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Q6ZRH7

- CTSRG_HUMAN

UniProt

Q6ZRH7 - CTSRG_HUMAN

Protein

Cation channel sperm-associated protein subunit gamma

Gene

CATSPERG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization By similarity.By similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. multicellular organismal development Source: UniProtKB-KW
    3. multicellular organism reproduction Source: Reactome
    4. single fertilization Source: Reactome
    5. spermatogenesis Source: UniProtKB-KW
    6. sperm-egg recognition Source: Reactome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_163875. Sperm Motility And Taxes.

    Protein family/group databases

    TCDBi1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cation channel sperm-associated protein subunit gamma
    Gene namesi
    Name:CATSPERG
    Synonyms:C19orf15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25243. CATSPERG.

    Subcellular locationi

    GO - Cellular componenti

    1. CatSper complex Source: UniProtKB
    2. plasma membrane Source: Reactome
    3. sperm principal piece Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165393235.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 11591124Cation channel sperm-associated protein subunit gammaPRO_0000019565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6ZRH7.
    PRIDEiQ6ZRH7.

    PTM databases

    PhosphoSiteiQ6ZRH7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6ZRH7.
    BgeeiQ6ZRH7.
    CleanExiHS_C19orf15.
    GenevestigatoriQ6ZRH7.

    Organism-specific databases

    HPAiHPA052777.

    Interactioni

    Subunit structurei

    Component of the CatSper complex.By similarity

    Protein-protein interaction databases

    BioGridi121787. 2 interactions.
    STRINGi9606.ENSP00000386950.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6ZRH7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini36 – 10661031ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1088 – 115972CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1067 – 108721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CATSPERG family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG28628.
    HOGENOMiHOG000089987.
    InParanoidiQ6ZRH7.
    KOiK16894.
    OMAiTEEIWYL.
    PhylomeDBiQ6ZRH7.
    TreeFamiTF337337.

    Family and domain databases

    InterProiIPR028246. CATSPERG.
    [Graphical view]
    PANTHERiPTHR14327. PTHR14327. 1 hit.
    PfamiPF15064. CATSPERG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6ZRH7-1 [UniParc]FASTAAdd to Basket

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    MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL     50
    NEFKRVGESG VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK 100
    INYSCEEKPS EDLVRMGHLT GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA 150
    APFRSKEPCM AEEVCSMSWY TPMPIKKGSV VMRVDISSNG LGTFIPDKRF 200
    QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL WHTVDQSPVL 250
    ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT 300
    IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV 350
    YFHSNGSEYI MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT 400
    TCSIIWSEYI AGEYTLLLLV ESGYGNASKR FQVVSYNTAS DDLELLYHIP 450
    EFIPEARGLE FLMILGTESY TSTAMAPKGI FCNPYNNLIF IWGNFLLQSS 500
    NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL LEGSYRVYQL 550
    FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ 600
    LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS 650
    PQRYTRQERY RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY 700
    ADPVHDPTWR WWANNKQDQD YYFFLASNWR SAGGVSIEMD SYEKIYNLES 750
    AYELPERIFL DKGTEYSFAI FLSAQGHSFR TQSELGTAFQ LHSQVDVGVV 800
    LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS GHHLMETSMT 850
    VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR 900
    LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV 950
    VGGGPTLDSL KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS 1000
    HESPGIEWLC LENAPCYDNV PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL 1050
    TFLLHIHGLP LSPKRALFII MVSASVFVGL VIFYIAFCLL WPLVVKGCTM 1100
    IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS RMTEDRAEPK 1150
    EAVERQLMT 1159
    Length:1,159
    Mass (Da):133,032
    Last modified:November 25, 2008 - v3
    Checksum:i6D11F84445A09CDF
    GO

    Sequence cautioni

    The sequence BAC87333.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 31910RQNQLVYYFT → HQLQGLLSRG in BAC87333. (PubMed:14702039)Curated
    Sequence conflicti943 – 9431Q → R in BAC87333. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291L → P.1 Publication
    Corresponds to variant rs2302182 [ dbSNP | Ensembl ].
    VAR_059631
    Natural varianti650 – 6501S → R.
    Corresponds to variant rs3745953 [ dbSNP | Ensembl ].
    VAR_059632
    Natural varianti1137 – 11371M → T.
    Corresponds to variant rs2286550 [ dbSNP | Ensembl ].
    VAR_059633

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005625 Genomic DNA. No translation available.
    AC005789 Genomic DNA. No translation available.
    AC026806 Genomic DNA. No translation available.
    AL133023 mRNA. Translation: CAH56391.1. Different termination.
    AK128220 mRNA. Translation: BAC87333.1. Different initiation.
    CCDSiCCDS12514.2.
    RefSeqiNP_067008.3. NM_021185.4.
    XP_005259171.1. XM_005259114.2.
    XP_005259172.1. XM_005259115.2.
    XP_006723371.1. XM_006723308.1.
    XP_006723372.1. XM_006723309.1.
    XP_006723374.1. XM_006723311.1.
    UniGeneiHs.324335.

    Genome annotation databases

    EnsembliENST00000409235; ENSP00000386962; ENSG00000099338.
    GeneIDi57828.
    KEGGihsa:57828.
    UCSCiuc002oif.4. human.

    Polymorphism databases

    DMDMi215274173.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC005625 Genomic DNA. No translation available.
    AC005789 Genomic DNA. No translation available.
    AC026806 Genomic DNA. No translation available.
    AL133023 mRNA. Translation: CAH56391.1 . Different termination.
    AK128220 mRNA. Translation: BAC87333.1 . Different initiation.
    CCDSi CCDS12514.2.
    RefSeqi NP_067008.3. NM_021185.4.
    XP_005259171.1. XM_005259114.2.
    XP_005259172.1. XM_005259115.2.
    XP_006723371.1. XM_006723308.1.
    XP_006723372.1. XM_006723309.1.
    XP_006723374.1. XM_006723311.1.
    UniGenei Hs.324335.

    3D structure databases

    ProteinModelPortali Q6ZRH7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121787. 2 interactions.
    STRINGi 9606.ENSP00000386950.

    Protein family/group databases

    TCDBi 1.A.1.19.1. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q6ZRH7.

    Polymorphism databases

    DMDMi 215274173.

    Proteomic databases

    PaxDbi Q6ZRH7.
    PRIDEi Q6ZRH7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409235 ; ENSP00000386962 ; ENSG00000099338 .
    GeneIDi 57828.
    KEGGi hsa:57828.
    UCSCi uc002oif.4. human.

    Organism-specific databases

    CTDi 57828.
    GeneCardsi GC19P038826.
    H-InvDB HIX0015091.
    HGNCi HGNC:25243. CATSPERG.
    HPAi HPA052777.
    MIMi 613452. gene.
    neXtProti NX_Q6ZRH7.
    PharmGKBi PA165393235.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG28628.
    HOGENOMi HOG000089987.
    InParanoidi Q6ZRH7.
    KOi K16894.
    OMAi TEEIWYL.
    PhylomeDBi Q6ZRH7.
    TreeFami TF337337.

    Enzyme and pathway databases

    Reactomei REACT_163875. Sperm Motility And Taxes.

    Miscellaneous databases

    GenomeRNAii 57828.
    NextBioi 64815.
    PROi Q6ZRH7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6ZRH7.
    Bgeei Q6ZRH7.
    CleanExi HS_C19orf15.
    Genevestigatori Q6ZRH7.

    Family and domain databases

    InterProi IPR028246. CATSPERG.
    [Graphical view ]
    PANTHERi PTHR14327. PTHR14327. 1 hit.
    Pfami PF15064. CATSPERG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-661, VARIANT PRO-29.
      Tissue: Testis.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-1159.
      Tissue: Testis.

    Entry informationi

    Entry nameiCTSRG_HUMAN
    AccessioniPrimary (citable) accession number: Q6ZRH7
    Secondary accession number(s): A6NEG6, Q659E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 87 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3