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Q6ZRR7

- LRRC9_HUMAN

UniProt

Q6ZRR7 - LRRC9_HUMAN

Protein

Leucine-rich repeat-containing protein 9

Gene

LRRC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeat-containing protein 9
    Gene namesi
    Name:LRRC9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:19848. LRRC9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14531453Leucine-rich repeat-containing protein 9PRO_0000337676Add
    BLAST

    Proteomic databases

    PaxDbiQ6ZRR7.
    PRIDEiQ6ZRR7.

    PTM databases

    PhosphoSiteiQ6ZRR7.

    Expressioni

    Gene expression databases

    BgeeiQ6ZRR7.
    GenevestigatoriQ6ZRR7.

    Organism-specific databases

    HPAiHPA040965.
    HPA041381.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000400899.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZRR7.
    SMRiQ6ZRR7. Positions 32-259, 693-1402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati53 – 7826LRR 1Add
    BLAST
    Repeati97 – 11923LRR 2Add
    BLAST
    Repeati120 – 14122LRR 3Add
    BLAST
    Repeati142 – 16423LRR 4Add
    BLAST
    Repeati166 – 18823LRR 5Add
    BLAST
    Repeati224 – 24825LRR 6Add
    BLAST
    Repeati264 – 28724LRR 7Add
    BLAST
    Repeati344 – 36724LRR 8Add
    BLAST
    Repeati671 – 69323LRR 9Add
    BLAST
    Repeati694 – 71522LRR 10Add
    BLAST
    Repeati716 – 73722LRR 11Add
    BLAST
    Repeati739 – 75820LRR 12Add
    BLAST
    Repeati759 – 78426LRR 13Add
    BLAST
    Repeati786 – 81227LRR 14Add
    BLAST
    Repeati886 – 90823LRR 15Add
    BLAST
    Repeati909 – 93022LRR 16Add
    BLAST
    Repeati931 – 95222LRR 17Add
    BLAST
    Repeati953 – 97523LRR 18Add
    BLAST
    Repeati976 – 100126LRR 19Add
    BLAST
    Repeati1023 – 104826LRR 20Add
    BLAST
    Repeati1092 – 111524LRR 21Add
    BLAST
    Repeati1116 – 113823LRR 22Add
    BLAST
    Repeati1139 – 116123LRR 23Add
    BLAST
    Repeati1201 – 122424LRR 24Add
    BLAST
    Repeati1225 – 124723LRR 25Add
    BLAST
    Repeati1248 – 127023LRR 26Add
    BLAST
    Repeati1272 – 129221LRR 27Add
    BLAST
    Repeati1293 – 131725LRR 28Add
    BLAST
    Repeati1319 – 134527LRR 29Add
    BLAST
    Repeati1365 – 138824LRR 30Add
    BLAST

    Sequence similaritiesi

    Contains 30 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    HOVERGENiHBG108106.
    InParanoidiQ6ZRR7.
    OMAiDHNRIRA.
    OrthoDBiEOG7QRQSX.
    PhylomeDBiQ6ZRR7.
    TreeFamiTF329042.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003603. U2A'_phosphoprotein32A_C.
    [Graphical view]
    PfamiPF12799. LRR_4. 2 hits.
    PF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00446. LRRcap. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 24 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZRR7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL     50
    SLFPNLTSLT IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL 100
    EKLYLYFNKI SKIENLEKLI KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA 150
    GNLINSIGRC LDSNEQLERL NLSGNQICSF KELTNLTRLP CLKDLCLNDP 200
    QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL ADTTAMKKIM 250
    YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA 300
    ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER 350
    VTFWNKKLDE IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR 400
    SDDWFNFCYE LILSRFCAWD FRTYGITGVK VKRIIKVNNR ILRLKFEEKF 450
    QKFLENEDMH DSESYRRMLE CLFYVFDPEV SVKKKHLLQI LEKGFKDSET 500
    SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK HELFRHGILL 550
    ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV 600
    RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV 650
    SVFSKDLKFD DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN 700
    LHGNSLSKLR DLSKLTGLRK LNISFNEFTC LDDVYHLYNL EYLDASHNHV 750
    ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN MLCKHTTSLL TLDIQHNPWQ 800
    KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR ITQLSLLRHS 850
    STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF 900
    EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS 950
    KMTKLTRLSI NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT 1000
    LVELYISNNY IAVNQEMHNL KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH 1050
    LPELKALDGI PIEPSETDSA KDLFGGRLTS DMIAERQGHS NFKQMQELNW 1100
    TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN VKVLCLNYNH 1150
    IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI 1200
    MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL 1250
    QELVVDHNRI RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF 1300
    LGYNKIQDIT ELEKLDVIST LRELTVYGNP ICRKMLHRHM LIFRLPNLQM 1350
    LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP VTHSPMDGRS FGQVKTPPIE 1400
    ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC LKRNEHTPRN 1450
    SPV 1453
    Length:1,453
    Mass (Da):166,911
    Last modified:May 20, 2008 - v2
    Checksum:i656BD856392E18C5
    GO
    Isoform 2 (identifier: Q6ZRR7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1106-1111: RTVDLI → SCIYFV
         1112-1453: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,111
    Mass (Da):128,055
    Checksum:iE4FD84AFADF8BC1F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti87 – 871C → R in BAC87242. (PubMed:14702039)Curated
    Sequence conflicti629 – 6291A → P in BAC87242. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1106 – 11116RTVDLI → SCIYFV in isoform 2. 1 PublicationVSP_033990
    Alternative sequencei1112 – 1453342Missing in isoform 2. 1 PublicationVSP_033991Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128037 mRNA. Translation: BAC87242.1.
    AL133299 Genomic DNA. No translation available.
    AL157911 Genomic DNA. No translation available.
    UniGeneiHs.666245.

    Genome annotation databases

    EnsembliENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
    ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]

    Polymorphism databases

    DMDMi189028874.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128037 mRNA. Translation: BAC87242.1 .
    AL133299 Genomic DNA. No translation available.
    AL157911 Genomic DNA. No translation available.
    UniGenei Hs.666245.

    3D structure databases

    ProteinModelPortali Q6ZRR7.
    SMRi Q6ZRR7. Positions 32-259, 693-1402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000400899.

    PTM databases

    PhosphoSitei Q6ZRR7.

    Polymorphism databases

    DMDMi 189028874.

    Proteomic databases

    PaxDbi Q6ZRR7.
    PRIDEi Q6ZRR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254271 ; ENSP00000454848 ; ENSG00000131951 . [Q6ZRR7-2 ]
    ENST00000445360 ; ENSP00000454748 ; ENSG00000131951 . [Q6ZRR7-1 ]

    Organism-specific databases

    GeneCardsi GC14P060386.
    HGNCi HGNC:19848. LRRC9.
    HPAi HPA040965.
    HPA041381.
    neXtProti NX_Q6ZRR7.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4886.
    HOVERGENi HBG108106.
    InParanoidi Q6ZRR7.
    OMAi DHNRIRA.
    OrthoDBi EOG7QRQSX.
    PhylomeDBi Q6ZRR7.
    TreeFami TF329042.

    Miscellaneous databases

    PROi Q6ZRR7.

    Gene expression databases

    Bgeei Q6ZRR7.
    Genevestigatori Q6ZRR7.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR025875. Leu-rich_rpt_4.
    IPR003603. U2A'_phosphoprotein32A_C.
    [Graphical view ]
    Pfami PF12799. LRR_4. 2 hits.
    PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00446. LRRcap. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 24 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiLRRC9_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZRR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3