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Q6ZRR7

- LRRC9_HUMAN

UniProt

Q6ZRR7 - LRRC9_HUMAN

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Protein

Leucine-rich repeat-containing protein 9

Gene

LRRC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 9
Gene namesi
Name:LRRC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:19848. LRRC9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14531453Leucine-rich repeat-containing protein 9PRO_0000337676Add
BLAST

Proteomic databases

PaxDbiQ6ZRR7.
PRIDEiQ6ZRR7.

PTM databases

PhosphoSiteiQ6ZRR7.

Expressioni

Gene expression databases

BgeeiQ6ZRR7.
ExpressionAtlasiQ6ZRR7. baseline.
GenevestigatoriQ6ZRR7.

Organism-specific databases

HPAiHPA040965.
HPA041381.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000400899.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR7.
SMRiQ6ZRR7. Positions 32-256, 693-1402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 7826LRR 1Add
BLAST
Repeati97 – 11923LRR 2Add
BLAST
Repeati120 – 14122LRR 3Add
BLAST
Repeati142 – 16423LRR 4Add
BLAST
Repeati166 – 18823LRR 5Add
BLAST
Repeati224 – 24825LRR 6Add
BLAST
Repeati264 – 28724LRR 7Add
BLAST
Repeati344 – 36724LRR 8Add
BLAST
Repeati671 – 69323LRR 9Add
BLAST
Repeati694 – 71522LRR 10Add
BLAST
Repeati716 – 73722LRR 11Add
BLAST
Repeati739 – 75820LRR 12Add
BLAST
Repeati759 – 78426LRR 13Add
BLAST
Repeati786 – 81227LRR 14Add
BLAST
Repeati886 – 90823LRR 15Add
BLAST
Repeati909 – 93022LRR 16Add
BLAST
Repeati931 – 95222LRR 17Add
BLAST
Repeati953 – 97523LRR 18Add
BLAST
Repeati976 – 100126LRR 19Add
BLAST
Repeati1023 – 104826LRR 20Add
BLAST
Repeati1092 – 111524LRR 21Add
BLAST
Repeati1116 – 113823LRR 22Add
BLAST
Repeati1139 – 116123LRR 23Add
BLAST
Repeati1201 – 122424LRR 24Add
BLAST
Repeati1225 – 124723LRR 25Add
BLAST
Repeati1248 – 127023LRR 26Add
BLAST
Repeati1272 – 129221LRR 27Add
BLAST
Repeati1293 – 131725LRR 28Add
BLAST
Repeati1319 – 134527LRR 29Add
BLAST
Repeati1365 – 138824LRR 30Add
BLAST

Sequence similaritiesi

Contains 30 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG108106.
InParanoidiQ6ZRR7.
OMAiDHNRIRA.
OrthoDBiEOG7QRQSX.
PhylomeDBiQ6ZRR7.
TreeFamiTF329042.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view]
PfamiPF12799. LRR_4. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00446. LRRcap. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6ZRR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL
60 70 80 90 100
SLFPNLTSLT IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL
110 120 130 140 150
EKLYLYFNKI SKIENLEKLI KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA
160 170 180 190 200
GNLINSIGRC LDSNEQLERL NLSGNQICSF KELTNLTRLP CLKDLCLNDP
210 220 230 240 250
QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL ADTTAMKKIM
260 270 280 290 300
YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA
310 320 330 340 350
ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER
360 370 380 390 400
VTFWNKKLDE IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR
410 420 430 440 450
SDDWFNFCYE LILSRFCAWD FRTYGITGVK VKRIIKVNNR ILRLKFEEKF
460 470 480 490 500
QKFLENEDMH DSESYRRMLE CLFYVFDPEV SVKKKHLLQI LEKGFKDSET
510 520 530 540 550
SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK HELFRHGILL
560 570 580 590 600
ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV
610 620 630 640 650
RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV
660 670 680 690 700
SVFSKDLKFD DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN
710 720 730 740 750
LHGNSLSKLR DLSKLTGLRK LNISFNEFTC LDDVYHLYNL EYLDASHNHV
760 770 780 790 800
ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN MLCKHTTSLL TLDIQHNPWQ
810 820 830 840 850
KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR ITQLSLLRHS
860 870 880 890 900
STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF
910 920 930 940 950
EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS
960 970 980 990 1000
KMTKLTRLSI NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT
1010 1020 1030 1040 1050
LVELYISNNY IAVNQEMHNL KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH
1060 1070 1080 1090 1100
LPELKALDGI PIEPSETDSA KDLFGGRLTS DMIAERQGHS NFKQMQELNW
1110 1120 1130 1140 1150
TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN VKVLCLNYNH
1160 1170 1180 1190 1200
IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI
1210 1220 1230 1240 1250
MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL
1260 1270 1280 1290 1300
QELVVDHNRI RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF
1310 1320 1330 1340 1350
LGYNKIQDIT ELEKLDVIST LRELTVYGNP ICRKMLHRHM LIFRLPNLQM
1360 1370 1380 1390 1400
LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP VTHSPMDGRS FGQVKTPPIE
1410 1420 1430 1440 1450
ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC LKRNEHTPRN

SPV
Length:1,453
Mass (Da):166,911
Last modified:May 20, 2008 - v2
Checksum:i656BD856392E18C5
GO
Isoform 2 (identifier: Q6ZRR7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1111: RTVDLI → SCIYFV
     1112-1453: Missing.

Note: No experimental confirmation available.

Show »
Length:1,111
Mass (Da):128,055
Checksum:iE4FD84AFADF8BC1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti87 – 871C → R in BAC87242. (PubMed:14702039)Curated
Sequence conflicti629 – 6291A → P in BAC87242. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1106 – 11116RTVDLI → SCIYFV in isoform 2. 1 PublicationVSP_033990
Alternative sequencei1112 – 1453342Missing in isoform 2. 1 PublicationVSP_033991Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128037 mRNA. Translation: BAC87242.1.
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGeneiHs.666245.

Genome annotation databases

EnsembliENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]

Polymorphism databases

DMDMi189028874.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK128037 mRNA. Translation: BAC87242.1 .
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGenei Hs.666245.

3D structure databases

ProteinModelPortali Q6ZRR7.
SMRi Q6ZRR7. Positions 32-256, 693-1402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000400899.

PTM databases

PhosphoSitei Q6ZRR7.

Polymorphism databases

DMDMi 189028874.

Proteomic databases

PaxDbi Q6ZRR7.
PRIDEi Q6ZRR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254271 ; ENSP00000454848 ; ENSG00000131951 . [Q6ZRR7-2 ]
ENST00000445360 ; ENSP00000454748 ; ENSG00000131951 . [Q6ZRR7-1 ]

Organism-specific databases

GeneCardsi GC14P060386.
HGNCi HGNC:19848. LRRC9.
HPAi HPA040965.
HPA041381.
neXtProti NX_Q6ZRR7.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00730000110223.
HOVERGENi HBG108106.
InParanoidi Q6ZRR7.
OMAi DHNRIRA.
OrthoDBi EOG7QRQSX.
PhylomeDBi Q6ZRR7.
TreeFami TF329042.

Miscellaneous databases

PROi Q6ZRR7.

Gene expression databases

Bgeei Q6ZRR7.
ExpressionAtlasi Q6ZRR7. baseline.
Genevestigatori Q6ZRR7.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR025875. Leu-rich_rpt_4.
IPR003603. U2A'_phosphoprotein32A_C.
[Graphical view ]
Pfami PF12799. LRR_4. 2 hits.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00446. LRRcap. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 24 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiLRRC9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3