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Q6ZSI9

- CAN12_HUMAN

UniProt

Q6ZSI9 - CAN12_HUMAN

Protein

Calpain-12

Gene

CAPN12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Calcium-regulated non-lysosomal thiol-protease.By similarity

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei105 – 1051By similarity
    Active sitei259 – 2591By similarity
    Active sitei283 – 2831By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi633 – 64412PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiC02.017.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-12 (EC:3.4.22.-)
    Alternative name(s):
    Calcium-activated neutral proteinase 12
    Short name:
    CANP 12
    Gene namesi
    Name:CAPN12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13249. CAPN12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134863447.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Calpain-12PRO_0000207730Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZSI9.
    PaxDbiQ6ZSI9.
    PRIDEiQ6ZSI9.

    PTM databases

    PhosphoSiteiQ6ZSI9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZSI9.
    BgeeiQ6ZSI9.
    CleanExiHS_CAPN12.
    GenevestigatoriQ6ZSI9.

    Organism-specific databases

    HPAiHPA043492.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331636.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZSI9.
    SMRiQ6ZSI9. Positions 14-713.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 341297Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini620 – 65536EF-handPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni342 – 540199Domain IIIAdd
    BLAST
    Regioni541 – 719179Domain IVAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation
    Contains 1 EF-hand domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG323867.
    HOGENOMiHOG000232035.
    HOVERGENiHBG012645.
    InParanoidiQ6ZSI9.
    KOiK04740.
    OMAiGLRTCEQ.
    PhylomeDBiQ6ZSI9.
    TreeFamiTF314748.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029545. CAPN12.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF280. PTHR10183:SF280. 1 hit.
    PfamiPF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZSI9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSSGRVTI QLVDEEAGVG AGRLQLFRGQ SYEAIRAACL DSGILFRDPY    50
    FPAGPDALGY DQLGPDSEKA KGVKWMRPHE FCAEPKFICE DMSRTDVCQG 100
    SLGNCWFLAA AASLTLYPRL LRRVVPPGQD FQHGYAGVFH FQLWQFGRWM 150
    DVVVDDRLPV REGKLMFVRS EQRNEFWAPL LEKAYAKLHG SYEVMRGGHM 200
    NEAFVDFTGG VGEVLYLRQN SMGLFSALRH ALAKESLVGA TALSDRGEYR 250
    TEEGLVKGHA YSITGTHKVF LGFTKVRLLR LRNPWGCVEW TGAWSDSCPR 300
    WDTLPTECRD ALLVKKEDGE FWMELRDFLL HFDTVQICSL SPEVLGPSPE 350
    GGGWHVHTFQ GRWVRGFNSG GSQPNAETFW TNPQFRLTLL EPDEEDDEDE 400
    EGPWGGWGAA GARGPARGGR TPKCTVLLSL IQRNRRRLRA KGLTYLTVGF 450
    HVFQIPEELL GLWDSPRSHA LLPRLLRADR SPLSARRDVT RRCCLRPGHY 500
    LVVPSTAHAG DEADFTLRVF SERRHTAVEI DDVISADLQS LQGPYLPLEL 550
    GLEQLFQELA GEEEELNASQ LQALLSIALE PARAHTSTPR EIGLRTCEQL 600
    LQCFGHGQSL ALHHFQQLWG YLLEWQAIFN KFDEDTSGTM NSYELRLALN 650
    AAGFHLNNQL TQTLTSRYRD SRLRVDFERF VSCVAHLTCI FCHCSQHLDG 700
    GEGVICLTHR QWMEVATFS 719
    Length:719
    Mass (Da):81,037
    Last modified:July 5, 2004 - v1
    Checksum:iBEACE2E5DD5839F2
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti287 – 2871C → R.
    Corresponds to variant rs12983010 [ dbSNP | Ensembl ].
    VAR_051516

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127398 mRNA. Translation: BAC86959.1.
    CCDSiCCDS12519.1.
    RefSeqiNP_653292.2. NM_144691.3.
    UniGeneiHs.731775.

    Genome annotation databases

    EnsembliENST00000328867; ENSP00000331636; ENSG00000182472.
    GeneIDi147968.
    KEGGihsa:147968.
    UCSCiuc002ojd.1. human.

    Polymorphism databases

    DMDMi54035703.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127398 mRNA. Translation: BAC86959.1 .
    CCDSi CCDS12519.1.
    RefSeqi NP_653292.2. NM_144691.3.
    UniGenei Hs.731775.

    3D structure databases

    ProteinModelPortali Q6ZSI9.
    SMRi Q6ZSI9. Positions 14-713.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331636.

    Protein family/group databases

    MEROPSi C02.017.

    PTM databases

    PhosphoSitei Q6ZSI9.

    Polymorphism databases

    DMDMi 54035703.

    Proteomic databases

    MaxQBi Q6ZSI9.
    PaxDbi Q6ZSI9.
    PRIDEi Q6ZSI9.

    Protocols and materials databases

    DNASUi 147968.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328867 ; ENSP00000331636 ; ENSG00000182472 .
    GeneIDi 147968.
    KEGGi hsa:147968.
    UCSCi uc002ojd.1. human.

    Organism-specific databases

    CTDi 147968.
    GeneCardsi GC19M039220.
    HGNCi HGNC:13249. CAPN12.
    HPAi HPA043492.
    MIMi 608839. gene.
    neXtProti NX_Q6ZSI9.
    PharmGKBi PA134863447.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323867.
    HOGENOMi HOG000232035.
    HOVERGENi HBG012645.
    InParanoidi Q6ZSI9.
    KOi K04740.
    OMAi GLRTCEQ.
    PhylomeDBi Q6ZSI9.
    TreeFami TF314748.

    Miscellaneous databases

    GenomeRNAii 147968.
    NextBioi 85797.
    PROi Q6ZSI9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZSI9.
    Bgeei Q6ZSI9.
    CleanExi HS_CAPN12.
    Genevestigatori Q6ZSI9.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029545. CAPN12.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF280. PTHR10183:SF280. 1 hit.
    Pfami PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.

    Entry informationi

    Entry nameiCAN12_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZSI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3