Q6ZRR7 (LRRC9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein 9

Gene names

Name:

LRRC9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1453 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 30 LRR (leucine-rich) repeats.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZRR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZRR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1111: RTVDLI → SCIYFV
     1112-1453: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1453	1453	Leucine-rich repeat-containing protein 9		PRO_0000337676
Regions
	Repeat	53 – 78	26	LRR 1
	Repeat	97 – 119	23	LRR 2
	Repeat	120 – 141	22	LRR 3
	Repeat	142 – 164	23	LRR 4
	Repeat	166 – 188	23	LRR 5
	Repeat	224 – 248	25	LRR 6
	Repeat	264 – 287	24	LRR 7
	Repeat	344 – 367	24	LRR 8
	Repeat	671 – 693	23	LRR 9
	Repeat	694 – 715	22	LRR 10
	Repeat	716 – 737	22	LRR 11
	Repeat	739 – 758	20	LRR 12
	Repeat	759 – 784	26	LRR 13
	Repeat	786 – 812	27	LRR 14
	Repeat	886 – 908	23	LRR 15
	Repeat	909 – 930	22	LRR 16
	Repeat	931 – 952	22	LRR 17
	Repeat	953 – 975	23	LRR 18
	Repeat	976 – 1001	26	LRR 19
	Repeat	1023 – 1048	26	LRR 20
	Repeat	1092 – 1115	24	LRR 21
	Repeat	1116 – 1138	23	LRR 22
	Repeat	1139 – 1161	23	LRR 23
	Repeat	1201 – 1224	24	LRR 24
	Repeat	1225 – 1247	23	LRR 25
	Repeat	1248 – 1270	23	LRR 26
	Repeat	1272 – 1292	21	LRR 27
	Repeat	1293 – 1317	25	LRR 28
	Repeat	1319 – 1345	27	LRR 29
	Repeat	1365 – 1388	24	LRR 30
Natural variations
	Alternative sequence	1106 – 1111	6	RTVDLI → SCIYFV in isoform 2.		VSP_033990
	Alternative sequence	1112 – 1453	342	Missing in isoform 2.		VSP_033991
Experimental info
	Sequence conflict	87	1	C → R in BAC87242. Ref.1
	Sequence conflict	629	1	A → P in BAC87242. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: 656BD856392E18C5	FASTA	1,453	166,911
	10 20 30 40 50 60 MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL SLFPNLTSLT 70 80 90 100 110 120 IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL EKLYLYFNKI SKIENLEKLI 130 140 150 160 170 180 KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA GNLINSIGRC LDSNEQLERL NLSGNQICSF 190 200 210 220 230 240 KELTNLTRLP CLKDLCLNDP QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL 250 260 270 280 290 300 ADTTAMKKIM YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA 310 320 330 340 350 360 ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER VTFWNKKLDE 370 380 390 400 410 420 IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR SDDWFNFCYE LILSRFCAWD 430 440 450 460 470 480 FRTYGITGVK VKRIIKVNNR ILRLKFEEKF QKFLENEDMH DSESYRRMLE CLFYVFDPEV 490 500 510 520 530 540 SVKKKHLLQI LEKGFKDSET SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK 550 560 570 580 590 600 HELFRHGILL ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV 610 620 630 640 650 660 RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV SVFSKDLKFD 670 680 690 700 710 720 DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN LHGNSLSKLR DLSKLTGLRK 730 740 750 760 770 780 LNISFNEFTC LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN 790 800 810 820 830 840 MLCKHTTSLL TLDIQHNPWQ KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR 850 860 870 880 890 900 ITQLSLLRHS STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF 910 920 930 940 950 960 EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS KMTKLTRLSI 970 980 990 1000 1010 1020 NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT LVELYISNNY IAVNQEMHNL 1030 1040 1050 1060 1070 1080 KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH LPELKALDGI PIEPSETDSA KDLFGGRLTS 1090 1100 1110 1120 1130 1140 DMIAERQGHS NFKQMQELNW TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN 1150 1160 1170 1180 1190 1200 VKVLCLNYNH IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI 1210 1220 1230 1240 1250 1260 MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL QELVVDHNRI 1270 1280 1290 1300 1310 1320 RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF LGYNKIQDIT ELEKLDVIST 1330 1340 1350 1360 1370 1380 LRELTVYGNP ICRKMLHRHM LIFRLPNLQM LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP 1390 1400 1410 1420 1430 1440 VTHSPMDGRS FGQVKTPPIE ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC 1450 LKRNEHTPRN SPV
	Isoform 2 [UniParc]. Checksum: E4FD84AFADF8BC1F	FASTA	1,111	128,055
	10 20 30 40 50 60 MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL SLFPNLTSLT 70 80 90 100 110 120 IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL EKLYLYFNKI SKIENLEKLI 130 140 150 160 170 180 KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA GNLINSIGRC LDSNEQLERL NLSGNQICSF 190 200 210 220 230 240 KELTNLTRLP CLKDLCLNDP QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL 250 260 270 280 290 300 ADTTAMKKIM YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA 310 320 330 340 350 360 ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER VTFWNKKLDE 370 380 390 400 410 420 IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR SDDWFNFCYE LILSRFCAWD 430 440 450 460 470 480 FRTYGITGVK VKRIIKVNNR ILRLKFEEKF QKFLENEDMH DSESYRRMLE CLFYVFDPEV 490 500 510 520 530 540 SVKKKHLLQI LEKGFKDSET SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK 550 560 570 580 590 600 HELFRHGILL ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV 610 620 630 640 650 660 RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV SVFSKDLKFD 670 680 690 700 710 720 DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN LHGNSLSKLR DLSKLTGLRK 730 740 750 760 770 780 LNISFNEFTC LDDVYHLYNL EYLDASHNHV ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN 790 800 810 820 830 840 MLCKHTTSLL TLDIQHNPWQ KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR 850 860 870 880 890 900 ITQLSLLRHS STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF 910 920 930 940 950 960 EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS KMTKLTRLSI 970 980 990 1000 1010 1020 NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT LVELYISNNY IAVNQEMHNL 1030 1040 1050 1060 1070 1080 KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH LPELKALDGI PIEPSETDSA KDLFGGRLTS 1090 1100 1110 DMIAERQGHS NFKQMQELNW TSSSISCIYF V

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

[2]

"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128037 mRNA. Translation: BAC87242.1. AL133299 Genomic DNA. No translation available. AL157911 Genomic DNA. No translation available.
IPI	IPI00394879. IPI00893208.
UniGene	Hs.666245.
3D structure databases
ProteinModelPortal	Q6ZRR7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000400899.
PTM databases
PhosphoSite	Q6ZRR7.
Polymorphism databases
DMDM	189028874.
Proteomic databases
PaxDb	Q6ZRR7.
PRIDE	Q6ZRR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254271; ENSP00000454848; ENSG00000131951. ENST00000445360; ENSP00000454748; ENSG00000131951.
Organism-specific databases
GeneCards	GC14P060386.
HGNC	HGNC:19848. LRRC9.
neXtProt	NX_Q6ZRR7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4886.
HOVERGEN	HBG108106.
InParanoid	Q6ZRR7.
Gene expression databases
ArrayExpress	Q6ZRR7.
Bgee	Q6ZRR7.
Genevestigator	Q6ZRR7.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR025875. Leu-rich_rpt_4. IPR003603. U2A'_phosphoprotein32A_C. [Graphical view]
Pfam	PF12799. LRR_4. 2 hits. [Graphical view]
SMART	SM00446. LRRcap. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 24 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LRRC9_HUMAN

Accession

Primary (citable) accession number: Q6ZRR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.