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Q6ZR52 (ZN493_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 493
Gene names
Name:ZNF493
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length646 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 22 C2H2-type zinc fingers.

Sequence caution

The sequence BAC04591.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC86997.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD92323.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZR52-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZR52-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...LQLRKGCKSM
Note: No experimental confirmation available.
Isoform 3 (identifier: Q6ZR52-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...SQDGLYLLTS
     2-646: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 646646Zinc finger protein 493
PRO_0000047616

Regions

Zinc finger26 – 4823C2H2-type 1; degenerate
Zinc finger54 – 7623C2H2-type 2
Zinc finger82 – 10423C2H2-type 3
Zinc finger109 – 13123C2H2-type 4; degenerate
Zinc finger137 – 15923C2H2-type 5
Zinc finger165 – 18723C2H2-type 6; degenerate
Zinc finger193 – 21523C2H2-type 7; degenerate
Zinc finger221 – 24323C2H2-type 8; degenerate
Zinc finger249 – 27123C2H2-type 9
Zinc finger277 – 29923C2H2-type 10
Zinc finger305 – 32723C2H2-type 11
Zinc finger333 – 35523C2H2-type 12
Zinc finger361 – 38323C2H2-type 13
Zinc finger389 – 41123C2H2-type 14
Zinc finger417 – 43923C2H2-type 15
Zinc finger445 – 46723C2H2-type 16
Zinc finger473 – 49523C2H2-type 17
Zinc finger501 – 52323C2H2-type 18
Zinc finger529 – 55123C2H2-type 19
Zinc finger557 – 57923C2H2-type 20
Zinc finger585 – 60723C2H2-type 21
Zinc finger613 – 63523C2H2-type 22

Natural variations

Alternative sequence11M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLGIAVSKPD LVTCLEQGKDPWNMKGHSTV VKPPVICSHFAEDFCPGPGI KDSFQKVILREYVKCGHKDL QLRKGCKSM in isoform 2.
VSP_038298
Alternative sequence11M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLAGIAVSKP DLVTCLEQGKDPWNMKGHST VVKPPVETGFHRFSQDGLYL LTS in isoform 3.
VSP_046656
Alternative sequence2 – 646645Missing in isoform 3.
VSP_046657
Natural variant1951C → F. Ref.1 Ref.2 Ref.3
Corresponds to variant rs4621113 [ dbSNP | Ensembl ].
VAR_052846
Natural variant2921L → V. Ref.1
Corresponds to variant rs10414834 [ dbSNP | Ensembl ].
VAR_052847

Experimental info

Sequence conflict1811T → I in BAC87465. Ref.1
Sequence conflict2021F → L in BAC87465. Ref.1
Sequence conflict3351C → R in BAC04591. Ref.1
Sequence conflict4481K → E in BAD92323. Ref.2
Sequence conflict5471H → Y in BAC86997. Ref.1
Isoform 3:
Sequence conflict941S → G in AAH06408. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 3.
Checksum: F6F677DF4F48FF55

FASTA64675,342
        10         20         30         40         50         60 
MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG KKPFKCKKCG 

        70         80         90        100        110        120 
KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH RRVHTGEKSY KYECGKSFNQ 

       130        140        150        160        170        180 
DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS YLTRHKLIHT REKPYKCEQY GKTFNQSSTL 

       190        200        210        220        230        240 
TGHKIIHNGE KPYKCEECGK AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK 

       250        260        270        280        290        300 
RIHTGEKPYK CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT 

       310        320        330        340        350        360 
GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK HRIIHTEEKP 

       370        380        390        400        410        420 
YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR SSTLTIHKMI HTGEKPYKCE 

       430        440        450        460        470        480 
ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC GKSFSVFSTL TKHKIIHTDK KPYKCEECGK 

       490        500        510        520        530        540 
AFNRSSILSI HKKIHTGEKP YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI 

       550        560        570        580        590        600 
FSTLTKHKII HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL 

       610        620        630        640 
IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK 

« Hide

Isoform 2 [UniParc].

Checksum: 35D56882C2BF4DC3
Show »

FASTA77489,824
Isoform 3 [UniParc].

Checksum: BB6060D29B1DA22F
Show »

FASTA10311,659

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS PHE-195 AND VAL-292.
Tissue: Brain, Kidney, Thalamus and Trachea.
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT PHE-195.
Tissue: Brain.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT PHE-195.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Uterus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095616 mRNA. Translation: BAC04591.1. Different initiation.
AK127476 mRNA. Translation: BAC86997.1. Different initiation.
AK128494 mRNA. Translation: BAC87465.1.
AB209086 mRNA. Translation: BAD92323.1. Different initiation.
BX648842 mRNA. No translation available.
AC010615 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84898.1.
BC006408 mRNA. Translation: AAH06408.1.
RefSeqNP_001070146.1. NM_001076678.2.
NP_663299.2. NM_145326.2.
NP_787106.4. NM_175910.6.
UniGeneHs.656558.

3D structure databases

ProteinModelPortalQ6ZR52.
SMRQ6ZR52. Positions 22-636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129880. 1 interaction.
STRING9606.ENSP00000376110.

PTM databases

PhosphoSiteQ6ZR52.

Polymorphism databases

DMDM145559547.

Proteomic databases

PaxDbQ6ZR52.
PRIDEQ6ZR52.

Protocols and materials databases

DNASU284443.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000339914; ENSP00000340651; ENSG00000196268. [Q6ZR52-3]
ENST00000355504; ENSP00000347691; ENSG00000196268. [Q6ZR52-1]
ENST00000392288; ENSP00000376110; ENSG00000196268. [Q6ZR52-2]
GeneID284443.
KEGGhsa:284443.
UCSCuc002npw.3. human. [Q6ZR52-2]
uc002npx.3. human. [Q6ZR52-1]

Organism-specific databases

CTD284443.
GeneCardsGC19P021579.
HGNCHGNC:23708. ZNF493.
neXtProtNX_Q6ZR52.
PharmGKBPA134932599.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ6ZR52.
OMAAFIWFST.
OrthoDBEOG7KSX7Q.
PhylomeDBQ6ZR52.
TreeFamTF343410.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ6ZR52.
BgeeQ6ZR52.
CleanExHS_ZNF493.
GenevestigatorQ6ZR52.

Family and domain databases

Gene3D3.30.160.60. 22 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 21 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284443.
NextBio94899.
PROQ6ZR52.

Entry information

Entry nameZN493_HUMAN
AccessionPrimary (citable) accession number: Q6ZR52
Secondary accession number(s): G5E974 expand/collapse secondary AC list , Q59GM3, Q6ZSF6, Q8N1Z6, Q8N965, Q9BR99
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM