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Q6ZSZ5

- ARHGI_HUMAN

UniProt

Q6ZSZ5 - ARHGI_HUMAN

Protein

Rho guanine nucleotide exchange factor 18

Gene

ARHGEF18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.3 Publications

    GO - Molecular functioni

    1. guanyl-nucleotide exchange factor activity Source: MGI
    2. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    GO - Biological processi

    1. actin cytoskeleton organization Source: MGI
    2. apoptotic signaling pathway Source: Reactome
    3. neurotrophin TRK receptor signaling pathway Source: Reactome
    4. positive regulation of apoptotic process Source: Reactome
    5. positive regulation of GTPase activity Source: GOC
    6. regulation of cell shape Source: MGI
    7. regulation of small GTPase mediated signal transduction Source: Reactome
    8. small GTPase mediated signal transduction Source: MGI
    9. transforming growth factor beta receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Enzyme and pathway databases

    ReactomeiREACT_11051. Rho GTPase cycle.
    REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rho guanine nucleotide exchange factor 18
    Alternative name(s):
    114 kDa Rho-specific guanine nucleotide exchange factor
    Short name:
    p114-Rho-GEF
    Short name:
    p114RhoGEF
    Septin-associated RhoGEF
    Short name:
    SA-RhoGEF
    Gene namesi
    Name:ARHGEF18
    Synonyms:KIAA0521
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17090. ARHGEF18.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Colocalizes with actin stress fibers.

    GO - Cellular componenti

    1. apical part of cell Source: MGI
    2. cell junction Source: Reactome
    3. cytoplasm Source: HPA
    4. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394630.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11731173Rho guanine nucleotide exchange factor 18PRO_0000341415Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZSZ5.
    PaxDbiQ6ZSZ5.
    PRIDEiQ6ZSZ5.

    PTM databases

    PhosphoSiteiQ6ZSZ5.

    Expressioni

    Tissue specificityi

    Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or not expressed in liver, skeletal muscle and testis.3 Publications

    Gene expression databases

    ArrayExpressiQ6ZSZ5.
    BgeeiQ6ZSZ5.
    CleanExiHS_ARHGEF18.
    GenevestigatoriQ6ZSZ5.

    Organism-specific databases

    HPAiHPA042689.

    Interactioni

    Subunit structurei

    Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2.2 Publications

    Protein-protein interaction databases

    BioGridi116950. 6 interactions.
    IntActiQ6ZSZ5. 1 interaction.
    STRINGi9606.ENSP00000352995.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZSZ5.
    SMRiQ6ZSZ5. Positions 220-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini259 – 456198DHPROSITE-ProRule annotationAdd
    BLAST
    Domaini496 – 598103PHPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili799 – 81921Sequence AnalysisAdd
    BLAST
    Coiled coili850 – 960111Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1104 – 115855Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG243163.
    HOGENOMiHOG000236361.
    HOVERGENiHBG104846.
    InParanoidiQ6ZSZ5.
    OMAiPRKWSEN.
    OrthoDBiEOG7JDQWP.
    PhylomeDBiQ6ZSZ5.
    TreeFamiTF325887.

    Family and domain databases

    Gene3Di1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view]
    PANTHERiPTHR22825. PTHR22825. 1 hit.
    PfamiPF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 1 hit.
    PROSITEiPS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZSZ5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTVGTNILP SRPAASANTA REDAALFSRR IPPRHKNGAA QPGAAPGPGA     50
    PGANMGNAHS KSGDRHSALP GRPELSFYGS FPRKWSENVF LDNELLTSKI 100
    LSVLRPQSER GFRAGDLRYP THFLSTNSVL ASVTASLKEH PRGTLLSDGS 150
    PALSRNVGMT VSQKGGPQPT PSPAGPGTQL GPITGEMDEA DSAFLKFKQT 200
    ADDSLSLTSP NTESIFVEDP YTASLRSEIE SDGHEFEAES WSLAVDAAYA 250
    KKQKREVVKR QDVLYELMQT EVHHVRTLKI MLKVYSRALQ EELQFSSKAI 300
    GRLFPCADDL LETHSHFLAR LKERRQESLE EGSDRNYVIQ KIGDLLVQQF 350
    SGENGERMKE KYGVFCSGHN EAVSHYKLLL QQNKKFQNLI KKIGNFSIVR 400
    RLGVQECILL VTQRITKYPV LVERIIQNTE AGTEDYEDLT QALNLIKDII 450
    SQVDAKVSEC EKGQRLREIA GKMDLKSSSK LKNGLTFRKE DMLQRQLHLE 500
    GMLCWKTTSG RLKDILAILL TDVLLLLQEK DQKYVFASVD SKPPVISLQK 550
    LIVREVANEE KAMFLISASL QGPEMYEIYT SSKEDRNAWM AHIQRAVESC 600
    PDEEEGPFSL PEEERKVVEA RATRLRDFQE RLSMKDQLIA QSLLEKQQIY 650
    LEMAEMGGLE DLPQPRGLFR GGDPSETLQG ELILKSAMSE IEGIQSLICR 700
    QLGSANGQAE DGGSSTGPPR RAETFAGYDC TNSPTKNGSF KKKVSSTDPR 750
    PRDWRGPPNS PDLKLSDSDI PGSSEESPQV VEAPGTESDP RLPTVLESEL 800
    VQRIQTLSQL LLNLQAVIAH QDSYVETQRA AIQEREKQFR LQSTRGNLLL 850
    EQERQRNFEK QREERAALEK LQSQLRHEQQ RWERERQWQH QELERAGARL 900
    QEREGEARQL RERLEQERAE LERQRQAYQH DLERLREAQR AVERERERLE 950
    LLRRLKKQNT APGALPPDTL AEAQPPSHPP SFNGEGLEGP RVSMLPSGVG 1000
    PEYAERPEVA RRDSAPTENR LAKSDVPIQL LSATNQFQRQ AAVQQQIPTK 1050
    LAASTKGGKD KGGKSRGSQR WESSASFDLK QQLLLNKLMG KDESTSRNRR 1100
    SLSPILPGRH SPAPPPDPGF PAPSPPPADS PSEGFSLKAG GTALLPGPPA 1150
    PSPLPATPLS AKEDASKEDV IFF 1173
    Length:1,173
    Mass (Da):130,780
    Last modified:May 18, 2010 - v3
    Checksum:iD986A1F85D48EE24
    GO
    Isoform 2 (identifier: Q6ZSZ5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-158: Missing.

    Show »
    Length:1,015
    Mass (Da):114,077
    Checksum:i03BD1D9224E422BD
    GO

    Sequence cautioni

    The sequence AAH77721.1 differs from that shown. Reason: Aberrant splicing.
    The sequence BAA25447.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031V → M in BAC86801. (PubMed:14702039)Curated
    Sequence conflicti183 – 1831I → V in BAC86801. (PubMed:14702039)Curated
    Sequence conflicti1107 – 11071P → S in BAC86801. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti701 – 7011Q → R.2 Publications
    Corresponds to variant rs2287918 [ dbSNP | Ensembl ].
    VAR_044066
    Natural varianti752 – 7521R → Q.
    Corresponds to variant rs2287920 [ dbSNP | Ensembl ].
    VAR_044067
    Natural varianti1019 – 10191N → S.2 Publications
    Corresponds to variant rs9329368 [ dbSNP | Ensembl ].
    VAR_063099

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 158158Missing in isoform 2. 2 PublicationsVSP_034315Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011093 mRNA. Translation: BAA25447.1. Different initiation.
    AK127045 mRNA. Translation: BAC86801.1.
    AC008878 Genomic DNA. No translation available.
    AC119396 Genomic DNA. No translation available.
    BC077721 mRNA. Translation: AAH77721.1. Sequence problems.
    CCDSiCCDS12177.1. [Q6ZSZ5-2]
    CCDS45946.1. [Q6ZSZ5-1]
    RefSeqiNP_001124427.1. NM_001130955.1. [Q6ZSZ5-1]
    NP_056133.2. NM_015318.3. [Q6ZSZ5-2]
    XP_006722771.1. XM_006722708.1. [Q6ZSZ5-2]
    XP_006722772.1. XM_006722709.1. [Q6ZSZ5-2]
    UniGeneiHs.465761.
    Hs.736818.

    Genome annotation databases

    EnsembliENST00000319670; ENSP00000319200; ENSG00000104880. [Q6ZSZ5-2]
    ENST00000359920; ENSP00000352995; ENSG00000104880. [Q6ZSZ5-1]
    GeneIDi23370.
    KEGGihsa:23370.
    UCSCiuc002mgh.3. human. [Q6ZSZ5-1]

    Polymorphism databases

    DMDMi296439444.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB011093 mRNA. Translation: BAA25447.1 . Different initiation.
    AK127045 mRNA. Translation: BAC86801.1 .
    AC008878 Genomic DNA. No translation available.
    AC119396 Genomic DNA. No translation available.
    BC077721 mRNA. Translation: AAH77721.1 . Sequence problems.
    CCDSi CCDS12177.1. [Q6ZSZ5-2 ]
    CCDS45946.1. [Q6ZSZ5-1 ]
    RefSeqi NP_001124427.1. NM_001130955.1. [Q6ZSZ5-1 ]
    NP_056133.2. NM_015318.3. [Q6ZSZ5-2 ]
    XP_006722771.1. XM_006722708.1. [Q6ZSZ5-2 ]
    XP_006722772.1. XM_006722709.1. [Q6ZSZ5-2 ]
    UniGenei Hs.465761.
    Hs.736818.

    3D structure databases

    ProteinModelPortali Q6ZSZ5.
    SMRi Q6ZSZ5. Positions 220-606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116950. 6 interactions.
    IntActi Q6ZSZ5. 1 interaction.
    STRINGi 9606.ENSP00000352995.

    PTM databases

    PhosphoSitei Q6ZSZ5.

    Polymorphism databases

    DMDMi 296439444.

    Proteomic databases

    MaxQBi Q6ZSZ5.
    PaxDbi Q6ZSZ5.
    PRIDEi Q6ZSZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319670 ; ENSP00000319200 ; ENSG00000104880 . [Q6ZSZ5-2 ]
    ENST00000359920 ; ENSP00000352995 ; ENSG00000104880 . [Q6ZSZ5-1 ]
    GeneIDi 23370.
    KEGGi hsa:23370.
    UCSCi uc002mgh.3. human. [Q6ZSZ5-1 ]

    Organism-specific databases

    CTDi 23370.
    GeneCardsi GC19P007459.
    HGNCi HGNC:17090. ARHGEF18.
    HPAi HPA042689.
    neXtProti NX_Q6ZSZ5.
    PharmGKBi PA128394630.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243163.
    HOGENOMi HOG000236361.
    HOVERGENi HBG104846.
    InParanoidi Q6ZSZ5.
    OMAi PRKWSEN.
    OrthoDBi EOG7JDQWP.
    PhylomeDBi Q6ZSZ5.
    TreeFami TF325887.

    Enzyme and pathway databases

    Reactomei REACT_11051. Rho GTPase cycle.
    REACT_120726. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
    REACT_13638. NRAGE signals death through JNK.
    REACT_18407. G alpha (12/13) signalling events.

    Miscellaneous databases

    ChiTaRSi ARHGEF18. human.
    GenomeRNAii 23370.
    NextBioi 45444.
    PROi Q6ZSZ5.

    Gene expression databases

    ArrayExpressi Q6ZSZ5.
    Bgeei Q6ZSZ5.
    CleanExi HS_ARHGEF18.
    Genevestigatori Q6ZSZ5.

    Family and domain databases

    Gene3Di 1.20.900.10. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR000219. DH-domain.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR015721. RhoGEF-like.
    [Graphical view ]
    PANTHERi PTHR22825. PTHR22825. 1 hit.
    Pfami PF00169. PH. 1 hit.
    PF00621. RhoGEF. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    SM00325. RhoGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 1 hit.
    PROSITEi PS50010. DH_2. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-701 AND SER-1019.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1156 (ISOFORM 2), VARIANTS ARG-701 AND SER-1019.
      Tissue: Lymph.
    5. "Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor."
      Blomquist A., Schwoerer G., Schablowski H., Psoma A., Lehnen M., Jakobs K.H., Ruemenapp U.
      Biochem. J. 352:319-325(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. Cited for: IDENTIFICATION.
    7. "G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production."
      Niu J., Profirovic J., Pan H., Vaiskunaite R., Voyno-Yasenetskaya T.
      Circ. Res. 93:848-856(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH GNB1 AND GNG2.
    8. "Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin."
      Nagata K., Inagaki M.
      Oncogene 24:65-76(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH SEPT9.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiARHGI_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZSZ5
    Secondary accession number(s): A8MV62
    , B5ME81, O60274, Q6DD92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 100 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3