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Protein

RNA-binding protein 43

Gene

RBM43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 43
Alternative name(s):
RNA-binding motif protein 43
Gene namesi
Name:RBM43
Synonyms:C2orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000184898.6.
HGNCiHGNC:24790. RBM43.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184898.
PharmGKBiPA162400761.

Polymorphism and mutation databases

BioMutaiRBM43.
DMDMi74711383.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642471 – 357RNA-binding protein 43Add BLAST357

Proteomic databases

EPDiQ6ZSC3.
PaxDbiQ6ZSC3.
PeptideAtlasiQ6ZSC3.
PRIDEiQ6ZSC3.

PTM databases

iPTMnetiQ6ZSC3.
PhosphoSitePlusiQ6ZSC3.

Expressioni

Gene expression databases

BgeeiENSG00000184898.
CleanExiHS_RBM43.
ExpressionAtlasiQ6ZSC3. baseline and differential.
GenevisibleiQ6ZSC3. HS.

Organism-specific databases

HPAiHPA038204.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150384EBI-2880658,EBI-724310

Protein-protein interaction databases

BioGridi131966. 5 interactors.
IntActiQ6ZSC3. 3 interactors.
STRINGi9606.ENSP00000331211.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSC3.
SMRiQ6ZSC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 104RRMPROSITE-ProRule annotationAdd BLAST90

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
GeneTreeiENSGT00390000007352.
HOGENOMiHOG000231959.
HOVERGENiHBG080503.
InParanoidiQ6ZSC3.
OMAiHIDIIGS.
OrthoDBiEOG091G0CSW.
PhylomeDBiQ6ZSC3.
TreeFamiTF335737.

Family and domain databases

InterProiView protein in InterPro
IPR035979. RBD_domain_sf.
IPR034463. RBM43.
IPR000504. RRM_dom.
PANTHERiPTHR15225:SF8. PTHR15225:SF8. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZSC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLNVKES KAPERTVVVA GLPVDLFSDQ LLAVLVKSHF QDIKNEGGDV
60 70 80 90 100
EDVIYPTRTK GVAYVIFKEK KVAENVIRQK KHWLARKTRH AELTVSLRVS
110 120 130 140 150
HFGDKIFSSV NAILDLSVFG KEVTLETLVK DLKKKIPSLS FSPLKPNGRI
160 170 180 190 200
SVEGSFLAVK RLRESLLARA CSLLEKDRNF TSEERKWNRQ NPQRNLQRSN
210 220 230 240 250
NSLASVRTLV PETARSGEML VLDTDVFLYL KHKCGSYEST LKKFHILSQE
260 270 280 290 300
KVDGEITTIC LKSIQVGSQP NNAKHVKELI EEWSHALYLK LRKETFILEG
310 320 330 340 350
KENREKRMIK RACEQLSSRY LEVLINLYRT HIDIIGSSSD TYLFKKGVMK

LIGQKVS
Length:357
Mass (Da):40,666
Last modified:July 5, 2004 - v1
Checksum:iD0EEA2B465888036
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033722259I → V. Corresponds to variant dbSNP:rs35749426Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127552 mRNA. Translation: BAC87031.1.
CH471058 Genomic DNA. Translation: EAX11514.1.
BC136410 mRNA. Translation: AAI36411.1.
BC136411 mRNA. Translation: AAI36412.1.
CCDSiCCDS2191.1.
RefSeqiNP_940959.1. NM_198557.2.
UniGeneiHs.302442.

Genome annotation databases

EnsembliENST00000331426; ENSP00000331211; ENSG00000184898.
GeneIDi375287.
KEGGihsa:375287.
UCSCiuc002txh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRBM43_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSC3
Secondary accession number(s): B2RMT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations