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Protein

Coiled-coil domain-containing protein 73

Gene

CCDC73

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 73
Alternative name(s):
Sarcoma antigen NY-SAR-79
Gene namesi
Name:CCDC73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23261. CCDC73.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485424.

Polymorphism and mutation databases

DMDMi146286064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10791079Coiled-coil domain-containing protein 73PRO_0000285294Add
BLAST

Proteomic databases

MaxQBiQ6ZRK6.
PaxDbiQ6ZRK6.
PeptideAtlasiQ6ZRK6.
PRIDEiQ6ZRK6.

PTM databases

iPTMnetiQ6ZRK6.
PhosphoSiteiQ6ZRK6.

Expressioni

Gene expression databases

BgeeiENSG00000186714.
CleanExiHS_CCDC73.
ExpressionAtlasiQ6ZRK6. baseline and differential.

Organism-specific databases

HPAiHPA038668.
HPA038669.

Interactioni

Protein-protein interaction databases

BioGridi138923. 1 interaction.
IntActiQ6ZRK6. 1 interaction.
STRINGi9606.ENSP00000335325.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili59 – 210152Sequence analysisAdd
BLAST
Coiled coili236 – 384149Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKRA. Eukaryota.
ENOG4112DB3. LUCA.
GeneTreeiENSGT00390000013482.
HOGENOMiHOG000111435.
HOVERGENiHBG101188.
InParanoidiQ6ZRK6.
OMAiIISFQHM.
OrthoDBiEOG091G00WY.
PhylomeDBiQ6ZRK6.
TreeFamiTF335743.

Family and domain databases

InterProiIPR031650. CCDC73.
[Graphical view]
PfamiPF15818. CCDC73. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZRK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESNFNTESS STFTLQSSSE TLFSIQLLDF KTSLLEALEE LRMRREAEIH
60 70 80 90 100
YEEQIGKIIV ETQELKWQKE TLQNQKETLA EQHKEAMAVF KKQLQMKMCA
110 120 130 140 150
LEEEKGKYQL ATEIKEKEIE GLKETLKALQ VSKYSLQKKV SEMEQKVQLH
160 170 180 190 200
LLAKEDYHKQ LSEIEKYYAT ITGQFGLVKE NHEKLEQNVR EAIQSNKRLS
210 220 230 240 250
ALNKKQEAEI CSLKKELKKA ASDLIKSKVT CQYKMGEENI NLTIKEQKFQ
260 270 280 290 300
ELQERLNMEL ELNEKINEEI THIQEEKQDI IISFQHMQQL LRQQIQANTE
310 320 330 340 350
MEAELKVLKE NNQTLERDNE LQREKVKENE EKFLNLQNEH EKALGTWKRH
360 370 380 390 400
AEELNGEINK IKNELSSLKE THIKLQEHYN KLCNQKTFEE DKKFQNVPEV
410 420 430 440 450
NNENSEMSTE KSENTIIQKY NTEQEIREEN MENFCSDTEY REKEEKKEGS
460 470 480 490 500
FIEEIIIDDL QLFEKSFKNE IDTVVSQDEN QSEISLSKTL SLDKEVISQG
510 520 530 540 550
QTSNVTDNRK SVTTEIKDKI CLEKDNGCTE FKSPNNHFVV LDTAIETEKI
560 570 580 590 600
HLERTRGLDV HHTDVNLEVE NNKTSFNSIL NETAHNTYHN NNKDVSENEP
610 620 630 640 650
FKQFRLLPGT REHALEKEIT NSDQTKADLD SSLDIKKNPV PCQKYSLRNS
660 670 680 690 700
SNVMLDDKQC KIKQIQLLTK KSECSILLSK QTSDFLQVCN DTLEKSELTV
710 720 730 740 750
PCDIVIDHHV SYAAFSANSK LLLKNSDKNV HSMSMLVKPN SSPGGKTMCK
760 770 780 790 800
NMSDMQNSQF NNCLGYLENT NVNISHLHLN NENSHASQAK DVKTAVHMKT
810 820 830 840 850
CTETEFSNKK NQIDENQVTE ATKNDLFLFV SINERQHTLL NNTEKTESLN
860 870 880 890 900
DIVSGKMFSE GQLEESHSFH IEPSGDLVNR SGRSTFDLST SDKKTEKTPV
910 920 930 940 950
YMNFSDPGPW SKVNHIESQT ASSSTPCISL LLKERPLDPS ENKKIISMAL
960 970 980 990 1000
CKNIGVDDVG KDIGPDTTSI NRVADTLNNW SIHPDPKGEP SEEKNAMAKT
1010 1020 1030 1040 1050
FYDSSFPTEH VKTKPLISTP LQSHLQAIKT TKNTSGDDDW QSLITNQLNK
1060 1070
SENLLSLEND NQPKKRKAEE TLEKNNRLK
Length:1,079
Mass (Da):124,154
Last modified:May 1, 2007 - v2
Checksum:i2EBE7434D7C7CB69
GO
Isoform 2 (identifier: Q6ZRK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     279-288: Missing.
     459-479: DLQLFEKSFKNEIDTVVSQDE → GNLKIILIFSNLYVDIYSKYF
     480-1079: Missing.

Note: No experimental confirmation available.
Show »
Length:469
Mass (Da):55,588
Checksum:i3A781281E7955D9E
GO

Sequence cautioni

The sequence AAH62749 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAO65175 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence BAC87304 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD18615 differs from that shown. Reason: Frameshift at position 448. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti374 – 3741K → E in BAD18615 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei279 – 28810Missing in isoform 2. 1 PublicationVSP_024861
Alternative sequencei459 – 47921DLQLF…VSQDE → GNLKIILIFSNLYVDIYSKY F in isoform 2. 1 PublicationVSP_024862Add
BLAST
Alternative sequencei480 – 1079600Missing in isoform 2. 1 PublicationVSP_024863Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128159 mRNA. Translation: BAC87304.1. Different initiation.
AK131470 mRNA. Translation: BAD18615.1. Frameshift.
BC062749 mRNA. Translation: AAH62749.1. Different initiation.
AY211922 mRNA. Translation: AAO65175.1. Sequence problems.
CCDSiCCDS41630.1. [Q6ZRK6-1]
RefSeqiNP_001008392.2. NM_001008391.3. [Q6ZRK6-1]
UniGeneiHs.706808.

Genome annotation databases

EnsembliENST00000335185; ENSP00000335325; ENSG00000186714. [Q6ZRK6-1]
GeneIDi493860.
KEGGihsa:493860.
UCSCiuc001mtv.5. human. [Q6ZRK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128159 mRNA. Translation: BAC87304.1. Different initiation.
AK131470 mRNA. Translation: BAD18615.1. Frameshift.
BC062749 mRNA. Translation: AAH62749.1. Different initiation.
AY211922 mRNA. Translation: AAO65175.1. Sequence problems.
CCDSiCCDS41630.1. [Q6ZRK6-1]
RefSeqiNP_001008392.2. NM_001008391.3. [Q6ZRK6-1]
UniGeneiHs.706808.

3D structure databases

ProteinModelPortaliQ6ZRK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138923. 1 interaction.
IntActiQ6ZRK6. 1 interaction.
STRINGi9606.ENSP00000335325.

PTM databases

iPTMnetiQ6ZRK6.
PhosphoSiteiQ6ZRK6.

Polymorphism and mutation databases

DMDMi146286064.

Proteomic databases

MaxQBiQ6ZRK6.
PaxDbiQ6ZRK6.
PeptideAtlasiQ6ZRK6.
PRIDEiQ6ZRK6.

Protocols and materials databases

DNASUi493860.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335185; ENSP00000335325; ENSG00000186714. [Q6ZRK6-1]
GeneIDi493860.
KEGGihsa:493860.
UCSCiuc001mtv.5. human. [Q6ZRK6-1]

Organism-specific databases

CTDi493860.
GeneCardsiCCDC73.
H-InvDBHIX0026167.
HGNCiHGNC:23261. CCDC73.
HPAiHPA038668.
HPA038669.
MIMi612328. gene.
neXtProtiNX_Q6ZRK6.
PharmGKBiPA143485424.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKRA. Eukaryota.
ENOG4112DB3. LUCA.
GeneTreeiENSGT00390000013482.
HOGENOMiHOG000111435.
HOVERGENiHBG101188.
InParanoidiQ6ZRK6.
OMAiIISFQHM.
OrthoDBiEOG091G00WY.
PhylomeDBiQ6ZRK6.
TreeFamiTF335743.

Miscellaneous databases

ChiTaRSiCCDC73. human.
GenomeRNAii493860.
PROiQ6ZRK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186714.
CleanExiHS_CCDC73.
ExpressionAtlasiQ6ZRK6. baseline and differential.

Family and domain databases

InterProiIPR031650. CCDC73.
[Graphical view]
PfamiPF15818. CCDC73. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD73_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRK6
Secondary accession number(s): Q6P5Q7, Q6ZMW0, Q86WE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.