Q6ZSG1 (RN165_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RING finger protein 165

Gene names

Name:

RNF165

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZSG1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZSG1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	RING finger protein 165		PRO_0000245587
Regions
	Zinc finger	294 – 335	42	RING-type; atypical
Amino acid modifications
	Glycosylation	199	1	N-linked (GlcNAc...) Ref.3
Natural variations
	Alternative sequence	1 – 192	192	Missing in isoform 2.		VSP_045128

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 93A5B777988C339C	FASTA	346	39,526
	10 20 30 40 50 60 MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS 70 80 90 100 110 120 QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR 130 140 150 160 170 180 LVSHPRRSQE RVSVHPHRLH PSFDFGQLQT PQPRYLAEGT DWDLSVDAGL SPAQFQVRPI 190 200 210 220 230 240 PQHYQHYLAT PRMHHFPRNS SSTQMVVHEI RNYPYPQLHF LALQGLNPSR HTSAVRESYE 250 260 270 280 290 300 ELLQLEDRLG NVTRGAVQNT IERFTFPHKY KKRRPQDGKG KKDEGEESDT DEKCTICLSM 310 320 330 340 LEDGEDVRRL PCMHLFHQLC VDQWLAMSKK CPICRVDIET QLGADS
	Isoform 2 [UniParc]. Checksum: 2444AC2D0D1D788A	FASTA	154	17,870
	10 20 30 40 50 60 MHHFPRNSSS TQMVVHEIRN YPYPQLHFLA LQGLNPSRHT SAVRESYEEL LQLEDRLGNV 70 80 90 100 110 120 TRGAVQNTIE RFTFPHKYKK RRPQDGKGKK DEGEESDTDE KCTICLSMLE DGEDVRRLPC 130 140 150 MHLFHQLCVD QWLAMSKKCP ICRVDIETQL GADS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum and Thalamus.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK127467 mRNA. Translation: BAC86992.1. AK122819 mRNA. Translation: BAG53743.1. AC015959 Genomic DNA. No translation available. AC018931 Genomic DNA. No translation available. AC021763 Genomic DNA. No translation available.
IPI	IPI00161541.
RefSeq	NP_001243687.1. NM_001256758.1. NP_689683.2. NM_152470.2.
UniGene	Hs.501114.
3D structure databases
ProteinModelPortal	Q6ZSG1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZSG1. 8 interactions.
STRING	9606.ENSP00000269439.
Polymorphism databases
DMDM	74762404.
Proteomic databases
PaxDb	Q6ZSG1.
PRIDE	Q6ZSG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269439; ENSP00000269439; ENSG00000141622. ENST00000543885; ENSP00000444285; ENSG00000141622.
GeneID	494470.
KEGG	hsa:494470.
UCSC	uc002lby.1. human.
Organism-specific databases
CTD	494470.
GeneCards	GC18P043914.
HGNC	HGNC:31696. RNF165.
HPA	HPA041615. HPA047798.
neXtProt	NX_Q6ZSG1.
PharmGKB	PA134972127.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG243435.
HOGENOM	HOG000154155.
HOVERGEN	HBG093904.
InParanoid	Q6ZSG1.
OMA	FSHQLQT.
OrthoDB	EOG4J6RRC.
PhylomeDB	Q6ZSG1.
Gene expression databases
ArrayExpress	Q6ZSG1.
Bgee	Q6ZSG1.
CleanEx	HS_RNF165.
Genevestigator	Q6ZSG1.
GermOnline	ENSG00000141622. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF13639. zf-RING_2. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	494470.
NextBio	111870.

Entry information

Entry name

RN165_HUMAN

Accession

Primary (citable) accession number: Q6ZSG1
Secondary accession number(s): B3KVD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.