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Protein

Zinc finger protein 493

Gene

ZNF493

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri54 – 7623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri82 – 10423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri109 – 13123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 493
Gene namesi
Name:ZNF493
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23708. ZNF493.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932599.

Polymorphism and mutation databases

BioMutaiZNF493.
DMDMi145559547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 646646Zinc finger protein 493PRO_0000047616Add
BLAST

Proteomic databases

PaxDbiQ6ZR52.
PeptideAtlasiQ6ZR52.
PRIDEiQ6ZR52.

PTM databases

iPTMnetiQ6ZR52.
PhosphoSiteiQ6ZR52.

Expressioni

Gene expression databases

BgeeiENSG00000196268.
CleanExiHS_ZNF493.
ExpressionAtlasiQ6ZR52. baseline and differential.
GenevisibleiQ6ZR52. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376110.

Structurei

3D structure databases

ProteinModelPortaliQ6ZR52.
SMRiQ6ZR52. Positions 24-635.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 22 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri26 – 4823C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri54 – 7623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri82 – 10423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri109 – 13123C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 7; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 22PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZR52.
OMAiAFIWFST.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZR52.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 21 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZR52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNECNVHKEG YNELNQYLTT TQSKIFQCDK YVKVFHKLLN SNRHNTKHTG
60 70 80 90 100
KKPFKCKKCG KSFCMLLHLC QHKRIHIREN SYRCEECGKA FIWFSTLTRH
110 120 130 140 150
RRVHTGEKSY KYECGKSFNQ DSNLTTHKRI HTGQKPYKCE ECGTSFYQFS
160 170 180 190 200
YLTRHKLIHT REKPYKCEQY GKTFNQSSTL TGHKIIHNGE KPYKCEECGK
210 220 230 240 250
AFSIFSTPTK HKIIHTEEKS HRCEEYCKAY KESSHLTTHK RIHTGEKPYK
260 270 280 290 300
CEECGKAFSI FSTLTKHKII HTEEKSHRCE ECGKAYKESS HLTTHKRIHT
310 320 330 340 350
GEKPYKCEEC GKTFSVFSIL TKHKIIHTEE KPYKCEECGK AFKRSSTLTK
360 370 380 390 400
HRIIHTEEKP YKCEECGKAF NQSSTLSIHK IIHTGEKPYK CEECGKAFKR
410 420 430 440 450
SSTLTIHKMI HTGEKPYKCE ECGKAFNRSS HLTTHKRIHT GHKPYKCKEC
460 470 480 490 500
GKSFSVFSTL TKHKIIHTDK KPYKCEECGK AFNRSSILSI HKKIHTGEKP
510 520 530 540 550
YKCEECGKAF KRSSHLAGHK QIHSVQKPYK CEECGKAFSI FSTLTKHKII
560 570 580 590 600
HTEEKPYKCE KCGKTFYRFS NLNTHKIIHT GEKPCKCEEC GKAFNHSSNL
610 620 630 640
IKHKLIHTGD KPYKCEACGK AFRRSSHLSR HKIIHIGIHT EETVQK
Length:646
Mass (Da):75,342
Last modified:April 17, 2007 - v3
Checksum:iF6F677DF4F48FF55
GO
Isoform 2 (identifier: Q6ZR52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...LQLRKGCKSM

Note: No experimental confirmation available.
Show »
Length:774
Mass (Da):89,824
Checksum:i35D56882C2BF4DC3
GO
Isoform 3 (identifier: Q6ZR52-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPGPPESLDM...SQDGLYLLTS
     2-646: Missing.

Show »
Length:103
Mass (Da):11,659
Checksum:iBB6060D29B1DA22F
GO

Sequence cautioni

The sequence BAC04591 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC86997 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD92323 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811T → I in BAC87465 (PubMed:14702039).Curated
Sequence conflicti202 – 2021F → L in BAC87465 (PubMed:14702039).Curated
Sequence conflicti335 – 3351C → R in BAC04591 (PubMed:14702039).Curated
Sequence conflicti448 – 4481K → E in BAD92323 (Ref. 2) Curated
Sequence conflicti547 – 5471H → Y in BAC86997 (PubMed:14702039).Curated
Isoform 3 (identifier: Q6ZR52-3)
Sequence conflicti94 – 941S → G in AAH06408 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951C → F.3 Publications
Corresponds to variant rs4621113 [ dbSNP | Ensembl ].
VAR_052846
Natural varianti292 – 2921L → V.1 Publication
Corresponds to variant rs10414834 [ dbSNP | Ensembl ].
VAR_052847

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLGIAVSKPD LVTCLEQGKDPWNMKGHSTV VKPPVICSHFAEDFCPGPGI KDSFQKVILREYVKCGHKDL QLRKGCKSM in isoform 2. 1 PublicationVSP_038298
Alternative sequencei1 – 11M → MPGPPESLDMGPLTFRDVAI EFSLEEWQCLDTAQQDLYRK VMLENYRNLVFLAGIAVSKP DLVTCLEQGKDPWNMKGHST VVKPPVETGFHRFSQDGLYL LTS in isoform 3. 1 PublicationVSP_046656
Alternative sequencei2 – 646645Missing in isoform 3. 1 PublicationVSP_046657Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095616 mRNA. Translation: BAC04591.1. Different initiation.
AK127476 mRNA. Translation: BAC86997.1. Different initiation.
AK128494 mRNA. Translation: BAC87465.1.
AB209086 mRNA. Translation: BAD92323.1. Different initiation.
BX648842 mRNA. No translation available.
AC010615 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84898.1.
BC006408 mRNA. Translation: AAH06408.1.
CCDSiCCDS12411.1. [Q6ZR52-3]
CCDS12412.1. [Q6ZR52-1]
CCDS42536.1. [Q6ZR52-2]
RefSeqiNP_001070146.1. NM_001076678.2. [Q6ZR52-2]
NP_663299.2. NM_145326.2. [Q6ZR52-3]
NP_787106.4. NM_175910.6. [Q6ZR52-1]
UniGeneiHs.656558.

Genome annotation databases

EnsembliENST00000339914; ENSP00000340651; ENSG00000196268. [Q6ZR52-3]
ENST00000355504; ENSP00000347691; ENSG00000196268. [Q6ZR52-1]
ENST00000392288; ENSP00000376110; ENSG00000196268. [Q6ZR52-2]
GeneIDi284443.
KEGGihsa:284443.
UCSCiuc002npu.4. human. [Q6ZR52-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095616 mRNA. Translation: BAC04591.1. Different initiation.
AK127476 mRNA. Translation: BAC86997.1. Different initiation.
AK128494 mRNA. Translation: BAC87465.1.
AB209086 mRNA. Translation: BAD92323.1. Different initiation.
BX648842 mRNA. No translation available.
AC010615 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84898.1.
BC006408 mRNA. Translation: AAH06408.1.
CCDSiCCDS12411.1. [Q6ZR52-3]
CCDS12412.1. [Q6ZR52-1]
CCDS42536.1. [Q6ZR52-2]
RefSeqiNP_001070146.1. NM_001076678.2. [Q6ZR52-2]
NP_663299.2. NM_145326.2. [Q6ZR52-3]
NP_787106.4. NM_175910.6. [Q6ZR52-1]
UniGeneiHs.656558.

3D structure databases

ProteinModelPortaliQ6ZR52.
SMRiQ6ZR52. Positions 24-635.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376110.

PTM databases

iPTMnetiQ6ZR52.
PhosphoSiteiQ6ZR52.

Polymorphism and mutation databases

BioMutaiZNF493.
DMDMi145559547.

Proteomic databases

PaxDbiQ6ZR52.
PeptideAtlasiQ6ZR52.
PRIDEiQ6ZR52.

Protocols and materials databases

DNASUi284443.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339914; ENSP00000340651; ENSG00000196268. [Q6ZR52-3]
ENST00000355504; ENSP00000347691; ENSG00000196268. [Q6ZR52-1]
ENST00000392288; ENSP00000376110; ENSG00000196268. [Q6ZR52-2]
GeneIDi284443.
KEGGihsa:284443.
UCSCiuc002npu.4. human. [Q6ZR52-1]

Organism-specific databases

CTDi284443.
GeneCardsiZNF493.
HGNCiHGNC:23708. ZNF493.
neXtProtiNX_Q6ZR52.
PharmGKBiPA134932599.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ZR52.
OMAiAFIWFST.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ZR52.
TreeFamiTF343410.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii284443.
PROiQ6ZR52.

Gene expression databases

BgeeiENSG00000196268.
CleanExiHS_ZNF493.
ExpressionAtlasiQ6ZR52. baseline and differential.
GenevisibleiQ6ZR52. HS.

Family and domain databases

Gene3Di3.30.160.60. 22 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 21 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 22 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN493_HUMAN
AccessioniPrimary (citable) accession number: Q6ZR52
Secondary accession number(s): G5E974
, Q59GM3, Q6ZSF6, Q8N1Z6, Q8N965, Q9BR99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.