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Protein

Protein FAM196A

Gene

FAM196A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM196A
Gene namesi
Name:FAM196A
Synonyms:C10orf141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:33859. FAM196A.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188916.
PharmGKBiPA165548646.

Polymorphism and mutation databases

BioMutaiFAM196A.
DMDMi74711413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294461 – 479Protein FAM196AAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZSG2.
PeptideAtlasiQ6ZSG2.
PRIDEiQ6ZSG2.

PTM databases

iPTMnetiQ6ZSG2.
PhosphoSitePlusiQ6ZSG2.

Expressioni

Gene expression databases

BgeeiENSG00000188916.
CleanExiHS_C10orf141.
GenevisibleiQ6ZSG2. HS.

Organism-specific databases

HPAiHPA035898.
HPA035899.

Interactioni

Protein-protein interaction databases

BioGridi568370. 33 interactors.
IntActiQ6ZSG2. 3 interactors.
STRINGi9606.ENSP00000429763.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili353 – 379Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the FAM196 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIQG. Eukaryota.
ENOG41119K1. LUCA.
GeneTreeiENSGT00530000063787.
HOGENOMiHOG000060316.
HOVERGENiHBG064694.
InParanoidiQ6ZSG2.
OMAiIVPHTEV.
OrthoDBiEOG091G05H4.
PhylomeDBiQ6ZSG2.
TreeFamiTF333465.

Family and domain databases

InterProiView protein in InterPro
IPR029337. FAM196.
PfamiView protein in Pfam
PF15265. FAM196. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKDTGKCI LTTSESEVEP AACLALEMKY ALDPNRQIKK RNKALQVRFK
60 70 80 90 100
DICEAQNEQR DTQLSSGQLG EKREAKPVSC RAAYRKYMTV PARRSIPNVT
110 120 130 140 150
KSTGVQTSPD LKKCYQTFPL DRKKGNLKSL PAADPFKSQN NGFLTDAKEK
160 170 180 190 200
NEAGPMEEAR PCGAGRVHKT TALVFHSNQH MNTVDQPLGV NCTEPCKSPE
210 220 230 240 250
PLSYGEAALQ NSTRPPSEEP DYQLLGRAKQ DRGRPNSEEP APPALRRVFK
260 270 280 290 300
TEVATVYAPA LSARAPEPGL SDSAAASQWS LCPADDERRR ATHLNGLQAP
310 320 330 340 350
SETALACSPP MQCLSPECSE QPSQTHTPPG LGNQPSPTAV AAGEECQRIV
360 370 380 390 400
PHTEVVDLKA QLQMMENLIS SSQETIKVLL GVIQELEKGE AHREGLSYRT
410 420 430 440 450
GQDTANCDTC RNSACIIYSV ELDFKQQEDK LQPVLRKLHP IEETQVIPSP
460 470
YSQETYSSTP KQKSKTESKK HGRWKLWFL
Length:479
Mass (Da):52,909
Last modified:July 5, 2004 - v1
Checksum:i839D6E8DB895F308
GO
Isoform 2 (identifier: Q6ZSG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-419: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):50,271
Checksum:i48F773B45275C828
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042679147A → V. Corresponds to variant dbSNP:rs11594560Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056622396 – 419Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127465 mRNA. Translation: BAC86991.1.
AL390920 Genomic DNA. No translation available.
BC131825 mRNA. Translation: AAI31826.1.
BC137112 mRNA. Translation: AAI37113.1.
BC144478 mRNA. Translation: AAI44479.1.
CCDSiCCDS31312.1. [Q6ZSG2-1]
RefSeqiNP_001034851.1. NM_001039762.2. [Q6ZSG2-1]
XP_005252751.1. XM_005252694.3. [Q6ZSG2-1]
XP_016872026.1. XM_017016537.1. [Q6ZSG2-1]
XP_016872027.1. XM_017016538.1. [Q6ZSG2-1]
XP_016872028.1. XM_017016539.1. [Q6ZSG2-1]
XP_016872029.1. XM_017016540.1. [Q6ZSG2-1]
XP_016872030.1. XM_017016541.1. [Q6ZSG2-1]
XP_016872031.1. XM_017016542.1. [Q6ZSG2-1]
UniGeneiHs.613882.

Genome annotation databases

EnsembliENST00000424811; ENSP00000428730; ENSG00000188916. [Q6ZSG2-2]
ENST00000522781; ENSP00000429763; ENSG00000188916. [Q6ZSG2-1]
ENST00000614311; ENSP00000479733; ENSG00000188916. [Q6ZSG2-2]
GeneIDi642938.
KEGGihsa:642938.
UCSCiuc001ljv.2. human. [Q6ZSG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF196A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSG2
Secondary accession number(s): B2RNT4, B7ZME7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families