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Q6ZSI9

- CAN12_HUMAN

UniProt

Q6ZSI9 - CAN12_HUMAN

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Protein

Calpain-12

Gene
CAPN12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease By similarity.

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051 By similarity
Active sitei259 – 2591 By similarity
Active sitei283 – 2831 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi633 – 64412 Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiC02.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-12 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 12
Short name:
CANP 12
Gene namesi
Name:CAPN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13249. CAPN12.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134863447.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Calpain-12PRO_0000207730Add
BLAST

Proteomic databases

MaxQBiQ6ZSI9.
PaxDbiQ6ZSI9.
PRIDEiQ6ZSI9.

PTM databases

PhosphoSiteiQ6ZSI9.

Expressioni

Gene expression databases

ArrayExpressiQ6ZSI9.
BgeeiQ6ZSI9.
CleanExiHS_CAPN12.
GenevestigatoriQ6ZSI9.

Organism-specific databases

HPAiHPA043492.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331636.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSI9.
SMRiQ6ZSI9. Positions 14-713.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 341297Calpain catalyticAdd
BLAST
Domaini620 – 65536EF-handAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni342 – 540199Domain IIIAdd
BLAST
Regioni541 – 719179Domain IVAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.
Contains 1 EF-hand domain.

Phylogenomic databases

eggNOGiNOG323867.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
InParanoidiQ6ZSI9.
KOiK04740.
OMAiGLRTCEQ.
PhylomeDBiQ6ZSI9.
TreeFamiTF314748.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029545. CAPN12.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF280. PTHR10183:SF280. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZSI9-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSGRVTI QLVDEEAGVG AGRLQLFRGQ SYEAIRAACL DSGILFRDPY    50
FPAGPDALGY DQLGPDSEKA KGVKWMRPHE FCAEPKFICE DMSRTDVCQG 100
SLGNCWFLAA AASLTLYPRL LRRVVPPGQD FQHGYAGVFH FQLWQFGRWM 150
DVVVDDRLPV REGKLMFVRS EQRNEFWAPL LEKAYAKLHG SYEVMRGGHM 200
NEAFVDFTGG VGEVLYLRQN SMGLFSALRH ALAKESLVGA TALSDRGEYR 250
TEEGLVKGHA YSITGTHKVF LGFTKVRLLR LRNPWGCVEW TGAWSDSCPR 300
WDTLPTECRD ALLVKKEDGE FWMELRDFLL HFDTVQICSL SPEVLGPSPE 350
GGGWHVHTFQ GRWVRGFNSG GSQPNAETFW TNPQFRLTLL EPDEEDDEDE 400
EGPWGGWGAA GARGPARGGR TPKCTVLLSL IQRNRRRLRA KGLTYLTVGF 450
HVFQIPEELL GLWDSPRSHA LLPRLLRADR SPLSARRDVT RRCCLRPGHY 500
LVVPSTAHAG DEADFTLRVF SERRHTAVEI DDVISADLQS LQGPYLPLEL 550
GLEQLFQELA GEEEELNASQ LQALLSIALE PARAHTSTPR EIGLRTCEQL 600
LQCFGHGQSL ALHHFQQLWG YLLEWQAIFN KFDEDTSGTM NSYELRLALN 650
AAGFHLNNQL TQTLTSRYRD SRLRVDFERF VSCVAHLTCI FCHCSQHLDG 700
GEGVICLTHR QWMEVATFS 719
Length:719
Mass (Da):81,037
Last modified:July 5, 2004 - v1
Checksum:iBEACE2E5DD5839F2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti287 – 2871C → R.
Corresponds to variant rs12983010 [ dbSNP | Ensembl ].
VAR_051516

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127398 mRNA. Translation: BAC86959.1.
CCDSiCCDS12519.1.
RefSeqiNP_653292.2. NM_144691.3.
UniGeneiHs.731775.

Genome annotation databases

EnsembliENST00000328867; ENSP00000331636; ENSG00000182472.
GeneIDi147968.
KEGGihsa:147968.
UCSCiuc002ojd.1. human.

Polymorphism databases

DMDMi54035703.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127398 mRNA. Translation: BAC86959.1 .
CCDSi CCDS12519.1.
RefSeqi NP_653292.2. NM_144691.3.
UniGenei Hs.731775.

3D structure databases

ProteinModelPortali Q6ZSI9.
SMRi Q6ZSI9. Positions 14-713.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331636.

Protein family/group databases

MEROPSi C02.017.

PTM databases

PhosphoSitei Q6ZSI9.

Polymorphism databases

DMDMi 54035703.

Proteomic databases

MaxQBi Q6ZSI9.
PaxDbi Q6ZSI9.
PRIDEi Q6ZSI9.

Protocols and materials databases

DNASUi 147968.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328867 ; ENSP00000331636 ; ENSG00000182472 .
GeneIDi 147968.
KEGGi hsa:147968.
UCSCi uc002ojd.1. human.

Organism-specific databases

CTDi 147968.
GeneCardsi GC19M039220.
HGNCi HGNC:13249. CAPN12.
HPAi HPA043492.
MIMi 608839. gene.
neXtProti NX_Q6ZSI9.
PharmGKBi PA134863447.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323867.
HOGENOMi HOG000232035.
HOVERGENi HBG012645.
InParanoidi Q6ZSI9.
KOi K04740.
OMAi GLRTCEQ.
PhylomeDBi Q6ZSI9.
TreeFami TF314748.

Miscellaneous databases

GenomeRNAii 147968.
NextBioi 85797.
PROi Q6ZSI9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZSI9.
Bgeei Q6ZSI9.
CleanExi HS_CAPN12.
Genevestigatori Q6ZSI9.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029545. CAPN12.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
PANTHERi PTHR10183:SF280. PTHR10183:SF280. 1 hit.
Pfami PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thalamus.

Entry informationi

Entry nameiCAN12_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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