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Protein

Zinc finger protein 621

Gene

ZNF621

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 621
Gene namesi
Name:ZNF621
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24787. ZNF621.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172888.
PharmGKBiPA134982950.

Polymorphism and mutation databases

DMDMi74762406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476931 – 439Zinc finger protein 621Add BLAST439

Proteomic databases

EPDiQ6ZSS3.
PaxDbiQ6ZSS3.
PeptideAtlasiQ6ZSS3.
PRIDEiQ6ZSS3.

PTM databases

iPTMnetiQ6ZSS3.
PhosphoSitePlusiQ6ZSS3.

Expressioni

Gene expression databases

BgeeiENSG00000172888.
CleanExiHS_ZNF621.
ExpressionAtlasiQ6ZSS3. baseline and differential.
GenevisibleiQ6ZSS3. HS.

Organism-specific databases

HPAiHPA065518.
HPA071440.

Interactioni

Protein-protein interaction databases

BioGridi130064. 6 interactors.
STRINGi9606.ENSP00000340841.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSS3.
SMRiQ6ZSS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 83KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139475.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZSS3.
KOiK09228.
OMAiNHIGEGP.
OrthoDBiEOG091G0O0Q.
PhylomeDBiQ6ZSS3.
TreeFamiTF350844.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 4 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL
60 70 80 90 100
VAFPFPKPAL ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK
110 120 130 140 150
QEASEETELH RMPVGGLLRN VSQHFDFKRK ALKQTFNLNP NLILRGGMKF
160 170 180 190 200
YECKECGKIF RYNSKLIRHQ MSHTGEKPFK CKECGKAFKS SYDCIVHEKN
210 220 230 240 250
HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC GKAFRRSAAY
260 270 280 290 300
LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF
310 320 330 340 350
TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV
360 370 380 390 400
LGPSLVSPQC SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM
410 420 430
LLPTSGIPSS SAQIVRVFQG LTPTVKPSPV ILTPSSHSS
Length:439
Mass (Da):49,205
Last modified:July 5, 2004 - v1
Checksum:i6E44DBCE808EA165
GO
Isoform 2 (identifier: Q6ZSS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-157: MKFYECKECG → SVEVRSLRPA
     158-439: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,718
Checksum:iC1A03A2CEB56C347
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016041148 – 157MKFYECKECG → SVEVRSLRPA in isoform 2. 1 Publication10
Alternative sequenceiVSP_016042158 – 439Missing in isoform 2. 1 PublicationAdd BLAST282

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074366 mRNA. Translation: BAB85061.1.
AK127181 mRNA. Translation: BAC86873.1.
CR749268 mRNA. Translation: CAH18124.1.
BC101619 mRNA. Translation: AAI01620.1.
BC113415 mRNA. Translation: AAI13416.1.
CCDSiCCDS2693.1. [Q6ZSS3-1]
CCDS74920.1. [Q6ZSS3-2]
RefSeqiNP_001091884.1. NM_001098414.2. [Q6ZSS3-1]
NP_001274174.1. NM_001287245.1. [Q6ZSS3-2]
NP_940886.1. NM_198484.4. [Q6ZSS3-1]
UniGeneiHs.19977.

Genome annotation databases

EnsembliENST00000310898; ENSP00000312144; ENSG00000172888. [Q6ZSS3-2]
ENST00000339296; ENSP00000340841; ENSG00000172888. [Q6ZSS3-1]
ENST00000403205; ENSP00000386051; ENSG00000172888. [Q6ZSS3-1]
GeneIDi285268.
KEGGihsa:285268.
UCSCiuc003ckm.4. human. [Q6ZSS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN621_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSS3
Secondary accession number(s): Q14DC7, Q8TE91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families