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Protein

C-type lectin domain family 17, member A

Gene

CLEC17A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi341 – 3411CalciumBy similarity
Metal bindingi343 – 3431CalciumBy similarity
Metal bindingi348 – 3481CalciumBy similarity
Metal bindingi360 – 3601CalciumBy similarity
Metal bindingi361 – 3611CalciumBy similarity

GO - Molecular functioni

  • fucose binding Source: UniProtKB
  • mannose binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Calcium, Lectin, Mannose-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 17, member A
Alternative name(s):
Prolectin
Gene namesi
Name:CLEC17A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34520. CLEC17A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 172172CytoplasmicSequence analysisAdd
BLAST
Transmembranei173 – 19321Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini194 – 378185ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164717947.

Polymorphism and mutation databases

BioMutaiCLEC17A.
DMDMi300669632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378C-type lectin domain family 17, member APRO_0000319428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi254 ↔ 265PROSITE-ProRule annotation
Disulfide bondi282 ↔ 372PROSITE-ProRule annotation
Glycosylationi285 – 2851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi350 ↔ 364PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6ZS10.
PeptideAtlasiQ6ZS10.
PRIDEiQ6ZS10.

PTM databases

iPTMnetiQ6ZS10.
PhosphoSiteiQ6ZS10.

Expressioni

Tissue specificityi

Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen.1 Publication

Gene expression databases

BgeeiENSG00000187912.
ExpressionAtlasiQ6ZS10. baseline and differential.

Interactioni

Subunit structurei

Oligomer; disulfide-linked.1 Publication

Protein-protein interaction databases

BioGridi132718. 1 interaction.
STRINGi9606.ENSP00000393719.

Structurei

3D structure databases

ProteinModelPortaliQ6ZS10.
SMRiQ6ZS10. Positions 254-373.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini261 – 373113C-type lectinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 225Poly-Glu
Compositional biasi44 – 485Poly-Glu
Compositional biasi70 – 745Poly-Glu

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKZI. Eukaryota.
ENOG41124PN. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000060221.
HOVERGENiHBG106632.
InParanoidiQ6ZS10.
KOiK17513.
OMAiEEDCASM.
OrthoDBiEOG091G0AT6.
PhylomeDBiQ6ZS10.
TreeFamiTF343491.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZS10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHNLYSITGY PDPPGTMEEE EEDDDYENST PPYKDLPPKP GTMEEEEEDD
60 70 80 90 100
DYENSTPPYK DLPPKPGTME EEEEDDDYEN STPPYKDLPP KPGSSAPPRP
110 120 130 140 150
PRAAKETEKP PLPCKPRNMT GLDLAAVTCP PPQLAVNLEP SPLQPSLAAT
160 170 180 190 200
PVPWLNQRSG GPGCCQKRWM VYLCLLVVTS LFLGCLGLTV TLIKYQELME
210 220 230 240 250
ELRMLSFQQM TWRTNMTGMA GLAGLKHDIA RVRADTNQSL VELWGLLDCR
260 270 280 290 300
RITCPEGWLP FEGKCYYFSP STKSWDEARM FCQENYSHLV IINSFAEHNF
310 320 330 340 350
VAKAHGSPRV YWLGLNDRAQ EGDWRWLDGS PVTLSFWEPE EPNNIHDEDC
360 370
ATMNKGGTWN DLSCYKTTYW ICERKCSC
Length:378
Mass (Da):42,935
Last modified:July 13, 2010 - v2
Checksum:iA2F0747289DABB6E
GO
Isoform 2 (identifier: Q6ZS10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-265: DCRRITCPEGWLPFEGKC → EFCGQGPWLSTGVLAGAE
     266-378: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:265
Mass (Da):29,380
Checksum:iE2C7F6CC3DBDE6B0
GO
Isoform 3 (identifier: Q6ZS10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-306: NFVAKAHG → LLGARGTQ
     307-378: Missing.

Show »
Length:306
Mass (Da):34,449
Checksum:i0ECADB6F2EF646AD
GO

Sequence cautioni

The sequence EAW84437 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 26518DCRRI…FEGKC → EFCGQGPWLSTGVLAGAE in isoform 2. 1 PublicationVSP_039405Add
BLAST
Alternative sequencei266 – 378113Missing in isoform 2. 1 PublicationVSP_039406Add
BLAST
Alternative sequencei299 – 3068NFVAKAHG → LLGARGTQ in isoform 3. 1 PublicationVSP_039407
Alternative sequencei307 – 37872Missing in isoform 3. 1 PublicationVSP_039408Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127809 mRNA. Translation: BAC87146.1.
AC010527 Genomic DNA. No translation available.
AC140008 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84437.1. Sequence problems.
BC140848 mRNA. Translation: AAI40849.1.
BC144665 mRNA. Translation: AAI44666.1.
CCDSiCCDS46002.2. [Q6ZS10-3]
CCDS56087.1. [Q6ZS10-1]
RefSeqiNP_001191047.1. NM_001204118.1. [Q6ZS10-1]
NP_997273.3. NM_207390.3. [Q6ZS10-3]
UniGeneiHs.567933.

Genome annotation databases

EnsembliENST00000339847; ENSP00000341620; ENSG00000187912. [Q6ZS10-2]
ENST00000417570; ENSP00000393719; ENSG00000187912. [Q6ZS10-1]
ENST00000547437; ENSP00000450065; ENSG00000187912. [Q6ZS10-3]
GeneIDi388512.
KEGGihsa:388512.
UCSCiuc010dzn.3. human. [Q6ZS10-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127809 mRNA. Translation: BAC87146.1.
AC010527 Genomic DNA. No translation available.
AC140008 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84437.1. Sequence problems.
BC140848 mRNA. Translation: AAI40849.1.
BC144665 mRNA. Translation: AAI44666.1.
CCDSiCCDS46002.2. [Q6ZS10-3]
CCDS56087.1. [Q6ZS10-1]
RefSeqiNP_001191047.1. NM_001204118.1. [Q6ZS10-1]
NP_997273.3. NM_207390.3. [Q6ZS10-3]
UniGeneiHs.567933.

3D structure databases

ProteinModelPortaliQ6ZS10.
SMRiQ6ZS10. Positions 254-373.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132718. 1 interaction.
STRINGi9606.ENSP00000393719.

PTM databases

iPTMnetiQ6ZS10.
PhosphoSiteiQ6ZS10.

Polymorphism and mutation databases

BioMutaiCLEC17A.
DMDMi300669632.

Proteomic databases

PaxDbiQ6ZS10.
PeptideAtlasiQ6ZS10.
PRIDEiQ6ZS10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339847; ENSP00000341620; ENSG00000187912. [Q6ZS10-2]
ENST00000417570; ENSP00000393719; ENSG00000187912. [Q6ZS10-1]
ENST00000547437; ENSP00000450065; ENSG00000187912. [Q6ZS10-3]
GeneIDi388512.
KEGGihsa:388512.
UCSCiuc010dzn.3. human. [Q6ZS10-1]

Organism-specific databases

CTDi388512.
GeneCardsiCLEC17A.
HGNCiHGNC:34520. CLEC17A.
MIMi616838. gene.
neXtProtiNX_Q6ZS10.
PharmGKBiPA164717947.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKZI. Eukaryota.
ENOG41124PN. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000060221.
HOVERGENiHBG106632.
InParanoidiQ6ZS10.
KOiK17513.
OMAiEEDCASM.
OrthoDBiEOG091G0AT6.
PhylomeDBiQ6ZS10.
TreeFamiTF343491.

Miscellaneous databases

GenomeRNAii388512.
PROiQ6ZS10.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187912.
ExpressionAtlasiQ6ZS10. baseline and differential.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCL17A_HUMAN
AccessioniPrimary (citable) accession number: Q6ZS10
Secondary accession number(s): A8MX68, B2RTX0, B7ZMM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 13, 2010
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.