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Q6ZRH7

- CTSRG_HUMAN

UniProt

Q6ZRH7 - CTSRG_HUMAN

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Protein

Cation channel sperm-associated protein subunit gamma

Gene

CATSPERG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity).By similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. multicellular organism reproduction Source: Reactome
  4. single fertilization Source: Reactome
  5. spermatogenesis Source: UniProtKB-KW
  6. sperm-egg recognition Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_163875. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit gamma
Gene namesi
Name:CATSPERG
Synonyms:C19orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25243. CATSPERG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 10661031ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1067 – 108721HelicalSequence AnalysisAdd
BLAST
Topological domaini1088 – 115972CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. CatSper complex Source: UniProtKB
  2. plasma membrane Source: Reactome
  3. sperm principal piece Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 11591124Cation channel sperm-associated protein subunit gammaPRO_0000019565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZRH7.
PaxDbiQ6ZRH7.
PRIDEiQ6ZRH7.

PTM databases

PhosphoSiteiQ6ZRH7.

Expressioni

Gene expression databases

BgeeiQ6ZRH7.
CleanExiHS_C19orf15.
ExpressionAtlasiQ6ZRH7. baseline and differential.
GenevestigatoriQ6ZRH7.

Organism-specific databases

HPAiHPA052777.

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

BioGridi121787. 2 interactions.
STRINGi9606.ENSP00000386950.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERG family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28628.
GeneTreeiENSGT00390000014139.
HOGENOMiHOG000089987.
InParanoidiQ6ZRH7.
KOiK16894.
OMAiTEEIWYL.
PhylomeDBiQ6ZRH7.
TreeFamiTF337337.

Family and domain databases

InterProiIPR028246. CATSPERG.
[Graphical view]
PANTHERiPTHR14327. PTHR14327. 1 hit.
PfamiPF15064. CATSPERG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZRH7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL
60 70 80 90 100
NEFKRVGESG VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK
110 120 130 140 150
INYSCEEKPS EDLVRMGHLT GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA
160 170 180 190 200
APFRSKEPCM AEEVCSMSWY TPMPIKKGSV VMRVDISSNG LGTFIPDKRF
210 220 230 240 250
QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL WHTVDQSPVL
260 270 280 290 300
ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT
310 320 330 340 350
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV
360 370 380 390 400
YFHSNGSEYI MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT
410 420 430 440 450
TCSIIWSEYI AGEYTLLLLV ESGYGNASKR FQVVSYNTAS DDLELLYHIP
460 470 480 490 500
EFIPEARGLE FLMILGTESY TSTAMAPKGI FCNPYNNLIF IWGNFLLQSS
510 520 530 540 550
NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL LEGSYRVYQL
560 570 580 590 600
FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ
610 620 630 640 650
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS
660 670 680 690 700
PQRYTRQERY RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY
710 720 730 740 750
ADPVHDPTWR WWANNKQDQD YYFFLASNWR SAGGVSIEMD SYEKIYNLES
760 770 780 790 800
AYELPERIFL DKGTEYSFAI FLSAQGHSFR TQSELGTAFQ LHSQVDVGVV
810 820 830 840 850
LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS GHHLMETSMT
860 870 880 890 900
VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR
910 920 930 940 950
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV
960 970 980 990 1000
VGGGPTLDSL KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS
1010 1020 1030 1040 1050
HESPGIEWLC LENAPCYDNV PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL
1060 1070 1080 1090 1100
TFLLHIHGLP LSPKRALFII MVSASVFVGL VIFYIAFCLL WPLVVKGCTM
1110 1120 1130 1140 1150
IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS RMTEDRAEPK

EAVERQLMT
Length:1,159
Mass (Da):133,032
Last modified:November 25, 2008 - v3
Checksum:i6D11F84445A09CDF
GO

Sequence cautioni

The sequence BAC87333.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 31910RQNQLVYYFT → HQLQGLLSRG in BAC87333. (PubMed:14702039)Curated
Sequence conflicti943 – 9431Q → R in BAC87333. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291L → P.1 Publication
Corresponds to variant rs2302182 [ dbSNP | Ensembl ].
VAR_059631
Natural varianti650 – 6501S → R.
Corresponds to variant rs3745953 [ dbSNP | Ensembl ].
VAR_059632
Natural varianti1137 – 11371M → T.
Corresponds to variant rs2286550 [ dbSNP | Ensembl ].
VAR_059633

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005625 Genomic DNA. No translation available.
AC005789 Genomic DNA. No translation available.
AC026806 Genomic DNA. No translation available.
AL133023 mRNA. Translation: CAH56391.1. Different termination.
AK128220 mRNA. Translation: BAC87333.1. Different initiation.
CCDSiCCDS12514.2.
RefSeqiNP_067008.3. NM_021185.4.
XP_005259171.1. XM_005259114.2.
XP_005259172.1. XM_005259115.2.
XP_006723371.1. XM_006723308.1.
XP_006723372.1. XM_006723309.1.
XP_006723374.1. XM_006723311.1.
UniGeneiHs.324335.

Genome annotation databases

EnsembliENST00000409235; ENSP00000386962; ENSG00000099338.
GeneIDi57828.
KEGGihsa:57828.
UCSCiuc002oif.4. human.

Polymorphism databases

DMDMi215274173.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005625 Genomic DNA. No translation available.
AC005789 Genomic DNA. No translation available.
AC026806 Genomic DNA. No translation available.
AL133023 mRNA. Translation: CAH56391.1 . Different termination.
AK128220 mRNA. Translation: BAC87333.1 . Different initiation.
CCDSi CCDS12514.2.
RefSeqi NP_067008.3. NM_021185.4.
XP_005259171.1. XM_005259114.2.
XP_005259172.1. XM_005259115.2.
XP_006723371.1. XM_006723308.1.
XP_006723372.1. XM_006723309.1.
XP_006723374.1. XM_006723311.1.
UniGenei Hs.324335.

3D structure databases

ProteinModelPortali Q6ZRH7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121787. 2 interactions.
STRINGi 9606.ENSP00000386950.

Protein family/group databases

TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q6ZRH7.

Polymorphism databases

DMDMi 215274173.

Proteomic databases

MaxQBi Q6ZRH7.
PaxDbi Q6ZRH7.
PRIDEi Q6ZRH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409235 ; ENSP00000386962 ; ENSG00000099338 .
GeneIDi 57828.
KEGGi hsa:57828.
UCSCi uc002oif.4. human.

Organism-specific databases

CTDi 57828.
GeneCardsi GC19P038826.
H-InvDB HIX0015091.
HGNCi HGNC:25243. CATSPERG.
HPAi HPA052777.
MIMi 613452. gene.
neXtProti NX_Q6ZRH7.
PharmGKBi PA165393235.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28628.
GeneTreei ENSGT00390000014139.
HOGENOMi HOG000089987.
InParanoidi Q6ZRH7.
KOi K16894.
OMAi TEEIWYL.
PhylomeDBi Q6ZRH7.
TreeFami TF337337.

Enzyme and pathway databases

Reactomei REACT_163875. Sperm Motility And Taxes.

Miscellaneous databases

GenomeRNAii 57828.
NextBioi 64815.
PROi Q6ZRH7.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZRH7.
CleanExi HS_C19orf15.
ExpressionAtlasi Q6ZRH7. baseline and differential.
Genevestigatori Q6ZRH7.

Family and domain databases

InterProi IPR028246. CATSPERG.
[Graphical view ]
PANTHERi PTHR14327. PTHR14327. 1 hit.
Pfami PF15064. CATSPERG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, VARIANT PRO-29.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
    Tissue: Testis.

Entry informationi

Entry nameiCTSRG_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRH7
Secondary accession number(s): A6NEG6, Q659E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3