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Protein

Zinc finger protein 621

Gene

ZNF621

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 621
Gene namesi
Name:ZNF621
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24787. ZNF621.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982950.

Polymorphism and mutation databases

DMDMi74762406.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 439439Zinc finger protein 621PRO_0000047693Add
BLAST

Proteomic databases

PaxDbiQ6ZSS3.
PRIDEiQ6ZSS3.

PTM databases

PhosphoSiteiQ6ZSS3.

Expressioni

Gene expression databases

BgeeiQ6ZSS3.
CleanExiHS_ZNF621.
ExpressionAtlasiQ6ZSS3. baseline and differential.
GenevisibleiQ6ZSS3. HS.

Interactioni

Protein-protein interaction databases

BioGridi130064. 5 interactions.
STRINGi9606.ENSP00000340841.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSS3.
SMRiQ6ZSS3. Positions 149-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 8373KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri207 – 22923C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25723C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri263 – 28523C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri319 – 34123C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZSS3.
KOiK09228.
OMAiIVRVFQG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZSS3.
TreeFamiTF350844.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQTTWPQES VTFEDVAVYF TQNQWASLDP AQRALYGEVM LENYANVASL
60 70 80 90 100
VAFPFPKPAL ISHLERGEAP WGPDPWDTEI LRGISQGGES WIKNEGLVIK
110 120 130 140 150
QEASEETELH RMPVGGLLRN VSQHFDFKRK ALKQTFNLNP NLILRGGMKF
160 170 180 190 200
YECKECGKIF RYNSKLIRHQ MSHTGEKPFK CKECGKAFKS SYDCIVHEKN
210 220 230 240 250
HIGEGPYECK ECGKGLSSNT ALTQHQRIHT GEKPYECKEC GKAFRRSAAY
260 270 280 290 300
LQHQRLHTGE KLYKCKECWK AFGCRSLFIV HQRIHTGEKP YQCKECGKAF
310 320 330 340 350
TQKIASIQHQ RVHTGEKPYE CKVCGKAFKW YGSFVQHQKL HPVEKKPVKV
360 370 380 390 400
LGPSLVSPQC SSPAIPPVLL QGSCSASAVA VPSLTFPHAV LIPTSGNFFM
410 420 430
LLPTSGIPSS SAQIVRVFQG LTPTVKPSPV ILTPSSHSS
Length:439
Mass (Da):49,205
Last modified:July 5, 2004 - v1
Checksum:i6E44DBCE808EA165
GO
Isoform 2 (identifier: Q6ZSS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-157: MKFYECKECG → SVEVRSLRPA
     158-439: Missing.

Note: No experimental confirmation available.
Show »
Length:157
Mass (Da):17,718
Checksum:iC1A03A2CEB56C347
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 15710MKFYECKECG → SVEVRSLRPA in isoform 2. 1 PublicationVSP_016041
Alternative sequencei158 – 439282Missing in isoform 2. 1 PublicationVSP_016042Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074366 mRNA. Translation: BAB85061.1.
AK127181 mRNA. Translation: BAC86873.1.
CR749268 mRNA. Translation: CAH18124.1.
BC101619 mRNA. Translation: AAI01620.1.
BC113415 mRNA. Translation: AAI13416.1.
CCDSiCCDS2693.1. [Q6ZSS3-1]
CCDS74920.1. [Q6ZSS3-2]
RefSeqiNP_001091884.1. NM_001098414.2. [Q6ZSS3-1]
NP_001274174.1. NM_001287245.1. [Q6ZSS3-2]
NP_940886.1. NM_198484.4. [Q6ZSS3-1]
UniGeneiHs.19977.

Genome annotation databases

EnsembliENST00000310898; ENSP00000312144; ENSG00000172888. [Q6ZSS3-2]
ENST00000339296; ENSP00000340841; ENSG00000172888. [Q6ZSS3-1]
ENST00000403205; ENSP00000386051; ENSG00000172888. [Q6ZSS3-1]
GeneIDi285268.
KEGGihsa:285268.
UCSCiuc003ckm.4. human. [Q6ZSS3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074366 mRNA. Translation: BAB85061.1.
AK127181 mRNA. Translation: BAC86873.1.
CR749268 mRNA. Translation: CAH18124.1.
BC101619 mRNA. Translation: AAI01620.1.
BC113415 mRNA. Translation: AAI13416.1.
CCDSiCCDS2693.1. [Q6ZSS3-1]
CCDS74920.1. [Q6ZSS3-2]
RefSeqiNP_001091884.1. NM_001098414.2. [Q6ZSS3-1]
NP_001274174.1. NM_001287245.1. [Q6ZSS3-2]
NP_940886.1. NM_198484.4. [Q6ZSS3-1]
UniGeneiHs.19977.

3D structure databases

ProteinModelPortaliQ6ZSS3.
SMRiQ6ZSS3. Positions 149-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130064. 5 interactions.
STRINGi9606.ENSP00000340841.

PTM databases

PhosphoSiteiQ6ZSS3.

Polymorphism and mutation databases

DMDMi74762406.

Proteomic databases

PaxDbiQ6ZSS3.
PRIDEiQ6ZSS3.

Protocols and materials databases

DNASUi285268.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310898; ENSP00000312144; ENSG00000172888. [Q6ZSS3-2]
ENST00000339296; ENSP00000340841; ENSG00000172888. [Q6ZSS3-1]
ENST00000403205; ENSP00000386051; ENSG00000172888. [Q6ZSS3-1]
GeneIDi285268.
KEGGihsa:285268.
UCSCiuc003ckm.4. human. [Q6ZSS3-1]

Organism-specific databases

CTDi285268.
GeneCardsiZNF621.
HGNCiHGNC:24787. ZNF621.
neXtProtiNX_Q6ZSS3.
PharmGKBiPA134982950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000123072.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZSS3.
KOiK09228.
OMAiIVRVFQG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6ZSS3.
TreeFamiTF350844.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii285268.
NextBioi95397.
PROiQ6ZSS3.

Gene expression databases

BgeeiQ6ZSS3.
CleanExiHS_ZNF621.
ExpressionAtlasiQ6ZSS3. baseline and differential.
GenevisibleiQ6ZSS3. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Corpus callosum and Hepatoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.

Entry informationi

Entry nameiZN621_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSS3
Secondary accession number(s): Q14DC7, Q8TE91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 16, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.