Q6ZRY4A2RRG0RBPS2_HUMANRNA-binding protein with multiple splicing 2RNA binding protein, mRNA processing factor 2RBPMS2Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Analysis of the DNA sequence and duplication history of human chromosome 15.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets.FUNCTIONSUBCELLULAR LOCATIONDOMAINHomodimerization of RBPMS2 through a new RRM-interaction motif is necessary to control smooth muscle plasticity.STRUCTURE BY NMR OF 27-117FUNCTIONRNA-BINDINGSUBUNITINTERACTION WITH EEF2MUTAGENESIS OF LEU-49RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (PubMed:25064856). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity). Acts as a pre-mRNA alternative splicing regulator (By similarity). Mediates ACTN1 and FLNB alternative splicing (By similarity). Likely binds to mRNA tandem CAC trinucleotide or CA dinucleotide motifs (PubMed:24860013).Homodimer (PubMed:25064856). Interacts with EEF2 (PubMed:25064856).Q6ZRY4Q5BKX5-3false3Q6ZRY4P19801false3Q6ZRY4Q03989false3Q6ZRY4O14503false3Q6ZRY4Q8N9W6-4false3Q6ZRY4Q5SWW7false3Q6ZRY4Q9UQM7false3Q6ZRY4Q14781-2false3Q6ZRY4Q9BZC1-2false3Q6ZRY4Q8IYX4false3Q6ZRY4Q6NXG1false3Q6ZRY4Q92567-2false3Q6ZRY4Q9NU39false4Q6ZRY4Q6VB84false3Q6ZRY4O75593false3Q6ZRY4Q96I24-2false3Q6ZRY4P07910false3Q6ZRY4P61978-2false3Q6ZRY4Q00839-2false3Q6ZRY4Q8IZ03false3Q6ZRY4Q13351false3Q6ZRY4Q96G42false3Q6ZRY4Q8IUC1false3Q6ZRY4Q3LI72false3Q6ZRY4Q3LI70false3Q6ZRY4Q3SYF9false3Q6ZRY4Q3LI64false3Q6ZRY4Q3LI66false3Q6ZRY4Q8IUC2false5Q6ZRY4Q14847-2false3Q6ZRY4Q9Y5V3false3Q6ZRY4Q13064false3Q6ZRY4P35548false3Q6ZRY4Q86VE0false3Q6ZRY4Q9HBE1-4false3Q6ZRY4Q15365false4Q6ZRY4O75864false3Q6ZRY4P86480false3Q6ZRY4Q9UKA9-2false3Q6ZRY4Q53GL6false3Q6ZRY4Q9NWB1-5false3Q6ZRY4O43251-10false5Q6ZRY4P98179false3Q6ZRY4Q96IZ5false3Q6ZRY4Q9BTD8false3Q6ZRY4Q8TBY0false3Q6ZRY4Q93062-3false3Q6ZRY4Q6ZRY4false3Q6ZRY4Q9BQY4false3Q6ZRY4Q13214-2false3Q6ZRY4P09012false6Q6ZRY4Q96LM6false3Q6ZRY4Q96SI9false3Q6ZRY4Q96A09false3Q6ZRY4Q01085-2false3Q6ZRY4Q6NVU6false3Q6ZRY4Q13432false3Q6ZRY4Q70EL1-9false3Q6ZRY4A5D8V6false3Q6ZRY4A0A0C4DGF1false3Q6ZRY4Q96K80false3Q6ZRY4Q9UDW3false3Q6ZRY4Q66K41-2false3CytoplasmNucleusCytoplasmStress granuleLocalized to cytoplasmic stress granules after oxidative stress.Q6ZRY4-11Q6ZRY4-22The RNA recognition motif (RRM) domain mediates binding to tandem CAC trinucleotide motif separated by a variable spacer region present on single-stranded RNA (PubMed:24860013). Can also bind to CA dinucleotide repeats (PubMed:24860013).3D-structureAcetylationAlternative splicingCytoplasmDevelopmental proteinNucleusReference proteomeRNA-bindingLELQMSNLKPDGEHGGSTGTGSGAGSGGALEEEVRTLFVSGLPVDIKPRELYLLFRPFKGYEGSLIKLTARQPVGFVIFDSRAGAEAAKNALNGIRFDPENPQTLRLEFAKANTKMAKSKLMATPNPSNVHPALGAHFIARDPYDLMGAALIPASPEAWAPYPLYTTELTPAISHAAFTYPTATAAAAALHAQVRWYPSSDTTQQGWKYRQFC
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