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Q6ZRS2

- SRCAP_HUMAN

UniProt

Q6ZRS2 - SRCAP_HUMAN

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Protein

Helicase SRCAP

Gene

SRCAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.6 Publications

Kineticsi

  1. KM=66 µM for ATP1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi643 – 6508ATPPROSITE-ProRule annotation
DNA bindingi2857 – 286913A.T hook 1Add
BLAST
DNA bindingi2936 – 294813A.T hook 2Add
BLAST
DNA bindingi3004 – 301613A.T hook 3Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. helicase activity Source: UniProtKB-KW
  4. histone acetyltransferase activity Source: ProtInc
  5. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. histone acetylation Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  3. transcription, DNA-templated Source: UniProtKB-KW
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Helicase SRCAP (EC:3.6.4.-)
Alternative name(s):
Domino homolog 2
Snf2-related CBP activator
Gene namesi
Name:SRCAP
Synonyms:KIAA0309
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:16974. SRCAP.

Subcellular locationi

Nucleus 1 PublicationPROSITE-ProRule annotation

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. nucleus Source: HPA
  3. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi136140. phenotype.
Orphaneti2044. Floating-Harbor syndrome.
PharmGKBiPA162404706.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 32303230Helicase SRCAPPRO_0000311236Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei572 – 5721Phosphothreonine1 Publication
Modified residuei2430 – 24301Phosphoserine1 Publication
Modified residuei2869 – 28691Phosphoserine1 Publication
Modified residuei3148 – 31481Phosphoserine3 Publications
Modified residuei3161 – 31611Phosphoserine1 Publication
Modified residuei3172 – 31721Phosphoserine1 Publication
Modified residuei3177 – 31771Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6ZRS2.
PaxDbiQ6ZRS2.
PRIDEiQ6ZRS2.

PTM databases

PhosphoSiteiQ6ZRS2.

Expressioni

Gene expression databases

BgeeiQ6ZRS2.
CleanExiHS_SRCAP.
ExpressionAtlasiQ6ZRS2. baseline and differential.
GenevestigatoriQ6ZRS2.

Organism-specific databases

HPAiHPA028929.

Interactioni

Subunit structurei

Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP.7 Publications

Protein-protein interaction databases

BioGridi116058. 28 interactions.
IntActiQ6ZRS2. 14 interactions.
MINTiMINT-123408.
STRINGi9606.ENSP00000262518.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRS2.
SMRiQ6ZRS2. Positions 611-930, 2023-2209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 19673HSAPROSITE-ProRule annotationAdd
BLAST
Domaini630 – 795166Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini2044 – 2197154Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi275 – 2784Poly-Pro
Compositional biasi293 – 563271Glu-richAdd
BLAST
Compositional biasi981 – 1883903Pro-richAdd
BLAST
Compositional biasi2227 – 2362136Glu-richAdd
BLAST
Compositional biasi2426 – 3023598Pro-richAdd
BLAST
Compositional biasi3179 – 31824Poly-Glu

Sequence similaritiesi

Contains 3 A.T hook DNA-binding domains.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00530000063427.
HOGENOMiHOG000168717.
InParanoidiQ6ZRS2.
KOiK11661.
OMAiPSSTQTM.
OrthoDBiEOG79CXXJ.
PhylomeDBiQ6ZRS2.
TreeFamiTF106424.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00929. ATHOOK.
SMARTiSM00384. AT_hook. 3 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZRS2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH
60 70 80 90 100
IAQDSSLDGP PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA
110 120 130 140 150
KHEAEIETRI AELRKEGFWS LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD
160 170 180 190 200
FAQERRWKRG VARKVVRMVI RHHEEQRQKE ERARREEQAK LRRIASTMAK
210 220 230 240 250
DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT EKYSDLLSQS
260 270 280 290 300
LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE
310 320 330 340 350
ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP
360 370 380 390 400
SQTPSSHDSD TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD
410 420 430 440 450
EEFTANEEEA EDEEDTIAAE EQLEGEVDHA MELSELAREG ELSMEELLQQ
460 470 480 490 500
YAGAYAPGSG SSEDEDEDEV DANSSDCEPE GPVEAEEPPQ EDSSSQSDSV
510 520 530 540 550
EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA DEEEEDDDFG
560 570 580 590 600
VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT
610 620 630 640 650
LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT
660 670 680 690 700
IQTISLLAHL ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG
710 720 730 740 750
AQKERKLKRQ GWTKPNAFHV CITSYKLVLQ DHQAFRRKNW RYLILDEAQN
760 770 780 790 800
IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN SLMELWSLMH FLMPHVFQSH
810 820 830 840 850
REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR VKVDVEKQMP
860 870 880 890 900
KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV
910 920 930 940 950
CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG
960 970 980 990 1000
LEGRVSRYEA DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP
1010 1020 1030 1040 1050
VPKQEGRTVV VVNNPRAPLG PVPVRPPPGP ELSAQPTPGP VPQVLPASLM
1060 1070 1080 1090 1100
VSASPAGPPL IPASRPPGPV LLPPLQPNSG SLPQVLPSPL GVLSGTSRPP
1110 1120 1130 1140 1150
TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP PAAATTTSTT
1160 1170 1180 1190 1200
TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN
1210 1220 1230 1240 1250
AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQRNVVH LVSAGGQHHL
1260 1270 1280 1290 1300
ISQPAHVALI QAVAPTPGPT PVSVLPSSTP STTPAPTGLS LPLAANQVPP
1310 1320 1330 1340 1350
TMVNNTGVVK IVVRQAPRDG LTPVPPLAPA PRPPSSGLPA VLNPRPTLTP
1360 1370 1380 1390 1400
GRLPTPTLGT ARAPMPTPTL VRPLLKLVHS PSPEVSASAP GAAPLTISSP
1410 1420 1430 1440 1450
LHVPSSLPGP ASSPMPIPNS SPLASPVSST VSVPLSSSLP ISVPTTLPAP
1460 1470 1480 1490 1500
ASAPLTIPIS APLTVSASGP ALLTSVTPPL APVVPAAPGP PSLAPSGASP
1510 1520 1530 1540 1550
SASALTLGLA TAPSLSSSQT PGHPLLLAPT SSHVPGLNST VAPACSPVLV
1560 1570 1580 1590 1600
PASALASPFP SAPNPAPAQA SLLAPASSAS QALATPLAPM AAPQTAILAP
1610 1620 1630 1640 1650
SPAPPLAPLP VLAPSPGAAP VLASSQTPVP VMAPSSTPGT SLASASPVPA
1660 1670 1680 1690 1700
PTPVLAPSST QTMLPAPVPS PLPSPASTQT LALAPALAPT LGGSSPSQTL
1710 1720 1730 1740 1750
SLGTGNPQGP FPTQTLSLTP ASSLVPTPAQ TLSLAPGPPL GPTQTLSLAP
1760 1770 1780 1790 1800
APPLAPASPV GPAPAHTLTL APASSSASLL APASVQTLTL SPAPVPTLGP
1810 1820 1830 1840 1850
AAAQTLALAP ASTQSPASQA SSLVVSASGA APLPVTMVSR LPVSKDEPDT
1860 1870 1880 1890 1900
LTLRSGPPSP PSTATSFGGP RPRRQPPPPP RSPFYLDSLE EKRKRQRSER
1910 1920 1930 1940 1950
LERIFQLSEA HGALAPVYGT EVLDFCTLPQ PVASPIGPRS PGPSHPTFWT
1960 1970 1980 1990 2000
YTEAAHRAVL FPQQRLDQLS EIIERFIFVM PPVEAPPPSL HACHPPPWLA
2010 2020 2030 2040 2050
PRQAAFQEQL ASELWPRARP LHRIVCNMRT QFPDLRLIQY DCGKLQTLAV
2060 2070 2080 2090 2100
LLRQLKAEGH RVLIFTQMTR MLDVLEQFLT YHGHLYLRLD GSTRVEQRQA
2110 2120 2130 2140 2150
LMERFNADKR IFCFILSTRS GGVGVNLTGA DTVVFYDSDW NPTMDAQAQD
2160 2170 2180 2190 2200
RCHRIGQTRD VHIYRLISER TVEENILKKA NQKRMLGDMA IEGGNFTTAY
2210 2220 2230 2240 2250
FKQQTIRELF DMPLEEPSSS SVPSAPEEEE ETVASKQTHI LEQALCRAED
2260 2270 2280 2290 2300
EEDIRAATQA KAEQVAELAE FNENDGFPAG EGEEAGRPGA EDEEMSRAEQ
2310 2320 2330 2340 2350
EIAALVEQLT PIERYAMKFL EASLEEVSRE ELKQAEEQVE AARKDLDQAK
2360 2370 2380 2390 2400
EEVFRLPQEE EEGPGAGDES SCGTGGGTHR RSKKAKAPER PGTRVSERLR
2410 2420 2430 2440 2450
GARAETQGAN HTPVISAHQT RSTTTPPRCS PARERVPRPA PRPRPTPASA
2460 2470 2480 2490 2500
PAAIPALVPV PVSAPVPISA PNPITILPVH ILPSPPPPSQ IPPCSSPACT
2510 2520 2530 2540 2550
PPPACTPPPA HTPPPAQTCL VTPSSPLLLG PPSVPISASV TNLPLGLRPE
2560 2570 2580 2590 2600
AELCAQALAS PESLELASVA SSETSSLSLV PPKDLLPVAV EILPVSEKNL
2610 2620 2630 2640 2650
SLTPSAPSLT LEAGSIPNGQ EQEAPDSAEG TTLTVLPEGE ELPLCVSESN
2660 2670 2680 2690 2700
GLELPPSAAS DEPLQEPLEA DRTSEELTEA KTPTSSPEKP QELVTAEVAA
2710 2720 2730 2740 2750
PSTSSSATSS PEGPSPARPP RRRTSADVEI RGQGTGRPGQ PPGPKVLRKL
2760 2770 2780 2790 2800
PGRLVTVVEE KELVRRRRQQ RGAASTLVPG VSETSASPGS PSVRSMSGPE
2810 2820 2830 2840 2850
SSPPIGGPCE AAPSSSLPTP PQQPFIARRH IELGVTGGGS PENGDGALLA
2860 2870 2880 2890 2900
ITPPAVKRRR GRPPKKNRSP ADAGRGVDEA PSSTLKGKTN GADPVPGPET
2910 2920 2930 2940 2950
LIVADPVLEP QLIPGPQPLG PQPVHRPNPL LSPVEKRRRG RPPKARDLPI
2960 2970 2980 2990 3000
PGTISSAGDG NSESRTQPPP HPSPLTPLPP LLVCPTATVA NTVTTVTIST
3010 3020 3030 3040 3050
SPPKRKRGRP PKNPPSPRPS QLPVLDRDST SVLESCGLGR RRQPQGQGES
3060 3070 3080 3090 3100
EGSSSDEDGS RPLTRLARLR LEAEGMRGRK SGGSMVVAVI QDDLDLADSG
3110 3120 3130 3140 3150
PGGLELTPPV VSLTPKLRST RLRPGSLVPP LETEKLPRKR AGAPVGGSPG
3160 3170 3180 3190 3200
LAKRGRLQPP SPLGPEGSVE ESEAEASGEE EEGDGTPRRR PGPRRLVGTT
3210 3220 3230
NQGDQRILRS SAPPSLAGPA VSHRGRKAKT
Length:3,230
Mass (Da):343,555
Last modified:May 18, 2010 - v3
Checksum:i3CFB74C7BDFBEAD0
GO
Isoform 2 (identifier: Q6ZRS2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Show »
Length:3,168
Mass (Da):337,445
Checksum:iB9A0D36717389361
GO
Isoform 3 (identifier: Q6ZRS2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1085-1181: VLPSPLGVLS...SPDMQARLPS → A
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Show »
Length:3,072
Mass (Da):327,838
Checksum:iEA4D60708B59DC5B
GO

Sequence cautioni

The sequence AAI59100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1147 – 11471T → A in BAC87237. (PubMed:14702039)Curated
Sequence conflicti1494 – 14941A → Q in AAD39760. (PubMed:10347196)Curated
Sequence conflicti2765 – 27651R → Q in AAD39760. (PubMed:10347196)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1085 – 118197VLPSP…ARLPS → A in isoform 3. 2 PublicationsVSP_029441Add
BLAST
Alternative sequencei1236 – 129863RNVVH…AANQV → M in isoform 2 and isoform 3. 3 PublicationsVSP_029442Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093249 Genomic DNA. No translation available.
AC106886 Genomic DNA. No translation available.
AK128030 mRNA. Translation: BAC87237.1.
AB002307 mRNA. Translation: BAA20768.2.
BC159099 mRNA. Translation: AAI59100.1. Different initiation.
AF143946 mRNA. Translation: AAD39760.1.
CCDSiCCDS10689.2. [Q6ZRS2-1]
RefSeqiNP_006653.2. NM_006662.2. [Q6ZRS2-1]
UniGeneiHs.620916.

Genome annotation databases

EnsembliENST00000262518; ENSP00000262518; ENSG00000080603. [Q6ZRS2-1]
ENST00000380361; ENSP00000369719; ENSG00000080603.
GeneIDi10847.
KEGGihsa:10847.
UCSCiuc002dze.1. human. [Q6ZRS2-1]
uc002dzg.1. human. [Q6ZRS2-2]

Polymorphism databases

DMDMi296452947.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093249 Genomic DNA. No translation available.
AC106886 Genomic DNA. No translation available.
AK128030 mRNA. Translation: BAC87237.1 .
AB002307 mRNA. Translation: BAA20768.2 .
BC159099 mRNA. Translation: AAI59100.1 . Different initiation.
AF143946 mRNA. Translation: AAD39760.1 .
CCDSi CCDS10689.2. [Q6ZRS2-1 ]
RefSeqi NP_006653.2. NM_006662.2. [Q6ZRS2-1 ]
UniGenei Hs.620916.

3D structure databases

ProteinModelPortali Q6ZRS2.
SMRi Q6ZRS2. Positions 611-930, 2023-2209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116058. 28 interactions.
IntActi Q6ZRS2. 14 interactions.
MINTi MINT-123408.
STRINGi 9606.ENSP00000262518.

PTM databases

PhosphoSitei Q6ZRS2.

Polymorphism databases

DMDMi 296452947.

Proteomic databases

MaxQBi Q6ZRS2.
PaxDbi Q6ZRS2.
PRIDEi Q6ZRS2.

Protocols and materials databases

DNASUi 10847.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262518 ; ENSP00000262518 ; ENSG00000080603 . [Q6ZRS2-1 ]
ENST00000380361 ; ENSP00000369719 ; ENSG00000080603 .
GeneIDi 10847.
KEGGi hsa:10847.
UCSCi uc002dze.1. human. [Q6ZRS2-1 ]
uc002dzg.1. human. [Q6ZRS2-2 ]

Organism-specific databases

CTDi 10847.
GeneCardsi GC16P030710.
GeneReviewsi SRCAP.
H-InvDB HIX0012970.
HGNCi HGNC:16974. SRCAP.
HPAi HPA028929.
MIMi 136140. phenotype.
611421. gene.
neXtProti NX_Q6ZRS2.
Orphaneti 2044. Floating-Harbor syndrome.
PharmGKBi PA162404706.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00530000063427.
HOGENOMi HOG000168717.
InParanoidi Q6ZRS2.
KOi K11661.
OMAi PSSTQTM.
OrthoDBi EOG79CXXJ.
PhylomeDBi Q6ZRS2.
TreeFami TF106424.

Miscellaneous databases

ChiTaRSi SRCAP. human.
GeneWikii SRCAP.
GenomeRNAii 10847.
NextBioi 41182.
PROi Q6ZRS2.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZRS2.
CleanExi HS_SRCAP.
ExpressionAtlasi Q6ZRS2. baseline and differential.
Genevestigatori Q6ZRS2.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR020478. AT_hook-like.
IPR017956. AT_hook_DNA-bd_motif.
IPR014012. Helicase/SANT-assoc_DNA-bd.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
PRINTSi PR00929. ATHOOK.
SMARTi SM00384. AT_hook. 3 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 4 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2427 (ISOFORM 1).
    Tissue: Testis.
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3).
    Tissue: Brain.
  4. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3).
  6. "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein."
    Johnston H., Kneer J., Chackalaparampil I., Yaciuk P., Chrivia J.
    J. Biol. Chem. 274:16370-16376(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-3230 (ISOFORM 2), INTERACTION WITH CREBBP, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.
  7. "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP."
    Ghosh A.K., Majumder M., Steele R., Yaciuk P., Chrivia J., Ray R., Ray R.B.
    J. Biol. Chem. 275:7184-7188(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCV NS5A, SUBCELLULAR LOCATION.
  8. "Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP."
    Monroy M.A., Ruhl D.D., Xu X., Granner D.K., Yaciuk P., Chrivia J.C.
    J. Biol. Chem. 276:40721-40726(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription."
    Xu X., Chackalaparampil I., Monroy M.A., Cannella M.T., Pesek E., Chrivia J., Yaciuk P.
    J. Virol. 75:10033-10040(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EP300 AND HADV-2 DBP.
  10. "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1."
    Monroy M.A., Schott N.M., Cox L., Chen J.D., Ruh M., Chrivia J.C.
    Mol. Endocrinol. 17:2519-2528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH CREBBP; CARM1 AND GRIP1.
  11. "Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans."
    Doyon Y., Selleck W., Lane W.S., Tan S., Cote J.
    Mol. Cell. Biol. 24:1884-1896(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A NUA4-RELATED COMPLEX.
  12. "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes."
    Cai Y., Jin J., Florens L., Swanson S.K., Kusch T., Li B., Workman J.L., Washburn M.P., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 280:13665-13670(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  13. "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway."
    Eissenberg J.C., Wong M., Chrivia J.C.
    Mol. Cell. Biol. 25:6559-6569(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes."
    Ruhl D.D., Jin J., Cai Y., Swanson S., Florens L., Washburn M.P., Conaway R.C., Conaway J.W., Chrivia J.C.
    Biochemistry 45:5671-5677(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY.
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2869 AND SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters."
    Wong M.M., Cox L.K., Chrivia J.C.
    J. Biol. Chem. 282:26132-26139(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  18. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2430, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; THR-572; SER-3161; SER-3172 AND SER-3177, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  22. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. Cited for: INVOLVEMENT IN FLHS.

Entry informationi

Entry nameiSRCAP_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRS2
Secondary accession number(s): B0JZA6
, O15026, Q7Z744, Q9Y5L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3