Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6ZSG1 (RN165_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RING finger protein 165
Gene names
Name:RNF165
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandMetal-binding
Zinc
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZSG1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZSG1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346RING finger protein 165
PRO_0000245587

Regions

Zinc finger294 – 33542RING-type; atypical

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Ref.3

Natural variations

Alternative sequence1 – 192192Missing in isoform 2.
VSP_045128

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 93A5B777988C339C

FASTA34639,526
        10         20         30         40         50         60 
MVLVHVGYLV LPVFGSVRNR GAPFQRSQHP HATSCRHFHL GPPQPQQLAP DFPLAHPVQS 

        70         80         90        100        110        120 
QPGLSAHMAP AHQHSGALHQ SLTPLPTLQF QDVTGPSFLP QALHQQYLLQ QQLLEAQHRR 

       130        140        150        160        170        180 
LVSHPRRSQE RVSVHPHRLH PSFDFGQLQT PQPRYLAEGT DWDLSVDAGL SPAQFQVRPI 

       190        200        210        220        230        240 
PQHYQHYLAT PRMHHFPRNS SSTQMVVHEI RNYPYPQLHF LALQGLNPSR HTSAVRESYE 

       250        260        270        280        290        300 
ELLQLEDRLG NVTRGAVQNT IERFTFPHKY KKRRPQDGKG KKDEGEESDT DEKCTICLSM 

       310        320        330        340 
LEDGEDVRRL PCMHLFHQLC VDQWLAMSKK CPICRVDIET QLGADS 

« Hide

Isoform 2 [UniParc].

Checksum: 2444AC2D0D1D788A
Show »

FASTA15417,870

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum and Thalamus.
[2]"DNA sequence and analysis of human chromosome 18."
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. expand/collapse author list , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.
Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK127467 mRNA. Translation: BAC86992.1.
AK122819 mRNA. Translation: BAG53743.1.
AC015959 Genomic DNA. No translation available.
AC018931 Genomic DNA. No translation available.
AC021763 Genomic DNA. No translation available.
RefSeqNP_001243687.1. NM_001256758.1.
NP_689683.2. NM_152470.2.
UniGeneHs.501114.

3D structure databases

ProteinModelPortalQ6ZSG1.
SMRQ6ZSG1. Positions 252-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid138966. 8 interactions.
DIPDIP-52693N.
IntActQ6ZSG1. 8 interactions.
STRING9606.ENSP00000269439.

Polymorphism databases

DMDM74762404.

Proteomic databases

PaxDbQ6ZSG1.
PRIDEQ6ZSG1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000269439; ENSP00000269439; ENSG00000141622. [Q6ZSG1-1]
ENST00000543885; ENSP00000444285; ENSG00000141622. [Q6ZSG1-2]
GeneID494470.
KEGGhsa:494470.
UCSCuc002lby.1. human. [Q6ZSG1-1]
uc010dnn.2. human.

Organism-specific databases

CTD494470.
GeneCardsGC18P043914.
HGNCHGNC:31696. RNF165.
HPAHPA041615.
HPA047798.
neXtProtNX_Q6ZSG1.
PharmGKBPA134972127.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG243435.
HOGENOMHOG000154155.
HOVERGENHBG093904.
InParanoidQ6ZSG1.
KOK17821.
OMAHSGTLHQ.
PhylomeDBQ6ZSG1.
TreeFamTF317681.

Gene expression databases

ArrayExpressQ6ZSG1.
BgeeQ6ZSG1.
CleanExHS_RNF165.
GenevestigatorQ6ZSG1.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13639. zf-RING_2. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
[Graphical view]
PROSITEPS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi494470.
NextBio111870.
PROQ6ZSG1.

Entry information

Entry nameRN165_HUMAN
AccessionPrimary (citable) accession number: Q6ZSG1
Secondary accession number(s): B3KVD1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: March 19, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM