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Protein

Uncharacterized protein C1orf122

Gene

C1orf122

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C1orf122
Alternative name(s):
Protein ALAESM
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24789. C1orf122.

Pathology & Biotechi

Organism-specific databases

DisGeNETi127687.
OpenTargetsiENSG00000197982.
PharmGKBiPA142672440.

Polymorphism and mutation databases

BioMutaiC1orf122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002541931 – 110Uncharacterized protein C1orf122Add BLAST110

Proteomic databases

EPDiQ6ZSJ8.
MaxQBiQ6ZSJ8.
PaxDbiQ6ZSJ8.
PeptideAtlasiQ6ZSJ8.
PRIDEiQ6ZSJ8.
TopDownProteomicsiQ6ZSJ8-1. [Q6ZSJ8-1]

PTM databases

iPTMnetiQ6ZSJ8.
PhosphoSitePlusiQ6ZSJ8.

Expressioni

Gene expression databases

BgeeiENSG00000197982.
CleanExiHS_C1orf122.
GenevisibleiQ6ZSJ8. HS.

Interactioni

Protein-protein interaction databases

BioGridi126077. 7 interactors.
IntActiQ6ZSJ8. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSJ8.
SMRiQ6ZSJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili36 – 68Sequence analysisAdd BLAST33

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410JCWU. Eukaryota.
ENOG41117TV. LUCA.
GeneTreeiENSGT00570000079623.
HOGENOMiHOG000111246.
InParanoidiQ6ZSJ8.
OMAiMEWGPGS.
OrthoDBiEOG091G11ZI.

Family and domain databases

InterProiIPR031714. DUF4726.
[Graphical view]
PfamiPF15855. DUF4726. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSJ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEWGPGSDWS RGEAAGVDRG KAGLGLGGRP PPQPPREERA QQLLDAVEQR
60 70 80 90 100
QRQLLDTIAA CEEMLRQLGR RRPEPAGGGN VSAKPGAPPQ PAVSARGGFP
110
KDAGDGAAEP
Length:110
Mass (Da):11,471
Last modified:September 22, 2009 - v2
Checksum:iC63352FB57850CFE
GO
Isoform 2 (identifier: Q6ZSJ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Note: No experimental confirmation available.
Show »
Length:47
Mass (Da):4,650
Checksum:iB2CDF8E8200DCF93
GO

Sequence cautioni

The sequence AAH57819 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC86950 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAH70085 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0466481 – 63Missing in isoform 2. CuratedAdd BLAST63

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127381 mRNA. Translation: BAC86950.1. Sequence problems.
AY517499 mRNA. Translation: AAS76640.1.
AL929472 Genomic DNA. Translation: CAH70085.1. Sequence problems.
BC057819 mRNA. Translation: AAH57819.1. Sequence problems.
CCDSiCCDS427.2. [Q6ZSJ8-1]
CCDS44112.1. [Q6ZSJ8-2]
RefSeqiNP_001136198.1. NM_001142726.1. [Q6ZSJ8-2]
NP_940848.2. NM_198446.2. [Q6ZSJ8-1]
UniGeneiHs.532749.

Genome annotation databases

EnsembliENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
GeneIDi127687.
KEGGihsa:127687.
UCSCiuc001ccd.3. human. [Q6ZSJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127381 mRNA. Translation: BAC86950.1. Sequence problems.
AY517499 mRNA. Translation: AAS76640.1.
AL929472 Genomic DNA. Translation: CAH70085.1. Sequence problems.
BC057819 mRNA. Translation: AAH57819.1. Sequence problems.
CCDSiCCDS427.2. [Q6ZSJ8-1]
CCDS44112.1. [Q6ZSJ8-2]
RefSeqiNP_001136198.1. NM_001142726.1. [Q6ZSJ8-2]
NP_940848.2. NM_198446.2. [Q6ZSJ8-1]
UniGeneiHs.532749.

3D structure databases

ProteinModelPortaliQ6ZSJ8.
SMRiQ6ZSJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126077. 7 interactors.
IntActiQ6ZSJ8. 1 interactor.

PTM databases

iPTMnetiQ6ZSJ8.
PhosphoSitePlusiQ6ZSJ8.

Polymorphism and mutation databases

BioMutaiC1orf122.

Proteomic databases

EPDiQ6ZSJ8.
MaxQBiQ6ZSJ8.
PaxDbiQ6ZSJ8.
PeptideAtlasiQ6ZSJ8.
PRIDEiQ6ZSJ8.
TopDownProteomicsiQ6ZSJ8-1. [Q6ZSJ8-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373042; ENSP00000362133; ENSG00000197982. [Q6ZSJ8-1]
ENST00000373043; ENSP00000362134; ENSG00000197982. [Q6ZSJ8-2]
ENST00000468084; ENSP00000434520; ENSG00000197982. [Q6ZSJ8-2]
GeneIDi127687.
KEGGihsa:127687.
UCSCiuc001ccd.3. human. [Q6ZSJ8-1]

Organism-specific databases

CTDi127687.
DisGeNETi127687.
GeneCardsiC1orf122.
HGNCiHGNC:24789. C1orf122.
neXtProtiNX_Q6ZSJ8.
OpenTargetsiENSG00000197982.
PharmGKBiPA142672440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCWU. Eukaryota.
ENOG41117TV. LUCA.
GeneTreeiENSGT00570000079623.
HOGENOMiHOG000111246.
InParanoidiQ6ZSJ8.
OMAiMEWGPGS.
OrthoDBiEOG091G11ZI.

Enzyme and pathway databases

BioCyciZFISH:G66-32749-MONOMER.

Miscellaneous databases

ChiTaRSiC1orf122. human.
GenomeRNAii127687.
PROiQ6ZSJ8.

Gene expression databases

BgeeiENSG00000197982.
CleanExiHS_C1orf122.
GenevisibleiQ6ZSJ8. HS.

Family and domain databases

InterProiIPR031714. DUF4726.
[Graphical view]
PfamiPF15855. DUF4726. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCA122_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSJ8
Secondary accession number(s): A2RQF4, E9PQ13, Q56A71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 22, 2009
Last modified: November 2, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.