Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6ZS82 (R9BP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Regulator of G-protein signaling 9-binding protein
Alternative name(s):
RGS9-anchoring protein
Gene names
Name:RGS9BP
Synonyms:R9AP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation By similarity.

Subunit structure

Specifically interacts with isoform RGS9-1of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP By similarity.

Subcellular location

Membrane; Single-pass type IV membrane protein By similarity.

Involvement in disease

Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.2

Sequence similarities

Belongs to the RGS7BP/RGS9BP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235Regulator of G-protein signaling 9-binding protein
PRO_0000287586

Regions

Topological domain1 – 210210Cytoplasmic Potential
Transmembrane211 – 23121Helical; Anchor for type IV membrane protein; Potential
Topological domain232 – 2354Extracellular Potential
Region153 – 20048SNARE-like By similarity
Coiled coil29 – 5426 Potential
Coiled coil144 – 16926 Potential

Natural variations

Natural variant961A → S. Ref.1
Corresponds to variant rs259290 [ dbSNP | Ensembl ].
VAR_032333

Sequences

Sequence LengthMass (Da)Tools
Q6ZS82 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 54A3CC6CBACAC014

FASTA23525,148
        10         20         30         40         50         60 
MAREECKALL DGLNKTTACY HHLVLTVGGS ADSQNLRQEL QKTRQKAQEL AVSTCARLTA 

        70         80         90        100        110        120 
VLRDRGLAAD ERAEFERLWV AFSGCLDLLE ADMRRALELG AAFPLHAPRR PLVRTGVAGA 

       130        140        150        160        170        180 
SSGVAARALS TRSLRLEAEG DFDVADLREL EREVLQVGEM IDNMEMKVNV PRWTVQARQA 

       190        200        210        220        230 
AGAELLSTVS AGPSSVVSLQ ERGGGCDPRK ALAAILFGAV LLAAVALAVC VAKLS 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-96.
Tissue: Cerebellum and Kidney.
[2]"Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation."
Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W.R., Hagstrom S.A., Arshavsky V.Y., Berson E.L., Dryja T.P.
Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN PERRS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK124499 mRNA. Translation: BAC85865.1.
AK127646 mRNA. Translation: BAC87072.1.
RefSeqNP_997274.2. NM_207391.2.
UniGeneHs.528491.

3D structure databases

ProteinModelPortalQ6ZS82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid132727. 1 interaction.
STRING9606.ENSP00000334134.

Polymorphism databases

DMDM74711357.

Proteomic databases

PaxDbQ6ZS82.
PRIDEQ6ZS82.

Protocols and materials databases

DNASU388531.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000334176; ENSP00000334134; ENSG00000186326.
GeneID388531.
KEGGhsa:388531.
UCSCuc002ntp.1. human.

Organism-specific databases

CTD388531.
GeneCardsGC19P033166.
HGNCHGNC:30304. RGS9BP.
HPAHPA049791.
MIM607814. gene.
608415. phenotype.
neXtProtNX_Q6ZS82.
Orphanet75374. Bradyopsia.
PharmGKBPA162401280.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40375.
HOGENOMHOG000136373.
HOVERGENHBG059498.
InParanoidQ6ZS82.
OMAMSVQNMK.
OrthoDBEOG7T4MMS.
PhylomeDBQ6ZS82.
TreeFamTF331562.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.

Gene expression databases

BgeeQ6ZS82.
CleanExHS_RGS9BP.
GenevestigatorQ6ZS82.

Family and domain databases

InterProIPR026512. RGS7BP/RGS9BP.
IPR026513. RGS9BP.
[Graphical view]
PANTHERPTHR21029. PTHR21029. 1 hit.
PTHR21029:SF1. PTHR21029:SF1. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi388531.
NextBio102108.
PROQ6ZS82.
SOURCESearch...

Entry information

Entry nameR9BP_HUMAN
AccessionPrimary (citable) accession number: Q6ZS82
Secondary accession number(s): Q6ZVJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM