Q6ZS86 (GLPK5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glycerol kinase 5
Short name=GK 5
Short name=Glycerokinase 5
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase 5

Gene names

Name:

GK5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	529 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate.
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycerol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZS86-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZS86-2)

The sequence of this isoform differs from the canonical sequence as follows:
     273-301: VADQQSAMFGECCFQTGDVKLTMGTGTFL → LKVPGYDQNICYIFGKGTIEPVFYHGSTL
     302-529: Missing.

Isoform 3 (identifier: Q6ZS86-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 529	529	Putative glycerol kinase 5		PRO_0000323754
Regions
	Nucleotide binding	439 – 444	6	ATP By similarity
Sites
	Binding site	28	1	Substrate By similarity
	Binding site	98	1	Substrate By similarity
	Binding site	275	1	Substrate By similarity
	Binding site	297	1	ATP By similarity
Natural variations
	Alternative sequence	1 – 279	279	Missing in isoform 3.		VSP_032121
	Alternative sequence	273 – 301	29	VADQQ…TGTFL → LKVPGYDQNICYIFGKGTIE PVFYHGSTL in isoform 2.		VSP_032122
	Alternative sequence	302 – 529	228	Missing in isoform 2.		VSP_032123
Experimental info
	Sequence conflict	339	1	T → I in BAC87068. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 28, 2011. Version 2. Checksum: 9ED7CB1DA4D9417D	FASTA	529	59,156
	10 20 30 40 50 60 MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV ENLYPQIGWV 70 80 90 100 110 120 EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT FITWNKKTGN HFHNFISWQD 130 140 150 160 170 180 LRAVELVKSW NNSLLMKIFH SSCRVLHFFT RSKRLFTASL FTFTTQQTSL RLVWILQNLT 190 200 210 220 230 240 EVQKAVEEEN CCFGTIDTWL LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI 250 260 270 280 290 300 PLSLLPPVRD TSHNFGSVDE EIFGVPIPIV ALVADQQSAM FGECCFQTGD VKLTMGTGTF 310 320 330 340 350 360 LDINTGNSLQ QTTGGFYPLI GWKIGQEVVC LAESNAGDTG TAIKWAQQLD LFTDAAETEK 370 380 390 400 410 420 MAKSLEDSEG VCFVPSFSGL QAPLNDPWAC ASFMGLKPST SKYHLVRAIL ESIAFRNKQL 430 440 450 460 470 480 YEMMKKEIHI PVRKIRADGG VCKNGFVMQM TSDLINENID RPADIDMSCL GAASLAGLAV 490 500 510 520 GFWTDKEELK KLRQSEVVFK PQKKCQEYEM SLENWAKAVK RSMNWYNKT
	Isoform 2 [UniParc]. Checksum: 12D1049F6270FF17	FASTA	301	33,916
	10 20 30 40 50 60 MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV ENLYPQIGWV 70 80 90 100 110 120 EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT FITWNKKTGN HFHNFISWQD 130 140 150 160 170 180 LRAVELVKSW NNSLLMKIFH SSCRVLHFFT RSKRLFTASL FTFTTQQTSL RLVWILQNLT 190 200 210 220 230 240 EVQKAVEEEN CCFGTIDTWL LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI 250 260 270 280 290 300 PLSLLPPVRD TSHNFGSVDE EIFGVPIPIV ALLKVPGYDQ NICYIFGKGT IEPVFYHGST L
	Isoform 3 [UniParc]. Checksum: D8A63C70DCD93D7D	FASTA	250	27,801
	10 20 30 40 50 60 MFGECCFQTG DVKLTMGTGT FLDINTGNSL QQTTGGFYPL IGWKIGQEVV CLAESNAGDT 70 80 90 100 110 120 GTAIKWAQQL DLFTDAAETE KMAKSLEDSE GVCFVPSFSG LQAPLNDPWA CASFMGLKPS 130 140 150 160 170 180 TSKYHLVRAI LESIAFRNKQ LYEMMKKEIH IPVRKIRADG GVCKNGFVMQ MTSDLINENI 190 200 210 220 230 240 DRPADIDMSC LGAASLAGLA VGFWTDKEEL KKLRQSEVVF KPQKKCQEYE MSLENWAKAV 250 KRSMNWYNKT

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Amygdala, Kidney and Trachea.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Blood.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090901 mRNA. Translation: BAC03542.1. AK127641 mRNA. Translation: BAC87068.1. AK313792 mRNA. Translation: BAG36529.1. AC108679 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78974.1. CH471052 Genomic DNA. Translation: EAW78975.1. BC032470 mRNA. Translation: AAH32470.1.
IPI	IPI00166847. IPI00744122. IPI00791183.
RefSeq	NP_001034636.1. NM_001039547.2.
UniGene	Hs.135904. Hs.706584.
3D structure databases
HSSP	HSSP built from PDB template 1GLC based on UniProtKB P0A6F3.
ProteinModelPortal	Q6ZS86.
SMR	Q6ZS86. Positions 17-527.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ZS86.
PTM databases
PhosphoSite	Q6ZS86.
Polymorphism databases
DMDM	74711361.
Proteomic databases
PRIDE	Q6ZS86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000392993; ENSP00000418001; ENSG00000175066.
GeneID	256356.
KEGG	hsa:256356.
UCSC	uc003eup.1. human. uc003euq.1. human.
Organism-specific databases
CTD	256356.
GeneCards	GC03M141876.
HGNC	HGNC:28635. GK5.
HPA	HPA042606.
neXtProt	NX_Q6ZS86.
PharmGKB	PA162389723.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16260.
GeneTree	ENSGT00530000063143.
HOVERGEN	HBG097793.
InParanoid	Q6ZS86.
PhylomeDB	Q6ZS86.
Gene expression databases
Bgee	Q6ZS86.
CleanEx	HS_GK5.
Genevestigator	Q6ZS86.
Family and domain databases
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
PANTHER	PTHR10196. FGGY_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
PROSITE	PS00933. FGGY_KINASES_1. False negative. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	92784.

Entry information

Entry name

GLPK5_HUMAN

Accession

Primary (citable) accession number: Q6ZS86
Secondary accession number(s): B2R9I2 , D3DNG2, Q8N2A7, Q8N5E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 28, 2011
Last modified:	January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.