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Q6ZRR7 (LRRC9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeat-containing protein 9
Gene names
Name:LRRC9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 30 LRR (leucine-rich) repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainLeucine-rich repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZRR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZRR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1111: RTVDLI → SCIYFV
     1112-1453: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14531453Leucine-rich repeat-containing protein 9
PRO_0000337676

Regions

Repeat53 – 7826LRR 1
Repeat97 – 11923LRR 2
Repeat120 – 14122LRR 3
Repeat142 – 16423LRR 4
Repeat166 – 18823LRR 5
Repeat224 – 24825LRR 6
Repeat264 – 28724LRR 7
Repeat344 – 36724LRR 8
Repeat671 – 69323LRR 9
Repeat694 – 71522LRR 10
Repeat716 – 73722LRR 11
Repeat739 – 75820LRR 12
Repeat759 – 78426LRR 13
Repeat786 – 81227LRR 14
Repeat886 – 90823LRR 15
Repeat909 – 93022LRR 16
Repeat931 – 95222LRR 17
Repeat953 – 97523LRR 18
Repeat976 – 100126LRR 19
Repeat1023 – 104826LRR 20
Repeat1092 – 111524LRR 21
Repeat1116 – 113823LRR 22
Repeat1139 – 116123LRR 23
Repeat1201 – 122424LRR 24
Repeat1225 – 124723LRR 25
Repeat1248 – 127023LRR 26
Repeat1272 – 129221LRR 27
Repeat1293 – 131725LRR 28
Repeat1319 – 134527LRR 29
Repeat1365 – 138824LRR 30

Natural variations

Alternative sequence1106 – 11116RTVDLI → SCIYFV in isoform 2.
VSP_033990
Alternative sequence1112 – 1453342Missing in isoform 2.
VSP_033991

Experimental info

Sequence conflict871C → R in BAC87242. Ref.1
Sequence conflict6291A → P in BAC87242. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: 656BD856392E18C5

FASTA1,453166,911
        10         20         30         40         50         60 
MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL SLFPNLTSLT 

        70         80         90        100        110        120 
IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL EKLYLYFNKI SKIENLEKLI 

       130        140        150        160        170        180 
KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA GNLINSIGRC LDSNEQLERL NLSGNQICSF 

       190        200        210        220        230        240 
KELTNLTRLP CLKDLCLNDP QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL 

       250        260        270        280        290        300 
ADTTAMKKIM YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA 

       310        320        330        340        350        360 
ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER VTFWNKKLDE 

       370        380        390        400        410        420 
IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR SDDWFNFCYE LILSRFCAWD 

       430        440        450        460        470        480 
FRTYGITGVK VKRIIKVNNR ILRLKFEEKF QKFLENEDMH DSESYRRMLE CLFYVFDPEV 

       490        500        510        520        530        540 
SVKKKHLLQI LEKGFKDSET SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK 

       550        560        570        580        590        600 
HELFRHGILL ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV 

       610        620        630        640        650        660 
RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV SVFSKDLKFD 

       670        680        690        700        710        720 
DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN LHGNSLSKLR DLSKLTGLRK 

       730        740        750        760        770        780 
LNISFNEFTC LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN 

       790        800        810        820        830        840 
MLCKHTTSLL TLDIQHNPWQ KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR 

       850        860        870        880        890        900 
ITQLSLLRHS STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF 

       910        920        930        940        950        960 
EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS KMTKLTRLSI 

       970        980        990       1000       1010       1020 
NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT LVELYISNNY IAVNQEMHNL 

      1030       1040       1050       1060       1070       1080 
KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH LPELKALDGI PIEPSETDSA KDLFGGRLTS 

      1090       1100       1110       1120       1130       1140 
DMIAERQGHS NFKQMQELNW TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN 

      1150       1160       1170       1180       1190       1200 
VKVLCLNYNH IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI 

      1210       1220       1230       1240       1250       1260 
MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL QELVVDHNRI 

      1270       1280       1290       1300       1310       1320 
RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF LGYNKIQDIT ELEKLDVIST 

      1330       1340       1350       1360       1370       1380 
LRELTVYGNP ICRKMLHRHM LIFRLPNLQM LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP 

      1390       1400       1410       1420       1430       1440 
VTHSPMDGRS FGQVKTPPIE ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC 

      1450 
LKRNEHTPRN SPV 

« Hide

Isoform 2 [UniParc].

Checksum: E4FD84AFADF8BC1F
Show »

FASTA1,111128,055

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Testis.
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK128037 mRNA. Translation: BAC87242.1.
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGeneHs.666245.

3D structure databases

ProteinModelPortalQ6ZRR7.
SMRQ6ZRR7. Positions 32-259, 693-1402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000400899.

PTM databases

PhosphoSiteQ6ZRR7.

Polymorphism databases

DMDM189028874.

Proteomic databases

PaxDbQ6ZRR7.
PRIDEQ6ZRR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]

Organism-specific databases

GeneCardsGC14P060386.
HGNCHGNC:19848. LRRC9.
HPAHPA040965.
HPA041381.
neXtProtNX_Q6ZRR7.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG4886.
HOVERGENHBG108106.
InParanoidQ6ZRR7.
OMADHNRIRA.
OrthoDBEOG7QRQSX.
PhylomeDBQ6ZRR7.
TreeFamTF329042.

Gene expression databases

BgeeQ6ZRR7.
GenevestigatorQ6ZRR7.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
PfamPF12799. LRR_4. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTSM00446. LRRcap. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 24 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ6ZRR7.

Entry information

Entry nameLRRC9_HUMAN
AccessionPrimary (citable) accession number: Q6ZRR7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM