Q6ZRR9 (DCDC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Doublecortin domain-containing protein 5

Gene names

Name:	DCDC5
Synonyms:	KIAA1493

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	648 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 2 doublecortin domains.
Sequence caution	The sequence BAC87240.1 differs from that shown. Reason: The sequence CAO03425.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 648	648	Doublecortin domain-containing protein 5		PRO_0000338616
Regions
	Domain	4 – 94	91	Doublecortin 1
	Domain	491 – 570	80	Doublecortin 2
Experimental info
	Sequence conflict	72	1	D → N in BAC87240. Ref.1
	Sequence conflict	341	1	K → R in BAC87240. Ref.1
	Sequence conflict	631	1	E → ALQ in BAC87240. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZRR9 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: 296E9E0594D74548	FASTA	648	72,753
	10 20 30 40 50 60 MKKPICKTTE PYAPVRLRVL QNGEKNKNRS VTILGPDISP GRKTQCTEIL NLPSAARRLY 70 80 90 100 110 120 NEKGKEIFAL KDLQRDELVY VSCGELWINP DLSIAQQKKQ IFLRNLESDI AKIQIFCSTH 130 140 150 160 170 180 KIEALVLEVQ SDIVSGSKLA VHKPVAIFGE EKQVTEPEEK QMQEDPLTTE NASSEILDSH 190 200 210 220 230 240 VRAHLRMKAC HTLPRYAWQE TSHDFDEDDS LPKKTEKGLF ENVEPQKKHS CSPKHSKLHK 250 260 270 280 290 300 HCHQQFEYRD GQIISHAAPQ LVLGVQGPNL RSGMEVVLVE KKSDGSHQRW IHQEDSRTFH 310 320 330 340 350 360 LVSNPDLVLA VSMTKTRNEV CGYPVIVQKY KPYNNGAANQ KWHYMKNIKA LVAFHSTALD 370 380 390 400 410 420 KEITSANYAG VCTSSVIKEE NIDQPGYCYL SPDGKRKTML CLACGQSMRT EKGLKQLLPG 430 440 450 460 470 480 VPFLCISGTK TQKPFLQGPF KVISVAEVDL SCDKAEKTLS YYQARLLSLR MKTCTQAASH 490 500 510 520 530 540 SGMAATHQKA VKIIAYKNGD GYRNGKLIVA GTFPMLLTEC TEQLGLARAA SKVYTKDGTP 550 560 570 580 590 600 IFTLRDLVLW ALDESFLQRD SEKQKQDAAP VGKEQIIVEK NPRMKVKNRL FAKSVTSDSL 610 620 630 640 DGIDKSLLTL ILRNPIAIWV SCGEPFLPPN ESRKIRETEL AKKGQNFG

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128035 mRNA. Translation: BAC87240.1. Sequence problems. AL135932 Genomic DNA. Translation: CAO03425.1. Sequence problems.
IPI	IPI00983555.
UniGene	Hs.530438. Hs.690460. Hs.729691. Hs.730375.
3D structure databases
ProteinModelPortal	Q6ZRR9.
SMR	Q6ZRR9. Positions 13-85, 243-344, 485-563.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6ZRR9.
PTM databases
PhosphoSite	Q6ZRR9.
Polymorphism databases
DMDM	190359182.
Proteomic databases
PRIDE	Q6ZRR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339794; ENSP00000341700; ENSG00000170959.
Organism-specific databases
GeneCards	GC11M030809.
HGNC	HGNC:24799. DCDC5.
HPA	HPA039014.
MIM	612321. gene.
neXtProt	NX_Q6ZRR9.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000012809.
HOVERGEN	HBG105685.
PhylomeDB	Q6ZRR9.
Gene expression databases
ArrayExpress	Q6ZRR9.
Bgee	Q6ZRR9.
CleanEx	HS_DCDC5.
Genevestigator	Q6ZRR9.
Family and domain databases
InterPro	IPR003533. Doublecortin_dom. IPR008997. Ricin_B-rel_lectin. IPR000772. Ricin_B_lectin. [Graphical view]
Gene3D	G3DSA:3.10.20.230. Doublecortin_dom. 2 hits.
Pfam	PF00652. Ricin_B_lectin. 1 hit. [Graphical view]
SUPFAM	SSF89837. Doublecortin_dom. 2 hits. SSF50370. RicinB_like. 1 hit.
PROSITE	PS50309. DC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

DCDC5_HUMAN

Accession

Primary (citable) accession number: Q6ZRR9
Secondary accession number(s): B1AL47

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	January 25, 2012
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.