Q6ZRI0 (OTOG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Otogelin

Gene names

Name:	OTOG
Synonyms:	OTGN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2925 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes By similarity.
Subcellular location	Apical cell membrane; Peripheral membrane protein; Extracellular side By similarity. Secreted › extracellular space By similarity. Note: Found in fiber-like structures during the maturation process of the tectorial membrane By similarity.
Post-translational modification	N-glycosylated By similarity. Not O-glycosylated By similarity.
Sequence similarities	Belongs to the otogelin family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 EGF-like domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 4 VWFD domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-arabinose metabolic process Inferred from electronic annotation. Source: InterPro adult locomotory behavior Inferred from electronic annotation. Source: Compara sensory perception of sound Inferred from electronic annotation. Source: Compara
Cellular_component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell proteinaceous extracellular matrix Inferred from electronic annotation. Source: Compara
Molecular_function	alpha-N-arabinofuranosidase activity Inferred from electronic annotation. Source: InterPro structural molecule activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6ZRI0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q6ZRI0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-985: Missing.
     986-1014: CTAYGDRHYRTFDGLPFDFVGACKVHLVK → MFPARGVPLHLEGEGVFPWGPGDVSLPYL
     1240-1249: PYDCDFFNKV → L
     2434-2575: Missing.
     2644-2644: E → G
     2645-2925: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 2925	2903	Otogelin		PRO_0000312148
Regions
	Domain	102 – 139	38	EGF-like
	Domain	151 – 353	203	VWFD 1
	Domain	513 – 727	215	VWFD 2
	Domain	768 – 832	65	TIL
	Domain	985 – 1187	203	VWFD 3
	Domain	2111 – 2323	213	VWFD 4
	Domain	2840 – 2925	86	CTCK
	Compositional bias	1482 – 1880	399	Pro-rich
	Compositional bias	2499 – 2647	149	Cys-rich
Amino acid modifications
	Glycosylation	914	1	N-linked (GlcNAc...) Potential
	Glycosylation	1478	1	N-linked (GlcNAc...) Potential
	Glycosylation	1612	1	N-linked (GlcNAc...) Potential
	Disulfide bond	106 ↔ 120		By similarity
	Disulfide bond	114 ↔ ?126		By similarity
	Disulfide bond	128 ↔ 138		By similarity
	Disulfide bond	2840 ↔ 2889		By similarity
	Disulfide bond	2854 ↔ 2903		By similarity
	Disulfide bond	2865 ↔ 2920		By similarity
	Disulfide bond	2869 ↔ 2922		By similarity
Natural variations
	Alternative sequence	1 – 985	985	Missing in isoform 2.		VSP_029709
	Alternative sequence	986 – 1014	29	CTAYG…VHLVK → MFPARGVPLHLEGEGVFPWG PGDVSLPYL in isoform 2.		VSP_029710
	Alternative sequence	1240 – 1249	10	PYDCDFFNKV → L in isoform 2.		VSP_029711
	Alternative sequence	2434 – 2575	142	Missing in isoform 2.		VSP_029712
	Alternative sequence	2644	1	E → G in isoform 2.		VSP_029713
	Alternative sequence	2645 – 2925	281	Missing in isoform 2.		VSP_029714
	Natural variant	375	1	T → S. Corresponds to variant rs7130190 [ dbSNP | Ensembl ].		VAR_037406
	Natural variant	391	1	A → D. Corresponds to variant rs61611064 [ dbSNP | Ensembl ].		VAR_061161
	Natural variant	659	1	T → M. Corresponds to variant rs7112749 [ dbSNP | Ensembl ].		VAR_037407
	Natural variant	692	1	S → P. Corresponds to variant rs7106548 [ dbSNP | Ensembl ].		VAR_037408
	Natural variant	919	1	A → T. Corresponds to variant rs2355466 [ dbSNP | Ensembl ].		VAR_037409
	Natural variant	1075	1	R → Q. Corresponds to variant rs11024333 [ dbSNP | Ensembl ].		VAR_037410
	Natural variant	1112	1	A → V. Corresponds to variant rs7936324 [ dbSNP | Ensembl ].		VAR_037411
	Natural variant	1129	1	P → L. Corresponds to variant rs7936354 [ dbSNP | Ensembl ].		VAR_037412
	Natural variant	1399	1	A → G. Corresponds to variant rs4491195 [ dbSNP | Ensembl ].		VAR_037413
	Natural variant	1646	1	P → L. Corresponds to variant rs2041028 [ dbSNP | Ensembl ].		VAR_037414
	Natural variant	1832	1	A → V. Corresponds to variant rs1003490 [ dbSNP | Ensembl ].		VAR_037415
	Natural variant	1947	1	T → M. Corresponds to variant rs7111528 [ dbSNP | Ensembl ].		VAR_037416
	Natural variant	2006	1	A → V. Corresponds to variant rs11024341 [ dbSNP | Ensembl ].		VAR_047262
	Natural variant	2750	1	R → Q. Corresponds to variant rs12422210 [ dbSNP | Ensembl ].		VAR_037417
	Natural variant	2909	1	W → S. Corresponds to variant rs11024357 [ dbSNP | Ensembl ].		VAR_037418
Experimental info
	Sequence conflict	1375	1	A → P in BAC87330. Ref.1
	Sequence conflict	2121	1	V → A in BAC87330. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: D3555CAA3D9AE5FA	FASTA	2,925	314,794
	10 20 30 40 50 60 MGVLASALCW LLCVWLPWGE QAAESLRVQR LGERVVDSGR SGARGMRNVK GMRNGPAQTR 70 80 90 100 110 120 VSSSSSHQEA TLAMGDKATV VGGQQAEAPD SVAMSSWERR LHRAKCAPSY LFSCFNGGEC 130 140 150 160 170 180 VHPAFCDCRR FNATGPRCQM VYNAGPERDS ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG 190 200 210 220 230 240 RHEPEGQSFS IQVHNDPQCG SSPYTCSRAV SLFFVGEQEI HLAKEVTHGG MRVQLPHVMG 250 260 270 280 290 300 SARLQQLAGY VIVRHQSAFT LAWDGASAVY IKMSPELLGW THGLCGNNNA DPKDDLVTSS 310 320 330 340 350 360 GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC EALLRPPFDA 370 380 390 400 410 420 CHAYVSPLPF TASCTSDLCQ SMGDVATWCR ALAEYARACA QAGRPLQGWR TQLRQCTVHC 430 440 450 460 470 480 KEKAFTYNEC IACCPASCHP RASCVDSEIA CVDGCYCPNG LIFEDGGCVA PAECPCEFHG 490 500 510 520 530 540 TLYPPGSVVK EDCNTCTCTS GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL 550 560 570 580 590 600 AKSRSSGTFT VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDV LLFDQYKIIP 610 620 630 640 650 660 PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG LCGTFNGNTQ 670 680 690 700 710 720 DDFLSPVGVP ESTPQLFGNS WKTLSACSPL VSGSPLDPCD VHLQAASYSV QACSVLTGEM 730 740 750 760 770 780 FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC ATLAHYAHLC RRHGLPVDFR ARLPACALSC 790 800 810 820 830 840 EASKEYSPCV APCGRTCQDL ASPEACGVDG GDDLSRDECV EGCACPPDTY LDTQADLCVP 850 860 870 880 890 900 RNQCSCHFQG VDYPPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL 910 920 930 940 950 960 ELSRERTCEQ QLLNLSVSAR GPCLSGCACP QGLLRHGDAC FLPEECPCTW KGKEYFPGDQ 970 980 990 1000 1010 1020 VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL PFDFVGACKV HLVKSTSDVS 1030 1040 1050 1060 1070 1080 FSVIVENVNC YSSGMICRKF ISINVGNSLI VFDDDSGNPS PESFLDDKQE VHTWRVGFFT 1090 1100 1110 1120 1130 1140 LVHFPQEHIT LLWDQRTTVH VQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF 1150 1160 1170 1180 1190 1200 GSSWAAVECP DTLDPRDMCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD 1210 1220 1230 1240 1250 1260 TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCP YDCDFFNKVL GKGPYQLSSL 1270 1280 1290 1300 1310 1320 AAGGALVGMK AVGDDIVLVR TEDVAPADIV SFLLTAALYK AKAHDPDVVS LEAADRPNFF 1330 1340 1350 1360 1370 1380 LHVTANGSLE LAKWQGRDTF QQHASFLLHR GTRQAGLVAL ESLAKPSSFL YVSGAVLALR 1390 1400 1410 1420 1430 1440 LYEHTEVFRR GTLFRLLDAK PSGAAYPICE WRYDACASPC FQTCRDPRAA SCRDVPRVEG 1450 1460 1470 1480 1490 1500 CVPVCPTPQV LDEVTQRCVY LEDCVEPAVW VPTEALGNET LPPSQGLPTP SDEEPQLSQE 1510 1520 1530 1540 1550 1560 SPRTPTHRPA LTPAAPLTTA LNPPVTATEE PVVSPGPTQT TLQQPLELTA SQLPAGPTES 1570 1580 1590 1600 1610 1620 PASKGVTASL LAIPHTPESS SLPVALQTPT PGMVSGAMET TRVTVIFAGS PNITVSSRSP 1630 1640 1650 1660 1670 1680 PAPRFPLMTK AVTVRGHGSL PVRTTPPQPS LTASPSSRPV ASPGAISRSP TSSGSHKAVL 1690 1700 1710 1720 1730 1740 TPAVTKVISR TGVPQPTQAQ SASSPSTPLT VAGTAAEQVP VSPLATRSLE IVLSTEKGEA 1750 1760 1770 1780 1790 1800 GHSQPMGSPA SPQPHPLPSA PPRPAQHTTM ATRSPALPPE TPAAASLSTA TDGLAATPFM 1810 1820 1830 1840 1850 1860 SLESTRPSQL LSGLPPDTSL PLAKVGTSAP VATPGPKASV ITTPLQPQAT TLPAQTLSPV 1870 1880 1890 1900 1910 1920 LPFTPAAMTQ AHPPTHIAPP AAGTAPGLLL GATLPTSGVL PVAEGTASMV SVVPRKSTTG 1930 1940 1950 1960 1970 1980 KVAILSKQVS LPTSMYGSAE GGPTELTPAT SHPLTPLVAE PEGAQAGTAL PVPTSYALSR 1990 2000 2010 2020 2030 2040 VSARTAPQDS MLVLLPQLAE AHGTSAGPHL AAEPVDEATT EPSGRSAPAL SIVEGLAEAL 2050 2060 2070 2080 2090 2100 ATTTEANTST TCVPIAEQDC VRHICLEGQL IRVNQSQHCP QGAAPPRCGI LGLAVRVGGD 2110 2120 2130 2140 2150 2160 RCCPLWECAC RCSIFPDLSF VTFDGSHVAL FKEAIYILSQ SPDEMLTVHV LDCKSANLGH 2170 2180 2190 2200 2210 2220 LNWPPFCLVM LNMTHLAHQV TIDRFNRKVT VDLQPVWPPV SRYGFRIEDT GHMYMILTPS 2230 2240 2250 2260 2270 2280 DIQIQWLHSS GLMIVEASKT SKAQGHGLCG ICDGDAANDL TLKDGSVVGG AEDPAPFLDS 2290 2300 2310 2320 2330 2340 WQVPSSLTSV GQTRFRPDSC ATTDCSPCLR MVSNRTFSAC HRFVPPESFC ELWIRDTKYV 2350 2360 2370 2380 2390 2400 QQPCVALTVY VAMCHKFHVC IEWRRSDYCP FLCSSDSTYQ ACVTACEPPK TCQDGILGPL 2410 2420 2430 2440 2450 2460 DPEHCQVLGE GCVCSEGTIL HRRHSALCIP EAKCACTDSM GVPRALGETW NSSLSGCCQH 2470 2480 2490 2500 2510 2520 QCQAPDTIVP VDLGCPSPRP ESCLRFGEVA LLLPTKDPCC LGTVCVCNQT LCEGLAPTCR 2530 2540 2550 2560 2570 2580 PGHRLLTHFQ EDSCCPSYSC ECDPDLCEAE LVPSCRQDQI LITGRLGDSC CTSYFCACGD 2590 2600 2610 2620 2630 2640 CPDSIPECQE GEALTVHRNT TELCCPLYQC VCENFRCPQV QCGLGTALVE VWSPDRCCPY 2650 2660 2670 2680 2690 2700 KSCECDCDTI PVPRCHLWEK SQLDEEFMHS VENVCGCAKY ECVKAPVCLS RELGVMQPGQ 2710 2720 2730 2740 2750 2760 TVVELSADGV CHTSRCTTVL DPLTNFYQIN TTSVLCDIHC EANQEYEHPR DLAACCGSCR 2770 2780 2790 2800 2810 2820 NVSCLFTFPN GTTSLFLPGA SWIADCARHH CSSTPLGAVL VRSPISCPPL NETECAKVGG 2830 2840 2850 2860 2870 2880 SVVPSLEGCC RTCKEDGRSC KKVTIRMTIR KNECRSSTPV NLVSCDGRCP SASIYNYNIN 2890 2900 2910 2920 TYARFCKCCR EVGLQRRSVQ LFCATNATWV PYTVQEPTDC ACQWS
	Isoform 2 [UniParc]. Checksum: CEFB9E9A41CE0FF2	FASTA	1,508	160,321
	10 20 30 40 50 60 MFPARGVPLH LEGEGVFPWG PGDVSLPYLS TSDVSFSVIV ENVNCYSSGM ICRKFISINV 70 80 90 100 110 120 GNSLIVFDDD SGNPSPESFL DDKQEVHTWR VGFFTLVHFP QEHITLLWDQ RTTVHVQAGP 130 140 150 160 170 180 QWQGQLAGLC GNFDLKTINE MRTPENLELT NPQEFGSSWA AVECPDTLDP RDMCVLNPLR 190 200 210 220 230 240 EPFAKKECSI LLSEVFEICH PVVDVTWFYS NCLTDTCGCS QGGDCECFCA SVSAYAHQCC 250 260 270 280 290 300 QHGVAVDWRT PRLCLLGKGP YQLSSLAAGG ALVGMKAVGD DIVLVRTEDV APADIVSFLL 310 320 330 340 350 360 TAALYKAKAH DPDVVSLEAA DRPNFFLHVT ANGSLELAKW QGRDTFQQHA SFLLHRGTRQ 370 380 390 400 410 420 AGLVALESLA KPSSFLYVSG AVLALRLYEH TEVFRRGTLF RLLDAKPSGA AYPICEWRYD 430 440 450 460 470 480 ACASPCFQTC RDPRAASCRD VPRVEGCVPV CPTPQVLDEV TQRCVYLEDC VEPAVWVPTE 490 500 510 520 530 540 ALGNETLPPS QGLPTPSDEE PQLSQESPRT PTHRPALTPA APLTTALNPP VTATEEPVVS 550 560 570 580 590 600 PGPTQTTLQQ PLELTASQLP AGPTESPASK GVTASLLAIP HTPESSSLPV ALQTPTPGMV 610 620 630 640 650 660 SGAMETTRVT VIFAGSPNIT VSSRSPPAPR FPLMTKAVTV RGHGSLPVRT TPPQPSLTAS 670 680 690 700 710 720 PSSRPVASPG AISRSPTSSG SHKAVLTPAV TKVISRTGVP QPTQAQSASS PSTPLTVAGT 730 740 750 760 770 780 AAEQVPVSPL ATRSLEIVLS TEKGEAGHSQ PMGSPASPQP HPLPSAPPRP AQHTTMATRS 790 800 810 820 830 840 PALPPETPAA ASLSTATDGL AATPFMSLES TRPSQLLSGL PPDTSLPLAK VGTSAPVATP 850 860 870 880 890 900 GPKASVITTP LQPQATTLPA QTLSPVLPFT PAAMTQAHPP THIAPPAAGT APGLLLGATL 910 920 930 940 950 960 PTSGVLPVAE GTASMVSVVP RKSTTGKVAI LSKQVSLPTS MYGSAEGGPT ELTPATSHPL 970 980 990 1000 1010 1020 TPLVAEPEGA QAGTALPVPT SYALSRVSAR TAPQDSMLVL LPQLAEAHGT SAGPHLAAEP 1030 1040 1050 1060 1070 1080 VDEATTEPSG RSAPALSIVE GLAEALATTT EANTSTTCVP IAEQDCVRHI CLEGQLIRVN 1090 1100 1110 1120 1130 1140 QSQHCPQGAA PPRCGILGLA VRVGGDRCCP LWECACRCSI FPDLSFVTFD GSHVALFKEA 1150 1160 1170 1180 1190 1200 IYILSQSPDE MLTVHVLDCK SANLGHLNWP PFCLVMLNMT HLAHQVTIDR FNRKVTVDLQ 1210 1220 1230 1240 1250 1260 PVWPPVSRYG FRIEDTGHMY MILTPSDIQI QWLHSSGLMI VEASKTSKAQ GHGLCGICDG 1270 1280 1290 1300 1310 1320 DAANDLTLKD GSVVGGAEDP APFLDSWQVP SSLTSVGQTR FRPDSCATTD CSPCLRMVSN 1330 1340 1350 1360 1370 1380 RTFSACHRFV PPESFCELWI RDTKYVQQPC VALTVYVAMC HKFHVCIEWR RSDYCPFLCS 1390 1400 1410 1420 1430 1440 SDSTYQACVT ACEPPKTCQD GILGPLDPEH CQVLGEGCVC SEGTILHRRH SALCIPEAKC 1450 1460 1470 1480 1490 1500 ACGDCPDSIP ECQEGEALTV HRNTTELCCP LYQCVCENFR CPQVQCGLGT ALVEVWSPDR CCPYKSCG

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.

[2]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128214 mRNA. Translation: BAC87330.1. AC124799 Genomic DNA. No translation available.
IPI	IPI00418765. IPI00853292.
RefSeq	XP_001717583.3. XM_001717531.3. XP_291816.8. XM_291816.8.
UniGene	Hs.688380.
3D structure databases
ProteinModelPortal	Q6ZRI0.
SMR	Q6ZRI0. Positions 418-474, 2371-2442, 2838-2923.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000382323.
PTM databases
PhosphoSite	Q6ZRI0.
Polymorphism databases
DMDM	215274227.
Proteomic databases
PaxDb	Q6ZRI0.
PRIDE	Q6ZRI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342528; ENSP00000341666; ENSG00000188162. ENST00000399391; ENSP00000382323; ENSG00000188162.
GeneID	340990.
KEGG	hsa:340990.
UCSC	uc001mnh.1. human.
Organism-specific databases
CTD	340990.
GeneCards	GC11P017530.
HGNC	HGNC:8516. OTOG.
MIM	604487. gene.
neXtProt	NX_Q6ZRI0.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOVERGEN	HBG108222.
InParanoid	Q6ZRI0.
OMA	PYFEQCR.
Gene expression databases
ArrayExpress	Q6ZRI0.
Bgee	Q6ZRI0.
CleanEx	HS_OTOG.
Genevestigator	Q6ZRI0.
Family and domain databases
InterPro	IPR007934. AbfB. IPR006207. Cys_knot_C. IPR000742. EG-like_dom. IPR002919. TIL_dom. IPR014853. Unchr_dom_Cys-rich. IPR001007. VWF_C. IPR001846. VWF_type-D. [Graphical view]
Pfam	PF05270. AbfB. 1 hit. PF08742. C8. 4 hits. PF01826. TIL. 1 hit. PF00094. VWD. 4 hits. [Graphical view]
SMART	SM00832. C8. 4 hits. SM00041. CT. 1 hit. SM00214. VWC. 2 hits. SM00216. VWD. 4 hits. [Graphical view]
SUPFAM	SSF110221. AbfB. 1 hit. SSF57567. Cysrich_TIL. 5 hits.
PROSITE	PS01225. CTCK_2. 1 hit. PS00022. EGF_1. False negative. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. PS51233. VWFD. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	340990.
NextBio	98054.
SOURCE	Search...

Entry information

Entry name

OTOG_HUMAN

Accession

Primary (citable) accession number: Q6ZRI0
Secondary accession number(s): A8MTX6, A8MUJ0, B7WPC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.