Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acidic amino acid decarboxylase GADL1

Gene

GADL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.1 Publication

Catalytic activityi

L-aspartate = beta-alanine + CO2.
3-sulfino-L-alanine = hypotaurine + CO2.

Cofactori

pyridoxal 5'-phosphate1 Publication

Kineticsi

  1. KM=2.72 mM for aspartate1 Publication
  2. KM=1.14 mM for cysteine sulfinic acid1 Publication
  1. Vmax=1.56 µmol/min/mg enzyme toward aspartate1 Publication
  2. Vmax=2.31 µmol/min/mg enzyme toward cysteine sulfinic acid1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic amino acid decarboxylase GADL1
Alternative name(s):
Aspartate 1-decarboxylase (EC:4.1.1.11)
Short name:
ADC
Short name:
HuADC
Cysteine sulfinic acid decarboxylase (EC:4.1.1.29)
Short name:
CSADC
Short name:
HuCSADC
Glutamate decarboxylase-like protein 1
Gene namesi
Name:GADL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27949. GADL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134944477.

Polymorphism and mutation databases

BioMutaiGADL1.
DMDMi269849753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Acidic amino acid decarboxylase GADL1PRO_0000312224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei333 – 3331N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ6ZQY3.
PeptideAtlasiQ6ZQY3.
PRIDEiQ6ZQY3.

PTM databases

iPTMnetiQ6ZQY3.
PhosphoSiteiQ6ZQY3.

Expressioni

Gene expression databases

BgeeiENSG00000144644.
CleanExiHS_GADL1.
GenevisibleiQ6ZQY3. HS.

Organism-specific databases

HPAiHPA039160.
HPA040229.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282538.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQY3.
SMRiQ6ZQY3. Positions 41-521.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ6ZQY3.
KOiK18966.
OMAiQEMIPSK.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ6ZQY3.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQY3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSDSDRQCP VDGDIDQQEM IPSKKNAVLV DGVVLNGPTT DAKAGEKFVE
60 70 80 90 100
EACRLIMEEV VLKATDVNEK VCEWRPPEQL KQLLDLEMRD SGEPPHKLLE
110 120 130 140 150
LCRDVIHYSV KTNHPRFFNQ LYAGLDYYSL VARFMTEALN PSVYTYEVSP
160 170 180 190 200
VFLLVEEAVL KKMIEFIGWK EGDGIFNPGG SVSNMYAMNL ARYKYCPDIK
210 220 230 240 250
EKGLSGSPRL ILFTSAECHY SMKKAASFLG IGTENVCFVE TDGRGKMIPE
260 270 280 290 300
ELEKQVWQAR KEGAAPFLVC ATSGTTVLGA FDPLDEIADI CERHSLWLHV
310 320 330 340 350
DASWGGSALM SRKHRKLLHG IHRADSVAWN PHKMLMAGIQ CCALLVKDKS
360 370 380 390 400
DLLKKCYSAK ASYLFQQDKF YDVSYDTGDK SIQCSRRPDA FKFWMTWKAL
410 420 430 440 450
GTLGLEERVN RALALSRYLV DEIKKREGFK LLMEPEYANI CFWYIPPSLR
460 470 480 490 500
EMEEGPEFWA KLNLVAPAIK ERMMKKGSLM LGYQPHRGKV NFFRQVVISP
510 520
QVSREDMDFL LDEIDLLGKD M
Length:521
Mass (Da):59,246
Last modified:November 24, 2009 - v4
Checksum:i8D11C50E7F25053B
GO
Isoform 2 (identifier: Q6ZQY3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-521: Missing.

Note: No experimental confirmation available.
Show »
Length:418
Mass (Da):47,128
Checksum:i535DE59A69D55ECA
GO

Sequence cautioni

The sequence AAH93701 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI11987 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87546 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661D → G in AL832766 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei419 – 521103Missing in isoform 2. 1 PublicationVSP_036227Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832766 mRNA. No translation available.
AC095029 Genomic DNA. No translation available.
AC138391 Genomic DNA. No translation available.
AK128643 mRNA. Translation: BAC87546.1. Different initiation.
BC093701 mRNA. Translation: AAH93701.1. Different initiation.
BC111986 mRNA. Translation: AAI11987.1. Different initiation.
CCDSiCCDS2649.2. [Q6ZQY3-1]
RefSeqiNP_997242.2. NM_207359.2. [Q6ZQY3-1]
UniGeneiHs.657052.

Genome annotation databases

EnsembliENST00000282538; ENSP00000282538; ENSG00000144644. [Q6ZQY3-1]
ENST00000454381; ENSP00000427059; ENSG00000144644. [Q6ZQY3-3]
GeneIDi339896.
KEGGihsa:339896.
UCSCiuc003cep.3. human. [Q6ZQY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL832766 mRNA. No translation available.
AC095029 Genomic DNA. No translation available.
AC138391 Genomic DNA. No translation available.
AK128643 mRNA. Translation: BAC87546.1. Different initiation.
BC093701 mRNA. Translation: AAH93701.1. Different initiation.
BC111986 mRNA. Translation: AAI11987.1. Different initiation.
CCDSiCCDS2649.2. [Q6ZQY3-1]
RefSeqiNP_997242.2. NM_207359.2. [Q6ZQY3-1]
UniGeneiHs.657052.

3D structure databases

ProteinModelPortaliQ6ZQY3.
SMRiQ6ZQY3. Positions 41-521.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000282538.

PTM databases

iPTMnetiQ6ZQY3.
PhosphoSiteiQ6ZQY3.

Polymorphism and mutation databases

BioMutaiGADL1.
DMDMi269849753.

Proteomic databases

PaxDbiQ6ZQY3.
PeptideAtlasiQ6ZQY3.
PRIDEiQ6ZQY3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282538; ENSP00000282538; ENSG00000144644. [Q6ZQY3-1]
ENST00000454381; ENSP00000427059; ENSG00000144644. [Q6ZQY3-3]
GeneIDi339896.
KEGGihsa:339896.
UCSCiuc003cep.3. human. [Q6ZQY3-1]

Organism-specific databases

CTDi339896.
GeneCardsiGADL1.
H-InvDBHIX0020375.
HGNCiHGNC:27949. GADL1.
HPAiHPA039160.
HPA040229.
MIMi615601. gene.
neXtProtiNX_Q6ZQY3.
PharmGKBiPA134944477.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ6ZQY3.
KOiK18966.
OMAiQEMIPSK.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ6ZQY3.
TreeFamiTF314688.

Enzyme and pathway databases

ReactomeiR-HSA-70614. Amino acid synthesis and interconversion (transamination).

Miscellaneous databases

ChiTaRSiGADL1. human.
GenomeRNAii339896.
PROiQ6ZQY3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144644.
CleanExiHS_GADL1.
GenevisibleiQ6ZQY3. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGADL1_HUMAN
AccessioniPrimary (citable) accession number: Q6ZQY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 24, 2009
Last modified: September 7, 2016
This is version 103 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.