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Protein

RNA-binding protein with multiple splicing 2

Gene

RBPMS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an increase of NOG mRNA levels, and thereby contributes to the negative regulation of the BMP signaling pathway. This promotes reversible dedifferentiation of smooth muscle cells and promotes smooth muscle cell proliferation.By similarity

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • nucleotide binding Source: InterPro
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein with multiple splicing 2
Gene namesi
Name:RBPMS2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:19098. RBPMS2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49L → E: Strongly reduces homodimerization and interaction with EEF2. Strongly reduces NOG mRNA binding. Loss of function in gastrointestinal smooth muscle cell differentiation. 1 Publication1
Mutagenesisi49L → Q: No effect on homodimerization. No effect on function in gastrointestinal smooth muscle cell differentiation. 1 Publication1

Organism-specific databases

DisGeNETi348093.
OpenTargetsiENSG00000166831.
PharmGKBiPA134871904.

Polymorphism and mutation databases

BioMutaiRBPMS2.
DMDMi74762401.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002749092 – 209RNA-binding protein with multiple splicing 2Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6ZRY4.
MaxQBiQ6ZRY4.
PaxDbiQ6ZRY4.
PeptideAtlasiQ6ZRY4.
PRIDEiQ6ZRY4.

PTM databases

iPTMnetiQ6ZRY4.
PhosphoSitePlusiQ6ZRY4.

Expressioni

Gene expression databases

BgeeiENSG00000166831.
CleanExiHS_RBPMS2.
GenevisibleiQ6ZRY4. HS.

Organism-specific databases

HPAiHPA058366.

Interactioni

Subunit structurei

Homodimer. Interacts with EEF2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPKP61978-24EBI-11987469,EBI-7060731
PRR20CP864794EBI-11987469,EBI-10172814
RBFOX2O43251-104EBI-11987469,EBI-11963050
RBPMSQ93062-34EBI-11987469,EBI-740343

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi131505. 7 interactors.
IntActiQ6ZRY4. 43 interactors.
STRINGi9606.ENSP00000300069.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 36Combined sources5
Helixi44 – 51Combined sources8
Beta strandi52 – 54Combined sources3
Beta strandi57 – 63Combined sources7
Beta strandi70 – 76Combined sources7
Helixi78 – 88Combined sources11
Beta strandi91 – 93Combined sources3
Beta strandi100 – 105Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9KNMR-A/B27-117[»]
ProteinModelPortaliQ6ZRY4.
SMRiQ6ZRY4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 108RRMPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 51Important for homodimerization1 PublicationAdd BLAST11

Sequence similaritiesi

Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1457. Eukaryota.
ENOG410XSBT. LUCA.
GeneTreeiENSGT00500000044861.
HOGENOMiHOG000017369.
HOVERGENiHBG069897.
InParanoidiQ6ZRY4.
OMAiNPSNVHP.
OrthoDBiEOG091G0K3T.
PhylomeDBiQ6ZRY4.
TreeFamiTF351070.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZRY4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNLKPDGEH GGSTGTGSGA GSGGALEEEV RTLFVSGLPV DIKPRELYLL
60 70 80 90 100
FRPFKGYEGS LIKLTARQPV GFVIFDSRAG AEAAKNALNG IRFDPENPQT
110 120 130 140 150
LRLEFAKANT KMAKSKLMAT PNPSNVHPAL GAHFIARDPY DLMGAALIPA
160 170 180 190 200
SPEAWAPYPL YTTELTPAIS HAAFTYPTAT AAAAALHAQV RWYPSSDTTQ

QGWKYRQFC
Length:209
Mass (Da):22,497
Last modified:July 5, 2004 - v1
Checksum:iE7924D0CD3AD860C
GO
Isoform 2 (identifier: Q6ZRY4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Note: No experimental confirmation available.
Show »
Length:98
Mass (Da):10,663
Checksum:i007A855887EAD5C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568961 – 111Missing in isoform 2. 1 PublicationAdd BLAST111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY369207 mRNA. Translation: AAQ73311.1.
AK127873 mRNA. Translation: BAC87172.1.
AC091582 Genomic DNA. No translation available.
AC100830 Genomic DNA. No translation available.
BC131612 mRNA. Translation: AAI31613.1.
CCDSiCCDS32271.1. [Q6ZRY4-1]
RefSeqiNP_919248.1. NM_194272.2. [Q6ZRY4-1]
UniGeneiHs.436518.

Genome annotation databases

EnsembliENST00000300069; ENSP00000300069; ENSG00000166831. [Q6ZRY4-1]
ENST00000560606; ENSP00000456720; ENSG00000166831. [Q6ZRY4-2]
GeneIDi348093.
KEGGihsa:348093.
UCSCiuc002anq.4. human. [Q6ZRY4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY369207 mRNA. Translation: AAQ73311.1.
AK127873 mRNA. Translation: BAC87172.1.
AC091582 Genomic DNA. No translation available.
AC100830 Genomic DNA. No translation available.
BC131612 mRNA. Translation: AAI31613.1.
CCDSiCCDS32271.1. [Q6ZRY4-1]
RefSeqiNP_919248.1. NM_194272.2. [Q6ZRY4-1]
UniGeneiHs.436518.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9KNMR-A/B27-117[»]
ProteinModelPortaliQ6ZRY4.
SMRiQ6ZRY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131505. 7 interactors.
IntActiQ6ZRY4. 43 interactors.
STRINGi9606.ENSP00000300069.

PTM databases

iPTMnetiQ6ZRY4.
PhosphoSitePlusiQ6ZRY4.

Polymorphism and mutation databases

BioMutaiRBPMS2.
DMDMi74762401.

Proteomic databases

EPDiQ6ZRY4.
MaxQBiQ6ZRY4.
PaxDbiQ6ZRY4.
PeptideAtlasiQ6ZRY4.
PRIDEiQ6ZRY4.

Protocols and materials databases

DNASUi348093.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300069; ENSP00000300069; ENSG00000166831. [Q6ZRY4-1]
ENST00000560606; ENSP00000456720; ENSG00000166831. [Q6ZRY4-2]
GeneIDi348093.
KEGGihsa:348093.
UCSCiuc002anq.4. human. [Q6ZRY4-1]

Organism-specific databases

CTDi348093.
DisGeNETi348093.
GeneCardsiRBPMS2.
HGNCiHGNC:19098. RBPMS2.
HPAiHPA058366.
neXtProtiNX_Q6ZRY4.
OpenTargetsiENSG00000166831.
PharmGKBiPA134871904.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1457. Eukaryota.
ENOG410XSBT. LUCA.
GeneTreeiENSGT00500000044861.
HOGENOMiHOG000017369.
HOVERGENiHBG069897.
InParanoidiQ6ZRY4.
OMAiNPSNVHP.
OrthoDBiEOG091G0K3T.
PhylomeDBiQ6ZRY4.
TreeFamiTF351070.

Miscellaneous databases

ChiTaRSiRBPMS2. human.
GenomeRNAii348093.
PROiQ6ZRY4.

Gene expression databases

BgeeiENSG00000166831.
CleanExiHS_RBPMS2.
GenevisibleiQ6ZRY4. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBPS2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRY4
Secondary accession number(s): A2RRG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.