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Q6ZRQ5

- MMS22_HUMAN

UniProt

Q6ZRQ5 - MMS22_HUMAN

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Protein

Protein MMS22-like

Gene

MMS22L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.3 Publications

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: UniProtKB
  2. replication fork processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MMS22-like
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 22-like
Gene namesi
Name:MMS22L
Synonyms:C6orf167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21475. MMS22L.

Subcellular locationi

Nucleus 2 Publications
Note: Localizes to DNA damage sites, accumulates at stressed replication forks.

GO - Cellular componenti

  1. nuclear replication fork Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12431243Protein MMS22-likePRO_0000260216Add
BLAST

Proteomic databases

MaxQBiQ6ZRQ5.
PaxDbiQ6ZRQ5.
PRIDEiQ6ZRQ5.

PTM databases

PhosphoSiteiQ6ZRQ5.

Expressioni

Gene expression databases

BgeeiQ6ZRQ5.
CleanExiHS_C6orf167.
ExpressionAtlasiQ6ZRQ5. baseline and differential.
GenevestigatoriQ6ZRQ5.

Interactioni

Subunit structurei

Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TONSLQ96HA75EBI-718662,EBI-1052467

Protein-protein interaction databases

BioGridi128982. 19 interactions.
IntActiQ6ZRQ5. 2 interactions.
MINTiMINT-1378146.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MMS22 family. MMS22L subfamily.Curated

Phylogenomic databases

eggNOGiNOG27315.
GeneTreeiENSGT00390000011769.
HOVERGENiHBG058755.
InParanoidiQ6ZRQ5.
OMAiEVGLQNF.
OrthoDBiEOG7K0ZBB.
PhylomeDBiQ6ZRQ5.
TreeFamiTF353832.

Family and domain databases

InterProiIPR029424. MMS22L_C.
IPR029425. MMS22L_N.
[Graphical view]
PfamiPF14911. MMS22L_C. 1 hit.
PF14910. MMS22L_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZRQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENCSAASTF LTDSLELELG TEWCKPPYFS CAVDNRGGGK HFSGESYLCS
60 70 80 90 100
GALKRLILNL DPLPTNFEED TLEIFGIQWV TETALVNSSR ELFHLFRQQL
110 120 130 140 150
YNLETLLQSS CDFGKVSTLH CKADNIRQQC VLFLHYVKVF IFRYLKVQNA
160 170 180 190 200
ESHVPVHPYE ALEAQLPSVL IDELHGLLLY IGHLSELPSV NIGAFVNQNQ
210 220 230 240 250
IKLFPPSWHL LHLHLDIHWL VLEILYMLGE KLKQVVYGHQ FMNLASDNLT
260 270 280 290 300
NISLFEEHCE TLLCDLISLS LNRYDKVRSS ESLMSDQCPC LCIKELWVLL
310 320 330 340 350
IHLLDHRSKW FVSESFWNWL NKLLKTLLEK SSDRRRSSMP VIQSRDPLGF
360 370 380 390 400
SWWIITHVAS FYKFDRHGVP DEMRKVESNW NFVEELLKKS ISVQGVILEE
410 420 430 440 450
QLRMYLHCCL TLCDFWEPNI AIVTILWEYY SKNLNSSFSI SWLPFKGLAN
460 470 480 490 500
TMKSPLSMLE MVKTCCCDKQ DQELYKSSSS YTIFLCILAK VVKKAMKSNG
510 520 530 540 550
PHPWKQVKGR IYSKFHQKRM EELTEVGLQN FFSLFLLLAA VAEVEDVASH
560 570 580 590 600
VLDLLNFLKP AFVTSQRALI WKGHMAFLLM YAQKNLDIGV LAEKFSCAFR
610 620 630 640 650
EKAKEFLVSK NEEMVQRQTI WTLLSIYIDG VQEVFETSYC LYPSHEKLLN
660 670 680 690 700
DGFSMLLRAC RESELRTVLS FLQAVLARIR SMHQQLCQEL QRDNVDLFVQ
710 720 730 740 750
SSLSAKERHL AAVASALWRH FFSFLKSQRM SQVVPFSQLA DAAADFTLLA
760 770 780 790 800
MDMPSTAPSD FQPQPVISII QLFGWDDIIC PQVVARYLSH VLQNSTLCEA
810 820 830 840 850
LSHSGYVSFQ ALTVRSWIRC VLQMYIKNLS GPDDLLIDKN LEEAVEKEYM
860 870 880 890 900
KQLVKLTRLL FNLSEVKSIF SKAQVEYLSI SEDPKKALVR FFEAVGVTYG
910 920 930 940 950
NVQTLSDKSA MVTKSLEYLG EVLKYIKPYL GKKVFSAGLQ LTYGMMGILV
960 970 980 990 1000
KSWAQIFATS KAQKLLFRII DCLLLPHAVL QQEKELPAPM LSAIQKSLPL
1010 1020 1030 1040 1050
YLQGMCIVCC QSQNPNAYLN QLLGNVIEQY IGRFLPASPY VSDLGQHPVL
1060 1070 1080 1090 1100
LALRNTATIP PISSLKKCIV QVIRKSYLEY KGSSPPPRLA SILAFILQLF
1110 1120 1130 1140 1150
KETNTDIYEV ELLLPGILKC LVLVSEPQVK RLATENLQYM VKACQVGSEE
1160 1170 1180 1190 1200
EPSSQLTSVF RQFIQDYGMR YYYQVYSILE TVATLDQQVV IHLISTLTQS
1210 1220 1230 1240
LKDSEQKWGL GRNIAQREAY SKLLSHLGQM GQDEMQRLEN DNT
Length:1,243
Mass (Da):142,321
Last modified:December 15, 2009 - v3
Checksum:iB63CE3030701CD71
GO

Sequence cautioni

The sequence CAI16668.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20426.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti292 – 2921C → R in BAC87254. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti419 – 4191N → D.
Corresponds to variant rs9374435 [ dbSNP | Ensembl ].
VAR_029013
Natural varianti564 – 5641T → M.1 Publication
Corresponds to variant rs9481410 [ dbSNP | Ensembl ].
VAR_029014
Natural varianti875 – 8751V → A.1 Publication
Corresponds to variant rs1737145 [ dbSNP | Ensembl ].
VAR_029015
Natural varianti1015 – 10151P → L.
Corresponds to variant rs10484830 [ dbSNP | Ensembl ].
VAR_029016

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128060 mRNA. Translation: BAC87254.1.
AL023656, AL590484 Genomic DNA. Translation: CAI20426.1. Sequence problems.
AL353679 Genomic DNA. No translation available.
AL590484, AL023656 Genomic DNA. Translation: CAI16668.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW48494.1.
CH471051 Genomic DNA. Translation: EAW48496.1.
CR749603 mRNA. Translation: CAH18398.1.
CR749822 mRNA. Translation: CAH18682.1.
CCDSiCCDS5039.1.
RefSeqiNP_940870.2. NM_198468.2.
XP_006715493.1. XM_006715430.1.
UniGeneiHs.444292.

Genome annotation databases

EnsembliENST00000275053; ENSP00000275053; ENSG00000146263.
GeneIDi253714.
KEGGihsa:253714.
UCSCiuc003ppb.3. human.

Polymorphism databases

DMDMi281185507.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128060 mRNA. Translation: BAC87254.1 .
AL023656 , AL590484 Genomic DNA. Translation: CAI20426.1 . Sequence problems.
AL353679 Genomic DNA. No translation available.
AL590484 , AL023656 Genomic DNA. Translation: CAI16668.1 . Sequence problems.
CH471051 Genomic DNA. Translation: EAW48494.1 .
CH471051 Genomic DNA. Translation: EAW48496.1 .
CR749603 mRNA. Translation: CAH18398.1 .
CR749822 mRNA. Translation: CAH18682.1 .
CCDSi CCDS5039.1.
RefSeqi NP_940870.2. NM_198468.2.
XP_006715493.1. XM_006715430.1.
UniGenei Hs.444292.

3D structure databases

ProteinModelPortali Q6ZRQ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128982. 19 interactions.
IntActi Q6ZRQ5. 2 interactions.
MINTi MINT-1378146.

PTM databases

PhosphoSitei Q6ZRQ5.

Polymorphism databases

DMDMi 281185507.

Proteomic databases

MaxQBi Q6ZRQ5.
PaxDbi Q6ZRQ5.
PRIDEi Q6ZRQ5.

Protocols and materials databases

DNASUi 253714.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000275053 ; ENSP00000275053 ; ENSG00000146263 .
GeneIDi 253714.
KEGGi hsa:253714.
UCSCi uc003ppb.3. human.

Organism-specific databases

CTDi 253714.
GeneCardsi GC06M097590.
H-InvDB HIX0025055.
HGNCi HGNC:21475. MMS22L.
neXtProti NX_Q6ZRQ5.
PharmGKBi PA134878007.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG27315.
GeneTreei ENSGT00390000011769.
HOVERGENi HBG058755.
InParanoidi Q6ZRQ5.
OMAi EVGLQNF.
OrthoDBi EOG7K0ZBB.
PhylomeDBi Q6ZRQ5.
TreeFami TF353832.

Miscellaneous databases

GeneWikii MMS22L.
GenomeRNAii 253714.
NextBioi 92148.
PROi Q6ZRQ5.

Gene expression databases

Bgeei Q6ZRQ5.
CleanExi HS_C6orf167.
ExpressionAtlasi Q6ZRQ5. baseline and differential.
Genevestigatori Q6ZRQ5.

Family and domain databases

InterProi IPR029424. MMS22L_C.
IPR029425. MMS22L_N.
[Graphical view ]
Pfami PF14911. MMS22L_C. 1 hit.
PF14910. MMS22L_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-564 AND ALA-875.
    Tissue: Testis.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-277 AND 1043-1243.
    Tissue: Fetal kidney and Uterine endothelium.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
  6. "Identification of the MMS22L-TONSL complex that promotes homologous recombination."
    Duro E., Lundin C., Ask K., Sanchez-Pulido L., MacArtney T.J., Toth R., Ponting C.P., Groth A., Helleday T., Rouse J.
    Mol. Cell 40:632-644(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
  7. "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability."
    O'Connell B.C., Adamson B., Lydeard J.R., Sowa M.E., Ciccia A., Bredemeyer A.L., Schlabach M., Gygi S.P., Elledge S.J., Harper J.W.
    Mol. Cell 40:645-657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMMS22_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRQ5
Secondary accession number(s): D6R9Y8
, D6RBQ4, E1P529, Q5THT2, Q68CQ6, Q68D32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 15, 2009
Last modified: October 29, 2014
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3