Q6ZRI8 (RHG36_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rho GTPase-activating protein 36

Gene names

Name:

ARHGAP36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state By similarity.
Sequence similarities	Contains 1 Rho-GAP domain.
Sequence caution	The sequence AAH63790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI41400.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC regulation of small GTPase mediated signal transduction Traceable author statement. Source: Reactome small GTPase mediated signal transduction Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZRI8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6ZRI8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MGGCIPFLKAARALCPRIMPPLLLLSAFIFLV → M

Isoform 3 (identifier: Q6ZRI8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q6ZRI8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: MGGCIPFLKAARALCPRIMPPLLLLSAFIFL → MAWILDCLFASAFEPRPRR

Note: No experimental confirmation available.

Isoform 5 (identifier: Q6ZRI8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 40	40	Potential
	Chain	41 – 547	507	Rho GTPase-activating protein 36		PRO_0000256699
Regions
	Domain	226 – 426	201	Rho-GAP
	Compositional bias	149 – 185	37	Arg-rich
Natural variations
	Alternative sequence	1 – 136	136	Missing in isoform 3.		VSP_021357
	Alternative sequence	1 – 48	48	Missing in isoform 5.		VSP_039235
	Alternative sequence	1 – 32	32	MGGCI…FIFLV → M in isoform 2.		VSP_021358
	Alternative sequence	1 – 31	31	MGGCI…AFIFL → MAWILDCLFASAFEPRPRR in isoform 4.		VSP_039236
Experimental info
	Sequence conflict	340	1	H → R in BAH12425. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 28EB8168F3928DF9	FASTA	547	61,664
	10 20 30 40 50 60 MGGCIPFLKA ARALCPRIMP PLLLLSAFIF LVSVLGGAPG HNPDRRTKMV SIHSLSELER 70 80 90 100 110 120 LKLQETAYHE LVARHFLSEF KPDRALPIDR PNTLDKWFLI LRGQQRAVSH KTFGISLEEV 130 140 150 160 170 180 LVNEFTRRKH LELTATMQVE EATGQAAGRR RGNVVRRVFG RIRRFFSRRR NEPTLPREFT 190 200 210 220 230 240 RRGRRGAVSV DSLAELEDGA LLLQTLQLSK ISFPIGQRLL GSKRKMSLNP IAKQIPQVVE 250 260 270 280 290 300 ACCQFIEKHG LSAVGIFTLE YSVQRVRQLR EEFDQGLDVV LDDNQNVHDV AALLKEFFRD 310 320 330 340 350 360 MKDSLLPDDL YMSFLLTATL KPQDQLSALQ LLVYLMPPCH SDTLERLLKA LHKITENCED 370 380 390 400 410 420 SIGIDGQLVP GNRMTSTNLA LVFGSALLKK GKFGKRESRK TKLGIDHYVA SVNVVRAMID 430 440 450 460 470 480 NWDVLFQVPP HIQRQVAKRV WKSSPEALDF IRRRNLRKIQ SARIKMEEDA LLSDPVETSA 490 500 510 520 530 540 EARAAVLAQS KPSDEGSSEE PAVPSGTARS HDDEEGAGNP PIPEQDRPLL RVPREKEAKT GVSYFFP
	Isoform 2 [UniParc]. Checksum: 15B94C6E4A812CD8	FASTA	516	58,340
	10 20 30 40 50 60 MSVLGGAPGH NPDRRTKMVS IHSLSELERL KLQETAYHEL VARHFLSEFK PDRALPIDRP 70 80 90 100 110 120 NTLDKWFLIL RGQQRAVSHK TFGISLEEVL VNEFTRRKHL ELTATMQVEE ATGQAAGRRR 130 140 150 160 170 180 GNVVRRVFGR IRRFFSRRRN EPTLPREFTR RGRRGAVSVD SLAELEDGAL LLQTLQLSKI 190 200 210 220 230 240 SFPIGQRLLG SKRKMSLNPI AKQIPQVVEA CCQFIEKHGL SAVGIFTLEY SVQRVRQLRE 250 260 270 280 290 300 EFDQGLDVVL DDNQNVHDVA ALLKEFFRDM KDSLLPDDLY MSFLLTATLK PQDQLSALQL 310 320 330 340 350 360 LVYLMPPCHS DTLERLLKAL HKITENCEDS IGIDGQLVPG NRMTSTNLAL VFGSALLKKG 370 380 390 400 410 420 KFGKRESRKT KLGIDHYVAS VNVVRAMIDN WDVLFQVPPH IQRQVAKRVW KSSPEALDFI 430 440 450 460 470 480 RRRNLRKIQS ARIKMEEDAL LSDPVETSAE ARAAVLAQSK PSDEGSSEEP AVPSGTARSH 490 500 510 DDEEGAGNPP IPEQDRPLLR VPREKEAKTG VSYFFP
	Isoform 3 [UniParc]. Checksum: 58C7DFD0D4CE3822	FASTA	411	46,230
	10 20 30 40 50 60 MQVEEATGQA AGRRRGNVVR RVFGRIRRFF SRRRNEPTLP REFTRRGRRG AVSVDSLAEL 70 80 90 100 110 120 EDGALLLQTL QLSKISFPIG QRLLGSKRKM SLNPIAKQIP QVVEACCQFI EKHGLSAVGI 130 140 150 160 170 180 FTLEYSVQRV RQLREEFDQG LDVVLDDNQN VHDVAALLKE FFRDMKDSLL PDDLYMSFLL 190 200 210 220 230 240 TATLKPQDQL SALQLLVYLM PPCHSDTLER LLKALHKITE NCEDSIGIDG QLVPGNRMTS 250 260 270 280 290 300 TNLALVFGSA LLKKGKFGKR ESRKTKLGID HYVASVNVVR AMIDNWDVLF QVPPHIQRQV 310 320 330 340 350 360 AKRVWKSSPE ALDFIRRRNL RKIQSARIKM EEDALLSDPV ETSAEARAAV LAQSKPSDEG 370 380 390 400 410 SSEEPAVPSG TARSHDDEEG AGNPPIPEQD RPLLRVPREK EAKTGVSYFF P
	Isoform 4 [UniParc]. Checksum: A2B54A40702F287F	FASTA	535	60,570
	10 20 30 40 50 60 MAWILDCLFA SAFEPRPRRV SVLGGAPGHN PDRRTKMVSI HSLSELERLK LQETAYHELV 70 80 90 100 110 120 ARHFLSEFKP DRALPIDRPN TLDKWFLILR GQQRAVSHKT FGISLEEVLV NEFTRRKHLE 130 140 150 160 170 180 LTATMQVEEA TGQAAGRRRG NVVRRVFGRI RRFFSRRRNE PTLPREFTRR GRRGAVSVDS 190 200 210 220 230 240 LAELEDGALL LQTLQLSKIS FPIGQRLLGS KRKMSLNPIA KQIPQVVEAC CQFIEKHGLS 250 260 270 280 290 300 AVGIFTLEYS VQRVRQLREE FDQGLDVVLD DNQNVHDVAA LLKEFFRDMK DSLLPDDLYM 310 320 330 340 350 360 SFLLTATLKP QDQLSALQLL VYLMPPCHSD TLERLLKALH KITENCEDSI GIDGQLVPGN 370 380 390 400 410 420 RMTSTNLALV FGSALLKKGK FGKRESRKTK LGIDHYVASV NVVRAMIDNW DVLFQVPPHI 430 440 450 460 470 480 QRQVAKRVWK SSPEALDFIR RRNLRKIQSA RIKMEEDALL SDPVETSAEA RAAVLAQSKP 490 500 510 520 530 SDEGSSEEPA VPSGTARSHD DEEGAGNPPI PEQDRPLLRV PREKEAKTGV SYFFP
	Isoform 5 [UniParc]. Checksum: 0D1D47E6A5A25B29	FASTA	499	56,565
	10 20 30 40 50 60 MVSIHSLSEL ERLKLQETAY HELVARHFLS EFKPDRALPI DRPNTLDKWF LILRGQQRAV 70 80 90 100 110 120 SHKTFGISLE EVLVNEFTRR KHLELTATMQ VEEATGQAAG RRRGNVVRRV FGRIRRFFSR 130 140 150 160 170 180 RRNEPTLPRE FTRRGRRGAV SVDSLAELED GALLLQTLQL SKISFPIGQR LLGSKRKMSL 190 200 210 220 230 240 NPIAKQIPQV VEACCQFIEK HGLSAVGIFT LEYSVQRVRQ LREEFDQGLD VVLDDNQNVH 250 260 270 280 290 300 DVAALLKEFF RDMKDSLLPD DLYMSFLLTA TLKPQDQLSA LQLLVYLMPP CHSDTLERLL 310 320 330 340 350 360 KALHKITENC EDSIGIDGQL VPGNRMTSTN LALVFGSALL KKGKFGKRES RKTKLGIDHY 370 380 390 400 410 420 VASVNVVRAM IDNWDVLFQV PPHIQRQVAK RVWKSSPEAL DFIRRRNLRK IQSARIKMEE 430 440 450 460 470 480 DALLSDPVET SAEARAAVLA QSKPSDEGSS EEPAVPSGTA RSHDDEEGAG NPPIPEQDRP 490 LLRVPREKEA KTGVSYFFP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5). Tissue: Adrenal gland, Amygdala, Testis and Tongue.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: PNS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK054620 mRNA. Translation: BAB70776.1. AK128203 mRNA. Translation: BAC87322.1. AK294274 mRNA. Translation: BAH11720.1. AK296748 mRNA. Translation: BAH12425.1. AL590131 Genomic DNA. Translation: CAI41399.1. AL590131 Genomic DNA. Translation: CAI41400.1. Different initiation. AL590131 Genomic DNA. Translation: CAI41401.1. AL590131 Genomic DNA. Translation: CAI41398.1. CH471107 Genomic DNA. Translation: EAX11793.1. BC063790 mRNA. Translation: AAH63790.1. Different initiation.
IPI	IPI00289435. IPI00642514. IPI00643199. IPI00964863. IPI00965160.
RefSeq	NP_659404.2. NM_144967.3.
UniGene	Hs.22905.
3D structure databases
HSSP	HSSP built from PDB template 1RGP based on UniProtKB Q07960.
ProteinModelPortal	Q6ZRI8.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZRI8.
Polymorphism databases
DMDM	74722974.
Proteomic databases
PaxDb	Q6ZRI8.
PRIDE	Q6ZRI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000276211; ENSP00000276211; ENSG00000147256. ENST00000370921; ENSP00000359959; ENSG00000147256. ENST00000370922; ENSP00000359960; ENSG00000147256. ENST00000412432; ENSP00000408515; ENSG00000147256. ENST00000423277; ENSP00000409218; ENSG00000147256.
GeneID	158763.
KEGG	hsa:158763.
UCSC	uc004evz.3. human. uc004ewa.3. human. uc004ewb.3. human.
Organism-specific databases
CTD	158763.
GeneCards	GC0XP130192.
HGNC	HGNC:26388. ARHGAP36.
HPA	HPA002064.
neXtProt	NX_Q6ZRI8.
PharmGKB	PA165756384.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG283137.
HOVERGEN	HBG056228.
InParanoid	Q6ZRI8.
OMA	FLSEFKP.
OrthoDB	EOG4XKV6S.
PhylomeDB	Q6ZRI8.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q6ZRI8.
Genevestigator	Q6ZRI8.
GermOnline	ENSG00000147256. Homo sapiens.
Family and domain databases
Gene3D	1.10.555.10. 2 hits.
InterPro	IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	158763.
NextBio	87792.

Entry information

Entry name

RHG36_HUMAN

Accession

Primary (citable) accession number: Q6ZRI8
Secondary accession number(s): B7Z234 , B7Z439, Q5JRL9, Q5JRM0, Q5JRM1, Q96NU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.