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Q6ZRH7 (CTSRG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cation channel sperm-associated protein subunit gamma
Gene names
Name:CATSPERG
Synonyms:C19orf15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.

Subunit structure

Component of the CatSper complex By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the CATSPERG family.

Sequence caution

The sequence BAC87333.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3535 Potential
Chain36 – 11591124Cation channel sperm-associated protein subunit gamma
PRO_0000019565

Regions

Topological domain36 – 10661031Extracellular Potential
Transmembrane1067 – 108721Helical; Potential
Topological domain1088 – 115972Cytoplasmic Potential

Amino acid modifications

Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation4261N-linked (GlcNAc...) Potential

Natural variations

Natural variant291L → P. Ref.2
Corresponds to variant rs2302182 [ dbSNP | Ensembl ].
VAR_059631
Natural variant6501S → R.
Corresponds to variant rs3745953 [ dbSNP | Ensembl ].
VAR_059632
Natural variant11371M → T.
Corresponds to variant rs2286550 [ dbSNP | Ensembl ].
VAR_059633

Experimental info

Sequence conflict310 – 31910RQNQLVYYFT → HQLQGLLSRG in BAC87333. Ref.3
Sequence conflict9431Q → R in BAC87333. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6ZRH7 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 6D11F84445A09CDF

FASTA1,159133,032
        10         20         30         40         50         60 
MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL NEFKRVGESG 

        70         80         90        100        110        120 
VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK INYSCEEKPS EDLVRMGHLT 

       130        140        150        160        170        180 
GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA APFRSKEPCM AEEVCSMSWY TPMPIKKGSV 

       190        200        210        220        230        240 
VMRVDISSNG LGTFIPDKRF QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL 

       250        260        270        280        290        300 
WHTVDQSPVL ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT 

       310        320        330        340        350        360 
IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV YFHSNGSEYI 

       370        380        390        400        410        420 
MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT TCSIIWSEYI AGEYTLLLLV 

       430        440        450        460        470        480 
ESGYGNASKR FQVVSYNTAS DDLELLYHIP EFIPEARGLE FLMILGTESY TSTAMAPKGI 

       490        500        510        520        530        540 
FCNPYNNLIF IWGNFLLQSS NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL 

       550        560        570        580        590        600 
LEGSYRVYQL FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ 

       610        620        630        640        650        660 
LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS PQRYTRQERY 

       670        680        690        700        710        720 
RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY ADPVHDPTWR WWANNKQDQD 

       730        740        750        760        770        780 
YYFFLASNWR SAGGVSIEMD SYEKIYNLES AYELPERIFL DKGTEYSFAI FLSAQGHSFR 

       790        800        810        820        830        840 
TQSELGTAFQ LHSQVDVGVV LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS 

       850        860        870        880        890        900 
GHHLMETSMT VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR 

       910        920        930        940        950        960 
LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV VGGGPTLDSL 

       970        980        990       1000       1010       1020 
KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS HESPGIEWLC LENAPCYDNV 

      1030       1040       1050       1060       1070       1080 
PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL TFLLHIHGLP LSPKRALFII MVSASVFVGL 

      1090       1100       1110       1120       1130       1140 
VIFYIAFCLL WPLVVKGCTM IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS 

      1150 
RMTEDRAEPK EAVERQLMT 

« Hide

References

[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, VARIANT PRO-29.
Tissue: Testis.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC005625 Genomic DNA. No translation available.
AC005789 Genomic DNA. No translation available.
AC026806 Genomic DNA. No translation available.
AL133023 mRNA. Translation: CAH56391.1. Different termination.
AK128220 mRNA. Translation: BAC87333.1. Different initiation.
CCDSCCDS12514.2.
RefSeqNP_067008.3. NM_021185.4.
XP_005259171.1. XM_005259114.2.
XP_005259172.1. XM_005259115.2.
XP_006723371.1. XM_006723308.1.
XP_006723372.1. XM_006723309.1.
XP_006723374.1. XM_006723311.1.
UniGeneHs.324335.

3D structure databases

ProteinModelPortalQ6ZRH7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121787. 2 interactions.
STRING9606.ENSP00000386950.

Protein family/group databases

TCDB1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ6ZRH7.

Polymorphism databases

DMDM215274173.

Proteomic databases

PaxDbQ6ZRH7.
PRIDEQ6ZRH7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409235; ENSP00000386962; ENSG00000099338.
GeneID57828.
KEGGhsa:57828.
UCSCuc002oif.4. human.

Organism-specific databases

CTD57828.
GeneCardsGC19P038826.
H-InvDBHIX0015091.
HGNCHGNC:25243. CATSPERG.
HPAHPA052777.
MIM613452. gene.
neXtProtNX_Q6ZRH7.
PharmGKBPA165393235.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28628.
HOGENOMHOG000089987.
InParanoidQ6ZRH7.
KOK16894.
OMATEEIWYL.
PhylomeDBQ6ZRH7.
TreeFamTF337337.

Enzyme and pathway databases

ReactomeREACT_163848. Reproduction.

Gene expression databases

ArrayExpressQ6ZRH7.
BgeeQ6ZRH7.
CleanExHS_C19orf15.
GenevestigatorQ6ZRH7.

Family and domain databases

InterProIPR028246. CATSPERG.
[Graphical view]
PANTHERPTHR14327. PTHR14327. 1 hit.
PfamPF15064. CATSPERG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57828.
NextBio64815.
PROQ6ZRH7.
SOURCESearch...

Entry information

Entry nameCTSRG_HUMAN
AccessionPrimary (citable) accession number: Q6ZRH7
Secondary accession number(s): A6NEG6, Q659E1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 85 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM