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Q6ZSG1

- RN165_HUMAN

UniProt

Q6ZSG1 - RN165_HUMAN

Protein

RING finger protein 165

Gene

RNF165

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri294 – 33542RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 165
    Gene namesi
    Name:RNF165
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:31696. RNF165.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134972127.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346RING finger protein 165PRO_0000245587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6ZSG1.
    PRIDEiQ6ZSG1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZSG1.
    BgeeiQ6ZSG1.
    CleanExiHS_RNF165.
    GenevestigatoriQ6ZSG1.

    Organism-specific databases

    HPAiHPA041615.
    HPA047798.

    Interactioni

    Protein-protein interaction databases

    BioGridi138966. 8 interactions.
    DIPiDIP-52693N.
    IntActiQ6ZSG1. 8 interactions.
    STRINGi9606.ENSP00000269439.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZSG1.
    SMRiQ6ZSG1. Positions 252-346.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri294 – 33542RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG243435.
    HOGENOMiHOG000154155.
    HOVERGENiHBG093904.
    InParanoidiQ6ZSG1.
    KOiK17821.
    OMAiHSGTLHQ.
    PhylomeDBiQ6ZSG1.
    TreeFamiTF317681.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13639. zf-RING_2. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZSG1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP    50
    DFPLAHPVQS QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP 100
    QALHQQYLLQ QQLLEAQHRR LVSHPRRSQE RVSVHPHRLH PSFDFGQLQT 150
    PQPRYLAEGT DWDLSVDAGL SPAQFQVRPI PQHYQHYLAT PRMHHFPRNS 200
    SSTQMVVHEI RNYPYPQLHF LALQGLNPSR HTSAVRESYE ELLQLEDRLG 250
    NVTRGAVQNT IERFTFPHKY KKRRPQDGKG KKDEGEESDT DEKCTICLSM 300
    LEDGEDVRRL PCMHLFHQLC VDQWLAMSKK CPICRVDIET QLGADS 346
    Length:346
    Mass (Da):39,526
    Last modified:July 5, 2004 - v1
    Checksum:i93A5B777988C339C
    GO
    Isoform 2 (identifier: Q6ZSG1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-192: Missing.

    Show »
    Length:154
    Mass (Da):17,870
    Checksum:i2444AC2D0D1D788A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 192192Missing in isoform 2. 1 PublicationVSP_045128Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127467 mRNA. Translation: BAC86992.1.
    AK122819 mRNA. Translation: BAG53743.1.
    AC015959 Genomic DNA. No translation available.
    AC018931 Genomic DNA. No translation available.
    AC021763 Genomic DNA. No translation available.
    CCDSiCCDS32823.1. [Q6ZSG1-1]
    CCDS58621.1. [Q6ZSG1-2]
    RefSeqiNP_001243687.1. NM_001256758.1. [Q6ZSG1-2]
    NP_689683.2. NM_152470.2. [Q6ZSG1-1]
    UniGeneiHs.501114.

    Genome annotation databases

    EnsembliENST00000269439; ENSP00000269439; ENSG00000141622. [Q6ZSG1-1]
    ENST00000543885; ENSP00000444285; ENSG00000141622. [Q6ZSG1-2]
    GeneIDi494470.
    KEGGihsa:494470.
    UCSCiuc002lby.1. human. [Q6ZSG1-1]
    uc010dnn.2. human.

    Polymorphism databases

    DMDMi74762404.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK127467 mRNA. Translation: BAC86992.1 .
    AK122819 mRNA. Translation: BAG53743.1 .
    AC015959 Genomic DNA. No translation available.
    AC018931 Genomic DNA. No translation available.
    AC021763 Genomic DNA. No translation available.
    CCDSi CCDS32823.1. [Q6ZSG1-1 ]
    CCDS58621.1. [Q6ZSG1-2 ]
    RefSeqi NP_001243687.1. NM_001256758.1. [Q6ZSG1-2 ]
    NP_689683.2. NM_152470.2. [Q6ZSG1-1 ]
    UniGenei Hs.501114.

    3D structure databases

    ProteinModelPortali Q6ZSG1.
    SMRi Q6ZSG1. Positions 252-346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 138966. 8 interactions.
    DIPi DIP-52693N.
    IntActi Q6ZSG1. 8 interactions.
    STRINGi 9606.ENSP00000269439.

    Polymorphism databases

    DMDMi 74762404.

    Proteomic databases

    PaxDbi Q6ZSG1.
    PRIDEi Q6ZSG1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269439 ; ENSP00000269439 ; ENSG00000141622 . [Q6ZSG1-1 ]
    ENST00000543885 ; ENSP00000444285 ; ENSG00000141622 . [Q6ZSG1-2 ]
    GeneIDi 494470.
    KEGGi hsa:494470.
    UCSCi uc002lby.1. human. [Q6ZSG1-1 ]
    uc010dnn.2. human.

    Organism-specific databases

    CTDi 494470.
    GeneCardsi GC18P043914.
    HGNCi HGNC:31696. RNF165.
    HPAi HPA041615.
    HPA047798.
    neXtProti NX_Q6ZSG1.
    PharmGKBi PA134972127.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG243435.
    HOGENOMi HOG000154155.
    HOVERGENi HBG093904.
    InParanoidi Q6ZSG1.
    KOi K17821.
    OMAi HSGTLHQ.
    PhylomeDBi Q6ZSG1.
    TreeFami TF317681.

    Miscellaneous databases

    GenomeRNAii 494470.
    NextBioi 111870.
    PROi Q6ZSG1.

    Gene expression databases

    ArrayExpressi Q6ZSG1.
    Bgeei Q6ZSG1.
    CleanExi HS_RNF165.
    Genevestigatori Q6ZSG1.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13639. zf-RING_2. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Thalamus.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199.
      Tissue: Liver.

    Entry informationi

    Entry nameiRN165_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZSG1
    Secondary accession number(s): B3KVD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3