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Q6ZQW0 (I23O2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Indoleamine 2,3-dioxygenase 2

Short name=IDO-2
EC=1.13.11.-
Alternative name(s):
Indoleamine 2,3-dioxygenase-like protein 1
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Gene names
Name:IDO2
Synonyms:INDOL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Ref.5

Catalytic activity

L-tryptophan + O2 = N-formyl-L-kynurenine. Ref.5

Cofactor

Binds 1 heme group per subunit By similarity.

Enzyme regulation

Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). Ref.5

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Tissue specificity

Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. Ref.5

Sequence similarities

Belongs to the indoleamine 2,3-dioxygenase family.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6ZQW0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6ZQW0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLHFHYYDTSNKIM
     146-159: FLEIGNLETIISFP → DGVSLCLPGWSAVA
     160-407: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Indoleamine 2,3-dioxygenase 2
PRO_0000285262

Sites

Metal binding3471Iron (heme proximal ligand) By similarity

Natural variations

Alternative sequence11M → MLHFHYYDTSNKIM in isoform 2.
VSP_024857
Alternative sequence146 – 15914FLEIG…IISFP → DGVSLCLPGWSAVA in isoform 2.
VSP_024858
Alternative sequence160 – 407248Missing in isoform 2.
VSP_024859
Natural variant2351R → W Reduced catalytic activity. Ref.5
Corresponds to variant rs10109853 [ dbSNP | Ensembl ].
VAR_032007

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 975E8257B5EC3730

FASTA40745,424
        10         20         30         40         50         60 
MEPHRPNVKT AVPLSLESYH ISEEYGFLLP DSLKELPDHY RPWMEIANKL PQLIDAHQLQ 

        70         80         90        100        110        120 
AHVDKMPLLS CQFLKGHREQ RLAHLVLSFL TMGYVWQEGE AQPAEVLPRN LALPFVEVSR 

       130        140        150        160        170        180 
NLGLPPILVH SDLVLTNWTK KDPDGFLEIG NLETIISFPG GESLHGFILV TALVEKEAVP 

       190        200        210        220        230        240 
GIKALVQATN AILQPNQEAL LQALQRLRLS IQDITKTLGQ MHDYVDPDIF YAGIRIFLSG 

       250        260        270        280        290        300 
WKDNPAMPAG LMYEGVSQEP LKYSGGSAAQ STVLHAFDEF LGIRHSKESG DFLYRMRDYM 

       310        320        330        340        350        360 
PPSHKAFIED IHSAPSLRDY ILSSGQDHLL TAYNQCVQAL AELRSYHITM VTKYLITAAA 

       370        380        390        400 
KAKHGKPNHL PGPPQALKDR GTGGTAVMSF LKSVRDKTLE SILHPRG 

« Hide

Isoform 2 [UniParc].

Checksum: B5C794259EDE4DCC
Show »

FASTA17219,610

References

« Hide 'large scale' references
[1]"Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice."
Ball H.J., Sanchez-Perez A., Weiser S., Austin C.J.D., Astelbauer F., Miu J., McQuillan J.A., Stocker R., Jermiin L.S., Hunt N.H.
Gene 396:203-213(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Uterus.
[3]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]"Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan."
Metz R., Duhadaway J.B., Kamasani U., Laury-Kleintop L., Muller A.J., Prendergast G.C.
Cancer Res. 67:7082-7087(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, TISSUE SPECIFICITY, VARIANT TRP-235.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF052681 mRNA. Translation: ABM69260.1.
AK128691 mRNA. Translation: BAC87573.1.
AC007991 Genomic DNA. No translation available.
AC087518 Genomic DNA. No translation available.
BC113496 mRNA. Translation: AAI13497.1.
BC113498 mRNA. Translation: AAI13499.1.
RefSeqNP_919270.2. NM_194294.2.
UniGeneHs.676257.

3D structure databases

ProteinModelPortalQ6ZQW0.
SMRQ6ZQW0. Positions 17-403.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6ZQW0.

Polymorphism databases

DMDM215274147.

Proteomic databases

PRIDEQ6ZQW0.

Protocols and materials databases

DNASU169355.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000389060; ENSP00000426447; ENSG00000188676. [Q6ZQW0-1]
GeneID169355.
KEGGhsa:169355.

Organism-specific databases

CTD169355.
GeneCardsGC08P039792.
H-InvDBHIX0007468.
HGNCHGNC:27269. IDO2.
MIM612129. gene.
neXtProtNX_Q6ZQW0.
PharmGKBPA164720782.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000190192.
InParanoidQ6ZQW0.
KOK00463.
OrthoDBEOG7NW695.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00333; UER00453.

Gene expression databases

ArrayExpressQ6ZQW0.
BgeeQ6ZQW0.
GenevestigatorQ6ZQW0.

Family and domain databases

InterProIPR000898. Indolamine_dOase.
[Graphical view]
PfamPF01231. IDO. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIDO2. human.
GenomeRNAi169355.
NextBio88803.
PROQ6ZQW0.
SOURCESearch...

Entry information

Entry nameI23O2_HUMAN
AccessionPrimary (citable) accession number: Q6ZQW0
Secondary accession number(s): A4UD41
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 25, 2008
Last modified: March 19, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM