Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 621

Gene

ZNF621

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 621
Gene namesi
Name:ZNF621
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000172888.11
HGNCiHGNC:24787 ZNF621
neXtProtiNX_Q6ZSS3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172888
PharmGKBiPA134982950

Polymorphism and mutation databases

DMDMi74762406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476931 – 439Zinc finger protein 621Add BLAST439

Proteomic databases

EPDiQ6ZSS3
PaxDbiQ6ZSS3
PeptideAtlasiQ6ZSS3
PRIDEiQ6ZSS3
ProteomicsDBi68235
68236 [Q6ZSS3-2]

PTM databases

iPTMnetiQ6ZSS3
PhosphoSitePlusiQ6ZSS3

Expressioni

Gene expression databases

BgeeiENSG00000172888
CleanExiHS_ZNF621
ExpressionAtlasiQ6ZSS3 baseline and differential
GenevisibleiQ6ZSS3 HS

Organism-specific databases

HPAiHPA065518
HPA071440

Interactioni

Protein-protein interaction databases

BioGridi130064, 6 interactors
STRINGi9606.ENSP00000340841

Structurei

3D structure databases

ProteinModelPortaliQ6ZSS3
SMRiQ6ZSS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 83KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00890000139475
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6ZSS3
KOiK09228
OMAiNHIGEGP
OrthoDBiEOG091G0O0Q
PhylomeDBiQ6ZSS3
TreeFamiTF350844

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL
60 70 80 90 100
VAFPFPKPAL ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK
110 120 130 140 150
QEASEETELH RMPVGGLLRN VSQHFDFKRK ALKQTFNLNP NLILRGGMKF
160 170 180 190 200
YECKECGKIF RYNSKLIRHQ MSHTGEKPFK CKECGKAFKS SYDCIVHEKN
210 220 230 240 250
HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC GKAFRRSAAY
260 270 280 290 300
LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF
310 320 330 340 350
TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV
360 370 380 390 400
LGPSLVSPQC SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM
410 420 430
LLPTSGIPSS SAQIVRVFQG LTPTVKPSPV ILTPSSHSS
Length:439
Mass (Da):49,205
Last modified:July 5, 2004 - v1
Checksum:i6E44DBCE808EA165
GO
Isoform 2 (identifier: Q6ZSS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-157: MKFYECKECG → SVEVRSLRPA
     158-439: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,718
Checksum:iC1A03A2CEB56C347
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016041148 – 157MKFYECKECG → SVEVRSLRPA in isoform 2. 1 Publication10
Alternative sequenceiVSP_016042158 – 439Missing in isoform 2. 1 PublicationAdd BLAST282

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074366 mRNA Translation: BAB85061.1
AK127181 mRNA Translation: BAC86873.1
CR749268 mRNA Translation: CAH18124.1
BC101619 mRNA Translation: AAI01620.1
BC113415 mRNA Translation: AAI13416.1
CCDSiCCDS2693.1 [Q6ZSS3-1]
CCDS74920.1 [Q6ZSS3-2]
RefSeqiNP_001091884.1, NM_001098414.2 [Q6ZSS3-1]
NP_001274174.1, NM_001287245.1 [Q6ZSS3-2]
NP_940886.1, NM_198484.4 [Q6ZSS3-1]
UniGeneiHs.19977

Genome annotation databases

EnsembliENST00000310898; ENSP00000312144; ENSG00000172888 [Q6ZSS3-2]
ENST00000339296; ENSP00000340841; ENSG00000172888 [Q6ZSS3-1]
ENST00000403205; ENSP00000386051; ENSG00000172888 [Q6ZSS3-1]
GeneIDi285268
KEGGihsa:285268
UCSCiuc003ckm.4 human [Q6ZSS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN621_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSS3
Secondary accession number(s): Q14DC7, Q8TE91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health