ID   CTSRG_HUMAN             Reviewed;        1159 AA.
AC   Q6ZRH7; A6NEG6; Q659E1;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 3.
DT   27-MAR-2024, entry version 138.
DE   RecName: Full=Cation channel sperm-associated auxiliary subunit gamma {ECO:0000312|HGNC:HGNC:25243};
DE   Flags: Precursor;
GN   Name=CATSPERG {ECO:0000312|HGNC:HGNC:25243}; Synonyms=C19orf15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, AND VARIANT PRO-29.
RC   TISSUE=Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- FUNCTION: Auxiliary component of the CatSper complex, a complex
CC       involved in sperm cell hyperactivation. Sperm cell hyperactivation is
CC       needed for sperm motility which is essential late in the preparation of
CC       sperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.
CC   -!- SUBUNIT: Component of the CatSper complex or CatSpermasome composed of
CC       the core pore-forming members CATSPER1, CATSPER2, CATSPER3 and CATSPER4
CC       as well as auxiliary members CATSPERB, CATSPERG, CATSPERD, CATSPERE,
CC       CATSPERZ, C2CD6/CATSPERT, TMEM249, TMEM262 and EFCAB9. HSPA1 may be an
CC       additional auxiliary complex member. The core complex members CATSPER1,
CC       CATSPER2, CATSPER3 and CATSPER4 form a heterotetrameric channel. The
CC       auxiliary CATSPERB, CATSPERG, CATSPERD and CATSPERE subunits form a
CC       pavilion-like structure over the pore which stabilizes the complex
CC       through interactions with CATSPER4, CATSPER3, CATSPER1 and CATSPER2
CC       respectively. TMEM262/CATSPERH interacts with CATSPERB, further
CC       stabilizing the complex. C2CD6/CATSPERT interacts at least with
CC       CATSPERD and is required for targeting the CatSper complex in the
CC       flagellar membrane. {ECO:0000250|UniProtKB:C6KI89}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane
CC       {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the CATSPERG family. {ECO:0000305}.
CC   -!- CAUTION: In mouse, Slco6c1 is an additional auxiliary subunit of the
CC       CatSper complex. It is unclear if the related SLCO6A1 protein performs
CC       the same role in non-rodent species. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC87333.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC005625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC026806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL133023; CAH56391.1; ALT_TERM; mRNA.
DR   EMBL; AK128220; BAC87333.1; ALT_INIT; mRNA.
DR   CCDS; CCDS12514.2; -.
DR   RefSeq; NP_067008.3; NM_021185.4.
DR   RefSeq; XP_005259171.1; XM_005259114.4.
DR   RefSeq; XP_005259172.1; XM_005259115.4.
DR   RefSeq; XP_006723371.1; XM_006723308.3.
DR   RefSeq; XP_006723374.1; XM_006723311.2.
DR   RefSeq; XP_011525476.1; XM_011527174.2.
DR   AlphaFoldDB; Q6ZRH7; -.
DR   SMR; Q6ZRH7; -.
DR   BioGRID; 121787; 4.
DR   STRING; 9606.ENSP00000386962; -.
DR   TCDB; 1.A.1.19.1; the voltage-gated ion channel (vic) superfamily.
DR   GlyCosmos; Q6ZRH7; 4 sites, No reported glycans.
DR   GlyGen; Q6ZRH7; 4 sites.
DR   iPTMnet; Q6ZRH7; -.
DR   PhosphoSitePlus; Q6ZRH7; -.
DR   BioMuta; CATSPERG; -.
DR   DMDM; 215274173; -.
DR   MassIVE; Q6ZRH7; -.
DR   MaxQB; Q6ZRH7; -.
DR   PaxDb; 9606-ENSP00000386962; -.
DR   PeptideAtlas; Q6ZRH7; -.
DR   ProteomicsDB; 68130; -.
DR   Antibodypedia; 30031; 24 antibodies from 12 providers.
DR   DNASU; 57828; -.
DR   Ensembl; ENST00000409235.8; ENSP00000386962.3; ENSG00000099338.23.
DR   GeneID; 57828; -.
DR   KEGG; hsa:57828; -.
DR   MANE-Select; ENST00000409235.8; ENSP00000386962.3; NM_021185.5; NP_067008.3.
DR   UCSC; uc002oih.5; human.
DR   AGR; HGNC:25243; -.
DR   CTD; 57828; -.
DR   GeneCards; CATSPERG; -.
DR   HGNC; HGNC:25243; CATSPERG.
DR   HPA; ENSG00000099338; Tissue enriched (testis).
DR   MIM; 613452; gene.
DR   neXtProt; NX_Q6ZRH7; -.
DR   OpenTargets; ENSG00000099338; -.
DR   PharmGKB; PA165393235; -.
DR   VEuPathDB; HostDB:ENSG00000099338; -.
DR   eggNOG; ENOG502QWAR; Eukaryota.
DR   GeneTree; ENSGT00390000014139; -.
DR   InParanoid; Q6ZRH7; -.
DR   OMA; SCSITWA; -.
DR   OrthoDB; 2916483at2759; -.
DR   PhylomeDB; Q6ZRH7; -.
DR   TreeFam; TF337337; -.
DR   PathwayCommons; Q6ZRH7; -.
DR   Reactome; R-HSA-1300642; Sperm Motility And Taxes.
DR   BioGRID-ORCS; 57828; 16 hits in 1143 CRISPR screens.
DR   ChiTaRS; CATSPERG; human.
DR   GenomeRNAi; 57828; -.
DR   Pharos; Q6ZRH7; Tdark.
DR   PRO; PR:Q6ZRH7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6ZRH7; Protein.
DR   Bgee; ENSG00000099338; Expressed in left testis and 98 other cell types or tissues.
DR   ExpressionAtlas; Q6ZRH7; baseline and differential.
DR   GO; GO:0036128; C:CatSper complex; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0097228; C:sperm principal piece; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR028246; CATSPERG.
DR   PANTHER; PTHR14327:SF1; CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA; 1.
DR   PANTHER; PTHR14327; CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA; 1.
DR   Pfam; PF15064; CATSPERG; 1.
DR   Genevisible; Q6ZRH7; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cilium; Developmental protein;
KW   Differentiation; Disulfide bond; Flagellum; Glycoprotein; Membrane;
KW   Reference proteome; Signal; Spermatogenesis; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..1159
FT                   /note="Cation channel sperm-associated auxiliary subunit
FT                   gamma"
FT                   /id="PRO_0000019565"
FT   TOPO_DOM        36..1065
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   TRANSMEM        1066..1087
FT                   /note="Helical"
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   TOPO_DOM        1088..1159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   REGION          1139..1159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        426
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        574
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        44..105
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        159..165
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        288..343
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        394..402
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        638..860
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        806..834
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        882..1046
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        909..918
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   DISULFID        1010..1016
FT                   /evidence="ECO:0000250|UniProtKB:C6KI89"
FT   VARIANT         29
FT                   /note="L -> P (in dbSNP:rs2302182)"
FT                   /evidence="ECO:0000269|PubMed:17974005"
FT                   /id="VAR_059631"
FT   VARIANT         650
FT                   /note="S -> R (in dbSNP:rs3745953)"
FT                   /id="VAR_059632"
FT   VARIANT         1137
FT                   /note="M -> T (in dbSNP:rs2286550)"
FT                   /id="VAR_059633"
FT   CONFLICT        310..319
FT                   /note="RQNQLVYYFT -> HQLQGLLSRG (in Ref. 3; BAC87333)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        943
FT                   /note="Q -> R (in Ref. 3; BAC87333)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1159 AA;  133032 MW;  6D11F84445A09CDF CRC64;
     MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL NEFKRVGESG
     VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK INYSCEEKPS EDLVRMGHLT
     GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA APFRSKEPCM AEEVCSMSWY TPMPIKKGSV
     VMRVDISSNG LGTFIPDKRF QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL
     WHTVDQSPVL ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
     IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV YFHSNGSEYI
     MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT TCSIIWSEYI AGEYTLLLLV
     ESGYGNASKR FQVVSYNTAS DDLELLYHIP EFIPEARGLE FLMILGTESY TSTAMAPKGI
     FCNPYNNLIF IWGNFLLQSS NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL
     LEGSYRVYQL FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
     LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS PQRYTRQERY
     RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY ADPVHDPTWR WWANNKQDQD
     YYFFLASNWR SAGGVSIEMD SYEKIYNLES AYELPERIFL DKGTEYSFAI FLSAQGHSFR
     TQSELGTAFQ LHSQVDVGVV LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS
     GHHLMETSMT VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
     LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV VGGGPTLDSL
     KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS HESPGIEWLC LENAPCYDNV
     PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL TFLLHIHGLP LSPKRALFII MVSASVFVGL
     VIFYIAFCLL WPLVVKGCTM IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS
     RMTEDRAEPK EAVERQLMT
//