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Q6ZSB9

- ZBT49_HUMAN

UniProt

Q6ZSB9 - ZBT49_HUMAN

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Protein

Zinc finger and BTB domain-containing protein 49

Gene
ZBTB49, ZNF509
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1Add
BLAST
Zinc fingeri423 – 44523C2H2-type 2Add
BLAST
Zinc fingeri451 – 47323C2H2-type 3Add
BLAST
Zinc fingeri479 – 50123C2H2-type 4Add
BLAST
Zinc fingeri507 – 52923C2H2-type 5Add
BLAST
Zinc fingeri535 – 55723C2H2-type 6Add
BLAST
Zinc fingeri563 – 58523C2H2-type 7Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 49
Alternative name(s):
Zinc finger protein 509
Gene namesi
Name:ZBTB49
Synonyms:ZNF509
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:19883. ZBTB49.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Zinc finger and BTB domain-containing protein 49PRO_0000047626Add
BLAST

Proteomic databases

PaxDbiQ6ZSB9.
PRIDEiQ6ZSB9.

PTM databases

PhosphoSiteiQ6ZSB9.

Expressioni

Gene expression databases

ArrayExpressiQ6ZSB9.
BgeeiQ6ZSB9.
CleanExiHS_ZNF509.
GenevestigatoriQ6ZSB9.

Organism-specific databases

HPAiHPA024450.

Interactioni

Protein-protein interaction databases

BioGridi127934. 3 interactions.
IntActiQ6ZSB9. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSB9.
SMRiQ6ZSB9. Positions 7-119, 362-585.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9167BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1Add
BLAST
Zinc fingeri423 – 44523C2H2-type 2Add
BLAST
Zinc fingeri451 – 47323C2H2-type 3Add
BLAST
Zinc fingeri479 – 50123C2H2-type 4Add
BLAST
Zinc fingeri507 – 52923C2H2-type 5Add
BLAST
Zinc fingeri535 – 55723C2H2-type 6Add
BLAST
Zinc fingeri563 – 58523C2H2-type 7Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000140405.
HOVERGENiHBG061540.
InParanoidiQ6ZSB9.
OMAiCTELPFK.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ6ZSB9.
TreeFamiTF330993.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
3.30.710.10. 1 hit.
InterProiIPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZSB9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF    50
RSLFQNSSSQ KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT 100
AQCLQVQNVL SLCHTFLKSA TVVQPPGMPC NSTLSLQSTL TPDATCVISE 150
NYPPHLLQEC SADAQQNKTL DESHPHASPS VNRHHSAGEI SKQAPDTSDG 200
SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP FAFSTSTDLT 250
TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ 300
MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS 350
QSAEEKESEE VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC 400
GKPFKHPSNL ELHKRSHTGE KPFECNICGK HFSQAGNLQT HLRRHSGEKP 450
YICEICGKRF AASGDVQRHI IIHSGEKPHL CDICGRGFSN FSNLKEHKKT 500
HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC GKCFGGSGDL 550
RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS 600
QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG 650
SYCKLRSMIQ PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG 700
GEPLQADGMA MIRSSLAALD NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW 750
GLAMKTLQNE NELDQ 765
Length:765
Mass (Da):85,061
Last modified:May 18, 2010 - v3
Checksum:i287EC40D48764399
GO
Isoform 2 (identifier: Q6ZSB9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-540: Missing.

Show »
Length:643
Mass (Da):71,222
Checksum:iE79A7A702A0B4CED
GO

Sequence cautioni

The sequence AAH16477.1 differs from that shown. Reason: Erroneous termination at position 372. Translated as Glu.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201Y → S.
Corresponds to variant rs2920217 [ dbSNP | Ensembl ].
VAR_057422
Natural varianti348 – 3481A → T.
Corresponds to variant rs4689254 [ dbSNP | Ensembl ].
VAR_057423
Natural varianti642 – 6421A → V.1 Publication
Corresponds to variant rs34293093 [ dbSNP | Ensembl ].
VAR_057424

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei419 – 540122Missing in isoform 2. VSP_016343Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti449 – 4491K → E in BAC87035. 1 Publication
Sequence conflicti506 – 5061V → I in BAC87035. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127560 mRNA. Translation: BAC87035.1.
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1. Sequence problems.
BC089401 mRNA. Translation: AAH89401.1.
AB209466 Transcribed RNA. Translation: BAD92703.1.
CCDSiCCDS3375.1. [Q6ZSB9-1]
RefSeqiNP_660334.3. NM_145291.3. [Q6ZSB9-1]
XP_006713927.1. XM_006713864.1. [Q6ZSB9-1]
UniGeneiHs.419997.

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826. [Q6ZSB9-1]
ENST00000355834; ENSP00000348091; ENSG00000168826. [Q6ZSB9-2]
GeneIDi166793.
KEGGihsa:166793.
UCSCiuc003ghu.3. human. [Q6ZSB9-1]
uc010icz.3. human. [Q6ZSB9-2]

Polymorphism databases

DMDMi296453078.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK127560 mRNA. Translation: BAC87035.1 .
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1 . Sequence problems.
BC089401 mRNA. Translation: AAH89401.1 .
AB209466 Transcribed RNA. Translation: BAD92703.1 .
CCDSi CCDS3375.1. [Q6ZSB9-1 ]
RefSeqi NP_660334.3. NM_145291.3. [Q6ZSB9-1 ]
XP_006713927.1. XM_006713864.1. [Q6ZSB9-1 ]
UniGenei Hs.419997.

3D structure databases

ProteinModelPortali Q6ZSB9.
SMRi Q6ZSB9. Positions 7-119, 362-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127934. 3 interactions.
IntActi Q6ZSB9. 2 interactions.

PTM databases

PhosphoSitei Q6ZSB9.

Polymorphism databases

DMDMi 296453078.

Proteomic databases

PaxDbi Q6ZSB9.
PRIDEi Q6ZSB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000337872 ; ENSP00000338807 ; ENSG00000168826 . [Q6ZSB9-1 ]
ENST00000355834 ; ENSP00000348091 ; ENSG00000168826 . [Q6ZSB9-2 ]
GeneIDi 166793.
KEGGi hsa:166793.
UCSCi uc003ghu.3. human. [Q6ZSB9-1 ]
uc010icz.3. human. [Q6ZSB9-2 ]

Organism-specific databases

CTDi 166793.
GeneCardsi GC04P004291.
HGNCi HGNC:19883. ZBTB49.
HPAi HPA024450.
neXtProti NX_Q6ZSB9.
PharmGKBi PA165664822.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000140405.
HOVERGENi HBG061540.
InParanoidi Q6ZSB9.
OMAi CTELPFK.
OrthoDBi EOG7KWSH5.
PhylomeDBi Q6ZSB9.
TreeFami TF330993.

Miscellaneous databases

GenomeRNAii 166793.
NextBioi 88623.
PROi Q6ZSB9.

Gene expression databases

ArrayExpressi Q6ZSB9.
Bgeei Q6ZSB9.
CleanExi HS_ZNF509.
Genevestigatori Q6ZSB9.

Family and domain databases

Gene3Di 2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
3.30.710.10. 1 hit.
InterProi IPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 52-765 (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-765 (ISOFORM 2), VARIANT VAL-642.
    Tissue: Lymph and Ovary.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 504-765.
    Tissue: Brain.

Entry informationi

Entry nameiZBT49_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSB9
Secondary accession number(s): Q59FJ4, Q5EBN0, Q8TB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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