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Q6ZRY4

- RBPS2_HUMAN

UniProt

Q6ZRY4 - RBPS2_HUMAN

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Protein

RNA-binding protein with multiple splicing 2

Gene

RBPMS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. nucleotide binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein with multiple splicing 2
Gene namesi
Name:RBPMS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19098. RBPMS2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134871904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 209208RNA-binding protein with multiple splicing 2PRO_0000274909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6ZRY4.
PRIDEiQ6ZRY4.

PTM databases

PhosphoSiteiQ6ZRY4.

Expressioni

Gene expression databases

BgeeiQ6ZRY4.
CleanExiHS_RBPMS2.
ExpressionAtlasiQ6ZRY4. baseline and differential.
GenevestigatoriQ6ZRY4.

Organism-specific databases

HPAiHPA058366.

Interactioni

Protein-protein interaction databases

BioGridi131505. 3 interactions.
STRINGi9606.ENSP00000300069.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRY4.
SMRiQ6ZRY4. Positions 30-111.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 10878RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG255204.
GeneTreeiENSGT00500000044861.
HOGENOMiHOG000017369.
HOVERGENiHBG069897.
InParanoidiQ6ZRY4.
OMAiSRQPVGF.
PhylomeDBiQ6ZRY4.
TreeFamiTF351070.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZRY4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNLKPDGEH GGSTGTGSGA GSGGALEEEV RTLFVSGLPV DIKPRELYLL
60 70 80 90 100
FRPFKGYEGS LIKLTARQPV GFVIFDSRAG AEAAKNALNG IRFDPENPQT
110 120 130 140 150
LRLEFAKANT KMAKSKLMAT PNPSNVHPAL GAHFIARDPY DLMGAALIPA
160 170 180 190 200
SPEAWAPYPL YTTELTPAIS HAAFTYPTAT AAAAALHAQV RWYPSSDTTQ

QGWKYRQFC
Length:209
Mass (Da):22,497
Last modified:July 5, 2004 - v1
Checksum:iE7924D0CD3AD860C
GO
Isoform 2 (identifier: Q6ZRY4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available

Show »
Length:98
Mass (Da):10,663
Checksum:i007A855887EAD5C4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_056896Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY369207 mRNA. Translation: AAQ73311.1.
AK127873 mRNA. Translation: BAC87172.1.
AC091582 Genomic DNA. No translation available.
AC100830 Genomic DNA. No translation available.
BC131612 mRNA. Translation: AAI31613.1.
CCDSiCCDS32271.1.
RefSeqiNP_919248.1. NM_194272.1.
UniGeneiHs.436518.

Genome annotation databases

EnsembliENST00000300069; ENSP00000300069; ENSG00000166831. [Q6ZRY4-1]
ENST00000560606; ENSP00000456720; ENSG00000166831. [Q6ZRY4-2]
GeneIDi348093.
KEGGihsa:348093.
UCSCiuc002anq.3. human. [Q6ZRY4-1]

Polymorphism databases

DMDMi74762401.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY369207 mRNA. Translation: AAQ73311.1 .
AK127873 mRNA. Translation: BAC87172.1 .
AC091582 Genomic DNA. No translation available.
AC100830 Genomic DNA. No translation available.
BC131612 mRNA. Translation: AAI31613.1 .
CCDSi CCDS32271.1.
RefSeqi NP_919248.1. NM_194272.1.
UniGenei Hs.436518.

3D structure databases

ProteinModelPortali Q6ZRY4.
SMRi Q6ZRY4. Positions 30-111.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131505. 3 interactions.
STRINGi 9606.ENSP00000300069.

PTM databases

PhosphoSitei Q6ZRY4.

Polymorphism databases

DMDMi 74762401.

Proteomic databases

PaxDbi Q6ZRY4.
PRIDEi Q6ZRY4.

Protocols and materials databases

DNASUi 348093.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300069 ; ENSP00000300069 ; ENSG00000166831 . [Q6ZRY4-1 ]
ENST00000560606 ; ENSP00000456720 ; ENSG00000166831 . [Q6ZRY4-2 ]
GeneIDi 348093.
KEGGi hsa:348093.
UCSCi uc002anq.3. human. [Q6ZRY4-1 ]

Organism-specific databases

CTDi 348093.
GeneCardsi GC15M065032.
HGNCi HGNC:19098. RBPMS2.
HPAi HPA058366.
neXtProti NX_Q6ZRY4.
PharmGKBi PA134871904.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG255204.
GeneTreei ENSGT00500000044861.
HOGENOMi HOG000017369.
HOVERGENi HBG069897.
InParanoidi Q6ZRY4.
OMAi SRQPVGF.
PhylomeDBi Q6ZRY4.
TreeFami TF351070.

Miscellaneous databases

ChiTaRSi RBPMS2. human.
GenomeRNAii 348093.
NextBioi 99336.
PROi Q6ZRY4.

Gene expression databases

Bgeei Q6ZRY4.
CleanExi HS_RBPMS2.
ExpressionAtlasi Q6ZRY4. baseline and differential.
Genevestigatori Q6ZRY4.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Huang C.Q., Wu S.L., Liu S.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRBPS2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRY4
Secondary accession number(s): A2RRG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3