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Protein

Uncharacterized protein C1orf122

Gene

C1orf122

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf122
Alternative name(s):
Protein ALAESM
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24789. C1orf122.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 110110Uncharacterized protein C1orf122PRO_0000254193Add
BLAST

Proteomic databases

MaxQBiQ6ZSJ8.
PaxDbiQ6ZSJ8.
PRIDEiQ6ZSJ8.

PTM databases

PhosphoSiteiQ6ZSJ8.

Expressioni

Gene expression databases

BgeeiQ6ZSJ8.
CleanExiHS_C1orf122.
GenevestigatoriQ6ZSJ8.

Interactioni

Protein-protein interaction databases

BioGridi126077. 4 interactions.
IntActiQ6ZSJ8. 1 interaction.
STRINGi9606.ENSP00000362133.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili36 – 6833Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG258495.
GeneTreeiENSGT00570000079623.
HOGENOMiHOG000111246.
InParanoidiQ6ZSJ8.
OrthoDBiEOG7GBG0F.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR
60 70 80 90 100
QRQLLDTIAA CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP
110
KDAGDGAAEP
Length:110
Mass (Da):11,471
Last modified:September 22, 2009 - v2
Checksum:iC63352FB57850CFE
GO
Isoform 2 (identifier: Q6ZSJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.

Show »
Length:47
Mass (Da):4,650
Checksum:iB2CDF8E8200DCF93
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6363Missing in isoform 2. CuratedVSP_046648Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127381 mRNA. Translation: BAC86950.1. Sequence problems.
AY517499 mRNA. Translation: AAS76640.1.
AL929472 Genomic DNA. Translation: CAH70085.1. Sequence problems.
BC057819 mRNA. Translation: AAH57819.1. Sequence problems.
CCDSiCCDS427.2. [Q6ZSJ8-1]
CCDS44112.1. [Q6ZSJ8-2]
RefSeqiNP_001136198.1. NM_001142726.1. [Q6ZSJ8-2]
NP_940848.2. NM_198446.2. [Q6ZSJ8-1]
UniGeneiHs.532749.

Genome annotation databases

EnsembliENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
GeneIDi127687.
KEGGihsa:127687.
UCSCiuc001ccd.2. human. [Q6ZSJ8-1]
uc010oii.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127381 mRNA. Translation: BAC86950.1. Sequence problems.
AY517499 mRNA. Translation: AAS76640.1.
AL929472 Genomic DNA. Translation: CAH70085.1. Sequence problems.
BC057819 mRNA. Translation: AAH57819.1. Sequence problems.
CCDSiCCDS427.2. [Q6ZSJ8-1]
CCDS44112.1. [Q6ZSJ8-2]
RefSeqiNP_001136198.1. NM_001142726.1. [Q6ZSJ8-2]
NP_940848.2. NM_198446.2. [Q6ZSJ8-1]
UniGeneiHs.532749.

3D structure databases

ProteinModelPortaliQ6ZSJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126077. 4 interactions.
IntActiQ6ZSJ8. 1 interaction.
STRINGi9606.ENSP00000362133.

PTM databases

PhosphoSiteiQ6ZSJ8.

Proteomic databases

MaxQBiQ6ZSJ8.
PaxDbiQ6ZSJ8.
PRIDEiQ6ZSJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
GeneIDi127687.
KEGGihsa:127687.
UCSCiuc001ccd.2. human. [Q6ZSJ8-1]
uc010oii.1. human.

Organism-specific databases

CTDi127687.
GeneCardsiGC01P038272.
HGNCiHGNC:24789. C1orf122.
neXtProtiNX_Q6ZSJ8.
PharmGKBiPA142672440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG258495.
GeneTreeiENSGT00570000079623.
HOGENOMiHOG000111246.
InParanoidiQ6ZSJ8.
OrthoDBiEOG7GBG0F.

Miscellaneous databases

ChiTaRSiC1orf122. human.
GenomeRNAii127687.
NextBioi82162.

Gene expression databases

BgeeiQ6ZSJ8.
CleanExiHS_C1orf122.
GenevestigatoriQ6ZSJ8.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Subthalamic nucleus.
  2. Chen S., Guo J.H., Yu L.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCA122_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSJ8
Secondary accession number(s): A2RQF4, E9PQ13, Q56A71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 22, 2009
Last modified: January 7, 2015
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.