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Protein

Putative glycerol kinase 5

Gene

GK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative glycerol kinase 5 (GK5), Glycerol kinase (GK), Putative glycerol kinase 3 (GK3P), Glycerol kinase 2 (GK2)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstrateBy similarity
Binding sitei98 – 981SubstrateBy similarity
Binding sitei275 – 2751SubstrateBy similarity
Binding sitei297 – 2971ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi439 – 4446ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycerol kinase 5 (EC:2.7.1.30)
Short name:
GK 5
Short name:
Glycerokinase 5
Alternative name(s):
ATP:glycerol 3-phosphotransferase 5
Gene namesi
Name:GK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28635. GK5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162389723.

Polymorphism and mutation databases

BioMutaiGK5.
DMDMi338817880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Putative glycerol kinase 5PRO_0000323754Add
BLAST

Proteomic databases

MaxQBiQ6ZS86.
PaxDbiQ6ZS86.
PRIDEiQ6ZS86.

PTM databases

iPTMnetiQ6ZS86.
PhosphoSiteiQ6ZS86.

Expressioni

Gene expression databases

BgeeiQ6ZS86.
CleanExiHS_GK5.
ExpressionAtlasiQ6ZS86. baseline and differential.
GenevisibleiQ6ZS86. HS.

Organism-specific databases

HPAiHPA042606.
HPA057998.

Interactioni

Protein-protein interaction databases

BioGridi129160. 1 interaction.
STRINGi9606.ENSP00000418001.

Structurei

3D structure databases

ProteinModelPortaliQ6ZS86.
SMRiQ6ZS86. Positions 20-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG097793.
InParanoidiQ6ZS86.
KOiK19583.
OMAiAAMFGEC.
OrthoDBiEOG73RBB3.
PhylomeDBiQ6ZS86.
TreeFamiTF321504.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZS86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV
60 70 80 90 100
ENLYPQIGWV EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT
110 120 130 140 150
FITWNKKTGN HFHNFISWQD LRAVELVKSW NNSLLMKIFH SSCRVLHFFT
160 170 180 190 200
RSKRLFTASL FTFTTQQTSL RLVWILQNLT EVQKAVEEEN CCFGTIDTWL
210 220 230 240 250
LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI PLSLLPPVRD
260 270 280 290 300
TSHNFGSVDE EIFGVPIPIV ALVADQQSAM FGECCFQTGD VKLTMGTGTF
310 320 330 340 350
LDINTGNSLQ QTTGGFYPLI GWKIGQEVVC LAESNAGDTG TAIKWAQQLD
360 370 380 390 400
LFTDAAETEK MAKSLEDSEG VCFVPSFSGL QAPLNDPWAC ASFMGLKPST
410 420 430 440 450
SKYHLVRAIL ESIAFRNKQL YEMMKKEIHI PVRKIRADGG VCKNGFVMQM
460 470 480 490 500
TSDLINENID RPADIDMSCL GAASLAGLAV GFWTDKEELK KLRQSEVVFK
510 520
PQKKCQEYEM SLENWAKAVK RSMNWYNKT
Length:529
Mass (Da):59,156
Last modified:June 28, 2011 - v2
Checksum:i9ED7CB1DA4D9417D
GO
Isoform 2 (identifier: Q6ZS86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-301: VADQQSAMFGECCFQTGDVKLTMGTGTFL → LKVPGYDQNICYIFGKGTIEPVFYHGSTL
     302-529: Missing.

Show »
Length:301
Mass (Da):33,916
Checksum:i12D1049F6270FF17
GO
Isoform 3 (identifier: Q6ZS86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Show »
Length:250
Mass (Da):27,801
Checksum:iD8A63C70DCD93D7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3391T → I in BAC87068 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 279279Missing in isoform 3. 1 PublicationVSP_032121Add
BLAST
Alternative sequencei273 – 30129VADQQ…TGTFL → LKVPGYDQNICYIFGKGTIE PVFYHGSTL in isoform 2. 2 PublicationsVSP_032122Add
BLAST
Alternative sequencei302 – 529228Missing in isoform 2. 2 PublicationsVSP_032123Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090901 mRNA. Translation: BAC03542.1.
AK127641 mRNA. Translation: BAC87068.1.
AK313792 mRNA. Translation: BAG36529.1.
AC108679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78974.1.
CH471052 Genomic DNA. Translation: EAW78975.1.
BC032470 mRNA. Translation: AAH32470.1.
CCDSiCCDS33871.1. [Q6ZS86-1]
RefSeqiNP_001034636.1. NM_001039547.2. [Q6ZS86-1]
UniGeneiHs.135904.
Hs.745523.

Genome annotation databases

EnsembliENST00000392993; ENSP00000418001; ENSG00000175066. [Q6ZS86-1]
ENST00000480757; ENSP00000419031; ENSG00000175066. [Q6ZS86-2]
ENST00000492097; ENSP00000420312; ENSG00000175066. [Q6ZS86-2]
GeneIDi256356.
KEGGihsa:256356.
UCSCiuc003euq.2. human. [Q6ZS86-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090901 mRNA. Translation: BAC03542.1.
AK127641 mRNA. Translation: BAC87068.1.
AK313792 mRNA. Translation: BAG36529.1.
AC108679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78974.1.
CH471052 Genomic DNA. Translation: EAW78975.1.
BC032470 mRNA. Translation: AAH32470.1.
CCDSiCCDS33871.1. [Q6ZS86-1]
RefSeqiNP_001034636.1. NM_001039547.2. [Q6ZS86-1]
UniGeneiHs.135904.
Hs.745523.

3D structure databases

ProteinModelPortaliQ6ZS86.
SMRiQ6ZS86. Positions 20-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129160. 1 interaction.
STRINGi9606.ENSP00000418001.

PTM databases

iPTMnetiQ6ZS86.
PhosphoSiteiQ6ZS86.

Polymorphism and mutation databases

BioMutaiGK5.
DMDMi338817880.

Proteomic databases

MaxQBiQ6ZS86.
PaxDbiQ6ZS86.
PRIDEiQ6ZS86.

Protocols and materials databases

DNASUi256356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392993; ENSP00000418001; ENSG00000175066. [Q6ZS86-1]
ENST00000480757; ENSP00000419031; ENSG00000175066. [Q6ZS86-2]
ENST00000492097; ENSP00000420312; ENSG00000175066. [Q6ZS86-2]
GeneIDi256356.
KEGGihsa:256356.
UCSCiuc003euq.2. human. [Q6ZS86-1]

Organism-specific databases

CTDi256356.
GeneCardsiGK5.
HGNCiHGNC:28635. GK5.
HPAiHPA042606.
HPA057998.
neXtProtiNX_Q6ZS86.
PharmGKBiPA162389723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG097793.
InParanoidiQ6ZS86.
KOiK19583.
OMAiAAMFGEC.
OrthoDBiEOG73RBB3.
PhylomeDBiQ6ZS86.
TreeFamiTF321504.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Miscellaneous databases

ChiTaRSiGK5. human.
GenomeRNAii256356.
NextBioi92784.
PROiQ6ZS86.

Gene expression databases

BgeeiQ6ZS86.
CleanExiHS_GK5.
ExpressionAtlasiQ6ZS86. baseline and differential.
GenevisibleiQ6ZS86. HS.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala, Kidney and Trachea.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Blood.

Entry informationi

Entry nameiGLPK5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZS86
Secondary accession number(s): B2R9I2
, D3DNG2, Q8N2A7, Q8N5E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: March 16, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.