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Protein

Zinc finger protein 493

Gene

ZNF493

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 48C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 76C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33386-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 493
Gene namesi
Name:ZNF493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23708. ZNF493.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196268.
PharmGKBiPA134932599.

Polymorphism and mutation databases

BioMutaiZNF493.
DMDMi145559547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476161 – 646Zinc finger protein 493Add BLAST646

Proteomic databases

MaxQBiQ6ZR52.
PaxDbiQ6ZR52.
PeptideAtlasiQ6ZR52.
PRIDEiQ6ZR52.

PTM databases

iPTMnetiQ6ZR52.
PhosphoSitePlusiQ6ZR52.

Expressioni

Gene expression databases

BgeeiENSG00000196268.
CleanExiHS_ZNF493.
ExpressionAtlasiQ6ZR52. baseline and differential.
GenevisibleiQ6ZR52. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376110.

Structurei

3D structure databases

ProteinModelPortaliQ6ZR52.
SMRiQ6ZR52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri26 – 48C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri54 – 76C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri82 – 104C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri109 – 131C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri137 – 159C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 8; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZR52.
OMAiAFIWFST.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZR52.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 21 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZR52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG
60 70 80 90 100
KKPFKCKKCG KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH
110 120 130 140 150
RRVHTGEKSY KYECGKSFNQ DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS
160 170 180 190 200
YLTRHKLIHT REKPYKCEQY GKTFNQSSTL TGHKIIHNGE KPYKCEECGK
210 220 230 240 250
AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK RIHTGEKPYK
260 270 280 290 300
CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT
310 320 330 340 350
GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK
360 370 380 390 400
HRIIHTEEKP YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR
410 420 430 440 450
SSTLTIHKMI HTGEKPYKCE ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC
460 470 480 490 500
GKSFSVFSTL TKHKIIHTDK KPYKCEECGK AFNRSSILSI HKKIHTGEKP
510 520 530 540 550
YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI FSTLTKHKII
560 570 580 590 600
HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL
610 620 630 640
IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK
Length:646
Mass (Da):75,342
Last modified:April 17, 2007 - v3
Checksum:iF6F677DF4F48FF55
GO
Isoform 2 (identifier: Q6ZR52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...LQLRKGCKSM

Note: No experimental confirmation available.
Show »
Length:774
Mass (Da):89,824
Checksum:i35D56882C2BF4DC3
GO
Isoform 3 (identifier: Q6ZR52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...SQDGLYLLTS
     2-646: Missing.

Show »
Length:103
Mass (Da):11,659
Checksum:iBB6060D29B1DA22F
GO

Sequence cautioni

The sequence BAC04591 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86997 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92323 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti181T → I in BAC87465 (PubMed:14702039).Curated1
Sequence conflicti202F → L in BAC87465 (PubMed:14702039).Curated1
Sequence conflicti335C → R in BAC04591 (PubMed:14702039).Curated1
Sequence conflicti448K → E in BAD92323 (Ref. 2) Curated1
Sequence conflicti547H → Y in BAC86997 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q6ZR52-3)
Sequence conflicti94S → G in AAH06408 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052846195C → F.3 PublicationsCorresponds to variant rs4621113dbSNPEnsembl.1
Natural variantiVAR_052847292L → V.1 PublicationCorresponds to variant rs10414834dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0382981M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLGIAVSKPD LVTCLEQGKDPWNMKGHSTV VKPPVICSHFAEDFCPGPGI KDSFQKVILREYVKCGHKDL QLRKGCKSM in isoform 2. 1 Publication1
Alternative sequenceiVSP_0466561M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLAGIAVSKP DLVTCLEQGKDPWNMKGHST VVKPPVETGFHRFSQDGLYL LTS in isoform 3. 1 Publication1
Alternative sequenceiVSP_0466572 – 646Missing in isoform 3. 1 PublicationAdd BLAST645

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095616 mRNA. Translation: BAC04591.1. Different initiation.
AK127476 mRNA. Translation: BAC86997.1. Different initiation.
AK128494 mRNA. Translation: BAC87465.1.
AB209086 mRNA. Translation: BAD92323.1. Different initiation.
BX648842 mRNA. No translation available.
AC010615 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84898.1.
BC006408 mRNA. Translation: AAH06408.1.
CCDSiCCDS12411.1. [Q6ZR52-3]
CCDS12412.1. [Q6ZR52-1]
CCDS42536.1. [Q6ZR52-2]
RefSeqiNP_001070146.1. NM_001076678.2. [Q6ZR52-2]
NP_663299.2. NM_145326.2. [Q6ZR52-3]
NP_787106.4. NM_175910.6. [Q6ZR52-1]
UniGeneiHs.656558.

Genome annotation databases

EnsembliENST00000339914; ENSP00000340651; ENSG00000196268. [Q6ZR52-3]
ENST00000355504; ENSP00000347691; ENSG00000196268. [Q6ZR52-1]
ENST00000392288; ENSP00000376110; ENSG00000196268. [Q6ZR52-2]
GeneIDi284443.
KEGGihsa:284443.
UCSCiuc002npu.4. human. [Q6ZR52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095616 mRNA. Translation: BAC04591.1. Different initiation.
AK127476 mRNA. Translation: BAC86997.1. Different initiation.
AK128494 mRNA. Translation: BAC87465.1.
AB209086 mRNA. Translation: BAD92323.1. Different initiation.
BX648842 mRNA. No translation available.
AC010615 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84898.1.
BC006408 mRNA. Translation: AAH06408.1.
CCDSiCCDS12411.1. [Q6ZR52-3]
CCDS12412.1. [Q6ZR52-1]
CCDS42536.1. [Q6ZR52-2]
RefSeqiNP_001070146.1. NM_001076678.2. [Q6ZR52-2]
NP_663299.2. NM_145326.2. [Q6ZR52-3]
NP_787106.4. NM_175910.6. [Q6ZR52-1]
UniGeneiHs.656558.

3D structure databases

ProteinModelPortaliQ6ZR52.
SMRiQ6ZR52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376110.

PTM databases

iPTMnetiQ6ZR52.
PhosphoSitePlusiQ6ZR52.

Polymorphism and mutation databases

BioMutaiZNF493.
DMDMi145559547.

Proteomic databases

MaxQBiQ6ZR52.
PaxDbiQ6ZR52.
PeptideAtlasiQ6ZR52.
PRIDEiQ6ZR52.

Protocols and materials databases

DNASUi284443.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339914; ENSP00000340651; ENSG00000196268. [Q6ZR52-3]
ENST00000355504; ENSP00000347691; ENSG00000196268. [Q6ZR52-1]
ENST00000392288; ENSP00000376110; ENSG00000196268. [Q6ZR52-2]
GeneIDi284443.
KEGGihsa:284443.
UCSCiuc002npu.4. human. [Q6ZR52-1]

Organism-specific databases

CTDi284443.
GeneCardsiZNF493.
HGNCiHGNC:23708. ZNF493.
neXtProtiNX_Q6ZR52.
OpenTargetsiENSG00000196268.
PharmGKBiPA134932599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZR52.
OMAiAFIWFST.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZR52.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-33386-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii284443.
PROiQ6ZR52.

Gene expression databases

BgeeiENSG00000196268.
CleanExiHS_ZNF493.
ExpressionAtlasiQ6ZR52. baseline and differential.
GenevisibleiQ6ZR52. HS.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 21 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN493_HUMAN
AccessioniPrimary (citable) accession number: Q6ZR52
Secondary accession number(s): G5E974
, Q59GM3, Q6ZSF6, Q8N1Z6, Q8N965, Q9BR99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.