ID   OTOG_HUMAN              Reviewed;        2925 AA.
AC   Q6ZRI0; A8MTX6; A8MUJ0; B7WPC4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   27-MAR-2024, entry version 143.
DE   RecName: Full=Otogelin;
DE   Flags: Precursor;
GN   Name=OTOG; Synonyms=OTGN;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   VARIANT DFNB18B LEU-2116.
RX   PubMed=23122587; DOI=10.1016/j.ajhg.2012.09.012;
RA   Schraders M., Ruiz-Palmero L., Kalay E., Oostrik J., del Castillo F.J.,
RA   Sezgin O., Beynon A.J., Strom T.M., Pennings R.J., Seco C.Z., Oonk A.M.,
RA   Kunst H.P., Dominguez-Ruiz M., Garcia-Arumi A.M., del Campo M.,
RA   Villamar M., Hoefsloot L.H., Moreno F., Admiraal R.J., del Castillo I.,
RA   Kremer H.;
RT   "Mutations of the gene encoding otogelin are a cause of autosomal-recessive
RT   nonsyndromic moderate hearing impairment.";
RL   Am. J. Hum. Genet. 91:883-889(2012).
RN   [4]
RP   VARIANT VAL-1089.
RX   PubMed=26733463; DOI=10.1136/jmedgenet-2015-103620;
RA   Watson C.M., Crinnion L.A., Murphy H., Newbould M., Harrison S.M.,
RA   Lascelles C., Antanaviciute A., Carr I.M., Sheridan E., Bonthron D.T.,
RA   Smith A.;
RT   "Deficiency of the myogenic factor MyoD causes a perinatally lethal fetal
RT   akinesia.";
RL   J. Med. Genet. 53:264-269(2016).
CC   -!- FUNCTION: Glycoprotein specific to acellular membranes of the inner
CC       ear. May be required for the anchoring of the otoconial membranes and
CC       cupulae to the underlying neuroepithelia in the vestibule. May be
CC       involved in the organization and/or stabilization of the fibrillar
CC       network that compose the tectorial membrane in the cochlea. May play a
CC       role in mechanotransduction processes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane
CC       {ECO:0000250|UniProtKB:O55225}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O55225}; Extracellular side
CC       {ECO:0000250|UniProtKB:O55225}. Secreted, extracellular space
CC       {ECO:0000250|UniProtKB:O55225}. Note=Found in fiber-like structures
CC       during the maturation process of the tectorial membrane.
CC       {ECO:0000250|UniProtKB:O55225}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZRI0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZRI0-2; Sequence=VSP_029709, VSP_029710, VSP_029711,
CC                                  VSP_029712, VSP_029713, VSP_029714;
CC   -!- PTM: N-glycosylated. Not O-glycosylated. {ECO:0000250}.
CC   -!- DISEASE: Deafness, autosomal recessive, 18B (DFNB18B) [MIM:614945]: A
CC       form of non-syndromic deafness characterized by a moderate hearing
CC       impairment, which can be associated with vestibular dysfunction, and a
CC       flat to shallow 'U' or slightly downsloping shaped audiograms.
CC       {ECO:0000269|PubMed:23122587}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the otogelin family. {ECO:0000305}.
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DR   EMBL; AK128214; BAC87330.1; -; mRNA.
DR   EMBL; AC124799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS76390.1; -. [Q6ZRI0-1]
DR   RefSeq; NP_001264198.1; NM_001277269.1. [Q6ZRI0-1]
DR   SMR; Q6ZRI0; -.
DR   BioGRID; 131110; 9.
DR   IntAct; Q6ZRI0; 7.
DR   STRING; 9606.ENSP00000382323; -.
DR   CarbonylDB; Q6ZRI0; -.
DR   GlyCosmos; Q6ZRI0; 5 sites, 1 glycan.
DR   GlyGen; Q6ZRI0; 5 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; Q6ZRI0; -.
DR   PhosphoSitePlus; Q6ZRI0; -.
DR   BioMuta; OTOG; -.
DR   DMDM; 215274227; -.
DR   MassIVE; Q6ZRI0; -.
DR   PaxDb; 9606-ENSP00000382323; -.
DR   PeptideAtlas; Q6ZRI0; -.
DR   Antibodypedia; 77421; 9 antibodies from 3 providers.
DR   DNASU; 340990; -.
DR   Ensembl; ENST00000399391.7; ENSP00000382323.2; ENSG00000188162.12. [Q6ZRI0-1]
DR   GeneID; 340990; -.
DR   KEGG; hsa:340990; -.
DR   UCSC; uc001mnh.1; human. [Q6ZRI0-1]
DR   AGR; HGNC:8516; -.
DR   CTD; 340990; -.
DR   DisGeNET; 340990; -.
DR   GeneCards; OTOG; -.
DR   HGNC; HGNC:8516; OTOG.
DR   HPA; ENSG00000188162; Tissue enhanced (pituitary).
DR   MalaCards; OTOG; -.
DR   MIM; 604487; gene.
DR   MIM; 614945; phenotype.
DR   neXtProt; NX_Q6ZRI0; -.
DR   OpenTargets; ENSG00000188162; -.
DR   Orphanet; 90636; Rare autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR   VEuPathDB; HostDB:ENSG00000188162; -.
DR   eggNOG; KOG1216; Eukaryota.
DR   GeneTree; ENSGT00940000157490; -.
DR   HOGENOM; CLU_248357_0_0_1; -.
DR   InParanoid; Q6ZRI0; -.
DR   OrthoDB; 2872912at2759; -.
DR   PhylomeDB; Q6ZRI0; -.
DR   TreeFam; TF300299; -.
DR   PathwayCommons; Q6ZRI0; -.
DR   Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR   BioGRID-ORCS; 340990; 6 hits in 1098 CRISPR screens.
DR   ChiTaRS; OTOG; human.
DR   GenomeRNAi; 340990; -.
DR   Pharos; Q6ZRI0; Tdark.
DR   PRO; PR:Q6ZRI0; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q6ZRI0; Protein.
DR   Bgee; ENSG00000188162; Expressed in primordial germ cell in gonad and 19 other cell types or tissues.
DR   ExpressionAtlas; Q6ZRI0; baseline and differential.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR   GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR   CDD; cd19941; TIL; 4.
DR   Gene3D; 2.80.10.50; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   InterPro; IPR007934; AbfB_ABD.
DR   InterPro; IPR036195; AbfB_ABD_sf.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR   PANTHER; PTHR11339:SF228; OTOGELIN; 1.
DR   Pfam; PF05270; AbfB; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 4.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 4.
DR   SUPFAM; SSF110221; AbfB domain; 1.
DR   SUPFAM; SSF57603; FnI-like domain; 2.
DR   SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51233; VWFD; 4.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Deafness; Disease variant;
KW   Disulfide bond; EGF-like domain; Glycoprotein; Membrane;
KW   Non-syndromic deafness; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..2925
FT                   /note="Otogelin"
FT                   /id="PRO_0000312148"
FT   DOMAIN          102..139
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DOMAIN          150..322
FT                   /note="VWFD 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          512..688
FT                   /note="VWFD 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          780..844
FT                   /note="TIL"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          984..1152
FT                   /note="VWFD 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          2110..2289
FT                   /note="VWFD 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DOMAIN          2840..2925
FT                   /note="CTCK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   REGION          39..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          316..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1476..1540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1636..1679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1693..1715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1737..1788
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1478..1506
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1643..1679
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1693..1713
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1749..1763
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        914
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1478
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        1612
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        106..120
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        114..126
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        128..138
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        152..285
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        199..206
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        514..652
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        536..687
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        558..566
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        986..1115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        1030..1037
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2112..2249
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   DISULFID        2840..2889
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        2854..2903
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        2865..2920
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   DISULFID        2869..2922
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00039"
FT   VAR_SEQ         1..985
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029709"
FT   VAR_SEQ         986..1014
FT                   /note="CTAYGDRHYRTFDGLPFDFVGACKVHLVK -> MFPARGVPLHLEGEGVFPW
FT                   GPGDVSLPYL (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029710"
FT   VAR_SEQ         1240..1249
FT                   /note="PYDCDFFNKV -> L (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029711"
FT   VAR_SEQ         2434..2575
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029712"
FT   VAR_SEQ         2644
FT                   /note="E -> G (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029713"
FT   VAR_SEQ         2645..2925
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_029714"
FT   VARIANT         375
FT                   /note="T -> S (in dbSNP:rs7130190)"
FT                   /id="VAR_037406"
FT   VARIANT         391
FT                   /note="A -> D (in dbSNP:rs61611064)"
FT                   /id="VAR_061161"
FT   VARIANT         659
FT                   /note="T -> M (in dbSNP:rs7112749)"
FT                   /id="VAR_037407"
FT   VARIANT         692
FT                   /note="S -> P (in dbSNP:rs7106548)"
FT                   /id="VAR_037408"
FT   VARIANT         919
FT                   /note="A -> T (in dbSNP:rs2355466)"
FT                   /id="VAR_037409"
FT   VARIANT         1075
FT                   /note="R -> Q (in dbSNP:rs11024333)"
FT                   /id="VAR_037410"
FT   VARIANT         1089
FT                   /note="I -> V (in dbSNP:rs56359117)"
FT                   /evidence="ECO:0000269|PubMed:26733463"
FT                   /id="VAR_084731"
FT   VARIANT         1112
FT                   /note="A -> V (in dbSNP:rs7936324)"
FT                   /id="VAR_037411"
FT   VARIANT         1129
FT                   /note="P -> L (in dbSNP:rs7936354)"
FT                   /id="VAR_037412"
FT   VARIANT         1399
FT                   /note="A -> G (in dbSNP:rs4491195)"
FT                   /id="VAR_037413"
FT   VARIANT         1646
FT                   /note="P -> L (in dbSNP:rs1256306888)"
FT                   /id="VAR_037414"
FT   VARIANT         1832
FT                   /note="A -> V (in dbSNP:rs1003490)"
FT                   /id="VAR_037415"
FT   VARIANT         1947
FT                   /note="T -> M (in dbSNP:rs7111528)"
FT                   /id="VAR_037416"
FT   VARIANT         2006
FT                   /note="A -> V (in dbSNP:rs11024341)"
FT                   /id="VAR_047262"
FT   VARIANT         2116
FT                   /note="P -> L (in DFNB18B; dbSNP:rs397514607)"
FT                   /evidence="ECO:0000269|PubMed:23122587"
FT                   /id="VAR_069250"
FT   VARIANT         2750
FT                   /note="R -> Q (in dbSNP:rs12422210)"
FT                   /id="VAR_037417"
FT   VARIANT         2909
FT                   /note="W -> S (in dbSNP:rs11024357)"
FT                   /id="VAR_037418"
FT   CONFLICT        1375
FT                   /note="A -> P (in Ref. 1; BAC87330)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        2121
FT                   /note="V -> A (in Ref. 1; BAC87330)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2925 AA;  314794 MW;  D3555CAA3D9AE5FA CRC64;
     MGVLASALCW LLCVWLPWGE QAAESLRVQR LGERVVDSGR SGARGMRNVK GMRNGPAQTR
     VSSSSSHQEA TLAMGDKATV VGGQQAEAPD SVAMSSWERR LHRAKCAPSY LFSCFNGGEC
     VHPAFCDCRR FNATGPRCQM VYNAGPERDS ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG
     RHEPEGQSFS IQVHNDPQCG SSPYTCSRAV SLFFVGEQEI HLAKEVTHGG MRVQLPHVMG
     SARLQQLAGY VIVRHQSAFT LAWDGASAVY IKMSPELLGW THGLCGNNNA DPKDDLVTSS
     GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC EALLRPPFDA
     CHAYVSPLPF TASCTSDLCQ SMGDVATWCR ALAEYARACA QAGRPLQGWR TQLRQCTVHC
     KEKAFTYNEC IACCPASCHP RASCVDSEIA CVDGCYCPNG LIFEDGGCVA PAECPCEFHG
     TLYPPGSVVK EDCNTCTCTS GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL
     AKSRSSGTFT VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDV LLFDQYKIIP
     PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG LCGTFNGNTQ
     DDFLSPVGVP ESTPQLFGNS WKTLSACSPL VSGSPLDPCD VHLQAASYSV QACSVLTGEM
     FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC ATLAHYAHLC RRHGLPVDFR ARLPACALSC
     EASKEYSPCV APCGRTCQDL ASPEACGVDG GDDLSRDECV EGCACPPDTY LDTQADLCVP
     RNQCSCHFQG VDYPPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL
     ELSRERTCEQ QLLNLSVSAR GPCLSGCACP QGLLRHGDAC FLPEECPCTW KGKEYFPGDQ
     VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL PFDFVGACKV HLVKSTSDVS
     FSVIVENVNC YSSGMICRKF ISINVGNSLI VFDDDSGNPS PESFLDDKQE VHTWRVGFFT
     LVHFPQEHIT LLWDQRTTVH VQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF
     GSSWAAVECP DTLDPRDMCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD
     TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCP YDCDFFNKVL GKGPYQLSSL
     AAGGALVGMK AVGDDIVLVR TEDVAPADIV SFLLTAALYK AKAHDPDVVS LEAADRPNFF
     LHVTANGSLE LAKWQGRDTF QQHASFLLHR GTRQAGLVAL ESLAKPSSFL YVSGAVLALR
     LYEHTEVFRR GTLFRLLDAK PSGAAYPICE WRYDACASPC FQTCRDPRAA SCRDVPRVEG
     CVPVCPTPQV LDEVTQRCVY LEDCVEPAVW VPTEALGNET LPPSQGLPTP SDEEPQLSQE
     SPRTPTHRPA LTPAAPLTTA LNPPVTATEE PVVSPGPTQT TLQQPLELTA SQLPAGPTES
     PASKGVTASL LAIPHTPESS SLPVALQTPT PGMVSGAMET TRVTVIFAGS PNITVSSRSP
     PAPRFPLMTK AVTVRGHGSL PVRTTPPQPS LTASPSSRPV ASPGAISRSP TSSGSHKAVL
     TPAVTKVISR TGVPQPTQAQ SASSPSTPLT VAGTAAEQVP VSPLATRSLE IVLSTEKGEA
     GHSQPMGSPA SPQPHPLPSA PPRPAQHTTM ATRSPALPPE TPAAASLSTA TDGLAATPFM
     SLESTRPSQL LSGLPPDTSL PLAKVGTSAP VATPGPKASV ITTPLQPQAT TLPAQTLSPV
     LPFTPAAMTQ AHPPTHIAPP AAGTAPGLLL GATLPTSGVL PVAEGTASMV SVVPRKSTTG
     KVAILSKQVS LPTSMYGSAE GGPTELTPAT SHPLTPLVAE PEGAQAGTAL PVPTSYALSR
     VSARTAPQDS MLVLLPQLAE AHGTSAGPHL AAEPVDEATT EPSGRSAPAL SIVEGLAEAL
     ATTTEANTST TCVPIAEQDC VRHICLEGQL IRVNQSQHCP QGAAPPRCGI LGLAVRVGGD
     RCCPLWECAC RCSIFPDLSF VTFDGSHVAL FKEAIYILSQ SPDEMLTVHV LDCKSANLGH
     LNWPPFCLVM LNMTHLAHQV TIDRFNRKVT VDLQPVWPPV SRYGFRIEDT GHMYMILTPS
     DIQIQWLHSS GLMIVEASKT SKAQGHGLCG ICDGDAANDL TLKDGSVVGG AEDPAPFLDS
     WQVPSSLTSV GQTRFRPDSC ATTDCSPCLR MVSNRTFSAC HRFVPPESFC ELWIRDTKYV
     QQPCVALTVY VAMCHKFHVC IEWRRSDYCP FLCSSDSTYQ ACVTACEPPK TCQDGILGPL
     DPEHCQVLGE GCVCSEGTIL HRRHSALCIP EAKCACTDSM GVPRALGETW NSSLSGCCQH
     QCQAPDTIVP VDLGCPSPRP ESCLRFGEVA LLLPTKDPCC LGTVCVCNQT LCEGLAPTCR
     PGHRLLTHFQ EDSCCPSYSC ECDPDLCEAE LVPSCRQDQI LITGRLGDSC CTSYFCACGD
     CPDSIPECQE GEALTVHRNT TELCCPLYQC VCENFRCPQV QCGLGTALVE VWSPDRCCPY
     KSCECDCDTI PVPRCHLWEK SQLDEEFMHS VENVCGCAKY ECVKAPVCLS RELGVMQPGQ
     TVVELSADGV CHTSRCTTVL DPLTNFYQIN TTSVLCDIHC EANQEYEHPR DLAACCGSCR
     NVSCLFTFPN GTTSLFLPGA SWIADCARHH CSSTPLGAVL VRSPISCPPL NETECAKVGG
     SVVPSLEGCC RTCKEDGRSC KKVTIRMTIR KNECRSSTPV NLVSCDGRCP SASIYNYNIN
     TYARFCKCCR EVGLQRRSVQ LFCATNATWV PYTVQEPTDC ACQWS
//