Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 136

Gene

TMEM136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 136
Gene namesi
Name:TMEM136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28280. TMEM136.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi219902.
OpenTargetsiENSG00000181264.
PharmGKBiPA144596257.

Polymorphism and mutation databases

BioMutaiTMEM136.
DMDMi308153509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002855831 – 245Transmembrane protein 136Add BLAST245

Proteomic databases

PaxDbiQ6ZRR5.
PRIDEiQ6ZRR5.

Expressioni

Gene expression databases

BgeeiENSG00000181264.
CleanExiHS_TMEM136.
GenevisibleiQ6ZRR5. HS.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 204TLCPROSITE-ProRule annotationAdd BLAST176

Sequence similaritiesi

Belongs to the TMEM136 family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00390000008162.
HOGENOMiHOG000007565.
HOVERGENiHBG107117.
InParanoidiQ6ZRR5.
OMAiAMYAVSW.
OrthoDBiEOG091G0PDX.
PhylomeDBiQ6ZRR5.
TreeFamiTF329126.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZRR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALALCLQVL CSLCGWLSLY ISFCHLNKHR SYEWSCRLVT FTHGVLSIGL
60 70 80 90 100
SAYIGFIDGP WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCVYFQSEGA
110 120 130 140 150
LMLAHHTLSI LGIIMALVLG ESGTEVNAVL FGSELTNPLL QMRWFLRETG
160 170 180 190 200
HYHSFTGDVV DFLFVALFTG VRIGVGACLL FCEMVSPTPK WFVKAGGVAM
210 220 230 240
YAVSWCFMFS IWRFAWRKSI KKYHAWRSRR SEERQLKHNG HLKIH
Length:245
Mass (Da):27,859
Last modified:October 5, 2010 - v2
Checksum:i18BC58C2528DDB61
GO
Isoform 2 (identifier: Q6ZRR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Show »
Length:126
Mass (Da):14,687
Checksum:i0C5C37ADE6C78CE6
GO
Isoform 3 (identifier: Q6ZRR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM

Show »
Length:267
Mass (Da):30,767
Checksum:i9B77A8BAA168D11E
GO
Isoform 4 (identifier: Q6ZRR5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,596
Checksum:i0BC8988CE159D9ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102M → I in BAC87244 (PubMed:14702039).Curated1
Sequence conflicti130L → P in BAG64992 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398531M → MTQCCFLRVHPLFFWFWSFH HRM in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_02487191 – 210WCVYF…CFMFS → C in isoform 2 and isoform 4. 2 PublicationsAdd BLAST120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128040 mRNA. Translation: BAC87244.1.
AK294713 mRNA. Translation: BAG57865.1.
AK304086 mRNA. Translation: BAG64992.1.
AP001150 Genomic DNA. No translation available.
BC015232 mRNA. Translation: AAH15232.2.
CCDSiCCDS55792.1. [Q6ZRR5-3]
CCDS55793.1. [Q6ZRR5-1]
CCDS8432.1. [Q6ZRR5-4]
RefSeqiNP_001185599.1. NM_001198670.1. [Q6ZRR5-3]
NP_001185600.1. NM_001198671.1. [Q6ZRR5-1]
NP_001185601.1. NM_001198672.1.
NP_001185602.1. NM_001198673.1.
NP_001185603.1. NM_001198674.1. [Q6ZRR5-2]
NP_001185604.1. NM_001198675.1.
NP_777586.1. NM_174926.2. [Q6ZRR5-4]
XP_016872816.1. XM_017017327.1. [Q6ZRR5-4]
UniGeneiHs.643516.

Genome annotation databases

EnsembliENST00000314475; ENSP00000312672; ENSG00000181264. [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264. [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264. [Q6ZRR5-4]
GeneIDi219902.
KEGGihsa:219902.
UCSCiuc001pxg.4. human. [Q6ZRR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128040 mRNA. Translation: BAC87244.1.
AK294713 mRNA. Translation: BAG57865.1.
AK304086 mRNA. Translation: BAG64992.1.
AP001150 Genomic DNA. No translation available.
BC015232 mRNA. Translation: AAH15232.2.
CCDSiCCDS55792.1. [Q6ZRR5-3]
CCDS55793.1. [Q6ZRR5-1]
CCDS8432.1. [Q6ZRR5-4]
RefSeqiNP_001185599.1. NM_001198670.1. [Q6ZRR5-3]
NP_001185600.1. NM_001198671.1. [Q6ZRR5-1]
NP_001185601.1. NM_001198672.1.
NP_001185602.1. NM_001198673.1.
NP_001185603.1. NM_001198674.1. [Q6ZRR5-2]
NP_001185604.1. NM_001198675.1.
NP_777586.1. NM_174926.2. [Q6ZRR5-4]
XP_016872816.1. XM_017017327.1. [Q6ZRR5-4]
UniGeneiHs.643516.

3D structure databases

ProteinModelPortaliQ6ZRR5.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiTMEM136.
DMDMi308153509.

Proteomic databases

PaxDbiQ6ZRR5.
PRIDEiQ6ZRR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314475; ENSP00000312672; ENSG00000181264. [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264. [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264. [Q6ZRR5-4]
GeneIDi219902.
KEGGihsa:219902.
UCSCiuc001pxg.4. human. [Q6ZRR5-1]

Organism-specific databases

CTDi219902.
DisGeNETi219902.
GeneCardsiTMEM136.
HGNCiHGNC:28280. TMEM136.
neXtProtiNX_Q6ZRR5.
OpenTargetsiENSG00000181264.
PharmGKBiPA144596257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00390000008162.
HOGENOMiHOG000007565.
HOVERGENiHBG107117.
InParanoidiQ6ZRR5.
OMAiAMYAVSW.
OrthoDBiEOG091G0PDX.
PhylomeDBiQ6ZRR5.
TreeFamiTF329126.

Miscellaneous databases

ChiTaRSiTMEM136. human.
GenomeRNAii219902.
PROiQ6ZRR5.

Gene expression databases

BgeeiENSG00000181264.
CleanExiHS_TMEM136.
GenevisibleiQ6ZRR5. HS.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM136_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR5
Secondary accession number(s): B4DGQ4, B4E230, Q8IZ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 5, 2010
Last modified: November 2, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.