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Protein

Calpain-12

Gene

CAPN12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei105By similarity1
Active sitei259By similarity1
Active sitei283By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi633 – 644PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.017

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-12 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 12
Short name:
CANP 12
Gene namesi
Name:CAPN12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000182472.8
HGNCiHGNC:13249 CAPN12
MIMi608839 gene
neXtProtiNX_Q6ZSI9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182472
PharmGKBiPA134863447

Polymorphism and mutation databases

BioMutaiCAPN12
DMDMi54035703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077301 – 719Calpain-12Add BLAST719

Proteomic databases

MaxQBiQ6ZSI9
PaxDbiQ6ZSI9
PeptideAtlasiQ6ZSI9
PRIDEiQ6ZSI9

PTM databases

iPTMnetiQ6ZSI9
PhosphoSitePlusiQ6ZSI9

Expressioni

Gene expression databases

BgeeiENSG00000182472
CleanExiHS_CAPN12
ExpressionAtlasiQ6ZSI9 baseline and differential
GenevisibleiQ6ZSI9 HS

Organism-specific databases

HPAiHPA043492
HPA053322

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331636

Structurei

3D structure databases

ProteinModelPortaliQ6ZSI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 341Calpain catalyticPROSITE-ProRule annotationAdd BLAST297
Domaini620 – 655EF-handPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni342 – 540Domain IIIAdd BLAST199
Regioni541 – 719Domain IVAdd BLAST179

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232035
HOVERGENiHBG012645
InParanoidiQ6ZSI9
KOiK04740
OMAiTDVCQGR
OrthoDBiEOG091G049E
PhylomeDBiQ6ZSI9
TreeFamiTF314748

Family and domain databases

CDDicd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029545 CAPN12
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF280 PTHR10183:SF280, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q6ZSI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSGRVTI QLVDEEAGVG AGRLQLFRGQ SYEAIRAACL DSGILFRDPY
60 70 80 90 100
FPAGPDALGY DQLGPDSEKA KGVKWMRPHE FCAEPKFICE DMSRTDVCQG
110 120 130 140 150
SLGNCWFLAA AASLTLYPRL LRRVVPPGQD FQHGYAGVFH FQLWQFGRWM
160 170 180 190 200
DVVVDDRLPV REGKLMFVRS EQRNEFWAPL LEKAYAKLHG SYEVMRGGHM
210 220 230 240 250
NEAFVDFTGG VGEVLYLRQN SMGLFSALRH ALAKESLVGA TALSDRGEYR
260 270 280 290 300
TEEGLVKGHA YSITGTHKVF LGFTKVRLLR LRNPWGCVEW TGAWSDSCPR
310 320 330 340 350
WDTLPTECRD ALLVKKEDGE FWMELRDFLL HFDTVQICSL SPEVLGPSPE
360 370 380 390 400
GGGWHVHTFQ GRWVRGFNSG GSQPNAETFW TNPQFRLTLL EPDEEDDEDE
410 420 430 440 450
EGPWGGWGAA GARGPARGGR TPKCTVLLSL IQRNRRRLRA KGLTYLTVGF
460 470 480 490 500
HVFQIPEELL GLWDSPRSHA LLPRLLRADR SPLSARRDVT RRCCLRPGHY
510 520 530 540 550
LVVPSTAHAG DEADFTLRVF SERRHTAVEI DDVISADLQS LQGPYLPLEL
560 570 580 590 600
GLEQLFQELA GEEEELNASQ LQALLSIALE PARAHTSTPR EIGLRTCEQL
610 620 630 640 650
LQCFGHGQSL ALHHFQQLWG YLLEWQAIFN KFDEDTSGTM NSYELRLALN
660 670 680 690 700
AAGFHLNNQL TQTLTSRYRD SRLRVDFERF VSCVAHLTCI FCHCSQHLDG
710
GEGVICLTHR QWMEVATFS
Length:719
Mass (Da):81,037
Last modified:July 5, 2004 - v1
Checksum:iBEACE2E5DD5839F2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051516287C → R. Corresponds to variant dbSNP:rs12983010Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127398 mRNA Translation: BAC86959.1
CCDSiCCDS12519.1
RefSeqiNP_653292.2, NM_144691.4
UniGeneiHs.731775

Genome annotation databases

EnsembliENST00000328867; ENSP00000331636; ENSG00000182472
GeneIDi147968
KEGGihsa:147968
UCSCiuc002ojd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAN12_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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