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Protein

RING finger protein 165

Gene

RNF165

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri294 – 335RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 165
Gene namesi
Name:RNF165
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:31696. RNF165.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi494470.
OpenTargetsiENSG00000141622.
PharmGKBiPA134972127.

Polymorphism and mutation databases

BioMutaiRNF165.
DMDMi74762404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455871 – 346RING finger protein 165Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi199N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZSG1.
PRIDEiQ6ZSG1.

Expressioni

Gene expression databases

BgeeiENSG00000141622.
CleanExiHS_RNF165.
ExpressionAtlasiQ6ZSG1. baseline and differential.
GenevisibleiQ6ZSG1. HS.

Organism-specific databases

HPAiHPA041615.
HPA047798.

Interactioni

Protein-protein interaction databases

BioGridi138966. 9 interactors.
DIPiDIP-52693N.
IntActiQ6ZSG1. 8 interactors.
STRINGi9606.ENSP00000269439.

Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi261 – 264Combined sources4
Beta strandi265 – 269Combined sources5
Turni295 – 297Combined sources3
Beta strandi306 – 309Combined sources4
Beta strandi315 – 317Combined sources3
Helixi318 – 328Combined sources11
Turni332 – 334Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D0IX-ray1.90A/B255-346[»]
5D0KX-ray2.65C/F/I/L255-346[»]
5D0MX-ray1.91C255-346[»]
ProteinModelPortaliQ6ZSG1.
SMRiQ6ZSG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri294 – 335RING-type; atypicalPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00730000110863.
HOGENOMiHOG000154155.
HOVERGENiHBG093904.
InParanoidiQ6ZSG1.
KOiK17821.
OMAiDFGHQLQ.
OrthoDBiEOG091G0WPK.
PhylomeDBiQ6ZSG1.
TreeFamiTF317681.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP
60 70 80 90 100
DFPLAHPVQS QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP
110 120 130 140 150
QALHQQYLLQ QQLLEAQHRR LVSHPRRSQE RVSVHPHRLH PSFDFGQLQT
160 170 180 190 200
PQPRYLAEGT DWDLSVDAGL SPAQFQVRPI PQHYQHYLAT PRMHHFPRNS
210 220 230 240 250
SSTQMVVHEI RNYPYPQLHF LALQGLNPSR HTSAVRESYE ELLQLEDRLG
260 270 280 290 300
NVTRGAVQNT IERFTFPHKY KKRRPQDGKG KKDEGEESDT DEKCTICLSM
310 320 330 340
LEDGEDVRRL PCMHLFHQLC VDQWLAMSKK CPICRVDIET QLGADS
Length:346
Mass (Da):39,526
Last modified:July 5, 2004 - v1
Checksum:i93A5B777988C339C
GO
Isoform 2 (identifier: Q6ZSG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Show »
Length:154
Mass (Da):17,870
Checksum:i2444AC2D0D1D788A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451281 – 192Missing in isoform 2. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127467 mRNA. Translation: BAC86992.1.
AK122819 mRNA. Translation: BAG53743.1.
AC015959 Genomic DNA. No translation available.
AC018931 Genomic DNA. No translation available.
AC021763 Genomic DNA. No translation available.
CCDSiCCDS32823.1. [Q6ZSG1-1]
CCDS58621.1. [Q6ZSG1-2]
RefSeqiNP_001243687.1. NM_001256758.1. [Q6ZSG1-2]
NP_689683.2. NM_152470.2. [Q6ZSG1-1]
UniGeneiHs.501114.

Genome annotation databases

EnsembliENST00000269439; ENSP00000269439; ENSG00000141622. [Q6ZSG1-1]
ENST00000543885; ENSP00000444285; ENSG00000141622. [Q6ZSG1-2]
GeneIDi494470.
KEGGihsa:494470.
UCSCiuc002lcb.2. human. [Q6ZSG1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127467 mRNA. Translation: BAC86992.1.
AK122819 mRNA. Translation: BAG53743.1.
AC015959 Genomic DNA. No translation available.
AC018931 Genomic DNA. No translation available.
AC021763 Genomic DNA. No translation available.
CCDSiCCDS32823.1. [Q6ZSG1-1]
CCDS58621.1. [Q6ZSG1-2]
RefSeqiNP_001243687.1. NM_001256758.1. [Q6ZSG1-2]
NP_689683.2. NM_152470.2. [Q6ZSG1-1]
UniGeneiHs.501114.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5D0IX-ray1.90A/B255-346[»]
5D0KX-ray2.65C/F/I/L255-346[»]
5D0MX-ray1.91C255-346[»]
ProteinModelPortaliQ6ZSG1.
SMRiQ6ZSG1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138966. 9 interactors.
DIPiDIP-52693N.
IntActiQ6ZSG1. 8 interactors.
STRINGi9606.ENSP00000269439.

Polymorphism and mutation databases

BioMutaiRNF165.
DMDMi74762404.

Proteomic databases

PaxDbiQ6ZSG1.
PRIDEiQ6ZSG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269439; ENSP00000269439; ENSG00000141622. [Q6ZSG1-1]
ENST00000543885; ENSP00000444285; ENSG00000141622. [Q6ZSG1-2]
GeneIDi494470.
KEGGihsa:494470.
UCSCiuc002lcb.2. human. [Q6ZSG1-1]

Organism-specific databases

CTDi494470.
DisGeNETi494470.
GeneCardsiRNF165.
HGNCiHGNC:31696. RNF165.
HPAiHPA041615.
HPA047798.
neXtProtiNX_Q6ZSG1.
OpenTargetsiENSG00000141622.
PharmGKBiPA134972127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800. Eukaryota.
ENOG41121N2. LUCA.
GeneTreeiENSGT00730000110863.
HOGENOMiHOG000154155.
HOVERGENiHBG093904.
InParanoidiQ6ZSG1.
KOiK17821.
OMAiDFGHQLQ.
OrthoDBiEOG091G0WPK.
PhylomeDBiQ6ZSG1.
TreeFamiTF317681.

Miscellaneous databases

GenomeRNAii494470.
PROiQ6ZSG1.

Gene expression databases

BgeeiENSG00000141622.
CleanExiHS_RNF165.
ExpressionAtlasiQ6ZSG1. baseline and differential.
GenevisibleiQ6ZSG1. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001841. Znf_RING.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRN165_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSG1
Secondary accession number(s): B3KVD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.