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Protein

RNA-binding protein 43

Gene

RBM43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32829-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 43
Alternative name(s):
RNA-binding motif protein 43
Gene namesi
Name:RBM43
Synonyms:C2orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:24790. RBM43.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184898.
PharmGKBiPA162400761.

Polymorphism and mutation databases

BioMutaiRBM43.
DMDMi74711383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642471 – 357RNA-binding protein 43Add BLAST357

Proteomic databases

EPDiQ6ZSC3.
PaxDbiQ6ZSC3.
PeptideAtlasiQ6ZSC3.
PRIDEiQ6ZSC3.

PTM databases

iPTMnetiQ6ZSC3.
PhosphoSitePlusiQ6ZSC3.

Expressioni

Gene expression databases

BgeeiENSG00000184898.
CleanExiHS_RBM43.
ExpressionAtlasiQ6ZSC3. baseline and differential.
GenevisibleiQ6ZSC3. HS.

Organism-specific databases

HPAiHPA038204.

Interactioni

Protein-protein interaction databases

IntActiQ6ZSC3. 3 interactors.
STRINGi9606.ENSP00000331211.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSC3.
SMRiQ6ZSC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 104RRMPROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00390000007352.
HOGENOMiHOG000231959.
HOVERGENiHBG080503.
InParanoidiQ6ZSC3.
OMAiHIDIIGS.
OrthoDBiEOG091G0CSW.
PhylomeDBiQ6ZSC3.
TreeFamiTF335737.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZSC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV
60 70 80 90 100
EDVIYPTRTK GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS
110 120 130 140 150
HFGDKIFSSV NAILDLSVFG KEVTLETLVK DLKKKIPSLS FSPLKPNGRI
160 170 180 190 200
SVEGSFLAVK RLRESLLARA CSLLEKDRNF TSEERKWNRQ NPQRNLQRSN
210 220 230 240 250
NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST LKKFHILSQE
260 270 280 290 300
KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG
310 320 330 340 350
KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK

LIGQKVS
Length:357
Mass (Da):40,666
Last modified:July 5, 2004 - v1
Checksum:iD0EEA2B465888036
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033722259I → V.Corresponds to variant rs35749426dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127552 mRNA. Translation: BAC87031.1.
CH471058 Genomic DNA. Translation: EAX11514.1.
BC136410 mRNA. Translation: AAI36411.1.
BC136411 mRNA. Translation: AAI36412.1.
CCDSiCCDS2191.1.
RefSeqiNP_940959.1. NM_198557.2.
UniGeneiHs.302442.

Genome annotation databases

EnsembliENST00000331426; ENSP00000331211; ENSG00000184898.
GeneIDi375287.
KEGGihsa:375287.
UCSCiuc002txh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127552 mRNA. Translation: BAC87031.1.
CH471058 Genomic DNA. Translation: EAX11514.1.
BC136410 mRNA. Translation: AAI36411.1.
BC136411 mRNA. Translation: AAI36412.1.
CCDSiCCDS2191.1.
RefSeqiNP_940959.1. NM_198557.2.
UniGeneiHs.302442.

3D structure databases

ProteinModelPortaliQ6ZSC3.
SMRiQ6ZSC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZSC3. 3 interactors.
STRINGi9606.ENSP00000331211.

PTM databases

iPTMnetiQ6ZSC3.
PhosphoSitePlusiQ6ZSC3.

Polymorphism and mutation databases

BioMutaiRBM43.
DMDMi74711383.

Proteomic databases

EPDiQ6ZSC3.
PaxDbiQ6ZSC3.
PeptideAtlasiQ6ZSC3.
PRIDEiQ6ZSC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331426; ENSP00000331211; ENSG00000184898.
GeneIDi375287.
KEGGihsa:375287.
UCSCiuc002txh.4. human.

Organism-specific databases

CTDi375287.
GeneCardsiRBM43.
HGNCiHGNC:24790. RBM43.
HPAiHPA038204.
neXtProtiNX_Q6ZSC3.
OpenTargetsiENSG00000184898.
PharmGKBiPA162400761.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00390000007352.
HOGENOMiHOG000231959.
HOVERGENiHBG080503.
InParanoidiQ6ZSC3.
OMAiHIDIIGS.
OrthoDBiEOG091G0CSW.
PhylomeDBiQ6ZSC3.
TreeFamiTF335737.

Enzyme and pathway databases

BioCyciZFISH:G66-32829-MONOMER.

Miscellaneous databases

GenomeRNAii375287.
PROiQ6ZSC3.

Gene expression databases

BgeeiENSG00000184898.
CleanExiHS_RBM43.
ExpressionAtlasiQ6ZSC3. baseline and differential.
GenevisibleiQ6ZSC3. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM43_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSC3
Secondary accession number(s): B2RMT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.