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Protein

Pleckstrin homology domain-containing family G member 7

Gene

PLEKHG7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family G member 7
Short name:
PH domain-containing family G member 7
Gene namesi
Name:PLEKHG7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:33829. PLEKHG7.

Pathology & Biotechi

Organism-specific databases

DisGeNETi440107.
OpenTargetsiENSG00000187510.
PharmGKBiPA162399708.

Polymorphism and mutation databases

BioMutaiPLEKHG7.
DMDMi74758773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172871 – 379Pleckstrin homology domain-containing family G member 7Add BLAST379

Proteomic databases

PaxDbiQ6ZR37.
PeptideAtlasiQ6ZR37.
PRIDEiQ6ZR37.

PTM databases

iPTMnetiQ6ZR37.
PhosphoSitePlusiQ6ZR37.

Expressioni

Gene expression databases

BgeeiENSG00000187510.
CleanExiHS_PLEKHG7.
ExpressionAtlasiQ6ZR37. baseline and differential.

Organism-specific databases

HPAiHPA060632.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000344961.

Structurei

3D structure databases

ProteinModelPortaliQ6ZR37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 176DHPROSITE-ProRule annotationAdd BLAST176
Domaini223 – 356PHPROSITE-ProRule annotationAdd BLAST134

Phylogenomic databases

eggNOGiKOG3521. Eukaryota.
ENOG410XRPT. LUCA.
GeneTreeiENSGT00510000046843.
HOGENOMiHOG000115560.
HOVERGENiHBG098838.
InParanoidiQ6ZR37.
OMAiWKRSTDS.
OrthoDBiEOG091G029R.
PhylomeDBiQ6ZR37.
TreeFamiTF316247.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZR37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFMNTLRYL QTHEYLLDVD LWRLFANLEE LTQTSLGFVN SLFGIIKDYV
60 70 80 90 100
DASEISSSLD FISVLTKYFR GSLCQSHQTY CLNYSAAIFY LESLRQRDDF
110 120 130 140 150
GIYLKWCEQN EQCRRLHVPE LLVAPLQRLT RYPLLLKNIW KRSMDSAEKI
160 170 180 190 200
MIYSIKEKVE KSIRDLEGKV KWLDNFQKFR YLQEIIVWPP LWDRDKRFFI
210 220 230 240 250
PECLKHIFKE HMAENILSPT SRHLLYEGKL TLAESTRFLD VYLFLFNDFL
260 270 280 290 300
LVTKTKCNKK KLGGSDPGLM CPSLTPELQA VIKEGGSCTV LDQPIPLDRL
310 320 330 340 350
VVKSIEPLHV SVFGLRNAFL IQHENRYRQC IAAFLLQAQT ENIKKTWMAQ
360 370
ITTAISCFTK SQETKKISLF TLPAESSEI
Length:379
Mass (Da):44,301
Last modified:July 5, 2004 - v1
Checksum:i301DD258B81B8D8C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05051399D → G. Corresponds to variant dbSNP:rs17790310Ensembl.1
Natural variantiVAR_050514212M → T. Corresponds to variant dbSNP:rs924326Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128530 mRNA. Translation: BAC87483.1.
BC137086 mRNA. Translation: AAI37087.1.
CCDSiCCDS31873.1.
RefSeqiNP_001004330.1. NM_001004330.2.
UniGeneiHs.591013.

Genome annotation databases

EnsembliENST00000344636; ENSP00000344961; ENSG00000187510.
GeneIDi440107.
KEGGihsa:440107.
UCSCiuc001tcj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128530 mRNA. Translation: BAC87483.1.
BC137086 mRNA. Translation: AAI37087.1.
CCDSiCCDS31873.1.
RefSeqiNP_001004330.1. NM_001004330.2.
UniGeneiHs.591013.

3D structure databases

ProteinModelPortaliQ6ZR37.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000344961.

PTM databases

iPTMnetiQ6ZR37.
PhosphoSitePlusiQ6ZR37.

Polymorphism and mutation databases

BioMutaiPLEKHG7.
DMDMi74758773.

Proteomic databases

PaxDbiQ6ZR37.
PeptideAtlasiQ6ZR37.
PRIDEiQ6ZR37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344636; ENSP00000344961; ENSG00000187510.
GeneIDi440107.
KEGGihsa:440107.
UCSCiuc001tcj.3. human.

Organism-specific databases

CTDi440107.
DisGeNETi440107.
GeneCardsiPLEKHG7.
HGNCiHGNC:33829. PLEKHG7.
HPAiHPA060632.
neXtProtiNX_Q6ZR37.
OpenTargetsiENSG00000187510.
PharmGKBiPA162399708.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3521. Eukaryota.
ENOG410XRPT. LUCA.
GeneTreeiENSGT00510000046843.
HOGENOMiHOG000115560.
HOVERGENiHBG098838.
InParanoidiQ6ZR37.
OMAiWKRSTDS.
OrthoDBiEOG091G029R.
PhylomeDBiQ6ZR37.
TreeFamiTF316247.

Miscellaneous databases

GenomeRNAii440107.
PROiQ6ZR37.

Gene expression databases

BgeeiENSG00000187510.
CleanExiHS_PLEKHG7.
ExpressionAtlasiQ6ZR37. baseline and differential.

Family and domain databases

Gene3Di1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR000219. DH-domain.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00621. RhoGEF. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SUPFAMiSSF48065. SSF48065. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPKHG7_HUMAN
AccessioniPrimary (citable) accession number: Q6ZR37
Secondary accession number(s): B2RNR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.