SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6ZRS2

- SRCAP_HUMAN

UniProt

Q6ZRS2 - SRCAP_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Helicase SRCAP

Gene
SRCAP, KIAA0309
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.6 Publications

Kineticsi

  1. KM=66 µM for ATP1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi643 – 6508ATP By similarity
DNA bindingi2857 – 286913A.T hook 1Add
BLAST
DNA bindingi2936 – 294813A.T hook 2Add
BLAST
DNA bindingi3004 – 301613A.T hook 3Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. histone acetyltransferase activity Source: ProtInc
  5. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. histone acetylation Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SRCAP (EC:3.6.4.-)
Alternative name(s):
Domino homolog 2
Snf2-related CBP activator
Gene namesi
Name:SRCAP
Synonyms:KIAA0309
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:16974. SRCAP.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. nucleus Source: HPA
  3. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi136140. phenotype.
Orphaneti2044. Floating-Harbor syndrome.
PharmGKBiPA162404706.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32303230Helicase SRCAPPRO_0000311236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei572 – 5721Phosphothreonine1 Publication
Modified residuei2430 – 24301Phosphoserine1 Publication
Modified residuei2869 – 28691Phosphoserine1 Publication
Modified residuei3148 – 31481Phosphoserine3 Publications
Modified residuei3161 – 31611Phosphoserine1 Publication
Modified residuei3172 – 31721Phosphoserine1 Publication
Modified residuei3177 – 31771Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZRS2.
PaxDbiQ6ZRS2.
PRIDEiQ6ZRS2.

PTM databases

PhosphoSiteiQ6ZRS2.

Expressioni

Gene expression databases

ArrayExpressiQ6ZRS2.
BgeeiQ6ZRS2.
CleanExiHS_SRCAP.
GenevestigatoriQ6ZRS2.

Organism-specific databases

HPAiHPA028929.

Interactioni

Subunit structurei

Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP.7 Publications

Protein-protein interaction databases

BioGridi116058. 23 interactions.
IntActiQ6ZRS2. 14 interactions.
MINTiMINT-123408.
STRINGi9606.ENSP00000262518.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRS2.
SMRiQ6ZRS2. Positions 611-930, 2023-2209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19673HSAAdd
BLAST
Domaini630 – 795166Helicase ATP-bindingAdd
BLAST
Domaini2044 – 2197154Helicase C-terminalAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 2784Poly-Pro
Compositional biasi293 – 563271Glu-richAdd
BLAST
Compositional biasi981 – 1883903Pro-richAdd
BLAST
Compositional biasi2227 – 2362136Glu-richAdd
BLAST
Compositional biasi2426 – 3023598Pro-richAdd
BLAST
Compositional biasi3179 – 31824Poly-Glu

Sequence similaritiesi

Contains 1 HSA domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0553.
HOGENOMiHOG000168717.
InParanoidiQ6ZRS2.
KOiK11661.
OMAiPSSTQTM.
OrthoDBiEOG79CXXJ.
PhylomeDBiQ6ZRS2.
TreeFamiTF106424.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00929. ATHOOK.
SMARTiSM00384. AT_hook. 3 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZRS2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH     50
IAQDSSLDGP PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA 100
KHEAEIETRI AELRKEGFWS LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD 150
FAQERRWKRG VARKVVRMVI RHHEEQRQKE ERARREEQAK LRRIASTMAK 200
DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT EKYSDLLSQS 250
LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE 300
ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP 350
SQTPSSHDSD TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD 400
EEFTANEEEA EDEEDTIAAE EQLEGEVDHA MELSELAREG ELSMEELLQQ 450
YAGAYAPGSG SSEDEDEDEV DANSSDCEPE GPVEAEEPPQ EDSSSQSDSV 500
EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA DEEEEDDDFG 550
VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT 600
LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT 650
IQTISLLAHL ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG 700
AQKERKLKRQ GWTKPNAFHV CITSYKLVLQ DHQAFRRKNW RYLILDEAQN 750
IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN SLMELWSLMH FLMPHVFQSH 800
REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR VKVDVEKQMP 850
KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV 900
CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG 950
LEGRVSRYEA DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP 1000
VPKQEGRTVV VVNNPRAPLG PVPVRPPPGP ELSAQPTPGP VPQVLPASLM 1050
VSASPAGPPL IPASRPPGPV LLPPLQPNSG SLPQVLPSPL GVLSGTSRPP 1100
TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP PAAATTTSTT 1150
TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN 1200
AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQRNVVH LVSAGGQHHL 1250
ISQPAHVALI QAVAPTPGPT PVSVLPSSTP STTPAPTGLS LPLAANQVPP 1300
TMVNNTGVVK IVVRQAPRDG LTPVPPLAPA PRPPSSGLPA VLNPRPTLTP 1350
GRLPTPTLGT ARAPMPTPTL VRPLLKLVHS PSPEVSASAP GAAPLTISSP 1400
LHVPSSLPGP ASSPMPIPNS SPLASPVSST VSVPLSSSLP ISVPTTLPAP 1450
ASAPLTIPIS APLTVSASGP ALLTSVTPPL APVVPAAPGP PSLAPSGASP 1500
SASALTLGLA TAPSLSSSQT PGHPLLLAPT SSHVPGLNST VAPACSPVLV 1550
PASALASPFP SAPNPAPAQA SLLAPASSAS QALATPLAPM AAPQTAILAP 1600
SPAPPLAPLP VLAPSPGAAP VLASSQTPVP VMAPSSTPGT SLASASPVPA 1650
PTPVLAPSST QTMLPAPVPS PLPSPASTQT LALAPALAPT LGGSSPSQTL 1700
SLGTGNPQGP FPTQTLSLTP ASSLVPTPAQ TLSLAPGPPL GPTQTLSLAP 1750
APPLAPASPV GPAPAHTLTL APASSSASLL APASVQTLTL SPAPVPTLGP 1800
AAAQTLALAP ASTQSPASQA SSLVVSASGA APLPVTMVSR LPVSKDEPDT 1850
LTLRSGPPSP PSTATSFGGP RPRRQPPPPP RSPFYLDSLE EKRKRQRSER 1900
LERIFQLSEA HGALAPVYGT EVLDFCTLPQ PVASPIGPRS PGPSHPTFWT 1950
YTEAAHRAVL FPQQRLDQLS EIIERFIFVM PPVEAPPPSL HACHPPPWLA 2000
PRQAAFQEQL ASELWPRARP LHRIVCNMRT QFPDLRLIQY DCGKLQTLAV 2050
LLRQLKAEGH RVLIFTQMTR MLDVLEQFLT YHGHLYLRLD GSTRVEQRQA 2100
LMERFNADKR IFCFILSTRS GGVGVNLTGA DTVVFYDSDW NPTMDAQAQD 2150
RCHRIGQTRD VHIYRLISER TVEENILKKA NQKRMLGDMA IEGGNFTTAY 2200
FKQQTIRELF DMPLEEPSSS SVPSAPEEEE ETVASKQTHI LEQALCRAED 2250
EEDIRAATQA KAEQVAELAE FNENDGFPAG EGEEAGRPGA EDEEMSRAEQ 2300
EIAALVEQLT PIERYAMKFL EASLEEVSRE ELKQAEEQVE AARKDLDQAK 2350
EEVFRLPQEE EEGPGAGDES SCGTGGGTHR RSKKAKAPER PGTRVSERLR 2400
GARAETQGAN HTPVISAHQT RSTTTPPRCS PARERVPRPA PRPRPTPASA 2450
PAAIPALVPV PVSAPVPISA PNPITILPVH ILPSPPPPSQ IPPCSSPACT 2500
PPPACTPPPA HTPPPAQTCL VTPSSPLLLG PPSVPISASV TNLPLGLRPE 2550
AELCAQALAS PESLELASVA SSETSSLSLV PPKDLLPVAV EILPVSEKNL 2600
SLTPSAPSLT LEAGSIPNGQ EQEAPDSAEG TTLTVLPEGE ELPLCVSESN 2650
GLELPPSAAS DEPLQEPLEA DRTSEELTEA KTPTSSPEKP QELVTAEVAA 2700
PSTSSSATSS PEGPSPARPP RRRTSADVEI RGQGTGRPGQ PPGPKVLRKL 2750
PGRLVTVVEE KELVRRRRQQ RGAASTLVPG VSETSASPGS PSVRSMSGPE 2800
SSPPIGGPCE AAPSSSLPTP PQQPFIARRH IELGVTGGGS PENGDGALLA 2850
ITPPAVKRRR GRPPKKNRSP ADAGRGVDEA PSSTLKGKTN GADPVPGPET 2900
LIVADPVLEP QLIPGPQPLG PQPVHRPNPL LSPVEKRRRG RPPKARDLPI 2950
PGTISSAGDG NSESRTQPPP HPSPLTPLPP LLVCPTATVA NTVTTVTIST 3000
SPPKRKRGRP PKNPPSPRPS QLPVLDRDST SVLESCGLGR RRQPQGQGES 3050
EGSSSDEDGS RPLTRLARLR LEAEGMRGRK SGGSMVVAVI QDDLDLADSG 3100
PGGLELTPPV VSLTPKLRST RLRPGSLVPP LETEKLPRKR AGAPVGGSPG 3150
LAKRGRLQPP SPLGPEGSVE ESEAEASGEE EEGDGTPRRR PGPRRLVGTT 3200
NQGDQRILRS SAPPSLAGPA VSHRGRKAKT 3230
Length:3,230
Mass (Da):343,555
Last modified:May 18, 2010 - v3
Checksum:i3CFB74C7BDFBEAD0
GO
Isoform 2 (identifier: Q6ZRS2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Show »
Length:3,168
Mass (Da):337,445
Checksum:iB9A0D36717389361
GO
Isoform 3 (identifier: Q6ZRS2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1085-1181: VLPSPLGVLS...SPDMQARLPS → A
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Show »
Length:3,072
Mass (Da):327,838
Checksum:iEA4D60708B59DC5B
GO

Sequence cautioni

The sequence AAI59100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1085 – 118197VLPSP…ARLPS → A in isoform 3. VSP_029441Add
BLAST
Alternative sequencei1236 – 129863RNVVH…AANQV → M in isoform 2 and isoform 3. VSP_029442Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1147 – 11471T → A in BAC87237. 1 Publication
Sequence conflicti1494 – 14941A → Q in AAD39760. 1 Publication
Sequence conflicti2765 – 27651R → Q in AAD39760. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093249 Genomic DNA. No translation available.
AC106886 Genomic DNA. No translation available.
AK128030 mRNA. Translation: BAC87237.1.
AB002307 mRNA. Translation: BAA20768.2.
BC159099 mRNA. Translation: AAI59100.1. Different initiation.
AF143946 mRNA. Translation: AAD39760.1.
CCDSiCCDS10689.2. [Q6ZRS2-1]
RefSeqiNP_006653.2. NM_006662.2. [Q6ZRS2-1]
UniGeneiHs.620916.

Genome annotation databases

EnsembliENST00000262518; ENSP00000262518; ENSG00000080603. [Q6ZRS2-1]
ENST00000344771; ENSP00000343042; ENSG00000080603. [Q6ZRS2-3]
ENST00000380361; ENSP00000369719; ENSG00000080603.
ENST00000395059; ENSP00000378499; ENSG00000080603. [Q6ZRS2-2]
GeneIDi10847.
KEGGihsa:10847.
UCSCiuc002dze.1. human. [Q6ZRS2-1]
uc002dzg.1. human. [Q6ZRS2-2]

Polymorphism databases

DMDMi296452947.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093249 Genomic DNA. No translation available.
AC106886 Genomic DNA. No translation available.
AK128030 mRNA. Translation: BAC87237.1 .
AB002307 mRNA. Translation: BAA20768.2 .
BC159099 mRNA. Translation: AAI59100.1 . Different initiation.
AF143946 mRNA. Translation: AAD39760.1 .
CCDSi CCDS10689.2. [Q6ZRS2-1 ]
RefSeqi NP_006653.2. NM_006662.2. [Q6ZRS2-1 ]
UniGenei Hs.620916.

3D structure databases

ProteinModelPortali Q6ZRS2.
SMRi Q6ZRS2. Positions 611-930, 2023-2209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116058. 23 interactions.
IntActi Q6ZRS2. 14 interactions.
MINTi MINT-123408.
STRINGi 9606.ENSP00000262518.

PTM databases

PhosphoSitei Q6ZRS2.

Polymorphism databases

DMDMi 296452947.

Proteomic databases

MaxQBi Q6ZRS2.
PaxDbi Q6ZRS2.
PRIDEi Q6ZRS2.

Protocols and materials databases

DNASUi 10847.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262518 ; ENSP00000262518 ; ENSG00000080603 . [Q6ZRS2-1 ]
ENST00000344771 ; ENSP00000343042 ; ENSG00000080603 . [Q6ZRS2-3 ]
ENST00000380361 ; ENSP00000369719 ; ENSG00000080603 .
ENST00000395059 ; ENSP00000378499 ; ENSG00000080603 . [Q6ZRS2-2 ]
GeneIDi 10847.
KEGGi hsa:10847.
UCSCi uc002dze.1. human. [Q6ZRS2-1 ]
uc002dzg.1. human. [Q6ZRS2-2 ]

Organism-specific databases

CTDi 10847.
GeneCardsi GC16P030710.
GeneReviewsi SRCAP.
H-InvDB HIX0012970.
HGNCi HGNC:16974. SRCAP.
HPAi HPA028929.
MIMi 136140. phenotype.
611421. gene.
neXtProti NX_Q6ZRS2.
Orphaneti 2044. Floating-Harbor syndrome.
PharmGKBi PA162404706.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0553.
HOGENOMi HOG000168717.
InParanoidi Q6ZRS2.
KOi K11661.
OMAi PSSTQTM.
OrthoDBi EOG79CXXJ.
PhylomeDBi Q6ZRS2.
TreeFami TF106424.

Miscellaneous databases

ChiTaRSi SRCAP. human.
GeneWikii SRCAP.
GenomeRNAii 10847.
NextBioi 41182.
PROi Q6ZRS2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZRS2.
Bgeei Q6ZRS2.
CleanExi HS_SRCAP.
Genevestigatori Q6ZRS2.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
PRINTSi PR00929. ATHOOK.
SMARTi SM00384. AT_hook. 3 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2427 (ISOFORM 1).
    Tissue: Testis.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3).
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3).
  6. "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein."
    Johnston H., Kneer J., Chackalaparampil I., Yaciuk P., Chrivia J.
    J. Biol. Chem. 274:16370-16376(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-3230 (ISOFORM 2), INTERACTION WITH CREBBP, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.
  7. "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP."
    Ghosh A.K., Majumder M., Steele R., Yaciuk P., Chrivia J., Ray R., Ray R.B.
    J. Biol. Chem. 275:7184-7188(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV NS5A, SUBCELLULAR LOCATION.
  8. "Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP."
    Monroy M.A., Ruhl D.D., Xu X., Granner D.K., Yaciuk P., Chrivia J.C.
    J. Biol. Chem. 276:40721-40726(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription."
    Xu X., Chackalaparampil I., Monroy M.A., Cannella M.T., Pesek E., Chrivia J., Yaciuk P.
    J. Virol. 75:10033-10040(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EP300 AND HADV-2 DBP.
  10. "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1."
    Monroy M.A., Schott N.M., Cox L., Chen J.D., Ruh M., Chrivia J.C.
    Mol. Endocrinol. 17:2519-2528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH CREBBP; CARM1 AND GRIP1.
  11. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."
    Doyon Y., Selleck W., Lane W.S., Tan S., Cote J.
    Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A NUA4-RELATED COMPLEX.
  12. "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes."
    Cai Y., Jin J., Florens L., Swanson S.K., Kusch T., Li B., Workman J.L., Washburn M.P., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 280:13665-13670(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  13. "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway."
    Eissenberg J.C., Wong M., Chrivia J.C.
    Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes."
    Ruhl D.D., Jin J., Cai Y., Swanson S., Florens L., Washburn M.P., Conaway R.C., Conaway J.W., Chrivia J.C.
    Biochemistry 45:5671-5677(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2869 AND SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters."
    Wong M.M., Cox L.K., Chrivia J.C.
    J. Biol. Chem. 282:26132-26139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; THR-572; SER-3161; SER-3172 AND SER-3177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. Cited for: INVOLVEMENT IN FLHS.

Entry informationi

Entry nameiSRCAP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRS2
Secondary accession number(s): B0JZA6
, O15026, Q7Z744, Q9Y5L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi