Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 49

Gene

ZBTB49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 49
Alternative name(s):
Zinc finger protein 509
Gene namesi
Name:ZBTB49
Synonyms:ZNF509
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19883. ZBTB49.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Zinc finger and BTB domain-containing protein 49PRO_0000047626Add
BLAST

Proteomic databases

MaxQBiQ6ZSB9.
PaxDbiQ6ZSB9.
PRIDEiQ6ZSB9.

PTM databases

PhosphoSiteiQ6ZSB9.

Expressioni

Gene expression databases

BgeeiQ6ZSB9.
CleanExiHS_ZNF509.
ExpressionAtlasiQ6ZSB9. baseline and differential.
GenevestigatoriQ6ZSB9.

Organism-specific databases

HPAiHPA024450.

Interactioni

Protein-protein interaction databases

BioGridi127934. 6 interactions.
IntActiQ6ZSB9. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSB9.
SMRiQ6ZSB9. Positions 7-119, 362-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9167BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000140405.
HOVERGENiHBG061540.
InParanoidiQ6ZSB9.
OMAiCTELPFK.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ6ZSB9.
TreeFamiTF330993.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
InterProiIPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF
60 70 80 90 100
RSLFQNSSSQ KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT
110 120 130 140 150
AQCLQVQNVL SLCHTFLKSA TVVQPPGMPC NSTLSLQSTL TPDATCVISE
160 170 180 190 200
NYPPHLLQEC SADAQQNKTL DESHPHASPS VNRHHSAGEI SKQAPDTSDG
210 220 230 240 250
SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP FAFSTSTDLT
260 270 280 290 300
TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ
310 320 330 340 350
MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS
360 370 380 390 400
QSAEEKESEE VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC
410 420 430 440 450
GKPFKHPSNL ELHKRSHTGE KPFECNICGK HFSQAGNLQT HLRRHSGEKP
460 470 480 490 500
YICEICGKRF AASGDVQRHI IIHSGEKPHL CDICGRGFSN FSNLKEHKKT
510 520 530 540 550
HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC GKCFGGSGDL
560 570 580 590 600
RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS
610 620 630 640 650
QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG
660 670 680 690 700
SYCKLRSMIQ PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG
710 720 730 740 750
GEPLQADGMA MIRSSLAALD NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW
760
GLAMKTLQNE NELDQ
Length:765
Mass (Da):85,061
Last modified:May 18, 2010 - v3
Checksum:i287EC40D48764399
GO
Isoform 2 (identifier: Q6ZSB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-540: Missing.

Show »
Length:643
Mass (Da):71,222
Checksum:iE79A7A702A0B4CED
GO

Sequence cautioni

The sequence AAH16477.1 differs from that shown. Reason: Erroneous termination at position 372. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti449 – 4491K → E in BAC87035 (PubMed:14702039).Curated
Sequence conflicti506 – 5061V → I in BAC87035 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201Y → S.
Corresponds to variant rs2920217 [ dbSNP | Ensembl ].
VAR_057422
Natural varianti348 – 3481A → T.
Corresponds to variant rs4689254 [ dbSNP | Ensembl ].
VAR_057423
Natural varianti642 – 6421A → V.1 Publication
Corresponds to variant rs34293093 [ dbSNP | Ensembl ].
VAR_057424

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei419 – 540122Missing in isoform 2. 1 PublicationVSP_016343Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127560 mRNA. Translation: BAC87035.1.
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1. Sequence problems.
BC089401 mRNA. Translation: AAH89401.1.
AB209466 Transcribed RNA. Translation: BAD92703.1.
CCDSiCCDS3375.1. [Q6ZSB9-1]
RefSeqiNP_660334.3. NM_145291.3. [Q6ZSB9-1]
XP_006713927.1. XM_006713864.1. [Q6ZSB9-1]
UniGeneiHs.419997.

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826. [Q6ZSB9-1]
GeneIDi166793.
KEGGihsa:166793.
UCSCiuc003ghu.3. human. [Q6ZSB9-1]
uc010icz.3. human. [Q6ZSB9-2]

Polymorphism databases

DMDMi296453078.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127560 mRNA. Translation: BAC87035.1.
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1. Sequence problems.
BC089401 mRNA. Translation: AAH89401.1.
AB209466 Transcribed RNA. Translation: BAD92703.1.
CCDSiCCDS3375.1. [Q6ZSB9-1]
RefSeqiNP_660334.3. NM_145291.3. [Q6ZSB9-1]
XP_006713927.1. XM_006713864.1. [Q6ZSB9-1]
UniGeneiHs.419997.

3D structure databases

ProteinModelPortaliQ6ZSB9.
SMRiQ6ZSB9. Positions 7-119, 362-585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127934. 6 interactions.
IntActiQ6ZSB9. 2 interactions.

PTM databases

PhosphoSiteiQ6ZSB9.

Polymorphism databases

DMDMi296453078.

Proteomic databases

MaxQBiQ6ZSB9.
PaxDbiQ6ZSB9.
PRIDEiQ6ZSB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826. [Q6ZSB9-1]
GeneIDi166793.
KEGGihsa:166793.
UCSCiuc003ghu.3. human. [Q6ZSB9-1]
uc010icz.3. human. [Q6ZSB9-2]

Organism-specific databases

CTDi166793.
GeneCardsiGC04P004291.
HGNCiHGNC:19883. ZBTB49.
HPAiHPA024450.
neXtProtiNX_Q6ZSB9.
PharmGKBiPA165664822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118922.
HOGENOMiHOG000140405.
HOVERGENiHBG061540.
InParanoidiQ6ZSB9.
OMAiCTELPFK.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ6ZSB9.
TreeFamiTF330993.

Miscellaneous databases

GenomeRNAii166793.
NextBioi88623.
PROiQ6ZSB9.

Gene expression databases

BgeeiQ6ZSB9.
CleanExiHS_ZNF509.
ExpressionAtlasiQ6ZSB9. baseline and differential.
GenevestigatoriQ6ZSB9.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
InterProiIPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-765 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-765 (ISOFORM 2), VARIANT VAL-642.
    Tissue: Lymph and Ovary.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 504-765.
    Tissue: Brain.

Entry informationi

Entry nameiZBT49_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSB9
Secondary accession number(s): Q59FJ4, Q5EBN0, Q8TB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.