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Q6ZRI0

- OTOG_HUMAN

UniProt

Q6ZRI0 - OTOG_HUMAN

Protein

Otogelin

Gene

OTOG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes By similarity.By similarity

    GO - Molecular functioni

    1. alpha-L-arabinofuranosidase activity Source: InterPro
    2. structural molecule activity Source: Ensembl

    GO - Biological processi

    1. adult locomotory behavior Source: Ensembl
    2. L-arabinose metabolic process Source: InterPro
    3. sensory perception of sound Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Otogelin
    Gene namesi
    Name:OTOG
    Synonyms:OTGN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8516. OTOG.

    Subcellular locationi

    Apical cell membrane By similarity; Peripheral membrane protein By similarity; Extracellular side By similarity. Secretedextracellular space By similarity
    Note: Found in fiber-like structures during the maturation process of the tectorial membrane.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. cytosol Source: Ensembl
    3. extracellular space Source: UniProtKB-SubCell
    4. proteinaceous extracellular matrix Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Deafness, autosomal recessive, 18B (DFNB18B) [MIM:614945]: A form of non-syndromic deafness characterized by a moderate hearing impairment, which can be associated with vestibular dysfunction, and a flat to shallow "U" or slightly downsloping shaped audiograms.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2116 – 21161P → L in DFNB18B. 1 Publication
    VAR_069250

    Keywords - Diseasei

    Deafness, Disease mutation, Non-syndromic deafness

    Organism-specific databases

    MIMi614945. phenotype.
    Orphaneti90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 29252903OtogelinPRO_0000312148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi106 ↔ 120By similarity
    Disulfide bondi114 ↔ ?126By similarity
    Disulfide bondi128 ↔ 138By similarity
    Glycosylationi914 – 9141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1478 – 14781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1612 – 16121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi2840 ↔ 2889By similarity
    Disulfide bondi2854 ↔ 2903By similarity
    Disulfide bondi2865 ↔ 2920By similarity
    Disulfide bondi2869 ↔ 2922By similarity

    Post-translational modificationi

    N-glycosylated. Not O-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ6ZRI0.
    PRIDEiQ6ZRI0.

    PTM databases

    PhosphoSiteiQ6ZRI0.

    Expressioni

    Gene expression databases

    BgeeiQ6ZRI0.
    CleanExiHS_OTOG.
    GenevestigatoriQ6ZRI0.

    Interactioni

    Protein-protein interaction databases

    BioGridi131110. 1 interaction.
    STRINGi9606.ENSP00000382323.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZRI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini102 – 13938EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 353203VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini513 – 727215VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini768 – 83265TILAdd
    BLAST
    Domaini985 – 1187203VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2111 – 2323213VWFD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini2840 – 292586CTCKPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1482 – 1880399Pro-richAdd
    BLAST
    Compositional biasi2499 – 2647149Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the otogelin family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 4 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG108222.
    InParanoidiQ6ZRI0.
    OMAiPYFEQCR.
    PhylomeDBiQ6ZRI0.
    TreeFamiTF300299.

    Family and domain databases

    InterProiIPR007934. AbfB.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF05270. AbfB. 1 hit.
    PF08742. C8. 4 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view]
    SMARTiSM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 4 hits.
    [Graphical view]
    SUPFAMiSSF110221. SSF110221. 1 hit.
    SSF57567. SSF57567. 4 hits.
    PROSITEiPS01225. CTCK_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS51233. VWFD. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6ZRI0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVLASALCW LLCVWLPWGE QAAESLRVQR LGERVVDSGR SGARGMRNVK     50
    GMRNGPAQTR VSSSSSHQEA TLAMGDKATV VGGQQAEAPD SVAMSSWERR 100
    LHRAKCAPSY LFSCFNGGEC VHPAFCDCRR FNATGPRCQM VYNAGPERDS 150
    ICRAWGQHHV ETFDGLYYYL SGKGSYTLVG RHEPEGQSFS IQVHNDPQCG 200
    SSPYTCSRAV SLFFVGEQEI HLAKEVTHGG MRVQLPHVMG SARLQQLAGY 250
    VIVRHQSAFT LAWDGASAVY IKMSPELLGW THGLCGNNNA DPKDDLVTSS 300
    GKLTDDVVEF VHSWQEQAPN QPPGPTTSSL PRPPCLQQNP GTMQGVYEQC 350
    EALLRPPFDA CHAYVSPLPF TASCTSDLCQ SMGDVATWCR ALAEYARACA 400
    QAGRPLQGWR TQLRQCTVHC KEKAFTYNEC IACCPASCHP RASCVDSEIA 450
    CVDGCYCPNG LIFEDGGCVA PAECPCEFHG TLYPPGSVVK EDCNTCTCTS 500
    GKWECSTAVC PAECSVTGDI HFTTFDGRRY TFPATCQYIL AKSRSSGTFT 550
    VTLQNAPCGL NQDGACVQSV SVILHQDPRR QVTLTQAGDV LLFDQYKIIP 600
    PYTDDAFEIR RLSSVFLRVR TNVGVRVLYD REGLRLYLQV DQRWVEDTVG 650
    LCGTFNGNTQ DDFLSPVGVP ESTPQLFGNS WKTLSACSPL VSGSPLDPCD 700
    VHLQAASYSV QACSVLTGEM FAPCSAFLSP VPYFEQCRRD ACRCGQPCLC 750
    ATLAHYAHLC RRHGLPVDFR ARLPACALSC EASKEYSPCV APCGRTCQDL 800
    ASPEACGVDG GDDLSRDECV EGCACPPDTY LDTQADLCVP RNQCSCHFQG 850
    VDYPPGDSDI PSLGHCHCKD GVMSCDSRAP AAACPAGQVF VNCSDLHTDL 900
    ELSRERTCEQ QLLNLSVSAR GPCLSGCACP QGLLRHGDAC FLPEECPCTW 950
    KGKEYFPGDQ VMSPCHTCVC QRGSFQCTLH PCASTCTAYG DRHYRTFDGL 1000
    PFDFVGACKV HLVKSTSDVS FSVIVENVNC YSSGMICRKF ISINVGNSLI 1050
    VFDDDSGNPS PESFLDDKQE VHTWRVGFFT LVHFPQEHIT LLWDQRTTVH 1100
    VQAGPQWQGQ LAGLCGNFDL KTINEMRTPE NLELTNPQEF GSSWAAVECP 1150
    DTLDPRDMCV LNPLREPFAK KECSILLSEV FEICHPVVDV TWFYSNCLTD 1200
    TCGCSQGGDC ECFCASVSAY AHQCCQHGVA VDWRTPRLCP YDCDFFNKVL 1250
    GKGPYQLSSL AAGGALVGMK AVGDDIVLVR TEDVAPADIV SFLLTAALYK 1300
    AKAHDPDVVS LEAADRPNFF LHVTANGSLE LAKWQGRDTF QQHASFLLHR 1350
    GTRQAGLVAL ESLAKPSSFL YVSGAVLALR LYEHTEVFRR GTLFRLLDAK 1400
    PSGAAYPICE WRYDACASPC FQTCRDPRAA SCRDVPRVEG CVPVCPTPQV 1450
    LDEVTQRCVY LEDCVEPAVW VPTEALGNET LPPSQGLPTP SDEEPQLSQE 1500
    SPRTPTHRPA LTPAAPLTTA LNPPVTATEE PVVSPGPTQT TLQQPLELTA 1550
    SQLPAGPTES PASKGVTASL LAIPHTPESS SLPVALQTPT PGMVSGAMET 1600
    TRVTVIFAGS PNITVSSRSP PAPRFPLMTK AVTVRGHGSL PVRTTPPQPS 1650
    LTASPSSRPV ASPGAISRSP TSSGSHKAVL TPAVTKVISR TGVPQPTQAQ 1700
    SASSPSTPLT VAGTAAEQVP VSPLATRSLE IVLSTEKGEA GHSQPMGSPA 1750
    SPQPHPLPSA PPRPAQHTTM ATRSPALPPE TPAAASLSTA TDGLAATPFM 1800
    SLESTRPSQL LSGLPPDTSL PLAKVGTSAP VATPGPKASV ITTPLQPQAT 1850
    TLPAQTLSPV LPFTPAAMTQ AHPPTHIAPP AAGTAPGLLL GATLPTSGVL 1900
    PVAEGTASMV SVVPRKSTTG KVAILSKQVS LPTSMYGSAE GGPTELTPAT 1950
    SHPLTPLVAE PEGAQAGTAL PVPTSYALSR VSARTAPQDS MLVLLPQLAE 2000
    AHGTSAGPHL AAEPVDEATT EPSGRSAPAL SIVEGLAEAL ATTTEANTST 2050
    TCVPIAEQDC VRHICLEGQL IRVNQSQHCP QGAAPPRCGI LGLAVRVGGD 2100
    RCCPLWECAC RCSIFPDLSF VTFDGSHVAL FKEAIYILSQ SPDEMLTVHV 2150
    LDCKSANLGH LNWPPFCLVM LNMTHLAHQV TIDRFNRKVT VDLQPVWPPV 2200
    SRYGFRIEDT GHMYMILTPS DIQIQWLHSS GLMIVEASKT SKAQGHGLCG 2250
    ICDGDAANDL TLKDGSVVGG AEDPAPFLDS WQVPSSLTSV GQTRFRPDSC 2300
    ATTDCSPCLR MVSNRTFSAC HRFVPPESFC ELWIRDTKYV QQPCVALTVY 2350
    VAMCHKFHVC IEWRRSDYCP FLCSSDSTYQ ACVTACEPPK TCQDGILGPL 2400
    DPEHCQVLGE GCVCSEGTIL HRRHSALCIP EAKCACTDSM GVPRALGETW 2450
    NSSLSGCCQH QCQAPDTIVP VDLGCPSPRP ESCLRFGEVA LLLPTKDPCC 2500
    LGTVCVCNQT LCEGLAPTCR PGHRLLTHFQ EDSCCPSYSC ECDPDLCEAE 2550
    LVPSCRQDQI LITGRLGDSC CTSYFCACGD CPDSIPECQE GEALTVHRNT 2600
    TELCCPLYQC VCENFRCPQV QCGLGTALVE VWSPDRCCPY KSCECDCDTI 2650
    PVPRCHLWEK SQLDEEFMHS VENVCGCAKY ECVKAPVCLS RELGVMQPGQ 2700
    TVVELSADGV CHTSRCTTVL DPLTNFYQIN TTSVLCDIHC EANQEYEHPR 2750
    DLAACCGSCR NVSCLFTFPN GTTSLFLPGA SWIADCARHH CSSTPLGAVL 2800
    VRSPISCPPL NETECAKVGG SVVPSLEGCC RTCKEDGRSC KKVTIRMTIR 2850
    KNECRSSTPV NLVSCDGRCP SASIYNYNIN TYARFCKCCR EVGLQRRSVQ 2900
    LFCATNATWV PYTVQEPTDC ACQWS 2925

    Note: No experimental confirmation available.

    Length:2,925
    Mass (Da):314,794
    Last modified:November 25, 2008 - v3
    Checksum:iD3555CAA3D9AE5FA
    GO
    Isoform 2 (identifier: Q6ZRI0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-985: Missing.
         986-1014: CTAYGDRHYRTFDGLPFDFVGACKVHLVK → MFPARGVPLHLEGEGVFPWGPGDVSLPYL
         1240-1249: PYDCDFFNKV → L
         2434-2575: Missing.
         2644-2644: E → G
         2645-2925: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,508
    Mass (Da):160,321
    Checksum:iCEFB9E9A41CE0FF2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1375 – 13751A → P in BAC87330. (PubMed:14702039)Curated
    Sequence conflicti2121 – 21211V → A in BAC87330. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti375 – 3751T → S.
    Corresponds to variant rs7130190 [ dbSNP | Ensembl ].
    VAR_037406
    Natural varianti391 – 3911A → D.
    Corresponds to variant rs61611064 [ dbSNP | Ensembl ].
    VAR_061161
    Natural varianti659 – 6591T → M.
    Corresponds to variant rs7112749 [ dbSNP | Ensembl ].
    VAR_037407
    Natural varianti692 – 6921S → P.
    Corresponds to variant rs7106548 [ dbSNP | Ensembl ].
    VAR_037408
    Natural varianti919 – 9191A → T.
    Corresponds to variant rs2355466 [ dbSNP | Ensembl ].
    VAR_037409
    Natural varianti1075 – 10751R → Q.
    Corresponds to variant rs11024333 [ dbSNP | Ensembl ].
    VAR_037410
    Natural varianti1112 – 11121A → V.
    Corresponds to variant rs7936324 [ dbSNP | Ensembl ].
    VAR_037411
    Natural varianti1129 – 11291P → L.
    Corresponds to variant rs7936354 [ dbSNP | Ensembl ].
    VAR_037412
    Natural varianti1399 – 13991A → G.
    Corresponds to variant rs4491195 [ dbSNP | Ensembl ].
    VAR_037413
    Natural varianti1646 – 16461P → L.
    Corresponds to variant rs2041028 [ dbSNP | Ensembl ].
    VAR_037414
    Natural varianti1832 – 18321A → V.
    Corresponds to variant rs1003490 [ dbSNP | Ensembl ].
    VAR_037415
    Natural varianti1947 – 19471T → M.
    Corresponds to variant rs7111528 [ dbSNP | Ensembl ].
    VAR_037416
    Natural varianti2006 – 20061A → V.
    Corresponds to variant rs11024341 [ dbSNP | Ensembl ].
    VAR_047262
    Natural varianti2116 – 21161P → L in DFNB18B. 1 Publication
    VAR_069250
    Natural varianti2750 – 27501R → Q.
    Corresponds to variant rs12422210 [ dbSNP | Ensembl ].
    VAR_037417
    Natural varianti2909 – 29091W → S.
    Corresponds to variant rs11024357 [ dbSNP | Ensembl ].
    VAR_037418

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 985985Missing in isoform 2. 1 PublicationVSP_029709Add
    BLAST
    Alternative sequencei986 – 101429CTAYG…VHLVK → MFPARGVPLHLEGEGVFPWG PGDVSLPYL in isoform 2. 1 PublicationVSP_029710Add
    BLAST
    Alternative sequencei1240 – 124910PYDCDFFNKV → L in isoform 2. 1 PublicationVSP_029711
    Alternative sequencei2434 – 2575142Missing in isoform 2. 1 PublicationVSP_029712Add
    BLAST
    Alternative sequencei2644 – 26441E → G in isoform 2. 1 PublicationVSP_029713
    Alternative sequencei2645 – 2925281Missing in isoform 2. 1 PublicationVSP_029714Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128214 mRNA. Translation: BAC87330.1.
    AC124799 Genomic DNA. No translation available.
    CCDSiCCDS59225.1. [Q6ZRI0-1]
    RefSeqiNP_001264198.1. NM_001277269.1. [Q6ZRI0-1]
    UniGeneiHs.688380.

    Genome annotation databases

    EnsembliENST00000342528; ENSP00000341666; ENSG00000188162. [Q6ZRI0-2]
    ENST00000399391; ENSP00000382323; ENSG00000188162. [Q6ZRI0-1]
    GeneIDi340990.
    KEGGihsa:340990.
    UCSCiuc001mnh.1. human. [Q6ZRI0-2]
    uc031pzc.1. human. [Q6ZRI0-1]

    Polymorphism databases

    DMDMi215274227.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK128214 mRNA. Translation: BAC87330.1 .
    AC124799 Genomic DNA. No translation available.
    CCDSi CCDS59225.1. [Q6ZRI0-1 ]
    RefSeqi NP_001264198.1. NM_001277269.1. [Q6ZRI0-1 ]
    UniGenei Hs.688380.

    3D structure databases

    ProteinModelPortali Q6ZRI0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131110. 1 interaction.
    STRINGi 9606.ENSP00000382323.

    PTM databases

    PhosphoSitei Q6ZRI0.

    Polymorphism databases

    DMDMi 215274227.

    Proteomic databases

    PaxDbi Q6ZRI0.
    PRIDEi Q6ZRI0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342528 ; ENSP00000341666 ; ENSG00000188162 . [Q6ZRI0-2 ]
    ENST00000399391 ; ENSP00000382323 ; ENSG00000188162 . [Q6ZRI0-1 ]
    GeneIDi 340990.
    KEGGi hsa:340990.
    UCSCi uc001mnh.1. human. [Q6ZRI0-2 ]
    uc031pzc.1. human. [Q6ZRI0-1 ]

    Organism-specific databases

    CTDi 340990.
    GeneCardsi GC11P017530.
    HGNCi HGNC:8516. OTOG.
    MIMi 604487. gene.
    614945. phenotype.
    neXtProti NX_Q6ZRI0.
    Orphaneti 90636. Autosomal recessive nonsyndromic sensorineural deafness type DFNB.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG108222.
    InParanoidi Q6ZRI0.
    OMAi PYFEQCR.
    PhylomeDBi Q6ZRI0.
    TreeFami TF300299.

    Miscellaneous databases

    GenomeRNAii 340990.
    NextBioi 98054.
    PROi Q6ZRI0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6ZRI0.
    CleanExi HS_OTOG.
    Genevestigatori Q6ZRI0.

    Family and domain databases

    InterProi IPR007934. AbfB.
    IPR006207. Cys_knot_C.
    IPR000742. EG-like_dom.
    IPR002919. TIL_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF05270. AbfB. 1 hit.
    PF08742. C8. 4 hits.
    PF01826. TIL. 1 hit.
    PF00094. VWD. 4 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 4 hits.
    SM00041. CT. 1 hit.
    SM00214. VWC. 2 hits.
    SM00216. VWD. 4 hits.
    [Graphical view ]
    SUPFAMi SSF110221. SSF110221. 1 hit.
    SSF57567. SSF57567. 4 hits.
    PROSITEi PS01225. CTCK_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS51233. VWFD. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: VARIANT DFNB18B LEU-2116.

    Entry informationi

    Entry nameiOTOG_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZRI0
    Secondary accession number(s): A8MTX6, A8MUJ0, B7WPC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 88 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3