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Protein

Putative glycerol kinase 5

Gene

GK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative glycerol kinase 5 (GK5), Glycerol kinase (GK), Glycerol kinase 3 (GK3P), Glycerol kinase 2 (GK2)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstrateBy similarity1
Binding sitei98SubstrateBy similarity1
Binding sitei275SubstrateBy similarity1
Binding sitei297ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi439 – 444ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS10873-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycerol kinase 5 (EC:2.7.1.30)
Short name:
GK 5
Short name:
Glycerokinase 5
Alternative name(s):
ATP:glycerol 3-phosphotransferase 5
Gene namesi
Name:GK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28635. GK5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175066.
PharmGKBiPA162389723.

Polymorphism and mutation databases

BioMutaiGK5.
DMDMi338817880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003237541 – 529Putative glycerol kinase 5Add BLAST529

Proteomic databases

EPDiQ6ZS86.
MaxQBiQ6ZS86.
PaxDbiQ6ZS86.
PeptideAtlasiQ6ZS86.
PRIDEiQ6ZS86.

PTM databases

iPTMnetiQ6ZS86.
PhosphoSitePlusiQ6ZS86.

Expressioni

Gene expression databases

BgeeiENSG00000175066.
CleanExiHS_GK5.
ExpressionAtlasiQ6ZS86. baseline and differential.
GenevisibleiQ6ZS86. HS.

Organism-specific databases

HPAiHPA042606.
HPA057998.

Interactioni

Protein-protein interaction databases

BioGridi129160. 1 interactor.
STRINGi9606.ENSP00000418001.

Structurei

3D structure databases

ProteinModelPortaliQ6ZS86.
SMRiQ6ZS86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG097793.
InParanoidiQ6ZS86.
KOiK19583.
OMAiSIMGATF.
OrthoDBiEOG091G07WU.
PhylomeDBiQ6ZS86.
TreeFamiTF321504.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZS86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLLTDPEQ RAQEPRYPGF VLGLDVGSSV IRCHVYDRAA RVCGSSVQKV
60 70 80 90 100
ENLYPQIGWV EIDPDVLWIQ FVAVIKEAVK AAGIQMNQIV GLGISTQRAT
110 120 130 140 150
FITWNKKTGN HFHNFISWQD LRAVELVKSW NNSLLMKIFH SSCRVLHFFT
160 170 180 190 200
RSKRLFTASL FTFTTQQTSL RLVWILQNLT EVQKAVEEEN CCFGTIDTWL
210 220 230 240 250
LYKLTKGSVY ATDFSNASTT GLFDPYKMCW SGMITSLISI PLSLLPPVRD
260 270 280 290 300
TSHNFGSVDE EIFGVPIPIV ALVADQQSAM FGECCFQTGD VKLTMGTGTF
310 320 330 340 350
LDINTGNSLQ QTTGGFYPLI GWKIGQEVVC LAESNAGDTG TAIKWAQQLD
360 370 380 390 400
LFTDAAETEK MAKSLEDSEG VCFVPSFSGL QAPLNDPWAC ASFMGLKPST
410 420 430 440 450
SKYHLVRAIL ESIAFRNKQL YEMMKKEIHI PVRKIRADGG VCKNGFVMQM
460 470 480 490 500
TSDLINENID RPADIDMSCL GAASLAGLAV GFWTDKEELK KLRQSEVVFK
510 520
PQKKCQEYEM SLENWAKAVK RSMNWYNKT
Length:529
Mass (Da):59,156
Last modified:June 28, 2011 - v2
Checksum:i9ED7CB1DA4D9417D
GO
Isoform 2 (identifier: Q6ZS86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     273-301: VADQQSAMFGECCFQTGDVKLTMGTGTFL → LKVPGYDQNICYIFGKGTIEPVFYHGSTL
     302-529: Missing.

Show »
Length:301
Mass (Da):33,916
Checksum:i12D1049F6270FF17
GO
Isoform 3 (identifier: Q6ZS86-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Show »
Length:250
Mass (Da):27,801
Checksum:iD8A63C70DCD93D7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti339T → I in BAC87068 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321211 – 279Missing in isoform 3. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_032122273 – 301VADQQ…TGTFL → LKVPGYDQNICYIFGKGTIE PVFYHGSTL in isoform 2. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_032123302 – 529Missing in isoform 2. 2 PublicationsAdd BLAST228

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090901 mRNA. Translation: BAC03542.1.
AK127641 mRNA. Translation: BAC87068.1.
AK313792 mRNA. Translation: BAG36529.1.
AC108679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78974.1.
CH471052 Genomic DNA. Translation: EAW78975.1.
BC032470 mRNA. Translation: AAH32470.1.
CCDSiCCDS33871.1. [Q6ZS86-1]
RefSeqiNP_001034636.1. NM_001039547.2. [Q6ZS86-1]
UniGeneiHs.135904.
Hs.745523.

Genome annotation databases

EnsembliENST00000392993; ENSP00000418001; ENSG00000175066. [Q6ZS86-1]
ENST00000480757; ENSP00000419031; ENSG00000175066. [Q6ZS86-2]
ENST00000492097; ENSP00000420312; ENSG00000175066. [Q6ZS86-2]
GeneIDi256356.
KEGGihsa:256356.
UCSCiuc003euq.2. human. [Q6ZS86-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090901 mRNA. Translation: BAC03542.1.
AK127641 mRNA. Translation: BAC87068.1.
AK313792 mRNA. Translation: BAG36529.1.
AC108679 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78974.1.
CH471052 Genomic DNA. Translation: EAW78975.1.
BC032470 mRNA. Translation: AAH32470.1.
CCDSiCCDS33871.1. [Q6ZS86-1]
RefSeqiNP_001034636.1. NM_001039547.2. [Q6ZS86-1]
UniGeneiHs.135904.
Hs.745523.

3D structure databases

ProteinModelPortaliQ6ZS86.
SMRiQ6ZS86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129160. 1 interactor.
STRINGi9606.ENSP00000418001.

PTM databases

iPTMnetiQ6ZS86.
PhosphoSitePlusiQ6ZS86.

Polymorphism and mutation databases

BioMutaiGK5.
DMDMi338817880.

Proteomic databases

EPDiQ6ZS86.
MaxQBiQ6ZS86.
PaxDbiQ6ZS86.
PeptideAtlasiQ6ZS86.
PRIDEiQ6ZS86.

Protocols and materials databases

DNASUi256356.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392993; ENSP00000418001; ENSG00000175066. [Q6ZS86-1]
ENST00000480757; ENSP00000419031; ENSG00000175066. [Q6ZS86-2]
ENST00000492097; ENSP00000420312; ENSG00000175066. [Q6ZS86-2]
GeneIDi256356.
KEGGihsa:256356.
UCSCiuc003euq.2. human. [Q6ZS86-1]

Organism-specific databases

CTDi256356.
GeneCardsiGK5.
HGNCiHGNC:28635. GK5.
HPAiHPA042606.
HPA057998.
neXtProtiNX_Q6ZS86.
OpenTargetsiENSG00000175066.
PharmGKBiPA162389723.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2517. Eukaryota.
COG0554. LUCA.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
HOVERGENiHBG097793.
InParanoidiQ6ZS86.
KOiK19583.
OMAiSIMGATF.
OrthoDBiEOG091G07WU.
PhylomeDBiQ6ZS86.
TreeFamiTF321504.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.
BioCyciZFISH:HS10873-MONOMER.

Miscellaneous databases

ChiTaRSiGK5. human.
GenomeRNAii256356.
PROiQ6ZS86.

Gene expression databases

BgeeiENSG00000175066.
CleanExiHS_GK5.
ExpressionAtlasiQ6ZS86. baseline and differential.
GenevisibleiQ6ZS86. HS.

Family and domain databases

InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
PROSITEiPS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLPK5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZS86
Secondary accession number(s): B2R9I2
, D3DNG2, Q8N2A7, Q8N5E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 28, 2011
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.