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Protein

Sulfhydryl oxidase 2

Gene

QSOX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. Also seems to play a role in regulating the sensitization of neuroblastoma cells for interferon-gamma-induced apoptosis.1 Publication

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADCuratedNote: Binds 1 FAD per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91NucleophileBy similarity1
Active sitei94NucleophileBy similarity1
Binding sitei426FADBy similarity1
Binding sitei433FADBy similarity1
Binding sitei437FADBy similarity1
Binding sitei478FADBy similarity1
Binding sitei482FADBy similarity1
Binding sitei527FADBy similarity1
Binding sitei530FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 512FADBy similarity8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciZFISH:HS15351-MONOMER.
BRENDAi1.8.3.2. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 2 (EC:1.8.3.2)
Alternative name(s):
Neuroblastoma-derived sulfhydryl oxidase
Quiescin Q6-like protein 1
Gene namesi
Name:QSOX2
Synonyms:QSCN6L1, SOXN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:30249. QSOX2.

Subcellular locationi

  • Membrane 1 Publication; Single-pass membrane protein 1 Publication
  • Secreted 1 Publication
  • Cell membrane Curated; Single-pass membrane protein Curated
  • Nucleus membrane Curated; Single-pass membrane protein Curated

  • Note: Seems to be predominantly targeted to the nuclear and outer plasma membrane.

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei662 – 682HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi169714.
OpenTargetsiENSG00000165661.
PharmGKBiPA162400588.

Polymorphism and mutation databases

BioMutaiQSOX2.
DMDMi158958335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000024953822 – 698Sulfhydryl oxidase 2Add BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi91 ↔ 94Redox-activePROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi266N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi418 ↔ 430PROSITE-ProRule annotation
Disulfide bondi476 ↔ 479PROSITE-ProRule annotation
Disulfide bondi536 ↔ 539PROSITE-ProRule annotation
Modified residuei579PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ6ZRP7.
MaxQBiQ6ZRP7.
PaxDbiQ6ZRP7.
PeptideAtlasiQ6ZRP7.
PRIDEiQ6ZRP7.

PTM databases

iPTMnetiQ6ZRP7.
PhosphoSitePlusiQ6ZRP7.

Expressioni

Tissue specificityi

Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles.1 Publication

Gene expression databases

BgeeiENSG00000165661.
CleanExiHS_QSOX2.
ExpressionAtlasiQ6ZRP7. baseline and differential.
GenevisibleiQ6ZRP7. HS.

Organism-specific databases

HPAiHPA012716.

Interactioni

Protein-protein interaction databases

BioGridi127987. 24 interactors.
IntActiQ6ZRP7. 12 interactors.
STRINGi9606.ENSP00000351536.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRP7.
SMRiQ6ZRP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 178ThioredoxinPROSITE-ProRule annotationAdd BLAST145
Domaini421 – 530ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi41 – 44Poly-Ala4
Compositional biasi588 – 591Poly-Glu4

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
GeneTreeiENSGT00390000008045.
HOVERGENiHBG080360.
InParanoidiQ6ZRP7.
KOiK10758.
OMAiRWKVKHH.
OrthoDBiEOG091G038J.
PhylomeDBiQ6ZRP7.
TreeFamiTF316749.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZRP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGAAVAR SPGIGAGPAL RARRSPPPRA ARLPRLLVLL AAAAVGPGAG
60 70 80 90 100
GAARLYRAGE DAVWVLDSGS VRGATANSSA AWLVQFYSSW CGHCIGYAPT
110 120 130 140 150
WRALAGDVRD WASAIRVAAL DCMEEKNQAV CHDYDIHFYP TFRYFKAFTK
160 170 180 190 200
EFTTGENFKG PDRELRTVRQ TMIDFLQNHT EGSRPPACPR LDPIQPSDVL
210 220 230 240 250
SLLDNRGSHY VAIVFESNSS YLGREVILDL IPYESIVVTR ALDGDKAFLE
260 270 280 290 300
KLGVSSVPSC YLIYPNGSHG LINVVKPLRA FFSSYLKSLP DVRKKSLPLP
310 320 330 340 350
EKPHKEENSE IVVWREFDKS KLYTVDLESG LHYLLRVELA AHKSLAGAEL
360 370 380 390 400
KTLKDFVTVL AKLFPGRPPV KKLLEMLQEW LASLPLDRIP YNAVLDLVNN
410 420 430 440 450
KMRISGIFLT NHIKWVGCQG SRSELRGYPC SLWKLFHTLT VEASTHPDAL
460 470 480 490 500
VGTGFEDDPQ AVLQTMRRYV HTFFGCKECG EHFEEMAKES MDSVKTPDQA
510 520 530 540 550
ILWLWKKHNM VNGRLAGHLS EDPRFPKLQW PTPDLCPACH EEIKGLASWD
560 570 580 590 600
EGHVLTFLKQ HYGRDNLLDT YSADQGDSSE GGTLARGEEE EKRLTPPEVS
610 620 630 640 650
HGDRDTQSVR PPGALGPRPA LPESLHHSLD GKLQSLDGPG AHKEVGGAAP
660 670 680 690
FLGVDFSSLD MSLCVVLYVA SSLFLMVMYF FFRVRSRRWK VKHHHPAV
Length:698
Mass (Da):77,529
Last modified:July 24, 2007 - v3
Checksum:i7F2B3F890AE657CF
GO

Sequence cautioni

The sequence BAC87262 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAC85331 differs from that shown. Reason: Frameshift at positions 354, 369, 616 and 618.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96G → A in CAC85331 (PubMed:14633699).Curated1
Sequence conflicti205N → K in BAC87262 (PubMed:14702039).Curated1
Sequence conflicti224R → W in CAC85331 (PubMed:14633699).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027435126K → E.Corresponds to variant rs12380852dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318051 mRNA. Translation: CAC85331.1. Frameshift.
AL138781, CR392000 Genomic DNA. Translation: CAI16881.2.
CR392000, AL138781 Genomic DNA. Translation: CAM28352.1.
AK128077 mRNA. Translation: BAC87262.1. Different initiation.
AL834369 mRNA. Translation: CAD39032.1.
CCDSiCCDS35178.1.
RefSeqiNP_859052.3. NM_181701.3.
UniGeneiHs.144073.

Genome annotation databases

EnsembliENST00000358701; ENSP00000351536; ENSG00000165661.
GeneIDi169714.
KEGGihsa:169714.
UCSCiuc010nbi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318051 mRNA. Translation: CAC85331.1. Frameshift.
AL138781, CR392000 Genomic DNA. Translation: CAI16881.2.
CR392000, AL138781 Genomic DNA. Translation: CAM28352.1.
AK128077 mRNA. Translation: BAC87262.1. Different initiation.
AL834369 mRNA. Translation: CAD39032.1.
CCDSiCCDS35178.1.
RefSeqiNP_859052.3. NM_181701.3.
UniGeneiHs.144073.

3D structure databases

ProteinModelPortaliQ6ZRP7.
SMRiQ6ZRP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127987. 24 interactors.
IntActiQ6ZRP7. 12 interactors.
STRINGi9606.ENSP00000351536.

PTM databases

iPTMnetiQ6ZRP7.
PhosphoSitePlusiQ6ZRP7.

Polymorphism and mutation databases

BioMutaiQSOX2.
DMDMi158958335.

Proteomic databases

EPDiQ6ZRP7.
MaxQBiQ6ZRP7.
PaxDbiQ6ZRP7.
PeptideAtlasiQ6ZRP7.
PRIDEiQ6ZRP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358701; ENSP00000351536; ENSG00000165661.
GeneIDi169714.
KEGGihsa:169714.
UCSCiuc010nbi.4. human.

Organism-specific databases

CTDi169714.
DisGeNETi169714.
GeneCardsiQSOX2.
H-InvDBHIX0008541.
HGNCiHGNC:30249. QSOX2.
HPAiHPA012716.
MIMi612860. gene.
neXtProtiNX_Q6ZRP7.
OpenTargetsiENSG00000165661.
PharmGKBiPA162400588.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1731. Eukaryota.
ENOG410XVJT. LUCA.
GeneTreeiENSGT00390000008045.
HOVERGENiHBG080360.
InParanoidiQ6ZRP7.
KOiK10758.
OMAiRWKVKHH.
OrthoDBiEOG091G038J.
PhylomeDBiQ6ZRP7.
TreeFamiTF316749.

Enzyme and pathway databases

BioCyciZFISH:HS15351-MONOMER.
BRENDAi1.8.3.2. 2681.

Miscellaneous databases

ChiTaRSiQSOX2. human.
GenomeRNAii169714.
PROiQ6ZRP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165661.
CleanExiHS_QSOX2.
ExpressionAtlasiQ6ZRP7. baseline and differential.
GenevisibleiQ6ZRP7. HS.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQSOX2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRP7
Secondary accession number(s): A2CEE0
, A6NLB0, Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.