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Q6ZSJ8

- CA122_HUMAN

UniProt

Q6ZSJ8 - CA122_HUMAN

Protein

Uncharacterized protein C1orf122

Gene

C1orf122

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C1orf122
    Alternative name(s):
    Protein ALAESM
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24789. C1orf122.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672440.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 110110Uncharacterized protein C1orf122PRO_0000254193Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZSJ8.
    PaxDbiQ6ZSJ8.
    PRIDEiQ6ZSJ8.

    PTM databases

    PhosphoSiteiQ6ZSJ8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZSJ8.
    BgeeiQ6ZSJ8.
    CleanExiHS_C1orf122.
    GenevestigatoriQ6ZSJ8.

    Interactioni

    Protein-protein interaction databases

    BioGridi126077. 1 interaction.
    IntActiQ6ZSJ8. 1 interaction.
    STRINGi9606.ENSP00000362133.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZSJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili36 – 6833Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG258495.
    HOGENOMiHOG000111246.
    OrthoDBiEOG7GBG0F.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZSJ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR    50
    QRQLLDTIAA CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP 100
    KDAGDGAAEP 110
    Length:110
    Mass (Da):11,471
    Last modified:September 22, 2009 - v2
    Checksum:iC63352FB57850CFE
    GO
    Isoform 2 (identifier: Q6ZSJ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-63: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:47
    Mass (Da):4,650
    Checksum:iB2CDF8E8200DCF93
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6363Missing in isoform 2. CuratedVSP_046648Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127381 mRNA. Translation: BAC86950.1. Sequence problems.
    AY517499 mRNA. Translation: AAS76640.1.
    AL929472 Genomic DNA. Translation: CAH70085.1. Sequence problems.
    BC057819 mRNA. Translation: AAH57819.1. Sequence problems.
    CCDSiCCDS427.2. [Q6ZSJ8-1]
    CCDS44112.1. [Q6ZSJ8-2]
    RefSeqiNP_001136198.1. NM_001142726.1. [Q6ZSJ8-2]
    NP_940848.2. NM_198446.2. [Q6ZSJ8-1]
    UniGeneiHs.532749.

    Genome annotation databases

    EnsembliENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
    ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
    ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
    GeneIDi127687.
    KEGGihsa:127687.
    UCSCiuc001ccd.2. human. [Q6ZSJ8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127381 mRNA. Translation: BAC86950.1 . Sequence problems.
    AY517499 mRNA. Translation: AAS76640.1 .
    AL929472 Genomic DNA. Translation: CAH70085.1 . Sequence problems.
    BC057819 mRNA. Translation: AAH57819.1 . Sequence problems.
    CCDSi CCDS427.2. [Q6ZSJ8-1 ]
    CCDS44112.1. [Q6ZSJ8-2 ]
    RefSeqi NP_001136198.1. NM_001142726.1. [Q6ZSJ8-2 ]
    NP_940848.2. NM_198446.2. [Q6ZSJ8-1 ]
    UniGenei Hs.532749.

    3D structure databases

    ProteinModelPortali Q6ZSJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126077. 1 interaction.
    IntActi Q6ZSJ8. 1 interaction.
    STRINGi 9606.ENSP00000362133.

    PTM databases

    PhosphoSitei Q6ZSJ8.

    Proteomic databases

    MaxQBi Q6ZSJ8.
    PaxDbi Q6ZSJ8.
    PRIDEi Q6ZSJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373042 ; ENSP00000362133 ; ENSG00000197982 . [Q6ZSJ8-1 ]
    ENST00000373043 ; ENSP00000362134 ; ENSG00000197982 . [Q6ZSJ8-2 ]
    ENST00000468084 ; ENSP00000434520 ; ENSG00000197982 . [Q6ZSJ8-2 ]
    GeneIDi 127687.
    KEGGi hsa:127687.
    UCSCi uc001ccd.2. human. [Q6ZSJ8-1 ]

    Organism-specific databases

    CTDi 127687.
    GeneCardsi GC01P038272.
    HGNCi HGNC:24789. C1orf122.
    neXtProti NX_Q6ZSJ8.
    PharmGKBi PA142672440.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258495.
    HOGENOMi HOG000111246.
    OrthoDBi EOG7GBG0F.

    Miscellaneous databases

    ChiTaRSi C1orf122. human.
    GenomeRNAii 127687.
    NextBioi 82162.

    Gene expression databases

    ArrayExpressi Q6ZSJ8.
    Bgeei Q6ZSJ8.
    CleanExi HS_C1orf122.
    Genevestigatori Q6ZSJ8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Subthalamic nucleus.
    2. Chen S., Guo J.H., Yu L.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCA122_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZSJ8
    Secondary accession number(s): A2RQF4, E9PQ13, Q56A71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: September 22, 2009
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM

    External Data

    Dasty 3