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Q6ZRR7

- LRRC9_HUMAN

UniProt

Q6ZRR7 - LRRC9_HUMAN

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Protein
Leucine-rich repeat-containing protein 9
Gene
LRRC9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 9
Gene namesi
Name:LRRC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19848. LRRC9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14531453Leucine-rich repeat-containing protein 9
PRO_0000337676Add
BLAST

Proteomic databases

PaxDbiQ6ZRR7.
PRIDEiQ6ZRR7.

PTM databases

PhosphoSiteiQ6ZRR7.

Expressioni

Gene expression databases

BgeeiQ6ZRR7.
GenevestigatoriQ6ZRR7.

Organism-specific databases

HPAiHPA040965.
HPA041381.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000400899.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR7.
SMRiQ6ZRR7. Positions 32-259, 693-1402.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 7826LRR 1
Add
BLAST
Repeati97 – 11923LRR 2
Add
BLAST
Repeati120 – 14122LRR 3
Add
BLAST
Repeati142 – 16423LRR 4
Add
BLAST
Repeati166 – 18823LRR 5
Add
BLAST
Repeati224 – 24825LRR 6
Add
BLAST
Repeati264 – 28724LRR 7
Add
BLAST
Repeati344 – 36724LRR 8
Add
BLAST
Repeati671 – 69323LRR 9
Add
BLAST
Repeati694 – 71522LRR 10
Add
BLAST
Repeati716 – 73722LRR 11
Add
BLAST
Repeati739 – 75820LRR 12
Add
BLAST
Repeati759 – 78426LRR 13
Add
BLAST
Repeati786 – 81227LRR 14
Add
BLAST
Repeati886 – 90823LRR 15
Add
BLAST
Repeati909 – 93022LRR 16
Add
BLAST
Repeati931 – 95222LRR 17
Add
BLAST
Repeati953 – 97523LRR 18
Add
BLAST
Repeati976 – 100126LRR 19
Add
BLAST
Repeati1023 – 104826LRR 20
Add
BLAST
Repeati1092 – 111524LRR 21
Add
BLAST
Repeati1116 – 113823LRR 22
Add
BLAST
Repeati1139 – 116123LRR 23
Add
BLAST
Repeati1201 – 122424LRR 24
Add
BLAST
Repeati1225 – 124723LRR 25
Add
BLAST
Repeati1248 – 127023LRR 26
Add
BLAST
Repeati1272 – 129221LRR 27
Add
BLAST
Repeati1293 – 131725LRR 28
Add
BLAST
Repeati1319 – 134527LRR 29
Add
BLAST
Repeati1365 – 138824LRR 30
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
HOVERGENiHBG108106.
InParanoidiQ6ZRR7.
OMAiDHNRIRA.
OrthoDBiEOG7QRQSX.
PhylomeDBiQ6ZRR7.
TreeFamiTF329042.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
PfamiPF12799. LRR_4. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZRR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL     50
SLFPNLTSLT IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL 100
EKLYLYFNKI SKIENLEKLI KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA 150
GNLINSIGRC LDSNEQLERL NLSGNQICSF KELTNLTRLP CLKDLCLNDP 200
QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL ADTTAMKKIM 250
YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA 300
ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER 350
VTFWNKKLDE IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR 400
SDDWFNFCYE LILSRFCAWD FRTYGITGVK VKRIIKVNNR ILRLKFEEKF 450
QKFLENEDMH DSESYRRMLE CLFYVFDPEV SVKKKHLLQI LEKGFKDSET 500
SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK HELFRHGILL 550
ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV 600
RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV 650
SVFSKDLKFD DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN 700
LHGNSLSKLR DLSKLTGLRK LNISFNEFTC LDDVYHLYNL EYLDASHNHV 750
ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN MLCKHTTSLL TLDIQHNPWQ 800
KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR ITQLSLLRHS 850
STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF 900
EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS 950
KMTKLTRLSI NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT 1000
LVELYISNNY IAVNQEMHNL KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH 1050
LPELKALDGI PIEPSETDSA KDLFGGRLTS DMIAERQGHS NFKQMQELNW 1100
TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN VKVLCLNYNH 1150
IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI 1200
MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL 1250
QELVVDHNRI RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF 1300
LGYNKIQDIT ELEKLDVIST LRELTVYGNP ICRKMLHRHM LIFRLPNLQM 1350
LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP VTHSPMDGRS FGQVKTPPIE 1400
ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC LKRNEHTPRN 1450
SPV 1453
Length:1,453
Mass (Da):166,911
Last modified:May 20, 2008 - v2
Checksum:i656BD856392E18C5
GO
Isoform 2 (identifier: Q6ZRR7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1111: RTVDLI → SCIYFV
     1112-1453: Missing.

Note: No experimental confirmation available.

Show »
Length:1,111
Mass (Da):128,055
Checksum:iE4FD84AFADF8BC1F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1106 – 11116RTVDLI → SCIYFV in isoform 2.
VSP_033990
Alternative sequencei1112 – 1453342Missing in isoform 2.
VSP_033991Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871C → R in BAC87242. 1 Publication
Sequence conflicti629 – 6291A → P in BAC87242. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128037 mRNA. Translation: BAC87242.1.
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGeneiHs.666245.

Genome annotation databases

EnsembliENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]

Polymorphism databases

DMDMi189028874.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128037 mRNA. Translation: BAC87242.1 .
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGenei Hs.666245.

3D structure databases

ProteinModelPortali Q6ZRR7.
SMRi Q6ZRR7. Positions 32-259, 693-1402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000400899.

PTM databases

PhosphoSitei Q6ZRR7.

Polymorphism databases

DMDMi 189028874.

Proteomic databases

PaxDbi Q6ZRR7.
PRIDEi Q6ZRR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254271 ; ENSP00000454848 ; ENSG00000131951 . [Q6ZRR7-2 ]
ENST00000445360 ; ENSP00000454748 ; ENSG00000131951 . [Q6ZRR7-1 ]

Organism-specific databases

GeneCardsi GC14P060386.
HGNCi HGNC:19848. LRRC9.
HPAi HPA040965.
HPA041381.
neXtProti NX_Q6ZRR7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
HOVERGENi HBG108106.
InParanoidi Q6ZRR7.
OMAi DHNRIRA.
OrthoDBi EOG7QRQSX.
PhylomeDBi Q6ZRR7.
TreeFami TF329042.

Miscellaneous databases

PROi Q6ZRR7.

Gene expression databases

Bgeei Q6ZRR7.
Genevestigatori Q6ZRR7.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view ]
Pfami PF12799. LRR_4. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00446. LRRcap. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 24 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLRRC9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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