Blomquist A., Schwoerer G., Schablowski H., Psoma A., Lehnen M., Jakobs K.H., Ruemenapp U. Biochem. J. 352:319-325(2000) [PubMed: 11085924] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]	"A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2." Acierno J.S. Jr., Kennedy J.C., Falardeau J.L., Leyne M., Bromley M.C., Colman M.W., Sun M., Bove C., Ashworth L.K., Chadwick L.H., Schiripo T., Ma S., Goldin E., Schiffmann R., Slaugenhaupt S.A. Genomics 73:203-210(2001) [PubMed: 11318610] [Abstract] Cited for: IDENTIFICATION.
[6]	"G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production." Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T. Circ. Res. 93:848-856(2003) [PubMed: 14512443] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH GNB1 AND GNG2.
[7]	"Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin." Nagata K., Inagaki M. Oncogene 24:65-76(2005) [PubMed: 15558029] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SEPT9.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1103, MASS SPECTROMETRY.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209; THR-212; SER-733; SER-1101; SER-1103; SER-1124 AND SER-1130, MASS SPECTROMETRY.
[10]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[11]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1103, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB011093 mRNA. Translation: BAA25447.1. Different initiation. AK127045 mRNA. Translation: BAC86801.1. BC077721 mRNA. Translation: AAH77721.1.
IPI	IPI00179437. IPI00480141. IPI00895907.
RefSeq	NP_001124427.1. NP_056133.2.
UniGene	Hs.465761
3D structure databases
HSSP	HSSP built from PDB template 1XCG based on UniProtKB O15085.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ZSZ5.
PTM databases
PhosphoSite	Q6ZSZ5.
Proteomic databases
PRIDE	Q6ZSZ5.
Genome annotation databases
Ensembl	ENST00000359920; ENSP00000352995; ENSG00000104880; Homo sapiens. [Genome view]
GeneID	23370.
KEGG	hsa:23370.
UCSC	uc002mgg.1. human.
Organism-specific databases
CTD	23370.
GeneCards	GC19P007351. GC19P007352.
HGNC	HGNC:17090. ARHGEF18.
PharmGKB	PA128394630.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG444567.
HOVERGEN	Q6ZSZ5.
InParanoid	Q6ZSZ5.
Enzyme and pathway databases
Reactome	REACT_11044. Signaling by Rho GTPases. REACT_11061. Signalling by NGF. REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q6ZSZ5.
Bgee	Q6ZSZ5.
CleanEx	HS_ARHGEF18.
Genevestigator	Q6ZSZ5.
Family and domain databases
InterPro	IPR000219. DH-domain. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR015721. RhoGEF-like. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
PANTHER	PTHR22825. RhoGEF_like. 1 hit.
Pfam	PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
PROSITE	PS00741. DH_1. False negative. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	45444.

Entry information

Entry name

ARHGI_HUMAN

Accession

Primary (citable) accession number: Q6ZSZ5
Secondary accession number(s): O60274, Q6DD92

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	December 15, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.