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Q6ZSZ5

- ARHGI_HUMAN

UniProt

Q6ZSZ5 - ARHGI_HUMAN

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Protein
Rho guanine nucleotide exchange factor 18
Gene
ARHGEF18, KIAA0521
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.3 Publications

GO - Molecular functioni

  1. Rho guanyl-nucleotide exchange factor activity Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

  1. actin cytoskeleton organization Source: MGI
  2. apoptotic signaling pathway Source: Reactome
  3. neurotrophin TRK receptor signaling pathway Source: Reactome
  4. positive regulation of apoptotic process Source: Reactome
  5. regulation of GTPase activity Source: GOC
  6. regulation of cell shape Source: MGI
  7. regulation of small GTPase mediated signal transduction Source: Reactome
  8. small GTPase mediated signal transduction Source: MGI
  9. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiREACT_11051. Rho GTPase cycle.
REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 18
Alternative name(s):
114 kDa Rho-specific guanine nucleotide exchange factor
Short name:
p114-Rho-GEF
Short name:
p114RhoGEF
Septin-associated RhoGEF
Short name:
SA-RhoGEF
Gene namesi
Synonyms:KIAA0521
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:17090. ARHGEF18.

Subcellular locationi

Cytoplasm
Note: Colocalizes with actin stress fibers.1 Publication

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. cell junction Source: Reactome
  3. cytoplasm Source: HPA
  4. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11731173Rho guanine nucleotide exchange factor 18
PRO_0000341415Add
BLAST

Proteomic databases

MaxQBiQ6ZSZ5.
PaxDbiQ6ZSZ5.
PRIDEiQ6ZSZ5.

PTM databases

PhosphoSiteiQ6ZSZ5.

Expressioni

Tissue specificityi

Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis.3 Publications

Gene expression databases

ArrayExpressiQ6ZSZ5.
BgeeiQ6ZSZ5.
CleanExiHS_ARHGEF18.
GenevestigatoriQ6ZSZ5.

Organism-specific databases

HPAiHPA042689.

Interactioni

Subunit structurei

Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2.2 Publications

Protein-protein interaction databases

BioGridi116950. 5 interactions.
IntActiQ6ZSZ5. 1 interaction.
STRINGi9606.ENSP00000352995.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSZ5.
SMRiQ6ZSZ5. Positions 220-606.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 456198DH
Add
BLAST
Domaini496 – 598103PH
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili799 – 81921 Reviewed prediction
Add
BLAST
Coiled coili850 – 960111 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1104 – 115855Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG243163.
HOGENOMiHOG000236361.
HOVERGENiHBG104846.
InParanoidiQ6ZSZ5.
OMAiPRKWSEN.
OrthoDBiEOG7JDQWP.
PhylomeDBiQ6ZSZ5.
TreeFamiTF325887.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015721. RhoGEF-like.
[Graphical view]
PANTHERiPTHR22825. PTHR22825. 1 hit.
PfamiPF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 1 hit.
PROSITEiPS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZSZ5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVTVGTNILP SRPAASANTA REDAALFSRR IPPRHKNGAA QPGAAPGPGA     50
PGANMGNAHS KSGDRHSALP GRPELSFYGS FPRKWSENVF LDNELLTSKI 100
LSVLRPQSER GFRAGDLRYP THFLSTNSVL ASVTASLKEH PRGTLLSDGS 150
PALSRNVGMT VSQKGGPQPT PSPAGPGTQL GPITGEMDEA DSAFLKFKQT 200
ADDSLSLTSP NTESIFVEDP YTASLRSEIE SDGHEFEAES WSLAVDAAYA 250
KKQKREVVKR QDVLYELMQT EVHHVRTLKI MLKVYSRALQ EELQFSSKAI 300
GRLFPCADDL LETHSHFLAR LKERRQESLE EGSDRNYVIQ KIGDLLVQQF 350
SGENGERMKE KYGVFCSGHN EAVSHYKLLL QQNKKFQNLI KKIGNFSIVR 400
RLGVQECILL VTQRITKYPV LVERIIQNTE AGTEDYEDLT QALNLIKDII 450
SQVDAKVSEC EKGQRLREIA GKMDLKSSSK LKNGLTFRKE DMLQRQLHLE 500
GMLCWKTTSG RLKDILAILL TDVLLLLQEK DQKYVFASVD SKPPVISLQK 550
LIVREVANEE KAMFLISASL QGPEMYEIYT SSKEDRNAWM AHIQRAVESC 600
PDEEEGPFSL PEEERKVVEA RATRLRDFQE RLSMKDQLIA QSLLEKQQIY 650
LEMAEMGGLE DLPQPRGLFR GGDPSETLQG ELILKSAMSE IEGIQSLICR 700
QLGSANGQAE DGGSSTGPPR RAETFAGYDC TNSPTKNGSF KKKVSSTDPR 750
PRDWRGPPNS PDLKLSDSDI PGSSEESPQV VEAPGTESDP RLPTVLESEL 800
VQRIQTLSQL LLNLQAVIAH QDSYVETQRA AIQEREKQFR LQSTRGNLLL 850
EQERQRNFEK QREERAALEK LQSQLRHEQQ RWERERQWQH QELERAGARL 900
QEREGEARQL RERLEQERAE LERQRQAYQH DLERLREAQR AVERERERLE 950
LLRRLKKQNT APGALPPDTL AEAQPPSHPP SFNGEGLEGP RVSMLPSGVG 1000
PEYAERPEVA RRDSAPTENR LAKSDVPIQL LSATNQFQRQ AAVQQQIPTK 1050
LAASTKGGKD KGGKSRGSQR WESSASFDLK QQLLLNKLMG KDESTSRNRR 1100
SLSPILPGRH SPAPPPDPGF PAPSPPPADS PSEGFSLKAG GTALLPGPPA 1150
PSPLPATPLS AKEDASKEDV IFF 1173
Length:1,173
Mass (Da):130,780
Last modified:May 18, 2010 - v3
Checksum:iD986A1F85D48EE24
GO
Isoform 2 (identifier: Q6ZSZ5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-158: Missing.

Show »
Length:1,015
Mass (Da):114,077
Checksum:i03BD1D9224E422BD
GO

Sequence cautioni

The sequence AAH77721.1 differs from that shown. Reason: Aberrant splicing.
The sequence BAA25447.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti701 – 7011Q → R.2 Publications
Corresponds to variant rs2287918 [ dbSNP | Ensembl ].
VAR_044066
Natural varianti752 – 7521R → Q.
Corresponds to variant rs2287920 [ dbSNP | Ensembl ].
VAR_044067
Natural varianti1019 – 10191N → S.2 Publications
Corresponds to variant rs9329368 [ dbSNP | Ensembl ].
VAR_063099

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 158158Missing in isoform 2.
VSP_034315Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031V → M in BAC86801. 1 Publication
Sequence conflicti183 – 1831I → V in BAC86801. 1 Publication
Sequence conflicti1107 – 11071P → S in BAC86801. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011093 mRNA. Translation: BAA25447.1. Different initiation.
AK127045 mRNA. Translation: BAC86801.1.
AC008878 Genomic DNA. No translation available.
AC119396 Genomic DNA. No translation available.
BC077721 mRNA. Translation: AAH77721.1. Sequence problems.
CCDSiCCDS12177.1. [Q6ZSZ5-2]
CCDS45946.1. [Q6ZSZ5-1]
RefSeqiNP_001124427.1. NM_001130955.1. [Q6ZSZ5-1]
NP_056133.2. NM_015318.3. [Q6ZSZ5-2]
XP_006722771.1. XM_006722708.1. [Q6ZSZ5-2]
XP_006722772.1. XM_006722709.1. [Q6ZSZ5-2]
UniGeneiHs.465761.
Hs.736818.

Genome annotation databases

EnsembliENST00000319670; ENSP00000319200; ENSG00000104880. [Q6ZSZ5-2]
ENST00000359920; ENSP00000352995; ENSG00000104880. [Q6ZSZ5-1]
GeneIDi23370.
KEGGihsa:23370.
UCSCiuc002mgh.3. human. [Q6ZSZ5-1]

Polymorphism databases

DMDMi296439444.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB011093 mRNA. Translation: BAA25447.1 . Different initiation.
AK127045 mRNA. Translation: BAC86801.1 .
AC008878 Genomic DNA. No translation available.
AC119396 Genomic DNA. No translation available.
BC077721 mRNA. Translation: AAH77721.1 . Sequence problems.
CCDSi CCDS12177.1. [Q6ZSZ5-2 ]
CCDS45946.1. [Q6ZSZ5-1 ]
RefSeqi NP_001124427.1. NM_001130955.1. [Q6ZSZ5-1 ]
NP_056133.2. NM_015318.3. [Q6ZSZ5-2 ]
XP_006722771.1. XM_006722708.1. [Q6ZSZ5-2 ]
XP_006722772.1. XM_006722709.1. [Q6ZSZ5-2 ]
UniGenei Hs.465761.
Hs.736818.

3D structure databases

ProteinModelPortali Q6ZSZ5.
SMRi Q6ZSZ5. Positions 220-606.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116950. 5 interactions.
IntActi Q6ZSZ5. 1 interaction.
STRINGi 9606.ENSP00000352995.

PTM databases

PhosphoSitei Q6ZSZ5.

Polymorphism databases

DMDMi 296439444.

Proteomic databases

MaxQBi Q6ZSZ5.
PaxDbi Q6ZSZ5.
PRIDEi Q6ZSZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319670 ; ENSP00000319200 ; ENSG00000104880 . [Q6ZSZ5-2 ]
ENST00000359920 ; ENSP00000352995 ; ENSG00000104880 . [Q6ZSZ5-1 ]
GeneIDi 23370.
KEGGi hsa:23370.
UCSCi uc002mgh.3. human. [Q6ZSZ5-1 ]

Organism-specific databases

CTDi 23370.
GeneCardsi GC19P007459.
HGNCi HGNC:17090. ARHGEF18.
HPAi HPA042689.
neXtProti NX_Q6ZSZ5.
PharmGKBi PA128394630.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG243163.
HOGENOMi HOG000236361.
HOVERGENi HBG104846.
InParanoidi Q6ZSZ5.
OMAi PRKWSEN.
OrthoDBi EOG7JDQWP.
PhylomeDBi Q6ZSZ5.
TreeFami TF325887.

Enzyme and pathway databases

Reactomei REACT_11051. Rho GTPase cycle.
REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
REACT_13638. NRAGE signals death through JNK.
REACT_18407. G alpha (12/13) signalling events.

Miscellaneous databases

ChiTaRSi ARHGEF18. human.
GenomeRNAii 23370.
NextBioi 45444.
PROi Q6ZSZ5.

Gene expression databases

ArrayExpressi Q6ZSZ5.
Bgeei Q6ZSZ5.
CleanExi HS_ARHGEF18.
Genevestigatori Q6ZSZ5.

Family and domain databases

Gene3Di 1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR000219. DH-domain.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR015721. RhoGEF-like.
[Graphical view ]
PANTHERi PTHR22825. PTHR22825. 1 hit.
Pfami PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 1 hit.
PROSITEi PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-701 AND SER-1019.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1156 (ISOFORM 2), VARIANTS ARG-701 AND SER-1019.
    Tissue: Lymph.
  5. "Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor."
    Blomquist A., Schwoerer G., Schablowski H., Psoma A., Lehnen M., Jakobs K.H., Ruemenapp U.
    Biochem. J. 352:319-325(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION.
  7. "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production."
    Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T.
    Circ. Res. 93:848-856(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH GNB1 AND GNG2.
  8. "Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin."
    Nagata K., Inagaki M.
    Oncogene 24:65-76(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SEPT9.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARHGI_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSZ5
Secondary accession number(s): A8MV62
, B5ME81, O60274, Q6DD92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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