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Protein

Doublecortin domain-containing protein 5

Gene

DCDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Doublecortin domain-containing protein 5
Gene namesi
Name:DCDC5
Synonyms:KIAA1493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24799. DCDC5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi190359182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386161 – 648Doublecortin domain-containing protein 5Add BLAST648

Proteomic databases

PRIDEiQ6ZRR9.

Expressioni

Gene expression databases

BgeeiENSG00000170959.
CleanExiHS_DCDC5.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR9.
SMRiQ6ZRR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 94Doublecortin 1PROSITE-ProRule annotationAdd BLAST91
Domaini491 – 570Doublecortin 2PROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Contains 2 doublecortin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000078278.
HOVERGENiHBG105685.
InParanoidiQ6ZRR9.
PhylomeDBiQ6ZRR9.
TreeFamiTF329467.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50309. DC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZRR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKPICKTTE PYAPVRLRVL QNGEKNKNRS VTILGPDISP GRKTQCTEIL
60 70 80 90 100
NLPSAARRLY NEKGKEIFAL KDLQRDELVY VSCGELWINP DLSIAQQKKQ
110 120 130 140 150
IFLRNLESDI AKIQIFCSTH KIEALVLEVQ SDIVSGSKLA VHKPVAIFGE
160 170 180 190 200
EKQVTEPEEK QMQEDPLTTE NASSEILDSH VRAHLRMKAC HTLPRYAWQE
210 220 230 240 250
TSHDFDEDDS LPKKTEKGLF ENVEPQKKHS CSPKHSKLHK HCHQQFEYRD
260 270 280 290 300
GQIISHAAPQ LVLGVQGPNL RSGMEVVLVE KKSDGSHQRW IHQEDSRTFH
310 320 330 340 350
LVSNPDLVLA VSMTKTRNEV CGYPVIVQKY KPYNNGAANQ KWHYMKNIKA
360 370 380 390 400
LVAFHSTALD KEITSANYAG VCTSSVIKEE NIDQPGYCYL SPDGKRKTML
410 420 430 440 450
CLACGQSMRT EKGLKQLLPG VPFLCISGTK TQKPFLQGPF KVISVAEVDL
460 470 480 490 500
SCDKAEKTLS YYQARLLSLR MKTCTQAASH SGMAATHQKA VKIIAYKNGD
510 520 530 540 550
GYRNGKLIVA GTFPMLLTEC TEQLGLARAA SKVYTKDGTP IFTLRDLVLW
560 570 580 590 600
ALDESFLQRD SEKQKQDAAP VGKEQIIVEK NPRMKVKNRL FAKSVTSDSL
610 620 630 640
DGIDKSLLTL ILRNPIAIWV SCGEPFLPPN ESRKIRETEL AKKGQNFG
Length:648
Mass (Da):72,753
Last modified:June 10, 2008 - v2
Checksum:i296E9E0594D74548
GO

Sequence cautioni

The sequence BAC87240 differs from that shown.Curated
The sequence CAO03425 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72D → N in BAC87240 (PubMed:14702039).Curated1
Sequence conflicti341K → R in BAC87240 (PubMed:14702039).Curated1
Sequence conflicti631E → ALQ in BAC87240 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128035 mRNA. Translation: BAC87240.1. Sequence problems.
AL135932 Genomic DNA. Translation: CAO03425.1. Sequence problems.
UniGeneiHs.530438.
Hs.729691.
Hs.730375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128035 mRNA. Translation: BAC87240.1. Sequence problems.
AL135932 Genomic DNA. Translation: CAO03425.1. Sequence problems.
UniGeneiHs.530438.
Hs.729691.
Hs.730375.

3D structure databases

ProteinModelPortaliQ6ZRR9.
SMRiQ6ZRR9.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi190359182.

Proteomic databases

PRIDEiQ6ZRR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiDCDC5.
HGNCiHGNC:24799. DCDC5.
MIMi612321. gene.
neXtProtiNX_Q6ZRR9.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000078278.
HOVERGENiHBG105685.
InParanoidiQ6ZRR9.
PhylomeDBiQ6ZRR9.
TreeFamiTF329467.

Miscellaneous databases

ChiTaRSiDCDC5. human.
PROiQ6ZRR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170959.
CleanExiHS_DCDC5.

Family and domain databases

Gene3Di3.10.20.230. 2 hits.
InterProiIPR003533. Doublecortin_dom.
IPR000772. Ricin_B_lectin.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50309. DC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCDC5_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR9
Secondary accession number(s): B1AL47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: November 2, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.