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Protein

Zinc finger and BTB domain-containing protein 49

Gene

ZBTB49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription.1 Publication
Isoform 1: Binds CDKN1A promoter and activates its transcription; this activity is further potentiated in the presence of EP300 (synergistic) and ZBTB17/Miz-1 (additive).1 Publication
Isoform 3: Activates RB1 transcription most probably by antagonizing ZBTB17 repression of RB1. Does not bind directly RB1 promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • sequence-specific DNA binding Source: UniProtKB
  • transcription coactivator binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

  • cell cycle arrest Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 49
Alternative name(s):
Zinc finger protein 509
Gene namesi
Name:ZBTB49
Synonyms:ZNF509
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:19883. ZBTB49.

Subcellular locationi

Isoform 1 :
  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Predominantly located in the nucleus.1 Publication
Isoform 3 :
  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165664822.

Polymorphism and mutation databases

BioMutaiZBTB49.
DMDMi296453078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Zinc finger and BTB domain-containing protein 49PRO_0000047626Add
BLAST

Proteomic databases

MaxQBiQ6ZSB9.
PaxDbiQ6ZSB9.
PRIDEiQ6ZSB9.

PTM databases

PhosphoSiteiQ6ZSB9.

Expressioni

Tissue specificityi

Highly expressed in normal epidermis and in other epithelial tissues, including in colon and lung. Tends to be down-regulated in colon, lung and skin cancer tissues.1 Publication

Inductioni

Induced by the DNA-damaging agent etoposide. This induction is mediated by TP53 at the transcriptional level.1 Publication

Gene expression databases

BgeeiQ6ZSB9.
CleanExiHS_ZNF509.
ExpressionAtlasiQ6ZSB9. baseline and differential.
GenevisibleiQ6ZSB9. HS.

Organism-specific databases

HPAiHPA024450.

Interactioni

Subunit structurei

Isoform 1 interacts with EP300 and KAT5/Tip60. The interaction with EP300 is direct and leads to synergistic induction of CDKN1A. On the CDKN1A promoter, forms a complex with ZBTB17/Miz-1; this interaction leads to additive CDKN1A transactivation. Isoform 3 also interacts with ZBTB17; this interaction may block ZBTB17 repressor activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-2859943,EBI-739624
GOPCQ9HD263EBI-2859943,EBI-349832
ZBTB8AQ96BR93EBI-2859943,EBI-742740

Protein-protein interaction databases

BioGridi127934. 7 interactions.
IntActiQ6ZSB9. 6 interactions.
STRINGi9606.ENSP00000338807.

Structurei

3D structure databases

ProteinModelPortaliQ6ZSB9.
SMRiQ6ZSB9. Positions 7-119, 362-587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 9167BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri423 – 44523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri451 – 47323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri479 – 50123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri507 – 52923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri535 – 55723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124025.
HOGENOMiHOG000140405.
HOVERGENiHBG061540.
InParanoidiQ6ZSB9.
OMAiMPVSVKL.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ6ZSB9.
TreeFamiTF330993.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
InterProiIPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZSB9-1) [UniParc]FASTAAdd to basket

Also known as: ZNF509L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF
60 70 80 90 100
RSLFQNSSSQ KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT
110 120 130 140 150
AQCLQVQNVL SLCHTFLKSA TVVQPPGMPC NSTLSLQSTL TPDATCVISE
160 170 180 190 200
NYPPHLLQEC SADAQQNKTL DESHPHASPS VNRHHSAGEI SKQAPDTSDG
210 220 230 240 250
SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP FAFSTSTDLT
260 270 280 290 300
TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ
310 320 330 340 350
MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS
360 370 380 390 400
QSAEEKESEE VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC
410 420 430 440 450
GKPFKHPSNL ELHKRSHTGE KPFECNICGK HFSQAGNLQT HLRRHSGEKP
460 470 480 490 500
YICEICGKRF AASGDVQRHI IIHSGEKPHL CDICGRGFSN FSNLKEHKKT
510 520 530 540 550
HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC GKCFGGSGDL
560 570 580 590 600
RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS
610 620 630 640 650
QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG
660 670 680 690 700
SYCKLRSMIQ PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG
710 720 730 740 750
GEPLQADGMA MIRSSLAALD NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW
760
GLAMKTLQNE NELDQ
Length:765
Mass (Da):85,061
Last modified:May 18, 2010 - v3
Checksum:i287EC40D48764399
GO
Isoform 2 (identifier: Q6ZSB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-540: Missing.

Note: No experimental confirmation available.
Show »
Length:643
Mass (Da):71,222
Checksum:iE79A7A702A0B4CED
GO
Isoform 3 (identifier: Q6ZSB9-3) [UniParc]FASTAAdd to basket

Also known as: ZNF509S1

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: E → N
     421-765: Missing.

Show »
Length:420
Mass (Da):46,868
Checksum:i7997383296FA2F67
GO
Isoform 4 (identifier: Q6ZSB9-4) [UniParc]FASTAAdd to basket

Also known as: ZNF509S2

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: E → R
     421-765: Missing.

Show »
Length:420
Mass (Da):46,911
Checksum:i69D7383296FA2F67
GO
Isoform 5 (identifier: Q6ZSB9-5) [UniParc]FASTAAdd to basket

Also known as: ZNF509S3

The sequence of this isoform differs from the canonical sequence as follows:
     460-466: FAASGDV → EMFWGIR
     467-765: Missing.

Show »
Length:466
Mass (Da):52,273
Checksum:i9ACE3214572EDD91
GO

Sequence cautioni

The sequence AAH16477.1 differs from that shown. Reason: Erroneous termination at position 372. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti449 – 4491K → E in BAC87035 (PubMed:14702039).Curated
Sequence conflicti506 – 5061V → I in BAC87035 (PubMed:14702039).Curated
Sequence conflicti618 – 6181S → P in BAF85240 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti320 – 3201Y → S.
Corresponds to variant rs2920217 [ dbSNP | Ensembl ].
VAR_057422
Natural varianti348 – 3481A → T.
Corresponds to variant rs4689254 [ dbSNP | Ensembl ].
VAR_057423
Natural varianti556 – 5561T → A.1 Publication
Corresponds to variant rs146575965 [ dbSNP | Ensembl ].
VAR_073227
Natural varianti642 – 6421A → V.1 Publication
Corresponds to variant rs34293093 [ dbSNP | Ensembl ].
VAR_057424

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei419 – 540122Missing in isoform 2. 1 PublicationVSP_016343Add
BLAST
Alternative sequencei420 – 4201E → N in isoform 3. 1 PublicationVSP_057623
Alternative sequencei420 – 4201E → R in isoform 4. 1 PublicationVSP_057624
Alternative sequencei421 – 765345Missing in isoform 3 and isoform 4. 1 PublicationVSP_057625Add
BLAST
Alternative sequencei460 – 4667FAASGDV → EMFWGIR in isoform 5. 1 PublicationVSP_057626
Alternative sequencei467 – 765299Missing in isoform 5. 1 PublicationVSP_057627Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127560 mRNA. Translation: BAC87035.1.
AK292551 mRNA. Translation: BAF85240.1.
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1. Sequence problems.
BC089401 mRNA. Translation: AAH89401.1.
BC109087 mRNA. Translation: AAI09088.1.
AB209466 Transcribed RNA. Translation: BAD92703.1.
CCDSiCCDS3375.1. [Q6ZSB9-1]
RefSeqiNP_660334.3. NM_145291.3. [Q6ZSB9-1]
XP_005248008.1. XM_005247951.3. [Q6ZSB9-5]
XP_006713927.1. XM_006713864.2. [Q6ZSB9-1]
XP_011511718.1. XM_011513416.1. [Q6ZSB9-2]
UniGeneiHs.419997.

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826.
GeneIDi166793.
KEGGihsa:166793.
UCSCiuc003ghu.3. human. [Q6ZSB9-1]
uc010icz.3. human. [Q6ZSB9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127560 mRNA. Translation: BAC87035.1.
AK292551 mRNA. Translation: BAF85240.1.
AC011744 Genomic DNA. No translation available.
AC105415 Genomic DNA. No translation available.
BC016477 mRNA. Translation: AAH16477.1. Sequence problems.
BC089401 mRNA. Translation: AAH89401.1.
BC109087 mRNA. Translation: AAI09088.1.
AB209466 Transcribed RNA. Translation: BAD92703.1.
CCDSiCCDS3375.1. [Q6ZSB9-1]
RefSeqiNP_660334.3. NM_145291.3. [Q6ZSB9-1]
XP_005248008.1. XM_005247951.3. [Q6ZSB9-5]
XP_006713927.1. XM_006713864.2. [Q6ZSB9-1]
XP_011511718.1. XM_011513416.1. [Q6ZSB9-2]
UniGeneiHs.419997.

3D structure databases

ProteinModelPortaliQ6ZSB9.
SMRiQ6ZSB9. Positions 7-119, 362-587.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127934. 7 interactions.
IntActiQ6ZSB9. 6 interactions.
STRINGi9606.ENSP00000338807.

PTM databases

PhosphoSiteiQ6ZSB9.

Polymorphism and mutation databases

BioMutaiZBTB49.
DMDMi296453078.

Proteomic databases

MaxQBiQ6ZSB9.
PaxDbiQ6ZSB9.
PRIDEiQ6ZSB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337872; ENSP00000338807; ENSG00000168826.
GeneIDi166793.
KEGGihsa:166793.
UCSCiuc003ghu.3. human. [Q6ZSB9-1]
uc010icz.3. human. [Q6ZSB9-2]

Organism-specific databases

CTDi166793.
GeneCardsiGC04P004291.
HGNCiHGNC:19883. ZBTB49.
HPAiHPA024450.
MIMi616238. gene.
neXtProtiNX_Q6ZSB9.
PharmGKBiPA165664822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00800000124025.
HOGENOMiHOG000140405.
HOVERGENiHBG061540.
InParanoidiQ6ZSB9.
OMAiMPVSVKL.
OrthoDBiEOG7KWSH5.
PhylomeDBiQ6ZSB9.
TreeFamiTF330993.

Miscellaneous databases

GenomeRNAii166793.
NextBioi88623.
PROiQ6ZSB9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZSB9.
CleanExiHS_ZNF509.
ExpressionAtlasiQ6ZSB9. baseline and differential.
GenevisibleiQ6ZSB9. HS.

Family and domain databases

Gene3Di2.30.30.20. 1 hit.
3.30.160.60. 7 hits.
InterProiIPR020542. Asp_carbamoyltrfase_reg_C.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Tongue.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-765 (ISOFORM 2), VARIANTS ALA-556 AND VAL-642.
    Tissue: Lymph and Ovary.
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 504-765.
    Tissue: Brain.
  5. "Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress."
    Jeon B.N., Kim M.K., Yoon J.H., Kim M.Y., An H., Noh H.J., Choi W.I., Koh D.I., Hur M.W.
    Nucleic Acids Res. 42:11447-11461(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION (ISOFORMS 1 AND 3), INTERACTION WITH EP300 AND KAT5 (ISOFORM 1), INTERACTION WITH ZBTB17 (ISOFORMS 1 AND 3), ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 5), SUBCELLULAR LOCATION (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, INDUCTION BY ETOPOSIDE.

Entry informationi

Entry nameiZBT49_HUMAN
AccessioniPrimary (citable) accession number: Q6ZSB9
Secondary accession number(s): A8K936
, Q32ML0, Q59FJ4, Q5EBN0, Q8TB80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 18, 2010
Last modified: July 22, 2015
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.