ID   Q6ZRU0_HUMAN            Unreviewed;       197 AA.
AC   Q6ZRU0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE   AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE   AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE   AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAC87219.1};
RN   [1] {ECO:0000313|EMBL:BAC87219.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis {ECO:0000313|EMBL:BAC87219.1};
RA   Kanehori K., Ishibashi T., Chiba Y., Fujimori K., Hiraoka S., Tanai H.,
RA   Watanabe S., Ishida S., Ono Y., Hotuta T., Watanabe M., Sugiyama T.,
RA   Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA   Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Matsuo K., Nakamura Y.,
RA   Sekine M., Kikuchi H., Kanda K., Wagatsuma M., Takahashi-Fujii A.,
RA   Oshima A., Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K.,
RA   Masuho Y., Nagai K., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC       to dystrophin at the costameres of striated muscle.
CC       {ECO:0000256|ARBA:ARBA00037766}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; AK127993; BAC87219.1; -; mRNA.
DR   AlphaFoldDB; Q6ZRU0; -.
DR   SMR; Q6ZRU0; -.
DR   MaxQB; Q6ZRU0; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR   Pfam; PF00038; Filament; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          1..197
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          96..123
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   197 AA;  22343 MW;  283C58A8536DEB3A CRC64;
     MNKVELESLL EGLTDEINFL RQLYEEEIWE LQSQISDTSV VLSMDSSRSL DMDSIIPEVK
     AQYKEIANGS WAEAEGMHQI KYEELQTLPG KHRNDLRYAK MEISEINRNI SRLQAQTEGL
     KGQRVSLEAA TADAEQYGEL AVKDANTKLS SWRPPCSGPS KTWCSSCAME HQELMNVKLA
     LDIKIATYRK LLEGEES
//