ID   LR74B_HUMAN             Reviewed;         392 AA.
AC   Q6ZQY2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 3.
DT   24-JAN-2024, entry version 117.
DE   RecName: Full=Leucine-rich repeat-containing protein 74B {ECO:0000312|HGNC:HGNC:34301};
GN   Name=LRRC74B {ECO:0000312|HGNC:HGNC:34301};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Trachea;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Fetal brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZQY2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZQY2-2; Sequence=VSP_031321;
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DR   EMBL; AK128646; BAC87547.1; -; mRNA.
DR   EMBL; AC002472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC028231; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS77654.1; -. [Q6ZQY2-1]
DR   RefSeq; NP_001277935.1; NM_001291006.1. [Q6ZQY2-1]
DR   AlphaFoldDB; Q6ZQY2; -.
DR   SMR; Q6ZQY2; -.
DR   STRING; 9606.ENSP00000394078; -.
DR   GlyCosmos; Q6ZQY2; 1 site, 1 glycan.
DR   GlyGen; Q6ZQY2; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6ZQY2; -.
DR   PhosphoSitePlus; Q6ZQY2; -.
DR   BioMuta; LRRC74B; -.
DR   MassIVE; Q6ZQY2; -.
DR   PaxDb; 9606-ENSP00000394078; -.
DR   PeptideAtlas; Q6ZQY2; -.
DR   Antibodypedia; 62520; 28 antibodies from 9 providers.
DR   DNASU; 400891; -.
DR   Ensembl; ENST00000442047.3; ENSP00000394078.2; ENSG00000187905.11. [Q6ZQY2-1]
DR   GeneID; 400891; -.
DR   KEGG; hsa:400891; -.
DR   MANE-Select; ENST00000442047.3; ENSP00000394078.2; NM_001291006.2; NP_001277935.1.
DR   UCSC; uc062bxn.1; human. [Q6ZQY2-1]
DR   AGR; HGNC:34301; -.
DR   CTD; 400891; -.
DR   GeneCards; LRRC74B; -.
DR   HGNC; HGNC:34301; LRRC74B.
DR   HPA; ENSG00000187905; Tissue enhanced (choroid plexus, fallopian tube).
DR   neXtProt; NX_Q6ZQY2; -.
DR   OpenTargets; ENSG00000187905; -.
DR   VEuPathDB; HostDB:ENSG00000187905; -.
DR   eggNOG; KOG4308; Eukaryota.
DR   GeneTree; ENSGT00940000154297; -.
DR   HOGENOM; CLU_017147_0_0_1; -.
DR   InParanoid; Q6ZQY2; -.
DR   OMA; CIKTGAC; -.
DR   OrthoDB; 5353818at2759; -.
DR   PathwayCommons; Q6ZQY2; -.
DR   SignaLink; Q6ZQY2; -.
DR   BioGRID-ORCS; 400891; 2 hits in 145 CRISPR screens.
DR   GenomeRNAi; 400891; -.
DR   Pharos; Q6ZQY2; Tdark.
DR   PRO; PR:Q6ZQY2; -.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; Q6ZQY2; Protein.
DR   Bgee; ENSG00000187905; Expressed in right uterine tube and 57 other cell types or tissues.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR24114; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR   PANTHER; PTHR24114:SF37; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 74B; 1.
DR   Pfam; PF13516; LRR_6; 7.
DR   SMART; SM00368; LRR_RI; 9.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..392
FT                   /note="Leucine-rich repeat-containing protein 74B"
FT                   /id="PRO_0000318964"
FT   REPEAT          106..129
FT                   /note="LRR 1"
FT   REPEAT          134..157
FT                   /note="LRR 2"
FT   REPEAT          162..185
FT                   /note="LRR 3"
FT   REPEAT          192..213
FT                   /note="LRR 4"
FT   REPEAT          220..241
FT                   /note="LRR 5"
FT   REPEAT          248..269
FT                   /note="LRR 6"
FT   REPEAT          276..297
FT                   /note="LRR 7"
FT   REPEAT          304..325
FT                   /note="LRR 8"
FT   REPEAT          334..356
FT                   /note="LRR 9"
FT   REGION          24..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         139..392
FT                   /note="DVDLSENQLGVAGAQALCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAH
FT                   TDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFL
FT                   KVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRIL
FT                   VVSRNPMRSEGCFGLLKSVQDNPASALELLDFSDIQVNAEFDGLASSVRGILPELCIKT
FT                   GACRVEYKKELLPVFRSALPASVPK -> GRCWVWGRWAGVSSFSSGMCLHR (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031321"
FT   VARIANT         3
FT                   /note="G -> R (in dbSNP:rs12170538)"
FT                   /id="VAR_038923"
FT   VARIANT         77
FT                   /note="R -> C (in dbSNP:rs9620774)"
FT                   /id="VAR_038924"
SQ   SEQUENCE   392 AA;  41621 MW;  F75C5F94A2158C66 CRC64;
     MRGSCERSGE DEEQKEEAMV ACGRLSGVPE AEQGPEANWD SDLETEGTDG LGELVRDTLY
     LRSCRAHSVV PISCFLRQGS AQELNLRHRG LGPQGARALA SSLSSNPYVK RLDLRDNGLC
     GAGAEALAGA LSKSSSIHDV DLSENQLGVA GAQALCAALT VNQAMRKMQL SGNGLEEQAA
     QHLAELLLAH TDLKSLDLSY NQLNDQAGET LGPALAENTG LTELNVSWNH LRGPGAVAFA
     RGLEANIFLK VLDISYNGFG DPGASAVGEA LKANNVLEEL NMSNNRISAM GALSLGLGLR
     VNQTLRILVV SRNPMRSEGC FGLLKSVQDN PASALELLDF SDIQVNAEFD GLASSVRGIL
     PELCIKTGAC RVEYKKELLP VFRSALPASV PK
//