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Protein

Leucine-rich repeat-containing protein 74B

Gene

LRRC74B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 74BImported
Gene namesi
Name:LRRC74BImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:34301. LRRC74B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003189641 – 392Leucine-rich repeat-containing protein 74BAdd BLAST392

Proteomic databases

PaxDbiQ6ZQY2.
PeptideAtlasiQ6ZQY2.
PRIDEiQ6ZQY2.

PTM databases

PhosphoSitePlusiQ6ZQY2.

Expressioni

Gene expression databases

BgeeiENSG00000187905.

Organism-specific databases

HPAiHPA049947.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000341179.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQY2.
SMRiQ6ZQY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati106 – 129LRR 1Add BLAST24
Repeati134 – 157LRR 2Add BLAST24
Repeati162 – 185LRR 3Add BLAST24
Repeati192 – 213LRR 4Add BLAST22
Repeati220 – 241LRR 5Add BLAST22
Repeati248 – 269LRR 6Add BLAST22
Repeati276 – 297LRR 7Add BLAST22
Repeati304 – 325LRR 8Add BLAST22
Repeati334 – 356LRR 9Add BLAST23

Sequence similaritiesi

Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000110609.
HOGENOMiHOG000155712.
HOVERGENiHBG108751.
OMAiDFSDIQV.
OrthoDBiEOG091G0I7O.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ZQY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGSCERSGE DEEQKEEAMV ACGRLSGVPE AEQGPEANWD SDLETEGTDG
60 70 80 90 100
LGELVRDTLY LRSCRAHSVV PISCFLRQGS AQELNLRHRG LGPQGARALA
110 120 130 140 150
SSLSSNPYVK RLDLRDNGLC GAGAEALAGA LSKSSSIHDV DLSENQLGVA
160 170 180 190 200
GAQALCAALT VNQAMRKMQL SGNGLEEQAA QHLAELLLAH TDLKSLDLSY
210 220 230 240 250
NQLNDQAGET LGPALAENTG LTELNVSWNH LRGPGAVAFA RGLEANIFLK
260 270 280 290 300
VLDISYNGFG DPGASAVGEA LKANNVLEEL NMSNNRISAM GALSLGLGLR
310 320 330 340 350
VNQTLRILVV SRNPMRSEGC FGLLKSVQDN PASALELLDF SDIQVNAEFD
360 370 380 390
GLASSVRGIL PELCIKTGAC RVEYKKELLP VFRSALPASV PK
Length:392
Mass (Da):41,621
Last modified:November 26, 2014 - v3
Checksum:iF75C5F94A2158C66
GO
Isoform 2 (identifier: Q6ZQY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-392: DVDLSENQLG...RSALPASVPK → GRCWVWGRWAGVSSFSSGMCLHR

Show »
Length:161
Mass (Da):17,279
Checksum:iCA4643C22000F493
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0389233G → R.Corresponds to variant rs12170538dbSNPEnsembl.1
Natural variantiVAR_03892477R → C.Corresponds to variant rs9620774dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031321139 – 392DVDLS…ASVPK → GRCWVWGRWAGVSSFSSGMC LHR in isoform 2. 2 PublicationsAdd BLAST254

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128646 mRNA. Translation: BAC87547.1.
AC002472 Genomic DNA. No translation available.
BC028231 mRNA. No translation available.
CCDSiCCDS77654.1. [Q6ZQY2-1]
RefSeqiNP_001277935.1. NM_001291006.1. [Q6ZQY2-1]
UniGeneiHs.291198.

Genome annotation databases

EnsembliENST00000442047; ENSP00000394078; ENSG00000187905. [Q6ZQY2-1]
GeneIDi400891.
KEGGihsa:400891.
UCSCiuc062bxn.1. human. [Q6ZQY2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128646 mRNA. Translation: BAC87547.1.
AC002472 Genomic DNA. No translation available.
BC028231 mRNA. No translation available.
CCDSiCCDS77654.1. [Q6ZQY2-1]
RefSeqiNP_001277935.1. NM_001291006.1. [Q6ZQY2-1]
UniGeneiHs.291198.

3D structure databases

ProteinModelPortaliQ6ZQY2.
SMRiQ6ZQY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000341179.

PTM databases

PhosphoSitePlusiQ6ZQY2.

Proteomic databases

PaxDbiQ6ZQY2.
PeptideAtlasiQ6ZQY2.
PRIDEiQ6ZQY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442047; ENSP00000394078; ENSG00000187905. [Q6ZQY2-1]
GeneIDi400891.
KEGGihsa:400891.
UCSCiuc062bxn.1. human. [Q6ZQY2-1]

Organism-specific databases

CTDi400891.
GeneCardsiLRRC74B.
HGNCiHGNC:34301. LRRC74B.
HPAiHPA049947.
neXtProtiNX_Q6ZQY2.
OpenTargetsiENSG00000187905.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4308. Eukaryota.
ENOG410ZBX3. LUCA.
GeneTreeiENSGT00730000110609.
HOGENOMiHOG000155712.
HOVERGENiHBG108751.
OMAiDFSDIQV.
OrthoDBiEOG091G0I7O.

Miscellaneous databases

GenomeRNAii400891.
PROiQ6ZQY2.

Gene expression databases

BgeeiENSG00000187905.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR74B_HUMAN
AccessioniPrimary (citable) accession number: Q6ZQY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 26, 2014
Last modified: November 2, 2016
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.