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Protein

Leucine-rich repeat-containing protein 9

Gene

LRRC9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 9
Gene namesi
Name:LRRC9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:19848. LRRC9.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131951.

Polymorphism and mutation databases

DMDMi189028874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003376761 – 1453Leucine-rich repeat-containing protein 9Add BLAST1453

Proteomic databases

EPDiQ6ZRR7.
PaxDbiQ6ZRR7.
PeptideAtlasiQ6ZRR7.
PRIDEiQ6ZRR7.

PTM databases

iPTMnetiQ6ZRR7.
PhosphoSitePlusiQ6ZRR7.

Expressioni

Gene expression databases

BgeeiENSG00000131951.
ExpressionAtlasiQ6ZRR7. baseline and differential.

Organism-specific databases

HPAiHPA040965.
HPA041381.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000454748.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati53 – 78LRR 1Add BLAST26
Repeati97 – 119LRR 2Add BLAST23
Repeati120 – 141LRR 3Add BLAST22
Repeati142 – 164LRR 4Add BLAST23
Repeati166 – 188LRR 5Add BLAST23
Repeati224 – 248LRR 6Add BLAST25
Repeati264 – 287LRR 7Add BLAST24
Repeati344 – 367LRR 8Add BLAST24
Repeati671 – 693LRR 9Add BLAST23
Repeati694 – 715LRR 10Add BLAST22
Repeati716 – 737LRR 11Add BLAST22
Repeati739 – 758LRR 12Add BLAST20
Repeati759 – 784LRR 13Add BLAST26
Repeati786 – 812LRR 14Add BLAST27
Repeati886 – 908LRR 15Add BLAST23
Repeati909 – 930LRR 16Add BLAST22
Repeati931 – 952LRR 17Add BLAST22
Repeati953 – 975LRR 18Add BLAST23
Repeati976 – 1001LRR 19Add BLAST26
Repeati1023 – 1048LRR 20Add BLAST26
Repeati1092 – 1115LRR 21Add BLAST24
Repeati1116 – 1138LRR 22Add BLAST23
Repeati1139 – 1161LRR 23Add BLAST23
Repeati1201 – 1224LRR 24Add BLAST24
Repeati1225 – 1247LRR 25Add BLAST23
Repeati1248 – 1270LRR 26Add BLAST23
Repeati1272 – 1292LRR 27Add BLAST21
Repeati1293 – 1317LRR 28Add BLAST25
Repeati1319 – 1345LRR 29Add BLAST27
Repeati1365 – 1388LRR 30Add BLAST24

Sequence similaritiesi

Contains 30 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG108106.
InParanoidiQ6ZRR7.
OMAiDHNRIRA.
OrthoDBiEOG091G0LJ8.
PhylomeDBiQ6ZRR7.
TreeFamiTF329042.

Family and domain databases

Gene3Di3.80.10.10. 7 hits.
3.90.228.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
PROSITEiPS51450. LRR. 24 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZRR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIESENLNQE EIIKELCLCN GLSYEMVGQE GSDTSKLEMF FLGYPRIVGL
60 70 80 90 100
SLFPNLTSLT IVAQDIKEIS GLEPCLQLKE LWIAECCIEK IEGLQECRNL
110 120 130 140 150
EKLYLYFNKI SKIENLEKLI KLKVLWLNHN TIKNIEGLQT LKNLKDLNLA
160 170 180 190 200
GNLINSIGRC LDSNEQLERL NLSGNQICSF KELTNLTRLP CLKDLCLNDP
210 220 230 240 250
QYTTNPVCLL CNYSTHVLYH LPCLQRFDTL DVSAKQIKEL ADTTAMKKIM
260 270 280 290 300
YYNMRIKTLQ RHLKEDLEKL NDQKCKLQKL PEERVKLFSF VKKTLERELA
310 320 330 340 350
ELKGSGKGHS DGSNNSKVTD PETLKSCETV TEEPSLQQKI LAKLNALNER
360 370 380 390 400
VTFWNKKLDE IEAIYHIEVK QKKKSHGLLI PLLLIELETV GNFHFEEGTR
410 420 430 440 450
SDDWFNFCYE LILSRFCAWD FRTYGITGVK VKRIIKVNNR ILRLKFEEKF
460 470 480 490 500
QKFLENEDMH DSESYRRMLE CLFYVFDPEV SVKKKHLLQI LEKGFKDSET
510 520 530 540 550
SKLPLKKEAI IVSNSLSISE CPRIEFLQQK HKDEKKISLK HELFRHGILL
560 570 580 590 600
ITKVFLGQSV QAHEKESISQ SNYPMVNSVF IPRKYLLNSV MGQRNCDCSV
610 620 630 640 650
RQCKWFVFDH DLVLPEYVVE FEYITMVKAP SLFSVFNNVI LEESKKNPEV
660 670 680 690 700
SVFSKDLKFD DEVIKMEPRI KARPKLISLD DKTILSLAKT SVYSHIVSLN
710 720 730 740 750
LHGNSLSKLR DLSKLTGLRK LNISFNEFTC LDDVYHLYNL EYLDASHNHV
760 770 780 790 800
ITLEGFRGLM KLKHLDLSWN QLKKSGNEIN MLCKHTTSLL TLDIQHNPWQ
810 820 830 840 850
KPATLRLSVI GRLKTLTHLN GVFISEEEAT AAMKFIAGTR ITQLSLLRHS
860 870 880 890 900
STKEERPRIL SIWPSAKILT QVSKLGPHLH LSGNCYLKIT ALNLDGQHLF
910 920 930 940 950
EITNLEKLEN LKWASFSNNN LTKMEGLESC INLEELTLDG NCISKIEGIS
960 970 980 990 1000
KMTKLTRLSI NNNLLTGWEE HTFDNMLHLH SLSLENNRIT SLSGLQKSFT
1010 1020 1030 1040 1050
LVELYISNNY IAVNQEMHNL KGLCNLVILD MCGNIIIWNQ ENYRLFVIFH
1060 1070 1080 1090 1100
LPELKALDGI PIEPSETDSA KDLFGGRLTS DMIAERQGHS NFKQMQELNW
1110 1120 1130 1140 1150
TSSSIRTVDL IPVDQFRNVC NVNLQNNHLT SFSGLIYLPN VKVLCLNYNH
1160 1170 1180 1190 1200
IESIMPRLKP QTHLTSRQLL YQKVPSSGYG QQGISKTNRD IMSSENLPPI
1210 1220 1230 1240 1250
MHSLEVLHLG YNGICNLIQL QLNRLRNLKF LFLQGNEISQ VEGLDNLVVL
1260 1270 1280 1290 1300
QELVVDHNRI RSFNDSAFAK PSSLLALHLE ENRLRELGKL QSLVKLEKLF
1310 1320 1330 1340 1350
LGYNKIQDIT ELEKLDVIST LRELTVYGNP ICRKMLHRHM LIFRLPNLQM
1360 1370 1380 1390 1400
LDGSPVNSDD RAKAEFHLAE LQAKKNSLIP VTHSPMDGRS FGQVKTPPIE
1410 1420 1430 1440 1450
ITNVLLPSGF SHYLGSDVTL TPEVEEFLGA TFQDQIECNC LKRNEHTPRN

SPV
Length:1,453
Mass (Da):166,911
Last modified:May 20, 2008 - v2
Checksum:i656BD856392E18C5
GO
Isoform 2 (identifier: Q6ZRR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1106-1111: RTVDLI → SCIYFV
     1112-1453: Missing.

Note: No experimental confirmation available.
Show »
Length:1,111
Mass (Da):128,055
Checksum:iE4FD84AFADF8BC1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti87C → R in BAC87242 (PubMed:14702039).Curated1
Sequence conflicti629A → P in BAC87242 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339901106 – 1111RTVDLI → SCIYFV in isoform 2. 1 Publication6
Alternative sequenceiVSP_0339911112 – 1453Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128037 mRNA. Translation: BAC87242.1.
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGeneiHs.666245.

Genome annotation databases

EnsembliENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]
UCSCiuc001xep.2. human. [Q6ZRR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128037 mRNA. Translation: BAC87242.1.
AL133299 Genomic DNA. No translation available.
AL157911 Genomic DNA. No translation available.
UniGeneiHs.666245.

3D structure databases

ProteinModelPortaliQ6ZRR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000454748.

PTM databases

iPTMnetiQ6ZRR7.
PhosphoSitePlusiQ6ZRR7.

Polymorphism and mutation databases

DMDMi189028874.

Proteomic databases

EPDiQ6ZRR7.
PaxDbiQ6ZRR7.
PeptideAtlasiQ6ZRR7.
PRIDEiQ6ZRR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254271; ENSP00000454848; ENSG00000131951. [Q6ZRR7-2]
ENST00000445360; ENSP00000454748; ENSG00000131951. [Q6ZRR7-1]
UCSCiuc001xep.2. human. [Q6ZRR7-1]

Organism-specific databases

GeneCardsiLRRC9.
HGNCiHGNC:19848. LRRC9.
HPAiHPA040965.
HPA041381.
neXtProtiNX_Q6ZRR7.
OpenTargetsiENSG00000131951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110223.
HOVERGENiHBG108106.
InParanoidiQ6ZRR7.
OMAiDHNRIRA.
OrthoDBiEOG091G0LJ8.
PhylomeDBiQ6ZRR7.
TreeFamiTF329042.

Miscellaneous databases

PROiQ6ZRR7.

Gene expression databases

BgeeiENSG00000131951.
ExpressionAtlasiQ6ZRR7. baseline and differential.

Family and domain databases

Gene3Di3.80.10.10. 7 hits.
3.90.228.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
SMARTiSM00369. LRR_TYP. 11 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 4 hits.
PROSITEiPS51450. LRR. 24 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRRC9_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.