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Protein

Dynein heavy chain 12, axonemal

Gene

DNAH12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1253 – 1260ATPSequence analysis8
Nucleotide bindingi1534 – 1541ATPSequence analysis8
Nucleotide bindingi1892 – 1899ATPSequence analysis8
Nucleotide bindingi2257 – 2264ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein heavy chain 12, axonemal
Alternative name(s):
Axonemal beta dynein heavy chain 12
Axonemal dynein heavy chain 12-like protein
Axonemal dynein heavy chain 7-like protein
Ciliary dynein heavy chain 12
Dynein heavy chain 7-like, axonemal
Dynein heavy chain domain-containing protein 2
Gene namesi
Name:DNAH12
Synonyms:DHC3, DLP12, DNAH12L, DNAH7L, DNAHC3, DNHD2, HDHC3, HL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:2943. DNAH12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi201625.
OpenTargetsiENSG00000174844.
PharmGKBiPA27397.

Polymorphism and mutation databases

BioMutaiDNAH12.
DMDMi226693521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003703241 – 3092Dynein heavy chain 12, axonemalAdd BLAST3092

Proteomic databases

EPDiQ6ZR08.
PeptideAtlasiQ6ZR08.
PRIDEiQ6ZR08.

PTM databases

iPTMnetiQ6ZR08.
PhosphoSitePlusiQ6ZR08.

Expressioni

Gene expression databases

BgeeiENSG00000174844.
ExpressionAtlasiQ6ZR08. baseline and differential.
GenevisibleiQ6ZR08. HS.

Organism-specific databases

HPAiHPA037493.
HPA058203.
HPA061365.

Interactioni

Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

Structurei

3D structure databases

ProteinModelPortaliQ6ZR08.
SMRiQ6ZR08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 1214StemBy similarityAdd BLAST1214
Regioni1215 – 1436AAA 1By similarityAdd BLAST222
Regioni1496 – 1636AAA 2By similarityAdd BLAST141
Regioni1853 – 2104AAA 3By similarityAdd BLAST252
Regioni2218 – 2660AAA 4By similarityAdd BLAST443
Regioni2661 – 2795StalkBy similarityAdd BLAST135
Regioni2874 – 3051AAA 5By similarityAdd BLAST178

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili592 – 665Sequence analysisAdd BLAST74
Coiled coili731 – 762Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1253 – 1260GPAGTGKT motif8
Motifi1303 – 1309CFDEFNR motif7

Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function (By similarity).By similarity

Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00820000127185.
HOGENOMiHOG000237308.
HOVERGENiHBG074257.
InParanoidiQ6ZR08.
KOiK10408.
PhylomeDBiQ6ZR08.
TreeFamiTF333463.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZR08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDANKAAIA AEKEALNLKL PPIVHLPENI GVDTPTQSKL LKYRRSKEQQ
60 70 80 90 100
QKINQLVIDG AKRNLDRTLG KRTPLLPPPD YPQTMTSEMK KKGFNYIYMK
110 120 130 140 150
QCVESSPLVP IQQEWLDHML RLIPESLKEG KEREELLESL INEVSSDFEN
160 170 180 190 200
SMKRYLVQSV LVKPPVKSLE DEGGPLPESP VGLDYSNPWH SSYVQARNQI
210 220 230 240 250
FSNLHIIHPT MKMLLDLGYT TFADTVLLDF TGIRAKGPID CESLKTDLSI
260 270 280 290 300
QTRNAEEKIM NTWYPKVINL FTKKEALEGV KPEKLDAFYS CVSTLMSNQL
310 320 330 340 350
KDLLRRTVEG FVKLFDPKDQ QRLPIFKIEL TFDDDKMEFY PTFQDLEDNV
360 370 380 390 400
LSLVERIAEA LQNVQTIPSW LSGTSTPVNL DTELPEHVLH WAVDTLKAAV
410 420 430 440 450
HRNLEGARKH YETYVEKYNW LLDGTAVENI ETFQTEDHTF DEYTEFIEKF
460 470 480 490 500
LSLASEIMLL PQWIHYTMVR LDCEDLKTGL TNKAKAFANI LLNDIASKYR
510 520 530 540 550
KENECICSEF EAIKEHALKV PETTEEMMDL ISYVEKARTV GIEELILRIQ
560 570 580 590 600
ESKRQMSYFL DVFLFPQEDL ALNATVLMWP RKINPIFDEN DELIENAKHK
610 620 630 640 650
KENELMAKRE KLILEIEKES RRMEEFTEFA ELERMQQYVT DVRQLQKRIQ
660 670 680 690 700
ESEEAVQFIN KEEELFKWEL TKYPELDKLK VNIEPYQKFF NFVLKWQRSE
710 720 730 740 750
KRWMDGGFLD LNGESMEADV EEFSREIFKT LKFFQTKLKK ELQEKRKAAR
760 770 780 790 800
KRSLEEEKIE EEPKDNATIT MCRMRARHWK QISEIVGYDL TPDSGTTLRK
810 820 830 840 850
VLKLNLTPYL EQFEVISAGA SKEFSLEKAM NTMIGTWEDI AFHISLYRDT
860 870 880 890 900
GVCILSSVDE IQAILDDQII KTQTMRGSPF IKPFEHEIKA WEDRLIRIQE
910 920 930 940 950
TIDEWLKVQA QWLYLEPIFC SEDIMQQMPE EGRQFQTVDR HWRDIMKFCA
960 970 980 990 1000
KDPKVLAATS LTGLLEKLQN CNELLEKIMK GLNAYLEKKR LFFPRFFFLS
1010 1020 1030 1040 1050
NDEMLEILSE TKDPLRVQPH LKKCFEGIAK LEFLPNLDIK AMYSSEGERV
1060 1070 1080 1090 1100
ELIALISTSA ARGAVEKWLI QVEDLMLRSV HDVIAAARLA YPESARRDWV
1110 1120 1130 1140 1150
REWPGQVVLC ISQMFWTSET QEVISGGTEG LKKYYKELQN QLNEIVELVR
1160 1170 1180 1190 1200
GKLSKQTRTT LGALVTIDVH ARDVVMDMIK MGVSHDTDFL WLAQLRYYWE
1210 1220 1230 1240 1250
NENARVRIIN CNVKYAYEYL GNSPRLVITP LTDRCYRTLI GAFYLNLGGA
1260 1270 1280 1290 1300
PEGPAGTGKT ETTKDLAKAL AVQCVVFNCS DGLDYLAMGK FFKGLASSGA
1310 1320 1330 1340 1350
WACFDEFNRI ELEVLSVVAQ QILCIQRAIQ QKLVVFVFEG TELKLNPNCF
1360 1370 1380 1390 1400
VAITMNPGYA GRSELPDNLK VLFRTVAMMV PNYALIAEIS LYSYGFLNAR
1410 1420 1430 1440 1450
PLSVKIVMTY RLCSEQLSSQ FHYDYGMRAV KAVLVAAGNL KLKYPNENED
1460 1470 1480 1490 1500
ILLLRSIKDV NEPKFLSHDI PLFNGITSDL FPGIKLPEAD YHEFLECAHE
1510 1520 1530 1540 1550
ACNVHNLQPV KFFLEKIIQT YEMMIVRHGF MLVGEPFAAK TKVLHVLADT
1560 1570 1580 1590 1600
LTLMNEHGYG EEEKVIYRTV NPKSITMGQL FGQFDPVSHE WTDGIVANTF
1610 1620 1630 1640 1650
REFALSETPD RKWVVFDGPI DTLWIESMNT VLDDNKKLCL MSGEIIQMSP
1660 1670 1680 1690 1700
QMSLIFETMD LSQASPATVS RCGMIYLEPS QLGWEPLVSS WLNSLKGPLC
1710 1720 1730 1740 1750
EPEYQALLRG LFAWLIPPSL NQRVELFQLN YLYTTIVSKI LKILITFRIS
1760 1770 1780 1790 1800
NYFKYVPLKT QCTFIKFFLH QQACFIFSLI WSIGGSCDTD GRRVFDTFIR
1810 1820 1830 1840 1850
LIILGKDDEN PVPDSVGKWE CPFDEKGLVY DYMYELKNKG RWVHWNELIK
1860 1870 1880 1890 1900
NTNLGDKQIK IQDIIVPTMD TIRYTFLMDL SITYAKPLLF VGPTGTGKSV
1910 1920 1930 1940 1950
YVKDKLMNHL EKDQYFPFYI NLSARTSANQ VQNIIMARLD KRRKGVFGPP
1960 1970 1980 1990 2000
MGKKCIIFID DMNMPALEKY GAQPPIELLR QFFDCGHWYD LKDTSKITLV
2010 2020 2030 2040 2050
DIELIAAMGP PGGGRNPVTP RCIRHFNICS INSFSDETMV RIFSSIVAFY
2060 2070 2080 2090 2100
LRTHEFPPEY FVIGNQIVNG TMEIYKQSVE NLLPTPTKSH YTFNLRDFSR
2110 2120 2130 2140 2150
VIRGCLLIER DAVANKHTMI RLFVHEVLRV FYDRLINDDD RRWLFQLTKT
2160 2170 2180 2190 2200
VIKDHFKESF HSIFSHLRKQ NAPVTEEDLR NLMFGDYMNP DLEGDDRVYI
2210 2220 2230 2240 2250
EIPNIHHFSD VVDQCLDEYN QTHKTRMNLV IFRYVLEHLS RICRVLKQSG
2260 2270 2280 2290 2300
GNALLVGLGG SGRQSLTRLA TSMAKMHIFQ PEISKSYGMN EWREDMKSFI
2310 2320 2330 2340 2350
AVPVTNRIVD NKSKILEKRL RYLNDHFTYN LYCNICRSLF EKDKLLFSFL
2360 2370 2380 2390 2400
LCANLLLARK EIEYQELMFL LTGGVSLKSA EKNPDPTWLQ DKSWEEICRA
2410 2420 2430 2440 2450
SEFPAFRGLR QHFCEHIYEW REIYDSKEPH NAKFPAPMDK NLNELQKIII
2460 2470 2480 2490 2500
LRCLRPDKIT PAITNYVTDK LGKKFVEPPP FDLTKSYLDS NCTIPLIFVL
2510 2520 2530 2540 2550
SPGADPMASL LKFANDKSMS GNKFQAISLG QGQGPIAAKM IKAAIEEGTW
2560 2570 2580 2590 2600
VCLQNCHLAV SWMPMLEKIC EDFTSETCNS SFRLWLTSYP SSKFPVTILQ
2610 2620 2630 2640 2650
NGVKMTNEPP TGLRLNLLQS YLTDPVSDPE FFKGCRGKEL AWEKLLFGVC
2660 2670 2680 2690 2700
FFHALVQERK KFGPLGWNIP YGFNESDLRI SIRQLQLFIN EYDTIPFEAI
2710 2720 2730 2740 2750
SYLTGECNYG GRVTDDWDRR LLLTMLADFY NLYIVENPHY KFSPSGNYFA
2760 2770 2780 2790 2800
PPKGTYEDYI EFIKKLPFTQ HPEIFGLHEN VDISKDLQQT KTLFESLLLT
2810 2820 2830 2840 2850
QGGSKQTGAS GSTDQILLEI TKDILNKLPS DFDIEMALRK YPVRYEESMN
2860 2870 2880 2890 2900
TVLVQEMERF NNLIITIRNT LRDLEKAIKG VVVMDSALEA LSGSLLVGKV
2910 2920 2930 2940 2950
PEIWAKRSYP SLKPLGSYIT DFLARLNFLQ DWYNSGKPCV FWLSGFFFTQ
2960 2970 2980 2990 3000
AFLTGAMQNY ARKYTTPIDL LGYEFEVIPS DTSDTSPEDG VYIHGLYLDG
3010 3020 3030 3040 3050
ARWDRESGLL AEQYPKLLFD LMPIIWIKPT QKSRIIKSDA YVCPLYKTSE
3060 3070 3080 3090
RKGTLSTTGH STNFVIAMLL KTDQPTRHWI KRGVALLCQL DD
Note: No experimental confirmation available.
Length:3,092
Mass (Da):356,942
Last modified:April 14, 2009 - v2
Checksum:iC40401DD227DDCD7
GO
Isoform 4 (identifier: Q6ZR08-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-457: FIEKFLSLASEI → ELDCWVVWEVYF
     458-3092: Missing.

Show »
Length:457
Mass (Da):52,686
Checksum:i13F5F8392901C7B3
GO
Isoform 2 (identifier: Q6ZR08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2367: Missing.
     2641-2686: Missing.

Note: No experimental confirmation available.
Show »
Length:679
Mass (Da):77,343
Checksum:i18999951FE963068
GO
Isoform 3 (identifier: Q6ZR08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1985: Missing.
     1986-2296: GHWYDLKDTS...YGMNEWREDM → MLCKKKKIPC...NLYINSIHDS
     2297-2310: Missing.

Note: No experimental confirmation available.
Show »
Length:1,093
Mass (Da):125,223
Checksum:i3BCFD7B7F1B7C93D
GO

Sequence cautioni

The sequence AAB09729 differs from that shown. Reason: Frameshift at positions 1211, 1213 and 1215.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13K → R in BAC86512 (PubMed:14702039).Curated1
Sequence conflicti1125S → G in AAB09729 (PubMed:8666668).Curated1
Sequence conflicti1170H → R in AAB09729 (PubMed:8666668).Curated1
Sequence conflicti1310 – 1311IE → NS in AAB09729 (PubMed:8666668).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03482932V → A.1 PublicationCorresponds to variant rs9311651dbSNPEnsembl.1
Natural variantiVAR_034830139S → N.Corresponds to variant rs6778837dbSNPEnsembl.1
Natural variantiVAR_034831224D → E.Corresponds to variant rs6445902dbSNPEnsembl.1
Natural variantiVAR_034832231T → A.Corresponds to variant rs7629743dbSNPEnsembl.1
Natural variantiVAR_060142467T → P.Corresponds to variant rs6806444dbSNPEnsembl.1
Natural variantiVAR_0601431549D → N.Corresponds to variant rs6773904dbSNPEnsembl.1
Natural variantiVAR_0601441704Y → H.Corresponds to variant rs4462937dbSNPEnsembl.1
Natural variantiVAR_0601451748R → C.Corresponds to variant rs17050836dbSNPEnsembl.1
Natural variantiVAR_0601461754K → N.Corresponds to variant rs17793014dbSNPEnsembl.1
Natural variantiVAR_0601471763T → I.Corresponds to variant rs4681982dbSNPEnsembl.1
Natural variantiVAR_0373902740Y → F.Corresponds to variant rs17057989dbSNPEnsembl.1
Natural variantiVAR_0373912893G → S.1 PublicationCorresponds to variant rs4060726dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0369201 – 2367Missing in isoform 2. 1 PublicationAdd BLAST2367
Alternative sequenceiVSP_0369211 – 1985Missing in isoform 3. 1 PublicationAdd BLAST1985
Alternative sequenceiVSP_039335446 – 457FIEKF…LASEI → ELDCWVVWEVYF in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_039336458 – 3092Missing in isoform 4. 1 PublicationAdd BLAST2635
Alternative sequenceiVSP_0369221986 – 2296GHWYD…WREDM → MLCKKKKIPCSEEFLLSKTL GDPVKIRAWNIAGLPTDTFS IDNGVIVNNCRRWPLMIDPQ GQANKWIKNSERENQLSVIK LSDSDYMRTLENCIQFGTPL LLENVGEELDPSLEPLLLRQ TFKQGGIDCIRLGEVIIEYS FDFKFYITTKLRNPHYMPEL ATKVSLLNFMITPEGLEDQL LGIVVAKERPELEEERNALI LQSAANKKQLKDIEKKILET LSSSEGNILEDESAIKVLDS AKMMSNEITKKQQIAEKTEL KIAESREGYRPIAKHSSVLF FSIADLANIDPMYQYSLTWF VNLYINSIHDS in isoform 3. 1 PublicationAdd BLAST311
Alternative sequenceiVSP_0369232297 – 2310Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0369242641 – 2686Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097746 mRNA. Translation: BAC05158.1.
AK126276 mRNA. Translation: BAC86512.1.
AK128592 mRNA. Translation: BAC87517.1.
AC092418 Genomic DNA. No translation available.
AC093928 Genomic DNA. No translation available.
AC121250 Genomic DNA. No translation available.
U53532 mRNA. Translation: AAB09729.1. Frameshift.
CCDSiCCDS33771.1. [Q6ZR08-4]
RefSeqiNP_940966.2. NM_198564.3. [Q6ZR08-4]
UniGeneiHs.201378.

Genome annotation databases

EnsembliENST00000311202; ENSP00000312554; ENSG00000174844. [Q6ZR08-4]
ENST00000351747; ENSP00000295937; ENSG00000174844. [Q6ZR08-1]
GeneIDi201625.
KEGGihsa:201625.
UCSCiuc003dit.2. human. [Q6ZR08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097746 mRNA. Translation: BAC05158.1.
AK126276 mRNA. Translation: BAC86512.1.
AK128592 mRNA. Translation: BAC87517.1.
AC092418 Genomic DNA. No translation available.
AC093928 Genomic DNA. No translation available.
AC121250 Genomic DNA. No translation available.
U53532 mRNA. Translation: AAB09729.1. Frameshift.
CCDSiCCDS33771.1. [Q6ZR08-4]
RefSeqiNP_940966.2. NM_198564.3. [Q6ZR08-4]
UniGeneiHs.201378.

3D structure databases

ProteinModelPortaliQ6ZR08.
SMRiQ6ZR08.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6ZR08.
PhosphoSitePlusiQ6ZR08.

Polymorphism and mutation databases

BioMutaiDNAH12.
DMDMi226693521.

Proteomic databases

EPDiQ6ZR08.
PeptideAtlasiQ6ZR08.
PRIDEiQ6ZR08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311202; ENSP00000312554; ENSG00000174844. [Q6ZR08-4]
ENST00000351747; ENSP00000295937; ENSG00000174844. [Q6ZR08-1]
GeneIDi201625.
KEGGihsa:201625.
UCSCiuc003dit.2. human. [Q6ZR08-1]

Organism-specific databases

CTDi201625.
DisGeNETi201625.
GeneCardsiDNAH12.
HGNCiHGNC:2943. DNAH12.
HPAiHPA037493.
HPA058203.
HPA061365.
MIMi603340. gene.
neXtProtiNX_Q6ZR08.
OpenTargetsiENSG00000174844.
PharmGKBiPA27397.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00820000127185.
HOGENOMiHOG000237308.
HOVERGENiHBG074257.
InParanoidiQ6ZR08.
KOiK10408.
PhylomeDBiQ6ZR08.
TreeFamiTF333463.

Enzyme and pathway databases

BioCyciZFISH:G66-33312-MONOMER.

Miscellaneous databases

ChiTaRSiDNAH12. human.
GenomeRNAii201625.
PROiQ6ZR08.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174844.
ExpressionAtlasiQ6ZR08. baseline and differential.
GenevisibleiQ6ZR08. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011704. ATPase_dyneun-rel_AAA.
IPR026983. DHC_fam.
IPR024317. Dynein_heavy_chain_D4_dom.
IPR004273. Dynein_heavy_dom.
IPR013602. Dynein_heavy_dom-2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10676. PTHR10676. 1 hit.
PfamiPF07728. AAA_5. 1 hit.
PF12780. AAA_8. 1 hit.
PF08393. DHC_N2. 1 hit.
PF03028. Dynein_heavy. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDYH12_HUMAN
AccessioniPrimary (citable) accession number: Q6ZR08
Secondary accession number(s): A6NGI2
, Q6ZTR8, Q8N7R9, Q8WXK2, Q92816
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally derived from a readthrough transcript including ASB14 and DNAH12. DNHD2 was thought to be a distinct gene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.