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Protein

Major facilitator superfamily domain-containing protein 6

Gene

MFSD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 6
Alternative name(s):
Macrophage MHC class I receptor 2 homolog
Gene namesi
Name:MFSD6
Synonyms:MMR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24711. MFSD6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence analysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence analysisAdd
BLAST
Transmembranei479 – 49921HelicalSequence analysisAdd
BLAST
Transmembranei507 – 52721HelicalSequence analysisAdd
BLAST
Transmembranei544 – 56421HelicalSequence analysisAdd
BLAST
Transmembranei579 – 59921HelicalSequence analysisAdd
BLAST
Transmembranei605 – 62521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164722278.

Polymorphism and mutation databases

BioMutaiMFSD6.
DMDMi187610244.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 791790Major facilitator superfamily domain-containing protein 6PRO_0000321940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei10 – 101PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6ZSS7.
MaxQBiQ6ZSS7.
PaxDbiQ6ZSS7.
PeptideAtlasiQ6ZSS7.
PRIDEiQ6ZSS7.

PTM databases

iPTMnetiQ6ZSS7.
PhosphoSiteiQ6ZSS7.
SwissPalmiQ6ZSS7.

Expressioni

Tissue specificityi

Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all.1 Publication

Gene expression databases

BgeeiQ6ZSS7.
CleanExiHS_MFSD6.
ExpressionAtlasiQ6ZSS7. baseline and differential.
GenevisibleiQ6ZSS7. HS.

Organism-specific databases

HPAiHPA022274.

Interactioni

Subunit structurei

May interact with HLA-B62.

Protein-protein interaction databases

IntActiQ6ZSS7. 4 interactions.
STRINGi9606.ENSP00000281416.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000230724.
HOVERGENiHBG100740.
InParanoidiQ6ZSS7.
OMAiSTHKVRG.
OrthoDBiEOG7X9G68.
PhylomeDBiQ6ZSS7.
TreeFamiTF314366.

Family and domain databases

InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZSS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP
60 70 80 90 100
EEEIDWIEKH CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP
110 120 130 140 150
SQSGLLVGIR YFIEFCSAPF WGVVADRFKK GKIVLLFSLL CWVLFNLGIG
160 170 180 190 200
FVKPATLRCV PKIRPTTHPT NASHQLTILP TNSSFTSFLT ISPKMREKRN
210 220 230 240 250
LLETRLNVSD TVTLPTAPNM NSEPTLQPQT GEITNRMMDL TLNSSTATPV
260 270 280 290 300
SPGSVTKETT TVIVTTTKSL PSDQVMLVYD QQEVEAIFLV ILVVVIIGEF
310 320 330 340 350
FSASSVTIVD TVTLQYLGKH RDRYGLQRMW GSLGWGLAML SVGIGIDYTH
360 370 380 390 400
IEVLIDGKGC KPPEYRNYQI VFIVFGVLMT MALIVATQFR FRYNHFKNDD
410 420 430 440 450
SKGKEVEIPQ VERNNSTESS EETPTTTSHS QAFNFWDLIK LLCSVQYGSV
460 470 480 490 500
LFVAWFMGFG YGFVFTFLYW HLEDLNGTTT LFGVCSVLSH VSELTAYFFS
510 520 530 540 550
HKLIELIGHI RVLYIGLACN TARYIYISYL ENAWTVLPME VLQGVTHAAI
560 570 580 590 600
WAACISYLSA AVPPELRTSA QGILQGLHLG LGRGCGAMIG GVLVNYFGAA
610 620 630 640 650
ATFRGIGMAC LVILLLFALI QWLAVPDEEE DKTMLAERIP VPSSPVPIAT
660 670 680 690 700
IDLVQQQTED VMPRIEPRLP PKKTKHQEEQ EDVNKPAWGV SSSPWVTFVY
710 720 730 740 750
ALYQIKEMMQ LTRDNRASEI QPLQGTNENR ENSPAGRAQP VPCETHSDPS
760 770 780 790
RNQPSPDAAA SQTQTSPAHP SVDPCTEESE EQQAQLAAGG H
Length:791
Mass (Da):88,088
Last modified:February 26, 2008 - v2
Checksum:iC623C7660D7BC73A
GO

Sequence cautioni

The sequence AAY24173.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90987.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAX10868.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti728 – 7281E → G in BAA90987 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti205 – 2051R → G.3 Publications
Corresponds to variant rs9646748 [ dbSNP | Ensembl ].
VAR_039388

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB472299 mRNA. Translation: BAI82196.1.
AK000167 mRNA. Translation: BAA90987.1. Different initiation.
AK127176 mRNA. Translation: BAC86869.1.
AC093388 Genomic DNA. Translation: AAY24173.1. Different initiation.
CH471058 Genomic DNA. Translation: EAX10868.1. Different initiation.
CH471058 Genomic DNA. Translation: EAX10867.1.
BC050537 mRNA. Translation: AAH50537.2.
CCDSiCCDS2306.1.
RefSeqiNP_060164.3. NM_017694.3.
XP_005246711.1. XM_005246654.2.
XP_011509670.1. XM_011511368.1.
UniGeneiHs.418581.
Hs.744117.

Genome annotation databases

EnsembliENST00000281416; ENSP00000281416; ENSG00000151690.
ENST00000392328; ENSP00000376141; ENSG00000151690.
GeneIDi54842.
KEGGihsa:54842.
UCSCiuc002urz.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB472299 mRNA. Translation: BAI82196.1.
AK000167 mRNA. Translation: BAA90987.1. Different initiation.
AK127176 mRNA. Translation: BAC86869.1.
AC093388 Genomic DNA. Translation: AAY24173.1. Different initiation.
CH471058 Genomic DNA. Translation: EAX10868.1. Different initiation.
CH471058 Genomic DNA. Translation: EAX10867.1.
BC050537 mRNA. Translation: AAH50537.2.
CCDSiCCDS2306.1.
RefSeqiNP_060164.3. NM_017694.3.
XP_005246711.1. XM_005246654.2.
XP_011509670.1. XM_011511368.1.
UniGeneiHs.418581.
Hs.744117.

3D structure databases

ProteinModelPortaliQ6ZSS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZSS7. 4 interactions.
STRINGi9606.ENSP00000281416.

PTM databases

iPTMnetiQ6ZSS7.
PhosphoSiteiQ6ZSS7.
SwissPalmiQ6ZSS7.

Polymorphism and mutation databases

BioMutaiMFSD6.
DMDMi187610244.

Proteomic databases

EPDiQ6ZSS7.
MaxQBiQ6ZSS7.
PaxDbiQ6ZSS7.
PeptideAtlasiQ6ZSS7.
PRIDEiQ6ZSS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281416; ENSP00000281416; ENSG00000151690.
ENST00000392328; ENSP00000376141; ENSG00000151690.
GeneIDi54842.
KEGGihsa:54842.
UCSCiuc002urz.2. human.

Organism-specific databases

CTDi54842.
GeneCardsiMFSD6.
H-InvDBHIX0002679.
HGNCiHGNC:24711. MFSD6.
HPAiHPA022274.
MIMi613476. gene.
neXtProtiNX_Q6ZSS7.
PharmGKBiPA164722278.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3762. Eukaryota.
ENOG410YMHR. LUCA.
GeneTreeiENSGT00530000063599.
HOGENOMiHOG000230724.
HOVERGENiHBG100740.
InParanoidiQ6ZSS7.
OMAiSTHKVRG.
OrthoDBiEOG7X9G68.
PhylomeDBiQ6ZSS7.
TreeFamiTF314366.

Miscellaneous databases

GenomeRNAii54842.
PROiQ6ZSS7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZSS7.
CleanExiHS_MFSD6.
ExpressionAtlasiQ6ZSS7. baseline and differential.
GenevisibleiQ6ZSS7. HS.

Family and domain databases

InterProiIPR024989. MFS_assoc_dom.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF12832. MFS_1_like. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes."
    Shimizu T., Tashiro-Yamaji J., Hayashi M., Inoue Y., Ibata M., Kubota T., Tanigawa N., Yoshida R.
    Gene 454:31-38(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-205, INTERACTION WITH HLA-B62, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-205.
    Tissue: Colon and Corpus callosum.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-205.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 247-791.
    Tissue: PNS.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMFSD6_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSS7
Secondary accession number(s): D3KSZ4, Q86TH2, Q9NXM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.