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Q6ZRQ5

- MMS22_HUMAN

UniProt

Q6ZRQ5 - MMS22_HUMAN

Protein

Protein MMS22-like

Gene

MMS22L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 3 (15 Dec 2009)
      Previous versions | rss
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    Functioni

    Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. double-strand break repair via homologous recombination Source: UniProtKB
    2. replication fork processing Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MMS22-like
    Alternative name(s):
    Methyl methanesulfonate-sensitivity protein 22-like
    Gene namesi
    Name:MMS22L
    Synonyms:C6orf167
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21475. MMS22L.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Localizes to DNA damage sites, accumulates at stressed replication forks.

    GO - Cellular componenti

    1. nuclear replication fork Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878007.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12431243Protein MMS22-likePRO_0000260216Add
    BLAST

    Proteomic databases

    MaxQBiQ6ZRQ5.
    PaxDbiQ6ZRQ5.
    PRIDEiQ6ZRQ5.

    PTM databases

    PhosphoSiteiQ6ZRQ5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZRQ5.
    BgeeiQ6ZRQ5.
    CleanExiHS_C6orf167.
    GenevestigatoriQ6ZRQ5.

    Interactioni

    Subunit structurei

    Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TONSLQ96HA75EBI-718662,EBI-1052467

    Protein-protein interaction databases

    BioGridi128982. 18 interactions.
    IntActiQ6ZRQ5. 2 interactions.
    MINTiMINT-1378146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZRQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MMS22 family. MMS22L subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG27315.
    HOVERGENiHBG058755.
    InParanoidiQ6ZRQ5.
    OMAiEVGLQNF.
    OrthoDBiEOG7K0ZBB.
    PhylomeDBiQ6ZRQ5.
    TreeFamiTF353832.

    Family and domain databases

    InterProiIPR029424. MMS22L_C.
    IPR029425. MMS22L_N.
    [Graphical view]
    PfamiPF14911. MMS22L_C. 1 hit.
    PF14910. MMS22L_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6ZRQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENCSAASTF LTDSLELELG TEWCKPPYFS CAVDNRGGGK HFSGESYLCS     50
    GALKRLILNL DPLPTNFEED TLEIFGIQWV TETALVNSSR ELFHLFRQQL 100
    YNLETLLQSS CDFGKVSTLH CKADNIRQQC VLFLHYVKVF IFRYLKVQNA 150
    ESHVPVHPYE ALEAQLPSVL IDELHGLLLY IGHLSELPSV NIGAFVNQNQ 200
    IKLFPPSWHL LHLHLDIHWL VLEILYMLGE KLKQVVYGHQ FMNLASDNLT 250
    NISLFEEHCE TLLCDLISLS LNRYDKVRSS ESLMSDQCPC LCIKELWVLL 300
    IHLLDHRSKW FVSESFWNWL NKLLKTLLEK SSDRRRSSMP VIQSRDPLGF 350
    SWWIITHVAS FYKFDRHGVP DEMRKVESNW NFVEELLKKS ISVQGVILEE 400
    QLRMYLHCCL TLCDFWEPNI AIVTILWEYY SKNLNSSFSI SWLPFKGLAN 450
    TMKSPLSMLE MVKTCCCDKQ DQELYKSSSS YTIFLCILAK VVKKAMKSNG 500
    PHPWKQVKGR IYSKFHQKRM EELTEVGLQN FFSLFLLLAA VAEVEDVASH 550
    VLDLLNFLKP AFVTSQRALI WKGHMAFLLM YAQKNLDIGV LAEKFSCAFR 600
    EKAKEFLVSK NEEMVQRQTI WTLLSIYIDG VQEVFETSYC LYPSHEKLLN 650
    DGFSMLLRAC RESELRTVLS FLQAVLARIR SMHQQLCQEL QRDNVDLFVQ 700
    SSLSAKERHL AAVASALWRH FFSFLKSQRM SQVVPFSQLA DAAADFTLLA 750
    MDMPSTAPSD FQPQPVISII QLFGWDDIIC PQVVARYLSH VLQNSTLCEA 800
    LSHSGYVSFQ ALTVRSWIRC VLQMYIKNLS GPDDLLIDKN LEEAVEKEYM 850
    KQLVKLTRLL FNLSEVKSIF SKAQVEYLSI SEDPKKALVR FFEAVGVTYG 900
    NVQTLSDKSA MVTKSLEYLG EVLKYIKPYL GKKVFSAGLQ LTYGMMGILV 950
    KSWAQIFATS KAQKLLFRII DCLLLPHAVL QQEKELPAPM LSAIQKSLPL 1000
    YLQGMCIVCC QSQNPNAYLN QLLGNVIEQY IGRFLPASPY VSDLGQHPVL 1050
    LALRNTATIP PISSLKKCIV QVIRKSYLEY KGSSPPPRLA SILAFILQLF 1100
    KETNTDIYEV ELLLPGILKC LVLVSEPQVK RLATENLQYM VKACQVGSEE 1150
    EPSSQLTSVF RQFIQDYGMR YYYQVYSILE TVATLDQQVV IHLISTLTQS 1200
    LKDSEQKWGL GRNIAQREAY SKLLSHLGQM GQDEMQRLEN DNT 1243
    Length:1,243
    Mass (Da):142,321
    Last modified:December 15, 2009 - v3
    Checksum:iB63CE3030701CD71
    GO

    Sequence cautioni

    The sequence CAI16668.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI20426.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti292 – 2921C → R in BAC87254. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti419 – 4191N → D.
    Corresponds to variant rs9374435 [ dbSNP | Ensembl ].
    VAR_029013
    Natural varianti564 – 5641T → M.1 Publication
    Corresponds to variant rs9481410 [ dbSNP | Ensembl ].
    VAR_029014
    Natural varianti875 – 8751V → A.1 Publication
    Corresponds to variant rs1737145 [ dbSNP | Ensembl ].
    VAR_029015
    Natural varianti1015 – 10151P → L.
    Corresponds to variant rs10484830 [ dbSNP | Ensembl ].
    VAR_029016

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128060 mRNA. Translation: BAC87254.1.
    AL023656, AL590484 Genomic DNA. Translation: CAI20426.1. Sequence problems.
    AL353679 Genomic DNA. No translation available.
    AL590484, AL023656 Genomic DNA. Translation: CAI16668.1. Sequence problems.
    CH471051 Genomic DNA. Translation: EAW48494.1.
    CH471051 Genomic DNA. Translation: EAW48496.1.
    CR749603 mRNA. Translation: CAH18398.1.
    CR749822 mRNA. Translation: CAH18682.1.
    CCDSiCCDS5039.1.
    RefSeqiNP_940870.2. NM_198468.2.
    XP_006715493.1. XM_006715430.1.
    UniGeneiHs.444292.

    Genome annotation databases

    EnsembliENST00000275053; ENSP00000275053; ENSG00000146263.
    GeneIDi253714.
    KEGGihsa:253714.
    UCSCiuc003ppb.3. human.

    Polymorphism databases

    DMDMi281185507.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128060 mRNA. Translation: BAC87254.1 .
    AL023656 , AL590484 Genomic DNA. Translation: CAI20426.1 . Sequence problems.
    AL353679 Genomic DNA. No translation available.
    AL590484 , AL023656 Genomic DNA. Translation: CAI16668.1 . Sequence problems.
    CH471051 Genomic DNA. Translation: EAW48494.1 .
    CH471051 Genomic DNA. Translation: EAW48496.1 .
    CR749603 mRNA. Translation: CAH18398.1 .
    CR749822 mRNA. Translation: CAH18682.1 .
    CCDSi CCDS5039.1.
    RefSeqi NP_940870.2. NM_198468.2.
    XP_006715493.1. XM_006715430.1.
    UniGenei Hs.444292.

    3D structure databases

    ProteinModelPortali Q6ZRQ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128982. 18 interactions.
    IntActi Q6ZRQ5. 2 interactions.
    MINTi MINT-1378146.

    PTM databases

    PhosphoSitei Q6ZRQ5.

    Polymorphism databases

    DMDMi 281185507.

    Proteomic databases

    MaxQBi Q6ZRQ5.
    PaxDbi Q6ZRQ5.
    PRIDEi Q6ZRQ5.

    Protocols and materials databases

    DNASUi 253714.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275053 ; ENSP00000275053 ; ENSG00000146263 .
    GeneIDi 253714.
    KEGGi hsa:253714.
    UCSCi uc003ppb.3. human.

    Organism-specific databases

    CTDi 253714.
    GeneCardsi GC06M097590.
    H-InvDB HIX0025055.
    HGNCi HGNC:21475. MMS22L.
    neXtProti NX_Q6ZRQ5.
    PharmGKBi PA134878007.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG27315.
    HOVERGENi HBG058755.
    InParanoidi Q6ZRQ5.
    OMAi EVGLQNF.
    OrthoDBi EOG7K0ZBB.
    PhylomeDBi Q6ZRQ5.
    TreeFami TF353832.

    Miscellaneous databases

    GeneWikii MMS22L.
    GenomeRNAii 253714.
    NextBioi 92148.
    PROi Q6ZRQ5.

    Gene expression databases

    ArrayExpressi Q6ZRQ5.
    Bgeei Q6ZRQ5.
    CleanExi HS_C6orf167.
    Genevestigatori Q6ZRQ5.

    Family and domain databases

    InterProi IPR029424. MMS22L_C.
    IPR029425. MMS22L_N.
    [Graphical view ]
    Pfami PF14911. MMS22L_C. 1 hit.
    PF14910. MMS22L_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS MET-564 AND ALA-875.
      Tissue: Testis.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-277 AND 1043-1243.
      Tissue: Fetal kidney and Uterine endothelium.
    5. Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
    6. "Identification of the MMS22L-TONSL complex that promotes homologous recombination."
      Duro E., Lundin C., Ask K., Sanchez-Pulido L., MacArtney T.J., Toth R., Ponting C.P., Groth A., Helleday T., Rouse J.
      Mol. Cell 40:632-644(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
    7. "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability."
      O'Connell B.C., Adamson B., Lydeard J.R., Sowa M.E., Ciccia A., Bredemeyer A.L., Schlabach M., Gygi S.P., Elledge S.J., Harper J.W.
      Mol. Cell 40:645-657(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE MMS22L-TONSL COMPLEX.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMMS22_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZRQ5
    Secondary accession number(s): D6R9Y8
    , D6RBQ4, E1P529, Q5THT2, Q68CQ6, Q68D32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: December 15, 2009
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3