Q6ZRS2 (SRCAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Helicase SRCAP
EC=3.6.4.-

Alternative name(s):
Domino homolog 2
Snf2-related CBP activator

Gene names

Name:	SRCAP
Synonyms:	KIAA0309

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	3230 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Ref.6 Ref.8 Ref.10 Ref.13 Ref.14 Ref.16
Subunit structure	Interacts with CREBBP and EP300. May be part of a complex containing SRCAP, CREBBP, CARM1 and GRIP1. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, VPS72, ACTR6 and ZNHIT1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with hepatitis C virus (HCV) NS5A and human adenovirus 2 DBP. Ref.6 Ref.7 Ref.9
Subcellular location	Nucleus Ref.7.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.15 Ref.17 Ref.18 Ref.19 Ref.20
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Contains 3 A.T hook DNA-binding domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain.
Biophysicochemical properties	Kinetic parameters: KM=66 µM for ATP Ref.6
Sequence caution	The sequence AAI59100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Host-virus interaction Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Activator Chromatin regulator Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi apparatus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA protein complex Inferred from direct assay Ref.11. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW histone acetyltransferase activity Traceable author statement. Source: ProtInc transcription coactivator activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZRS2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZRS2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Isoform 3 (identifier: Q6ZRS2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1085-1181: VLPSPLGVLS...SPDMQARLPS → A
     1236-1298: RNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQV → M

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 3230	3230	Helicase SRCAP		PRO_0000311236
Regions
	Domain	124 – 196	73	HSA
	Domain	630 – 795	166	Helicase ATP-binding
	Domain	2044 – 2197	154	Helicase C-terminal
	Nucleotide binding	643 – 650	8	ATP By similarity
	DNA binding	2857 – 2869	13	A.T hook 1
	DNA binding	2936 – 2948	13	A.T hook 2
	DNA binding	3004 – 3016	13	A.T hook 3
	Compositional bias	275 – 278	4	Poly-Pro
	Compositional bias	293 – 563	271	Glu-rich
	Compositional bias	981 – 1883	903	Pro-rich
	Compositional bias	2227 – 2362	136	Glu-rich
	Compositional bias	2426 – 3023	598	Pro-rich
	Compositional bias	3179 – 3182	4	Poly-Glu
Amino acid modifications
	Modified residue	248	1	Phosphoserine Ref.17
	Modified residue	258	1	Phosphoserine Ref.19
	Modified residue	274	1	Phosphoserine Ref.20
	Modified residue	562	1	Phosphoserine Ref.20
	Modified residue	568	1	Phosphoserine Ref.20
	Modified residue	572	1	Phosphothreonine Ref.20
	Modified residue	2258	1	Phosphothreonine Ref.17
	Modified residue	2425	1	Phosphothreonine Ref.18
	Modified residue	2430	1	Phosphoserine Ref.18
	Modified residue	2787	1	Phosphoserine Ref.19 Ref.20
	Modified residue	2790	1	Phosphoserine Ref.19 Ref.20
	Modified residue	2869	1	Phosphoserine Ref.15
	Modified residue	3148	1	Phosphoserine Ref.15 Ref.19 Ref.20
	Modified residue	3161	1	Phosphoserine Ref.20
	Modified residue	3168	1	Phosphoserine Ref.19
	Modified residue	3172	1	Phosphoserine Ref.20
	Modified residue	3177	1	Phosphoserine Ref.19 Ref.20
Natural variations
	Alternative sequence	1085 – 1181	97	VLPSP…ARLPS → A in isoform 3.		VSP_029441
	Alternative sequence	1236 – 1298	63	RNVVH…AANQV → M in isoform 2 and isoform 3.		VSP_029442
Experimental info
	Sequence conflict	1147	1	T → A in BAC87237. Ref.2
	Sequence conflict	1494	1	A → Q in AAD39760. Ref.6
	Sequence conflict	2765	1	R → Q in AAD39760. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 3CFB74C7BDFBEAD0	FASTA	3,230	343,555
	10 20 30 40 50 60 MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH IAQDSSLDGP 70 80 90 100 110 120 PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA KHEAEIETRI AELRKEGFWS 130 140 150 160 170 180 LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD FAQERRWKRG VARKVVRMVI RHHEEQRQKE 190 200 210 220 230 240 ERARREEQAK LRRIASTMAK DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT 250 260 270 280 290 300 EKYSDLLSQS LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE 310 320 330 340 350 360 ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP SQTPSSHDSD 370 380 390 400 410 420 TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD EEFTANEEEA EDEEDTIAAE 430 440 450 460 470 480 EQLEGEVDHA MELSELAREG ELSMEELLQQ YAGAYAPGSG SSEDEDEDEV DANSSDCEPE 490 500 510 520 530 540 GPVEAEEPPQ EDSSSQSDSV EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA 550 560 570 580 590 600 DEEEEDDDFG VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT 610 620 630 640 650 660 LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT IQTISLLAHL 670 680 690 700 710 720 ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG AQKERKLKRQ GWTKPNAFHV 730 740 750 760 770 780 CITSYKLVLQ DHQAFRRKNW RYLILDEAQN IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN 790 800 810 820 830 840 SLMELWSLMH FLMPHVFQSH REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR 850 860 870 880 890 900 VKVDVEKQMP KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV 910 920 930 940 950 960 CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG LEGRVSRYEA 970 980 990 1000 1010 1020 DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP VPKQEGRTVV VVNNPRAPLG 1030 1040 1050 1060 1070 1080 PVPVRPPPGP ELSAQPTPGP VPQVLPASLM VSASPAGPPL IPASRPPGPV LLPPLQPNSG 1090 1100 1110 1120 1130 1140 SLPQVLPSPL GVLSGTSRPP TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP 1150 1160 1170 1180 1190 1200 PAAATTTSTT TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN 1210 1220 1230 1240 1250 1260 AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQRNVVH LVSAGGQHHL ISQPAHVALI 1270 1280 1290 1300 1310 1320 QAVAPTPGPT PVSVLPSSTP STTPAPTGLS LPLAANQVPP TMVNNTGVVK IVVRQAPRDG 1330 1340 1350 1360 1370 1380 LTPVPPLAPA PRPPSSGLPA VLNPRPTLTP GRLPTPTLGT ARAPMPTPTL VRPLLKLVHS 1390 1400 1410 1420 1430 1440 PSPEVSASAP GAAPLTISSP LHVPSSLPGP ASSPMPIPNS SPLASPVSST VSVPLSSSLP 1450 1460 1470 1480 1490 1500 ISVPTTLPAP ASAPLTIPIS APLTVSASGP ALLTSVTPPL APVVPAAPGP PSLAPSGASP 1510 1520 1530 1540 1550 1560 SASALTLGLA TAPSLSSSQT PGHPLLLAPT SSHVPGLNST VAPACSPVLV PASALASPFP 1570 1580 1590 1600 1610 1620 SAPNPAPAQA SLLAPASSAS QALATPLAPM AAPQTAILAP SPAPPLAPLP VLAPSPGAAP 1630 1640 1650 1660 1670 1680 VLASSQTPVP VMAPSSTPGT SLASASPVPA PTPVLAPSST QTMLPAPVPS PLPSPASTQT 1690 1700 1710 1720 1730 1740 LALAPALAPT LGGSSPSQTL SLGTGNPQGP FPTQTLSLTP ASSLVPTPAQ TLSLAPGPPL 1750 1760 1770 1780 1790 1800 GPTQTLSLAP APPLAPASPV GPAPAHTLTL APASSSASLL APASVQTLTL SPAPVPTLGP 1810 1820 1830 1840 1850 1860 AAAQTLALAP ASTQSPASQA SSLVVSASGA APLPVTMVSR LPVSKDEPDT LTLRSGPPSP 1870 1880 1890 1900 1910 1920 PSTATSFGGP RPRRQPPPPP RSPFYLDSLE EKRKRQRSER LERIFQLSEA HGALAPVYGT 1930 1940 1950 1960 1970 1980 EVLDFCTLPQ PVASPIGPRS PGPSHPTFWT YTEAAHRAVL FPQQRLDQLS EIIERFIFVM 1990 2000 2010 2020 2030 2040 PPVEAPPPSL HACHPPPWLA PRQAAFQEQL ASELWPRARP LHRIVCNMRT QFPDLRLIQY 2050 2060 2070 2080 2090 2100 DCGKLQTLAV LLRQLKAEGH RVLIFTQMTR MLDVLEQFLT YHGHLYLRLD GSTRVEQRQA 2110 2120 2130 2140 2150 2160 LMERFNADKR IFCFILSTRS GGVGVNLTGA DTVVFYDSDW NPTMDAQAQD RCHRIGQTRD 2170 2180 2190 2200 2210 2220 VHIYRLISER TVEENILKKA NQKRMLGDMA IEGGNFTTAY FKQQTIRELF DMPLEEPSSS 2230 2240 2250 2260 2270 2280 SVPSAPEEEE ETVASKQTHI LEQALCRAED EEDIRAATQA KAEQVAELAE FNENDGFPAG 2290 2300 2310 2320 2330 2340 EGEEAGRPGA EDEEMSRAEQ EIAALVEQLT PIERYAMKFL EASLEEVSRE ELKQAEEQVE 2350 2360 2370 2380 2390 2400 AARKDLDQAK EEVFRLPQEE EEGPGAGDES SCGTGGGTHR RSKKAKAPER PGTRVSERLR 2410 2420 2430 2440 2450 2460 GARAETQGAN HTPVISAHQT RSTTTPPRCS PARERVPRPA PRPRPTPASA PAAIPALVPV 2470 2480 2490 2500 2510 2520 PVSAPVPISA PNPITILPVH ILPSPPPPSQ IPPCSSPACT PPPACTPPPA HTPPPAQTCL 2530 2540 2550 2560 2570 2580 VTPSSPLLLG PPSVPISASV TNLPLGLRPE AELCAQALAS PESLELASVA SSETSSLSLV 2590 2600 2610 2620 2630 2640 PPKDLLPVAV EILPVSEKNL SLTPSAPSLT LEAGSIPNGQ EQEAPDSAEG TTLTVLPEGE 2650 2660 2670 2680 2690 2700 ELPLCVSESN GLELPPSAAS DEPLQEPLEA DRTSEELTEA KTPTSSPEKP QELVTAEVAA 2710 2720 2730 2740 2750 2760 PSTSSSATSS PEGPSPARPP RRRTSADVEI RGQGTGRPGQ PPGPKVLRKL PGRLVTVVEE 2770 2780 2790 2800 2810 2820 KELVRRRRQQ RGAASTLVPG VSETSASPGS PSVRSMSGPE SSPPIGGPCE AAPSSSLPTP 2830 2840 2850 2860 2870 2880 PQQPFIARRH IELGVTGGGS PENGDGALLA ITPPAVKRRR GRPPKKNRSP ADAGRGVDEA 2890 2900 2910 2920 2930 2940 PSSTLKGKTN GADPVPGPET LIVADPVLEP QLIPGPQPLG PQPVHRPNPL LSPVEKRRRG 2950 2960 2970 2980 2990 3000 RPPKARDLPI PGTISSAGDG NSESRTQPPP HPSPLTPLPP LLVCPTATVA NTVTTVTIST 3010 3020 3030 3040 3050 3060 SPPKRKRGRP PKNPPSPRPS QLPVLDRDST SVLESCGLGR RRQPQGQGES EGSSSDEDGS 3070 3080 3090 3100 3110 3120 RPLTRLARLR LEAEGMRGRK SGGSMVVAVI QDDLDLADSG PGGLELTPPV VSLTPKLRST 3130 3140 3150 3160 3170 3180 RLRPGSLVPP LETEKLPRKR AGAPVGGSPG LAKRGRLQPP SPLGPEGSVE ESEAEASGEE 3190 3200 3210 3220 3230 EEGDGTPRRR PGPRRLVGTT NQGDQRILRS SAPPSLAGPA VSHRGRKAKT
	Isoform 2 [UniParc]. Checksum: B9A0D36717389361	FASTA	3,168	337,445
	10 20 30 40 50 60 MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH IAQDSSLDGP 70 80 90 100 110 120 PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA KHEAEIETRI AELRKEGFWS 130 140 150 160 170 180 LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD FAQERRWKRG VARKVVRMVI RHHEEQRQKE 190 200 210 220 230 240 ERARREEQAK LRRIASTMAK DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT 250 260 270 280 290 300 EKYSDLLSQS LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE 310 320 330 340 350 360 ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP SQTPSSHDSD 370 380 390 400 410 420 TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD EEFTANEEEA EDEEDTIAAE 430 440 450 460 470 480 EQLEGEVDHA MELSELAREG ELSMEELLQQ YAGAYAPGSG SSEDEDEDEV DANSSDCEPE 490 500 510 520 530 540 GPVEAEEPPQ EDSSSQSDSV EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA 550 560 570 580 590 600 DEEEEDDDFG VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT 610 620 630 640 650 660 LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT IQTISLLAHL 670 680 690 700 710 720 ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG AQKERKLKRQ GWTKPNAFHV 730 740 750 760 770 780 CITSYKLVLQ DHQAFRRKNW RYLILDEAQN IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN 790 800 810 820 830 840 SLMELWSLMH FLMPHVFQSH REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR 850 860 870 880 890 900 VKVDVEKQMP KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV 910 920 930 940 950 960 CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG LEGRVSRYEA 970 980 990 1000 1010 1020 DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP VPKQEGRTVV VVNNPRAPLG 1030 1040 1050 1060 1070 1080 PVPVRPPPGP ELSAQPTPGP VPQVLPASLM VSASPAGPPL IPASRPPGPV LLPPLQPNSG 1090 1100 1110 1120 1130 1140 SLPQVLPSPL GVLSGTSRPP TPTLSLKPTP PAPVRLSPAP PPGSSSLLKP LTVPPGYTFP 1150 1160 1170 1180 1190 1200 PAAATTTSTT TATATTTAVP APTPAPQRLI LSPDMQARLP SGEVVSIGQL ASLAQRPVAN 1210 1220 1230 1240 1250 1260 AGGSKPLTFQ IQGNKLTLTG AQVRQLAVGQ PRPLQMPPTM VNNTGVVKIV VRQAPRDGLT 1270 1280 1290 1300 1310 1320 PVPPLAPAPR PPSSGLPAVL NPRPTLTPGR LPTPTLGTAR APMPTPTLVR PLLKLVHSPS 1330 1340 1350 1360 1370 1380 PEVSASAPGA APLTISSPLH VPSSLPGPAS SPMPIPNSSP LASPVSSTVS VPLSSSLPIS 1390 1400 1410 1420 1430 1440 VPTTLPAPAS APLTIPISAP LTVSASGPAL LTSVTPPLAP VVPAAPGPPS LAPSGASPSA 1450 1460 1470 1480 1490 1500 SALTLGLATA PSLSSSQTPG HPLLLAPTSS HVPGLNSTVA PACSPVLVPA SALASPFPSA 1510 1520 1530 1540 1550 1560 PNPAPAQASL LAPASSASQA LATPLAPMAA PQTAILAPSP APPLAPLPVL APSPGAAPVL 1570 1580 1590 1600 1610 1620 ASSQTPVPVM APSSTPGTSL ASASPVPAPT PVLAPSSTQT MLPAPVPSPL PSPASTQTLA 1630 1640 1650 1660 1670 1680 LAPALAPTLG GSSPSQTLSL GTGNPQGPFP TQTLSLTPAS SLVPTPAQTL SLAPGPPLGP 1690 1700 1710 1720 1730 1740 TQTLSLAPAP PLAPASPVGP APAHTLTLAP ASSSASLLAP ASVQTLTLSP APVPTLGPAA 1750 1760 1770 1780 1790 1800 AQTLALAPAS TQSPASQASS LVVSASGAAP LPVTMVSRLP VSKDEPDTLT LRSGPPSPPS 1810 1820 1830 1840 1850 1860 TATSFGGPRP RRQPPPPPRS PFYLDSLEEK RKRQRSERLE RIFQLSEAHG ALAPVYGTEV 1870 1880 1890 1900 1910 1920 LDFCTLPQPV ASPIGPRSPG PSHPTFWTYT EAAHRAVLFP QQRLDQLSEI IERFIFVMPP 1930 1940 1950 1960 1970 1980 VEAPPPSLHA CHPPPWLAPR QAAFQEQLAS ELWPRARPLH RIVCNMRTQF PDLRLIQYDC 1990 2000 2010 2020 2030 2040 GKLQTLAVLL RQLKAEGHRV LIFTQMTRML DVLEQFLTYH GHLYLRLDGS TRVEQRQALM 2050 2060 2070 2080 2090 2100 ERFNADKRIF CFILSTRSGG VGVNLTGADT VVFYDSDWNP TMDAQAQDRC HRIGQTRDVH 2110 2120 2130 2140 2150 2160 IYRLISERTV EENILKKANQ KRMLGDMAIE GGNFTTAYFK QQTIRELFDM PLEEPSSSSV 2170 2180 2190 2200 2210 2220 PSAPEEEEET VASKQTHILE QALCRAEDEE DIRAATQAKA EQVAELAEFN ENDGFPAGEG 2230 2240 2250 2260 2270 2280 EEAGRPGAED EEMSRAEQEI AALVEQLTPI ERYAMKFLEA SLEEVSREEL KQAEEQVEAA 2290 2300 2310 2320 2330 2340 RKDLDQAKEE VFRLPQEEEE GPGAGDESSC GTGGGTHRRS KKAKAPERPG TRVSERLRGA 2350 2360 2370 2380 2390 2400 RAETQGANHT PVISAHQTRS TTTPPRCSPA RERVPRPAPR PRPTPASAPA AIPALVPVPV 2410 2420 2430 2440 2450 2460 SAPVPISAPN PITILPVHIL PSPPPPSQIP PCSSPACTPP PACTPPPAHT PPPAQTCLVT 2470 2480 2490 2500 2510 2520 PSSPLLLGPP SVPISASVTN LPLGLRPEAE LCAQALASPE SLELASVASS ETSSLSLVPP 2530 2540 2550 2560 2570 2580 KDLLPVAVEI LPVSEKNLSL TPSAPSLTLE AGSIPNGQEQ EAPDSAEGTT LTVLPEGEEL 2590 2600 2610 2620 2630 2640 PLCVSESNGL ELPPSAASDE PLQEPLEADR TSEELTEAKT PTSSPEKPQE LVTAEVAAPS 2650 2660 2670 2680 2690 2700 TSSSATSSPE GPSPARPPRR RTSADVEIRG QGTGRPGQPP GPKVLRKLPG RLVTVVEEKE 2710 2720 2730 2740 2750 2760 LVRRRRQQRG AASTLVPGVS ETSASPGSPS VRSMSGPESS PPIGGPCEAA PSSSLPTPPQ 2770 2780 2790 2800 2810 2820 QPFIARRHIE LGVTGGGSPE NGDGALLAIT PPAVKRRRGR PPKKNRSPAD AGRGVDEAPS 2830 2840 2850 2860 2870 2880 STLKGKTNGA DPVPGPETLI VADPVLEPQL IPGPQPLGPQ PVHRPNPLLS PVEKRRRGRP 2890 2900 2910 2920 2930 2940 PKARDLPIPG TISSAGDGNS ESRTQPPPHP SPLTPLPPLL VCPTATVANT VTTVTISTSP 2950 2960 2970 2980 2990 3000 PKRKRGRPPK NPPSPRPSQL PVLDRDSTSV LESCGLGRRR QPQGQGESEG SSSDEDGSRP 3010 3020 3030 3040 3050 3060 LTRLARLRLE AEGMRGRKSG GSMVVAVIQD DLDLADSGPG GLELTPPVVS LTPKLRSTRL 3070 3080 3090 3100 3110 3120 RPGSLVPPLE TEKLPRKRAG APVGGSPGLA KRGRLQPPSP LGPEGSVEES EAEASGEEEE 3130 3140 3150 3160 GDGTPRRRPG PRRLVGTTNQ GDQRILRSSA PPSLAGPAVS HRGRKAKT
	Isoform 3 [UniParc]. Checksum: EA4D60708B59DC5B	FASTA	3,072	327,838
	10 20 30 40 50 60 MQSSPSPAHP QLPVLQTQMV SDGMTGSNPV SPASSSSPAS SGAGGISPQH IAQDSSLDGP 70 80 90 100 110 120 PGPPDGATVP LEGFSLSQAA DLANKGPKWE KSHAEIAEQA KHEAEIETRI AELRKEGFWS 130 140 150 160 170 180 LKRLPKVPEP PRPKGHWDYL CEEMQWLSAD FAQERRWKRG VARKVVRMVI RHHEEQRQKE 190 200 210 220 230 240 ERARREEQAK LRRIASTMAK DVRQFWSNVE KVVQFKQQSR LEEKRKKALD LHLDFIVGQT 250 260 270 280 290 300 EKYSDLLSQS LNQPLTSSKA GSSPCLGSSS AASSPPPPAS RLDDEDGDFQ PQEDEEEDDE 310 320 330 340 350 360 ETIEVEEQQE GNDAEAQRRE IELLRREGEL PLEELLRSLP PQLLEGPSSP SQTPSSHDSD 370 380 390 400 410 420 TRDGPEEGAE EEPPQVLEIK PPPSAVTQRN KQPWHPDEDD EEFTANEEEA EDEEDTIAAE 430 440 450 460 470 480 EQLEGEVDHA MELSELAREG ELSMEELLQQ YAGAYAPGSG SSEDEDEDEV DANSSDCEPE 490 500 510 520 530 540 GPVEAEEPPQ EDSSSQSDSV EDRSEDEEDE HSEEEETSGS SASEESESEE SEDAQSQSQA 550 560 570 580 590 600 DEEEEDDDFG VEYLLARDEE QSEADAGSGP PTPGPTTLGP KKEITDIAAA AESLQPKGYT 610 620 630 640 650 660 LATTQVKTPI PLLLRGQLRE YQHIGLDWLV TMYEKKLNGI LADEMGLGKT IQTISLLAHL 670 680 690 700 710 720 ACEKGNWGPH LIIVPTSVML NWEMELKRWC PSFKILTYYG AQKERKLKRQ GWTKPNAFHV 730 740 750 760 770 780 CITSYKLVLQ DHQAFRRKNW RYLILDEAQN IKNFKSQRWQ SLLNFNSQRR LLLTGTPLQN 790 800 810 820 830 840 SLMELWSLMH FLMPHVFQSH REFKEWFSNP LTGMIEGSQE YNEGLVKRLH KVLRPFLLRR 850 860 870 880 890 900 VKVDVEKQMP KKYEHVIRCR LSKRQRCLYD DFMAQTTTKE TLATGHFMSV INILMQLRKV 910 920 930 940 950 960 CNHPNLFDPR PVTSPFITPG ICFSTASLVL RATDVHPLQR IDMGRFDLIG LEGRVSRYEA 970 980 990 1000 1010 1020 DTFLPRHRLS RRVLLEVATA PDPPPRPKPV KMKVNRMLQP VPKQEGRTVV VVNNPRAPLG 1030 1040 1050 1060 1070 1080 PVPVRPPPGP ELSAQPTPGP VPQVLPASLM VSASPAGPPL IPASRPPGPV LLPPLQPNSG 1090 1100 1110 1120 1130 1140 SLPQAGEVVS IGQLASLAQR PVANAGGSKP LTFQIQGNKL TLTGAQVRQL AVGQPRPLQM 1150 1160 1170 1180 1190 1200 PPTMVNNTGV VKIVVRQAPR DGLTPVPPLA PAPRPPSSGL PAVLNPRPTL TPGRLPTPTL 1210 1220 1230 1240 1250 1260 GTARAPMPTP TLVRPLLKLV HSPSPEVSAS APGAAPLTIS SPLHVPSSLP GPASSPMPIP 1270 1280 1290 1300 1310 1320 NSSPLASPVS STVSVPLSSS LPISVPTTLP APASAPLTIP ISAPLTVSAS GPALLTSVTP 1330 1340 1350 1360 1370 1380 PLAPVVPAAP GPPSLAPSGA SPSASALTLG LATAPSLSSS QTPGHPLLLA PTSSHVPGLN 1390 1400 1410 1420 1430 1440 STVAPACSPV LVPASALASP FPSAPNPAPA QASLLAPASS ASQALATPLA PMAAPQTAIL 1450 1460 1470 1480 1490 1500 APSPAPPLAP LPVLAPSPGA APVLASSQTP VPVMAPSSTP GTSLASASPV PAPTPVLAPS 1510 1520 1530 1540 1550 1560 STQTMLPAPV PSPLPSPAST QTLALAPALA PTLGGSSPSQ TLSLGTGNPQ GPFPTQTLSL 1570 1580 1590 1600 1610 1620 TPASSLVPTP AQTLSLAPGP PLGPTQTLSL APAPPLAPAS PVGPAPAHTL TLAPASSSAS 1630 1640 1650 1660 1670 1680 LLAPASVQTL TLSPAPVPTL GPAAAQTLAL APASTQSPAS QASSLVVSAS GAAPLPVTMV 1690 1700 1710 1720 1730 1740 SRLPVSKDEP DTLTLRSGPP SPPSTATSFG GPRPRRQPPP PPRSPFYLDS LEEKRKRQRS 1750 1760 1770 1780 1790 1800 ERLERIFQLS EAHGALAPVY GTEVLDFCTL PQPVASPIGP RSPGPSHPTF WTYTEAAHRA 1810 1820 1830 1840 1850 1860 VLFPQQRLDQ LSEIIERFIF VMPPVEAPPP SLHACHPPPW LAPRQAAFQE QLASELWPRA 1870 1880 1890 1900 1910 1920 RPLHRIVCNM RTQFPDLRLI QYDCGKLQTL AVLLRQLKAE GHRVLIFTQM TRMLDVLEQF 1930 1940 1950 1960 1970 1980 LTYHGHLYLR LDGSTRVEQR QALMERFNAD KRIFCFILST RSGGVGVNLT GADTVVFYDS 1990 2000 2010 2020 2030 2040 DWNPTMDAQA QDRCHRIGQT RDVHIYRLIS ERTVEENILK KANQKRMLGD MAIEGGNFTT 2050 2060 2070 2080 2090 2100 AYFKQQTIRE LFDMPLEEPS SSSVPSAPEE EEETVASKQT HILEQALCRA EDEEDIRAAT 2110 2120 2130 2140 2150 2160 QAKAEQVAEL AEFNENDGFP AGEGEEAGRP GAEDEEMSRA EQEIAALVEQ LTPIERYAMK 2170 2180 2190 2200 2210 2220 FLEASLEEVS REELKQAEEQ VEAARKDLDQ AKEEVFRLPQ EEEEGPGAGD ESSCGTGGGT 2230 2240 2250 2260 2270 2280 HRRSKKAKAP ERPGTRVSER LRGARAETQG ANHTPVISAH QTRSTTTPPR CSPARERVPR 2290 2300 2310 2320 2330 2340 PAPRPRPTPA SAPAAIPALV PVPVSAPVPI SAPNPITILP VHILPSPPPP SQIPPCSSPA 2350 2360 2370 2380 2390 2400 CTPPPACTPP PAHTPPPAQT CLVTPSSPLL LGPPSVPISA SVTNLPLGLR PEAELCAQAL 2410 2420 2430 2440 2450 2460 ASPESLELAS VASSETSSLS LVPPKDLLPV AVEILPVSEK NLSLTPSAPS LTLEAGSIPN 2470 2480 2490 2500 2510 2520 GQEQEAPDSA EGTTLTVLPE GEELPLCVSE SNGLELPPSA ASDEPLQEPL EADRTSEELT 2530 2540 2550 2560 2570 2580 EAKTPTSSPE KPQELVTAEV AAPSTSSSAT SSPEGPSPAR PPRRRTSADV EIRGQGTGRP 2590 2600 2610 2620 2630 2640 GQPPGPKVLR KLPGRLVTVV EEKELVRRRR QQRGAASTLV PGVSETSASP GSPSVRSMSG 2650 2660 2670 2680 2690 2700 PESSPPIGGP CEAAPSSSLP TPPQQPFIAR RHIELGVTGG GSPENGDGAL LAITPPAVKR 2710 2720 2730 2740 2750 2760 RRGRPPKKNR SPADAGRGVD EAPSSTLKGK TNGADPVPGP ETLIVADPVL EPQLIPGPQP 2770 2780 2790 2800 2810 2820 LGPQPVHRPN PLLSPVEKRR RGRPPKARDL PIPGTISSAG DGNSESRTQP PPHPSPLTPL 2830 2840 2850 2860 2870 2880 PPLLVCPTAT VANTVTTVTI STSPPKRKRG RPPKNPPSPR PSQLPVLDRD STSVLESCGL 2890 2900 2910 2920 2930 2940 GRRRQPQGQG ESEGSSSDED GSRPLTRLAR LRLEAEGMRG RKSGGSMVVA VIQDDLDLAD 2950 2960 2970 2980 2990 3000 SGPGGLELTP PVVSLTPKLR STRLRPGSLV PPLETEKLPR KRAGAPVGGS PGLAKRGRLQ 3010 3020 3030 3040 3050 3060 PPSPLGPEGS VEESEAEASG EEEEGDGTPR RRPGPRRLVG TTNQGDQRIL RSSAPPSLAG 3070 PAVSHRGRKA KT

References

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[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-2427 (ISOFORM 1). Tissue: Testis.
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3). Tissue: Brain.
[4]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-3230 (ISOFORM 3).
[6]	"Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein." Johnston H., Kneer J., Chackalaparampil I., Yaciuk P., Chrivia J. J. Biol. Chem. 274:16370-16376(1999) [PubMed: 10347196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 128-3230 (ISOFORM 2), INTERACTION WITH CREBBP, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.
[7]	"Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP." Ghosh A.K., Majumder M., Steele R., Yaciuk P., Chrivia J., Ray R., Ray R.B. J. Biol. Chem. 275:7184-7188(2000) [PubMed: 10702287] [Abstract] Cited for: INTERACTION WITH HCV NS5A, SUBCELLULAR LOCATION.
[8]	"Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP." Monroy M.A., Ruhl D.D., Xu X., Granner D.K., Yaciuk P., Chrivia J.C. J. Biol. Chem. 276:40721-40726(2001) [PubMed: 11522779] [Abstract] Cited for: FUNCTION.
[9]	"Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription." Xu X., Chackalaparampil I., Monroy M.A., Cannella M.T., Pesek E., Chrivia J., Yaciuk P. J. Virol. 75:10033-10040(2001) [PubMed: 11581372] [Abstract] Cited for: INTERACTION WITH EP300 AND HADV-2 DBP.
[10]	"SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1." Monroy M.A., Schott N.M., Cox L., Chen J.D., Ruh M., Chrivia J.C. Mol. Endocrinol. 17:2519-2528(2003) [PubMed: 14500758] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN COMPLEX WITH CREBBP; CARM1 AND GRIP1.
[11]	"Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans." Doyon Y., Selleck W., Lane W.S., Tan S., Cote J. Mol. Cell. Biol. 24:1884-1896(2004) [PubMed: 14966270] [Abstract] Cited for: IDENTIFICATION IN A NUA4-RELATED COMPLEX.
[12]	"The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes." Cai Y., Jin J., Florens L., Swanson S.K., Kusch T., Li B., Workman J.L., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:13665-13670(2005) [PubMed: 15647280] [Abstract] Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, MASS SPECTROMETRY.
[13]	"Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway." Eissenberg J.C., Wong M., Chrivia J.C. Mol. Cell. Biol. 25:6559-6569(2005) [PubMed: 16024792] [Abstract] Cited for: FUNCTION.
[14]	"Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes." Ruhl D.D., Jin J., Cai Y., Swanson S., Florens L., Washburn M.P., Conaway R.C., Conaway J.W., Chrivia J.C. Biochemistry 45:5671-5677(2006) [PubMed: 16634648] [Abstract] Cited for: IDENTIFICATION IN THE SRCAP COMPLEX, FUNCTION, MASS SPECTROMETRY.
[15]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2869 AND SER-3148, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters." Wong M.M., Cox L.K., Chrivia J.C. J. Biol. Chem. 282:26132-26139(2007) [PubMed: 17617668] [Abstract] Cited for: FUNCTION.
[17]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248 AND THR-2258, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[18]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2425 AND SER-2430, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[19]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258; SER-2787; SER-2790; SER-3148; SER-3168 AND SER-3177, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[20]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274; SER-562; SER-568; THR-572; SER-2787; SER-2790; SER-3148; SER-3161; SER-3172 AND SER-3177, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC093249 Genomic DNA. No translation available. AC106886 Genomic DNA. No translation available. AK128030 mRNA. Translation: BAC87237.1. AB002307 mRNA. Translation: BAA20768.2. BC159099 mRNA. Translation: AAI59100.1. Different initiation. AF143946 mRNA. Translation: AAD39760.1.
IPI	IPI00009101. IPI00444046. IPI00550342.
RefSeq	NP_006653.2. NM_006662.2.
UniGene	Hs.647334.
3D structure databases
HSSP	HSSP built from PDB template 1Z63 based on UniProtKB Q97XQ5.
ProteinModelPortal	Q6ZRS2.
SMR	Q6ZRS2. Positions 611-910.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6ZRS2. 12 interactions.
MINT	MINT-123408.
STRING	Q6ZRS2.
PTM databases
PhosphoSite	Q6ZRS2.
Polymorphism databases
DMDM	296452947.
Proteomic databases
PRIDE	Q6ZRS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262518; ENSP00000262518; ENSG00000080603. ENST00000344771; ENSP00000343042; ENSG00000080603. ENST00000380361; ENSP00000369719; ENSG00000080603.
GeneID	10847.
KEGG	hsa:10847.
UCSC	uc002dze.1. human. uc002dzg.1. human.
Organism-specific databases
CTD	10847.
GeneCards	GC16P030710.
H-InvDB	HIX0012970.
HGNC	HGNC:16974. SRCAP.
HPA	HPA028929.
MIM	611421. gene.
neXtProt	NX_Q6ZRS2.
PharmGKB	PA162404706.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000063427.
HOGENOM	HBG281654.
InParanoid	Q6ZRS2.
OMA	GSHRRSK.
OrthoDB	EOG4B2SWB.
PhylomeDB	Q6ZRS2.
Gene expression databases
ArrayExpress	Q6ZRS2.
Bgee	Q6ZRS2.
CleanEx	HS_SRCAP.
Genevestigator	Q6ZRS2.
Family and domain databases
InterPro	IPR020478. AT_hook-like. IPR017956. AT_hook_DNA-bd_motif. IPR014001. DEAD-like_helicase. IPR014012. Helicase/SANT-assoc_DNA-bd. IPR001650. Helicase_C. IPR006562. HSA. IPR000330. SNF2_N. [Graphical view]
KO	K11661.
Pfam	PF00271. Helicase_C. 1 hit. PF07529. HSA. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
PRINTS	PR00929. ATHOOK.
SMART	SM00384. AT_hook. 3 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS51204. HSA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41182.
SOURCE	Search...

Entry information

Entry name

SRCAP_HUMAN

Accession

Primary (citable) accession number: Q6ZRS2
Secondary accession number(s): B0JZA6 , O15026, Q7Z744, Q9Y5L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.