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Protein

Transmembrane protein 136

Gene

TMEM136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 136
Gene namesi
Name:TMEM136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28280. TMEM136.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei75 – 9521HelicalSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596257.

Polymorphism and mutation databases

BioMutaiTMEM136.
DMDMi308153509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Transmembrane protein 136PRO_0000285583Add
BLAST

Proteomic databases

PaxDbiQ6ZRR5.
PRIDEiQ6ZRR5.

Expressioni

Gene expression databases

BgeeiQ6ZRR5.
CleanExiHS_TMEM136.
GenevisibleiQ6ZRR5. HS.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 204176TLCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM136 family.Curated
Contains 1 TLC (TRAM/LAG1/CLN8) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00390000008162.
HOGENOMiHOG000007565.
HOVERGENiHBG107117.
InParanoidiQ6ZRR5.
OMAiAMYAVSW.
OrthoDBiEOG7F24VJ.
PhylomeDBiQ6ZRR5.
TreeFamiTF329126.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZRR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALALCLQVL CSLCGWLSLY ISFCHLNKHR SYEWSCRLVT FTHGVLSIGL
60 70 80 90 100
SAYIGFIDGP WPFTHPGSPN TPLQVHVLCL TLGYFIFDLG WCVYFQSEGA
110 120 130 140 150
LMLAHHTLSI LGIIMALVLG ESGTEVNAVL FGSELTNPLL QMRWFLRETG
160 170 180 190 200
HYHSFTGDVV DFLFVALFTG VRIGVGACLL FCEMVSPTPK WFVKAGGVAM
210 220 230 240
YAVSWCFMFS IWRFAWRKSI KKYHAWRSRR SEERQLKHNG HLKIH
Length:245
Mass (Da):27,859
Last modified:October 5, 2010 - v2
Checksum:i18BC58C2528DDB61
GO
Isoform 2 (identifier: Q6ZRR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Show »
Length:126
Mass (Da):14,687
Checksum:i0C5C37ADE6C78CE6
GO
Isoform 3 (identifier: Q6ZRR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM

Show »
Length:267
Mass (Da):30,767
Checksum:i9B77A8BAA168D11E
GO
Isoform 4 (identifier: Q6ZRR5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTQCCFLRVHPLFFWFWSFHHRM
     91-210: WCVYFQSEGA...YAVSWCFMFS → C

Note: No experimental confirmation available.
Show »
Length:148
Mass (Da):17,596
Checksum:i0BC8988CE159D9ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021M → I in BAC87244 (PubMed:14702039).Curated
Sequence conflicti130 – 1301L → P in BAG64992 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MTQCCFLRVHPLFFWFWSFH HRM in isoform 3 and isoform 4. 2 PublicationsVSP_039853
Alternative sequencei91 – 210120WCVYF…CFMFS → C in isoform 2 and isoform 4. 2 PublicationsVSP_024871Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128040 mRNA. Translation: BAC87244.1.
AK294713 mRNA. Translation: BAG57865.1.
AK304086 mRNA. Translation: BAG64992.1.
AP001150 Genomic DNA. No translation available.
BC015232 mRNA. Translation: AAH15232.2.
CCDSiCCDS55792.1. [Q6ZRR5-3]
CCDS55793.1. [Q6ZRR5-1]
CCDS8432.1. [Q6ZRR5-4]
RefSeqiNP_001185599.1. NM_001198670.1. [Q6ZRR5-3]
NP_001185600.1. NM_001198671.1. [Q6ZRR5-1]
NP_001185601.1. NM_001198672.1.
NP_001185602.1. NM_001198673.1.
NP_001185603.1. NM_001198674.1. [Q6ZRR5-2]
NP_001185604.1. NM_001198675.1.
NP_777586.1. NM_174926.2. [Q6ZRR5-4]
XP_006718848.1. XM_006718785.2. [Q6ZRR5-1]
UniGeneiHs.643516.

Genome annotation databases

EnsembliENST00000314475; ENSP00000312672; ENSG00000181264. [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264. [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264. [Q6ZRR5-4]
GeneIDi219902.
KEGGihsa:219902.
UCSCiuc001pxg.4. human. [Q6ZRR5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128040 mRNA. Translation: BAC87244.1.
AK294713 mRNA. Translation: BAG57865.1.
AK304086 mRNA. Translation: BAG64992.1.
AP001150 Genomic DNA. No translation available.
BC015232 mRNA. Translation: AAH15232.2.
CCDSiCCDS55792.1. [Q6ZRR5-3]
CCDS55793.1. [Q6ZRR5-1]
CCDS8432.1. [Q6ZRR5-4]
RefSeqiNP_001185599.1. NM_001198670.1. [Q6ZRR5-3]
NP_001185600.1. NM_001198671.1. [Q6ZRR5-1]
NP_001185601.1. NM_001198672.1.
NP_001185602.1. NM_001198673.1.
NP_001185603.1. NM_001198674.1. [Q6ZRR5-2]
NP_001185604.1. NM_001198675.1.
NP_777586.1. NM_174926.2. [Q6ZRR5-4]
XP_006718848.1. XM_006718785.2. [Q6ZRR5-1]
UniGeneiHs.643516.

3D structure databases

ProteinModelPortaliQ6ZRR5.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiTMEM136.
DMDMi308153509.

Proteomic databases

PaxDbiQ6ZRR5.
PRIDEiQ6ZRR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314475; ENSP00000312672; ENSG00000181264. [Q6ZRR5-3]
ENST00000375095; ENSP00000364236; ENSG00000181264. [Q6ZRR5-1]
ENST00000529187; ENSP00000434862; ENSG00000181264. [Q6ZRR5-4]
GeneIDi219902.
KEGGihsa:219902.
UCSCiuc001pxg.4. human. [Q6ZRR5-1]

Organism-specific databases

CTDi219902.
GeneCardsiTMEM136.
HGNCiHGNC:28280. TMEM136.
neXtProtiNX_Q6ZRR5.
PharmGKBiPA144596257.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4474. Eukaryota.
ENOG410Z5I9. LUCA.
GeneTreeiENSGT00390000008162.
HOGENOMiHOG000007565.
HOVERGENiHBG107117.
InParanoidiQ6ZRR5.
OMAiAMYAVSW.
OrthoDBiEOG7F24VJ.
PhylomeDBiQ6ZRR5.
TreeFamiTF329126.

Miscellaneous databases

ChiTaRSiTMEM136. human.
GenomeRNAii219902.
PROiQ6ZRR5.

Gene expression databases

BgeeiQ6ZRR5.
CleanExiHS_TMEM136.
GenevisibleiQ6ZRR5. HS.

Family and domain databases

InterProiIPR006634. TLC-dom.
[Graphical view]
PfamiPF03798. TRAM_LAG1_CLN8. 1 hit.
[Graphical view]
SMARTiSM00724. TLC. 1 hit.
[Graphical view]
PROSITEiPS50922. TLC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain, Testis and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Pancreas.

Entry informationi

Entry nameiTM136_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRR5
Secondary accession number(s): B4DGQ4, B4E230, Q8IZ79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.