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Protein

Cation channel sperm-associated protein subunit gamma

Gene

CATSPERG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1300642 Sperm Motility And Taxes

Protein family/group databases

TCDBi1.A.1.19.1 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit gamma
Gene namesi
Name:CATSPERG
Synonyms:C19orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099338.22
HGNCiHGNC:25243 CATSPERG
MIMi613452 gene
neXtProtiNX_Q6ZRH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 1066ExtracellularSequence analysisAdd BLAST1031
Transmembranei1067 – 1087HelicalSequence analysisAdd BLAST21
Topological domaini1088 – 1159CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000099338
PharmGKBiPA165393235

Polymorphism and mutation databases

BioMutaiCATSPERG
DMDMi215274173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000001956536 – 1159Cation channel sperm-associated protein subunit gammaAdd BLAST1124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZRH7
PaxDbiQ6ZRH7
PeptideAtlasiQ6ZRH7
PRIDEiQ6ZRH7

PTM databases

iPTMnetiQ6ZRH7
PhosphoSitePlusiQ6ZRH7

Expressioni

Gene expression databases

BgeeiENSG00000099338
CleanExiHS_C19orf15
ExpressionAtlasiQ6ZRH7 baseline and differential
GenevisibleiQ6ZRH7 HS

Organism-specific databases

HPAiHPA052777

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

BioGridi121787, 1 interactor
STRINGi9606.ENSP00000386962

Structurei

3D structure databases

ProteinModelPortaliQ6ZRH7
SMRiQ6ZRH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERG family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGN7 Eukaryota
ENOG411294J LUCA
GeneTreeiENSGT00390000014139
HOGENOMiHOG000089987
InParanoidiQ6ZRH7
KOiK16894
OMAiQGNLMVP
OrthoDBiEOG091G00WW
PhylomeDBiQ6ZRH7
TreeFamiTF337337

Family and domain databases

InterProiView protein in InterPro
IPR028246 CATSPERG
PANTHERiPTHR14327 PTHR14327, 1 hit
PfamiView protein in Pfam
PF15064 CATSPERG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZRH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL
60 70 80 90 100
NEFKRVGESG VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK
110 120 130 140 150
INYSCEEKPS EDLVRMGHLT GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA
160 170 180 190 200
APFRSKEPCM AEEVCSMSWY TPMPIKKGSV VMRVDISSNG LGTFIPDKRF
210 220 230 240 250
QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL WHTVDQSPVL
260 270 280 290 300
ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
310 320 330 340 350
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV
360 370 380 390 400
YFHSNGSEYI MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT
410 420 430 440 450
TCSIIWSEYI AGEYTLLLLV ESGYGNASKR FQVVSYNTAS DDLELLYHIP
460 470 480 490 500
EFIPEARGLE FLMILGTESY TSTAMAPKGI FCNPYNNLIF IWGNFLLQSS
510 520 530 540 550
NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL LEGSYRVYQL
560 570 580 590 600
FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
610 620 630 640 650
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS
660 670 680 690 700
PQRYTRQERY RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY
710 720 730 740 750
ADPVHDPTWR WWANNKQDQD YYFFLASNWR SAGGVSIEMD SYEKIYNLES
760 770 780 790 800
AYELPERIFL DKGTEYSFAI FLSAQGHSFR TQSELGTAFQ LHSQVDVGVV
810 820 830 840 850
LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS GHHLMETSMT
860 870 880 890 900
VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
910 920 930 940 950
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV
960 970 980 990 1000
VGGGPTLDSL KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS
1010 1020 1030 1040 1050
HESPGIEWLC LENAPCYDNV PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL
1060 1070 1080 1090 1100
TFLLHIHGLP LSPKRALFII MVSASVFVGL VIFYIAFCLL WPLVVKGCTM
1110 1120 1130 1140 1150
IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS RMTEDRAEPK

EAVERQLMT
Length:1,159
Mass (Da):133,032
Last modified:November 25, 2008 - v3
Checksum:i6D11F84445A09CDF
GO

Sequence cautioni

The sequence BAC87333 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti310 – 319RQNQLVYYFT → HQLQGLLSRG in BAC87333 (PubMed:14702039).Curated10
Sequence conflicti943Q → R in BAC87333 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05963129L → P1 PublicationCorresponds to variant dbSNP:rs2302182Ensembl.1
Natural variantiVAR_059632650S → R. Corresponds to variant dbSNP:rs3745953Ensembl.1
Natural variantiVAR_0596331137M → T. Corresponds to variant dbSNP:rs2286550Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005625 Genomic DNA No translation available.
AC005789 Genomic DNA No translation available.
AC026806 Genomic DNA No translation available.
AL133023 mRNA Translation: CAH56391.1 Different termination.
AK128220 mRNA Translation: BAC87333.1 Different initiation.
CCDSiCCDS12514.2
RefSeqiNP_067008.3, NM_021185.4
XP_005259171.1, XM_005259114.4
XP_005259172.1, XM_005259115.4
XP_006723371.1, XM_006723308.3
XP_006723374.1, XM_006723311.2
XP_011525476.1, XM_011527174.2
UniGeneiHs.324335

Genome annotation databases

EnsembliENST00000409235; ENSP00000386962; ENSG00000099338
GeneIDi57828
KEGGihsa:57828
UCSCiuc002oih.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTSRG_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRH7
Secondary accession number(s): A6NEG6, Q659E1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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