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Protein

Protein FAM196A

Gene

FAM196A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM196A
Gene namesi
Name:FAM196A
Synonyms:C10orf141
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000188916.8
HGNCiHGNC:33859 FAM196A
neXtProtiNX_Q6ZSG2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188916
PharmGKBiPA165548646

Polymorphism and mutation databases

BioMutaiFAM196A
DMDMi74711413

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003294461 – 479Protein FAM196AAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6ZSG2
PeptideAtlasiQ6ZSG2
PRIDEiQ6ZSG2

PTM databases

iPTMnetiQ6ZSG2
PhosphoSitePlusiQ6ZSG2

Expressioni

Gene expression databases

BgeeiENSG00000188916
CleanExiHS_C10orf141
GenevisibleiQ6ZSG2 HS

Organism-specific databases

HPAiHPA035898
HPA035899

Interactioni

Protein-protein interaction databases

BioGridi568370, 33 interactors
IntActiQ6ZSG2, 3 interactors
STRINGi9606.ENSP00000429763

Structurei

3D structure databases

ProteinModelPortaliQ6ZSG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili353 – 379Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the FAM196 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIQG Eukaryota
ENOG41119K1 LUCA
GeneTreeiENSGT00530000063787
HOGENOMiHOG000060316
HOVERGENiHBG064694
InParanoidiQ6ZSG2
OMAiSQWSLCP
OrthoDBiEOG091G05H4
PhylomeDBiQ6ZSG2
TreeFamiTF333465

Family and domain databases

InterProiView protein in InterPro
IPR029337 FAM196
PANTHERiPTHR28682 PTHR28682, 1 hit
PfamiView protein in Pfam
PF15265 FAM196, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSKDTGKCI LTTSESEVEP AACLALEMKY ALDPNRQIKK RNKALQVRFK
60 70 80 90 100
DICEAQNEQR DTQLSSGQLG EKREAKPVSC RAAYRKYMTV PARRSIPNVT
110 120 130 140 150
KSTGVQTSPD LKKCYQTFPL DRKKGNLKSL PAADPFKSQN NGFLTDAKEK
160 170 180 190 200
NEAGPMEEAR PCGAGRVHKT TALVFHSNQH MNTVDQPLGV NCTEPCKSPE
210 220 230 240 250
PLSYGEAALQ NSTRPPSEEP DYQLLGRAKQ DRGRPNSEEP APPALRRVFK
260 270 280 290 300
TEVATVYAPA LSARAPEPGL SDSAAASQWS LCPADDERRR ATHLNGLQAP
310 320 330 340 350
SETALACSPP MQCLSPECSE QPSQTHTPPG LGNQPSPTAV AAGEECQRIV
360 370 380 390 400
PHTEVVDLKA QLQMMENLIS SSQETIKVLL GVIQELEKGE AHREGLSYRT
410 420 430 440 450
GQDTANCDTC RNSACIIYSV ELDFKQQEDK LQPVLRKLHP IEETQVIPSP
460 470
YSQETYSSTP KQKSKTESKK HGRWKLWFL
Length:479
Mass (Da):52,909
Last modified:July 5, 2004 - v1
Checksum:i839D6E8DB895F308
GO
Isoform 2 (identifier: Q6ZSG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     396-419: Missing.

Note: No experimental confirmation available.
Show »
Length:455
Mass (Da):50,271
Checksum:i48F773B45275C828
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042679147A → V. Corresponds to variant dbSNP:rs11594560Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056622396 – 419Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127465 mRNA Translation: BAC86991.1
AL390920 Genomic DNA No translation available.
BC131825 mRNA Translation: AAI31826.1
BC137112 mRNA Translation: AAI37113.1
BC144478 mRNA Translation: AAI44479.1
CCDSiCCDS31312.1 [Q6ZSG2-1]
RefSeqiNP_001034851.1, NM_001039762.2 [Q6ZSG2-1]
XP_005252751.1, XM_005252694.3 [Q6ZSG2-1]
XP_016872026.1, XM_017016537.1 [Q6ZSG2-1]
XP_016872027.1, XM_017016538.1 [Q6ZSG2-1]
XP_016872028.1, XM_017016539.1 [Q6ZSG2-1]
XP_016872029.1, XM_017016540.1 [Q6ZSG2-1]
XP_016872030.1, XM_017016541.1 [Q6ZSG2-1]
XP_016872031.1, XM_017016542.1 [Q6ZSG2-1]
UniGeneiHs.613882

Genome annotation databases

EnsembliENST00000424811; ENSP00000428730; ENSG00000188916 [Q6ZSG2-2]
ENST00000522781; ENSP00000429763; ENSG00000188916 [Q6ZSG2-1]
ENST00000614311; ENSP00000479733; ENSG00000188916 [Q6ZSG2-2]
GeneIDi642938
KEGGihsa:642938
UCSCiuc001ljv.2 human [Q6ZSG2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF196A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSG2
Secondary accession number(s): B2RNT4, B7ZME7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health