ID   ZN493_HUMAN             Reviewed;         646 AA.
AC   Q6ZR52; G5E974; Q59GM3; Q6ZSF6; Q8N1Z6; Q8N965; Q9BR99;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 3.
DT   27-MAR-2024, entry version 168.
DE   RecName: Full=Zinc finger protein 493;
GN   Name=ZNF493;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS PHE-195
RP   AND VAL-292.
RC   TISSUE=Brain, Kidney, Thalamus, and Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PHE-195.
RC   TISSUE=Brain;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT PHE-195.
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q6ZR52-3; Q9H3R5: CENPH; NbExp=3; IntAct=EBI-12856290, EBI-1003700;
CC       Q6ZR52-3; Q14696: MESD; NbExp=3; IntAct=EBI-12856290, EBI-6165891;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q6ZR52-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZR52-2; Sequence=VSP_038298;
CC       Name=3;
CC         IsoId=Q6ZR52-3; Sequence=VSP_046656, VSP_046657;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04591.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC86997.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAD92323.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK095616; BAC04591.1; ALT_INIT; mRNA.
DR   EMBL; AK127476; BAC86997.1; ALT_INIT; mRNA.
DR   EMBL; AK128494; BAC87465.1; -; mRNA.
DR   EMBL; AB209086; BAD92323.1; ALT_INIT; mRNA.
DR   EMBL; BX648842; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC010615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471106; EAW84898.1; -; Genomic_DNA.
DR   EMBL; BC006408; AAH06408.1; -; mRNA.
DR   CCDS; CCDS12411.1; -. [Q6ZR52-3]
DR   CCDS; CCDS12412.1; -. [Q6ZR52-1]
DR   CCDS; CCDS42536.1; -. [Q6ZR52-2]
DR   RefSeq; NP_001070146.1; NM_001076678.2. [Q6ZR52-2]
DR   RefSeq; NP_663299.2; NM_145326.2. [Q6ZR52-3]
DR   RefSeq; NP_787106.4; NM_175910.6. [Q6ZR52-1]
DR   AlphaFoldDB; Q6ZR52; -.
DR   SMR; Q6ZR52; -.
DR   BioGRID; 129880; 4.
DR   IntAct; Q6ZR52; 2.
DR   GlyGen; Q6ZR52; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6ZR52; -.
DR   PhosphoSitePlus; Q6ZR52; -.
DR   SwissPalm; Q6ZR52; -.
DR   BioMuta; ZNF493; -.
DR   DMDM; 145559547; -.
DR   jPOST; Q6ZR52; -.
DR   MassIVE; Q6ZR52; -.
DR   MaxQB; Q6ZR52; -.
DR   PaxDb; 9606-ENSP00000376110; -.
DR   PeptideAtlas; Q6ZR52; -.
DR   ProteomicsDB; 68112; -. [Q6ZR52-1]
DR   ProteomicsDB; 68113; -. [Q6ZR52-2]
DR   Antibodypedia; 55042; 61 antibodies from 12 providers.
DR   DNASU; 284443; -.
DR   Ensembl; ENST00000339914.6; ENSP00000340651.6; ENSG00000196268.12. [Q6ZR52-3]
DR   Ensembl; ENST00000355504.4; ENSP00000347691.4; ENSG00000196268.12. [Q6ZR52-1]
DR   Ensembl; ENST00000392288.7; ENSP00000376110.2; ENSG00000196268.12. [Q6ZR52-2]
DR   GeneID; 284443; -.
DR   KEGG; hsa:284443; -.
DR   MANE-Select; ENST00000392288.7; ENSP00000376110.2; NM_001076678.3; NP_001070146.1. [Q6ZR52-2]
DR   UCSC; uc002npu.4; human. [Q6ZR52-1]
DR   AGR; HGNC:23708; -.
DR   CTD; 284443; -.
DR   DisGeNET; 284443; -.
DR   GeneCards; ZNF493; -.
DR   HGNC; HGNC:23708; ZNF493.
DR   HPA; ENSG00000196268; Low tissue specificity.
DR   neXtProt; NX_Q6ZR52; -.
DR   OpenTargets; ENSG00000196268; -.
DR   PharmGKB; PA134932599; -.
DR   VEuPathDB; HostDB:ENSG00000196268; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000161765; -.
DR   HOGENOM; CLU_002678_17_1_1; -.
DR   InParanoid; Q6ZR52; -.
DR   OMA; RSSILXI; -.
DR   OrthoDB; 4625752at2759; -.
DR   PhylomeDB; Q6ZR52; -.
DR   TreeFam; TF343410; -.
DR   PathwayCommons; Q6ZR52; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q6ZR52; -.
DR   BioGRID-ORCS; 284443; 11 hits in 1141 CRISPR screens.
DR   ChiTaRS; ZNF493; human.
DR   GenomeRNAi; 284443; -.
DR   Pharos; Q6ZR52; Tdark.
DR   PRO; PR:Q6ZR52; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6ZR52; Protein.
DR   Bgee; ENSG00000196268; Expressed in visceral pleura and 187 other cell types or tissues.
DR   ExpressionAtlas; Q6ZR52; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 21.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR24399:SF66; NOVEL KRAB BOX AND ZINC FINGER, C2H2 TYPE DOMAIN CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR   Pfam; PF00096; zf-C2H2; 17.
DR   SMART; SM00355; ZnF_C2H2; 21.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 11.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 22.
DR   Genevisible; Q6ZR52; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..646
FT                   /note="Zinc finger protein 493"
FT                   /id="PRO_0000047616"
FT   ZN_FING         26..48
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         54..76
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         82..104
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         109..131
FT                   /note="C2H2-type 4; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         137..159
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         165..187
FT                   /note="C2H2-type 6; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         193..215
FT                   /note="C2H2-type 7; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         221..243
FT                   /note="C2H2-type 8; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         249..271
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         277..299
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         305..327
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         333..355
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         361..383
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         389..411
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         417..439
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         445..467
FT                   /note="C2H2-type 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         473..495
FT                   /note="C2H2-type 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         501..523
FT                   /note="C2H2-type 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         529..551
FT                   /note="C2H2-type 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         557..579
FT                   /note="C2H2-type 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         585..607
FT                   /note="C2H2-type 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         613..635
FT                   /note="C2H2-type 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         1
FT                   /note="M -> MPGPPESLDMGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYR
FT                   NLVFLGIAVSKPDLVTCLEQGKDPWNMKGHSTVVKPPVICSHFAEDFCPGPGIKDSFQK
FT                   VILREYVKCGHKDLQLRKGCKSM (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17974005"
FT                   /id="VSP_038298"
FT   VAR_SEQ         1
FT                   /note="M -> MPGPPESLDMGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLENYR
FT                   NLVFLAGIAVSKPDLVTCLEQGKDPWNMKGHSTVVKPPVETGFHRFSQDGLYLLTS
FT                   (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_046656"
FT   VAR_SEQ         2..646
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_046657"
FT   VARIANT         195
FT                   /note="C -> F (in dbSNP:rs4621113)"
FT                   /evidence="ECO:0000269|PubMed:14702039,
FT                   ECO:0000269|PubMed:17974005, ECO:0000269|Ref.2"
FT                   /id="VAR_052846"
FT   VARIANT         292
FT                   /note="L -> V (in dbSNP:rs10414834)"
FT                   /evidence="ECO:0000269|PubMed:14702039"
FT                   /id="VAR_052847"
FT   CONFLICT        181
FT                   /note="T -> I (in Ref. 1; BAC87465)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="F -> L (in Ref. 1; BAC87465)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        335
FT                   /note="C -> R (in Ref. 1; BAC04591)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        448
FT                   /note="K -> E (in Ref. 2; BAD92323)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        547
FT                   /note="H -> Y (in Ref. 1; BAC86997)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        Q6ZR52-3:94
FT                   /note="S -> G (in Ref. 6; AAH06408)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   646 AA;  75342 MW;  F6F677DF4F48FF55 CRC64;
     MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG KKPFKCKKCG
     KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH RRVHTGEKSY KYECGKSFNQ
     DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS YLTRHKLIHT REKPYKCEQY GKTFNQSSTL
     TGHKIIHNGE KPYKCEECGK AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK
     RIHTGEKPYK CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT
     GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK HRIIHTEEKP
     YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR SSTLTIHKMI HTGEKPYKCE
     ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC GKSFSVFSTL TKHKIIHTDK KPYKCEECGK
     AFNRSSILSI HKKIHTGEKP YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI
     FSTLTKHKII HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL
     IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK
//