SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6ZRH7

- CTSRG_HUMAN

UniProt

Q6ZRH7 - CTSRG_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Cation channel sperm-associated protein subunit gamma
Gene
CATSPERG, C19orf15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organism reproduction Source: Reactome
  3. multicellular organismal development Source: UniProtKB-KW
  4. single fertilization Source: Reactome
  5. sperm-egg recognition Source: Reactome
  6. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_163875. Sperm Motility And Taxes.

Protein family/group databases

TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit gamma
Gene namesi
Synonyms:C19orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25243. CATSPERG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini36 – 10661031Extracellular Reviewed prediction
Add
BLAST
Transmembranei1067 – 108721Helical; Reviewed prediction
Add
BLAST
Topological domaini1088 – 115972Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. CatSper complex Source: UniProtKB
  2. plasma membrane Source: Reactome
  3. sperm principal piece Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165393235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed prediction
Add
BLAST
Chaini36 – 11591124Cation channel sperm-associated protein subunit gamma
PRO_0000019565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi426 – 4261N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6ZRH7.
PRIDEiQ6ZRH7.

PTM databases

PhosphoSiteiQ6ZRH7.

Expressioni

Gene expression databases

ArrayExpressiQ6ZRH7.
BgeeiQ6ZRH7.
CleanExiHS_C19orf15.
GenevestigatoriQ6ZRH7.

Organism-specific databases

HPAiHPA052777.

Interactioni

Subunit structurei

Component of the CatSper complex By similarity.

Protein-protein interaction databases

BioGridi121787. 2 interactions.
STRINGi9606.ENSP00000386950.

Structurei

3D structure databases

ProteinModelPortaliQ6ZRH7.

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERG family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG28628.
HOGENOMiHOG000089987.
InParanoidiQ6ZRH7.
KOiK16894.
OMAiTEEIWYL.
PhylomeDBiQ6ZRH7.
TreeFamiTF337337.

Family and domain databases

InterProiIPR028246. CATSPERG.
[Graphical view]
PANTHERiPTHR14327. PTHR14327. 1 hit.
PfamiPF15064. CATSPERG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZRH7-1 [UniParc]FASTAAdd to Basket

« Hide

MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL     50
NEFKRVGESG VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK 100
INYSCEEKPS EDLVRMGHLT GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA 150
APFRSKEPCM AEEVCSMSWY TPMPIKKGSV VMRVDISSNG LGTFIPDKRF 200
QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL WHTVDQSPVL 250
ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT 300
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV 350
YFHSNGSEYI MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT 400
TCSIIWSEYI AGEYTLLLLV ESGYGNASKR FQVVSYNTAS DDLELLYHIP 450
EFIPEARGLE FLMILGTESY TSTAMAPKGI FCNPYNNLIF IWGNFLLQSS 500
NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL LEGSYRVYQL 550
FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ 600
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS 650
PQRYTRQERY RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY 700
ADPVHDPTWR WWANNKQDQD YYFFLASNWR SAGGVSIEMD SYEKIYNLES 750
AYELPERIFL DKGTEYSFAI FLSAQGHSFR TQSELGTAFQ LHSQVDVGVV 800
LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS GHHLMETSMT 850
VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR 900
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV 950
VGGGPTLDSL KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS 1000
HESPGIEWLC LENAPCYDNV PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL 1050
TFLLHIHGLP LSPKRALFII MVSASVFVGL VIFYIAFCLL WPLVVKGCTM 1100
IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS RMTEDRAEPK 1150
EAVERQLMT 1159
Length:1,159
Mass (Da):133,032
Last modified:November 25, 2008 - v3
Checksum:i6D11F84445A09CDF
GO

Sequence cautioni

The sequence BAC87333.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291L → P.1 Publication
Corresponds to variant rs2302182 [ dbSNP | Ensembl ].
VAR_059631
Natural varianti650 – 6501S → R.
Corresponds to variant rs3745953 [ dbSNP | Ensembl ].
VAR_059632
Natural varianti1137 – 11371M → T.
Corresponds to variant rs2286550 [ dbSNP | Ensembl ].
VAR_059633

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 31910RQNQLVYYFT → HQLQGLLSRG in BAC87333. 1 Publication
Sequence conflicti943 – 9431Q → R in BAC87333. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005625 Genomic DNA. No translation available.
AC005789 Genomic DNA. No translation available.
AC026806 Genomic DNA. No translation available.
AL133023 mRNA. Translation: CAH56391.1. Different termination.
AK128220 mRNA. Translation: BAC87333.1. Different initiation.
CCDSiCCDS12514.2.
RefSeqiNP_067008.3. NM_021185.4.
XP_005259171.1. XM_005259114.2.
XP_005259172.1. XM_005259115.2.
XP_006723371.1. XM_006723308.1.
XP_006723372.1. XM_006723309.1.
XP_006723374.1. XM_006723311.1.
UniGeneiHs.324335.

Genome annotation databases

EnsembliENST00000409235; ENSP00000386962; ENSG00000099338.
GeneIDi57828.
KEGGihsa:57828.
UCSCiuc002oif.4. human.

Polymorphism databases

DMDMi215274173.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC005625 Genomic DNA. No translation available.
AC005789 Genomic DNA. No translation available.
AC026806 Genomic DNA. No translation available.
AL133023 mRNA. Translation: CAH56391.1 . Different termination.
AK128220 mRNA. Translation: BAC87333.1 . Different initiation.
CCDSi CCDS12514.2.
RefSeqi NP_067008.3. NM_021185.4.
XP_005259171.1. XM_005259114.2.
XP_005259172.1. XM_005259115.2.
XP_006723371.1. XM_006723308.1.
XP_006723372.1. XM_006723309.1.
XP_006723374.1. XM_006723311.1.
UniGenei Hs.324335.

3D structure databases

ProteinModelPortali Q6ZRH7.
ModBasei Search...

Protein-protein interaction databases

BioGridi 121787. 2 interactions.
STRINGi 9606.ENSP00000386950.

Protein family/group databases

TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q6ZRH7.

Polymorphism databases

DMDMi 215274173.

Proteomic databases

PaxDbi Q6ZRH7.
PRIDEi Q6ZRH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000409235 ; ENSP00000386962 ; ENSG00000099338 .
GeneIDi 57828.
KEGGi hsa:57828.
UCSCi uc002oif.4. human.

Organism-specific databases

CTDi 57828.
GeneCardsi GC19P038826.
H-InvDB HIX0015091.
HGNCi HGNC:25243. CATSPERG.
HPAi HPA052777.
MIMi 613452. gene.
neXtProti NX_Q6ZRH7.
PharmGKBi PA165393235.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG28628.
HOGENOMi HOG000089987.
InParanoidi Q6ZRH7.
KOi K16894.
OMAi TEEIWYL.
PhylomeDBi Q6ZRH7.
TreeFami TF337337.

Enzyme and pathway databases

Reactomei REACT_163875. Sperm Motility And Taxes.

Miscellaneous databases

GenomeRNAii 57828.
NextBioi 64815.
PROi Q6ZRH7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6ZRH7.
Bgeei Q6ZRH7.
CleanExi HS_C19orf15.
Genevestigatori Q6ZRH7.

Family and domain databases

InterProi IPR028246. CATSPERG.
[Graphical view ]
PANTHERi PTHR14327. PTHR14327. 1 hit.
Pfami PF15064. CATSPERG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, VARIANT PRO-29.
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
    Tissue: Testis.

Entry informationi

Entry nameiCTSRG_HUMAN
AccessioniPrimary (citable) accession number: Q6ZRH7
Secondary accession number(s): A6NEG6, Q659E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi