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Q6ZS82

- R9BP_HUMAN

UniProt

Q6ZS82 - R9BP_HUMAN

Protein

Regulator of G-protein signaling 9-binding protein

Gene

RGS9BP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation By similarity.By similarity

    GO - Biological processi

    1. detection of light stimulus involved in visual perception Source: Ensembl
    2. negative regulation of signal transduction Source: UniProtKB-KW
    3. phototransduction, visible light Source: Reactome
    4. regulation of rhodopsin mediated signaling pathway Source: Reactome
    5. rhodopsin mediated signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Sensory transduction, Vision

    Enzyme and pathway databases

    ReactomeiREACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of G-protein signaling 9-binding protein
    Alternative name(s):
    RGS9-anchoring protein
    Gene namesi
    Name:RGS9BP
    Synonyms:R9AP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:30304. RGS9BP.

    Subcellular locationi

    Membrane By similarity; Single-pass type IV membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Prolonged electroretinal response suppression (PERRS) [MIM:608415]: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi608415. phenotype.
    Orphaneti75374. Bradyopsia.
    PharmGKBiPA162401280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Regulator of G-protein signaling 9-binding proteinPRO_0000287586Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZS82.
    PRIDEiQ6ZS82.

    Expressioni

    Gene expression databases

    BgeeiQ6ZS82.
    CleanExiHS_RGS9BP.
    GenevestigatoriQ6ZS82.

    Organism-specific databases

    HPAiHPA049791.

    Interactioni

    Subunit structurei

    Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi132727. 1 interaction.
    STRINGi9606.ENSP00000334134.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZS82.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 210210CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini232 – 2354ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei211 – 23121Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni153 – 20048SNARE-likeBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili29 – 5426Sequence AnalysisAdd
    BLAST
    Coiled coili144 – 16926Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RGS7BP/RGS9BP family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40375.
    HOGENOMiHOG000136373.
    HOVERGENiHBG059498.
    InParanoidiQ6ZS82.
    OMAiIQTGMTG.
    OrthoDBiEOG7T4MMS.
    PhylomeDBiQ6ZS82.
    TreeFamiTF331562.

    Family and domain databases

    InterProiIPR026512. RGS7BP/RGS9BP.
    IPR026513. RGS9BP.
    [Graphical view]
    PANTHERiPTHR21029. PTHR21029. 1 hit.
    PTHR21029:SF1. PTHR21029:SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6ZS82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAREECKALL DGLNKTTACY HHLVLTVGGS ADSQNLRQEL QKTRQKAQEL    50
    AVSTCARLTA VLRDRGLAAD ERAEFERLWV AFSGCLDLLE ADMRRALELG 100
    AAFPLHAPRR PLVRTGVAGA SSGVAARALS TRSLRLEAEG DFDVADLREL 150
    EREVLQVGEM IDNMEMKVNV PRWTVQARQA AGAELLSTVS AGPSSVVSLQ 200
    ERGGGCDPRK ALAAILFGAV LLAAVALAVC VAKLS 235
    Length:235
    Mass (Da):25,148
    Last modified:July 5, 2004 - v1
    Checksum:i54A3CC6CBACAC014
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961A → S.1 Publication
    Corresponds to variant rs259290 [ dbSNP | Ensembl ].
    VAR_032333

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124499 mRNA. Translation: BAC85865.1.
    AK127646 mRNA. Translation: BAC87072.1.
    CCDSiCCDS12424.1.
    RefSeqiNP_997274.2. NM_207391.2.
    UniGeneiHs.528491.

    Genome annotation databases

    EnsembliENST00000334176; ENSP00000334134; ENSG00000186326.
    GeneIDi388531.
    KEGGihsa:388531.
    UCSCiuc002ntp.1. human.

    Polymorphism databases

    DMDMi74711357.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK124499 mRNA. Translation: BAC85865.1 .
    AK127646 mRNA. Translation: BAC87072.1 .
    CCDSi CCDS12424.1.
    RefSeqi NP_997274.2. NM_207391.2.
    UniGenei Hs.528491.

    3D structure databases

    ProteinModelPortali Q6ZS82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 132727. 1 interaction.
    STRINGi 9606.ENSP00000334134.

    Polymorphism databases

    DMDMi 74711357.

    Proteomic databases

    PaxDbi Q6ZS82.
    PRIDEi Q6ZS82.

    Protocols and materials databases

    DNASUi 388531.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334176 ; ENSP00000334134 ; ENSG00000186326 .
    GeneIDi 388531.
    KEGGi hsa:388531.
    UCSCi uc002ntp.1. human.

    Organism-specific databases

    CTDi 388531.
    GeneCardsi GC19P033166.
    HGNCi HGNC:30304. RGS9BP.
    HPAi HPA049791.
    MIMi 607814. gene.
    608415. phenotype.
    neXtProti NX_Q6ZS82.
    Orphaneti 75374. Bradyopsia.
    PharmGKBi PA162401280.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40375.
    HOGENOMi HOG000136373.
    HOVERGENi HBG059498.
    InParanoidi Q6ZS82.
    OMAi IQTGMTG.
    OrthoDBi EOG7T4MMS.
    PhylomeDBi Q6ZS82.
    TreeFami TF331562.

    Enzyme and pathway databases

    Reactomei REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    GenomeRNAii 388531.
    NextBioi 102108.
    PROi Q6ZS82.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZS82.
    CleanExi HS_RGS9BP.
    Genevestigatori Q6ZS82.

    Family and domain databases

    InterProi IPR026512. RGS7BP/RGS9BP.
    IPR026513. RGS9BP.
    [Graphical view ]
    PANTHERi PTHR21029. PTHR21029. 1 hit.
    PTHR21029:SF1. PTHR21029:SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-96.
      Tissue: Cerebellum and Kidney.
    2. "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation."
      Nishiguchi K.M., Sandberg M.A., Kooijman A.C., Martemyanov K.A., Pott J.W.R., Hagstrom S.A., Arshavsky V.Y., Berson E.L., Dryja T.P.
      Nature 427:75-78(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PERRS.

    Entry informationi

    Entry nameiR9BP_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZS82
    Secondary accession number(s): Q6ZVJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3