Q6ZQV5 (ZN788_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 788

Gene names

Name:

ZNF788

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 17 C2H2-type zinc fingers.
Sequence caution	The sequence BAC87366.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	Zinc finger protein 788		PRO_0000293696
Regions
	Zinc finger	56 – 78	23	C2H2-type 1
	Zinc finger	112 – 134	23	C2H2-type 2
	Zinc finger	140 – 162	23	C2H2-type 3
	Zinc finger	168 – 190	23	C2H2-type 4
	Zinc finger	196 – 218	23	C2H2-type 5
	Zinc finger	224 – 246	23	C2H2-type 6
	Zinc finger	252 – 274	23	C2H2-type 7
	Zinc finger	280 – 302	23	C2H2-type 8
	Zinc finger	308 – 330	23	C2H2-type 9
	Zinc finger	390 – 412	23	C2H2-type 10
	Zinc finger	418 – 440	23	C2H2-type 11; degenerate
	Zinc finger	446 – 468	23	C2H2-type 12
	Zinc finger	474 – 496	23	C2H2-type 13
	Zinc finger	502 – 524	23	C2H2-type 14
	Zinc finger	530 – 552	23	C2H2-type 15; degenerate
	Zinc finger	558 – 580	23	C2H2-type 16
	Zinc finger	586 – 608	23	C2H2-type 17; degenerate
Experimental info
	Sequence conflict	7	1	R → G in BAC87578. Ref.1
	Sequence conflict	167	1	C → R in BAC87366. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6ZQV5 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: D82640F0060AE848	FASTA	615	71,992
	10 20 30 40 50 60 MNVRILRRHL VFPFIFIVIK ELTLEGTPMN VNNLENPLDA PQNFKCMQGL SVEKPYKCKK 70 80 90 100 110 120 CEKAFNNLSS FQIHERMHRG GKYHACKGSG NTYRFSGFYH RHKMPHAGGK FYGCKKCGKA 130 140 150 160 170 180 FISFCAFRYH QRTHTKEKPY ACKQCGKAYI SYTSFQYHQL NHTGAKCYEC KQCGKGFDLP 190 200 210 220 230 240 NSIRYHEMTH TGEKPHECKQ CGKTFRCASS LRIHGRTHTG EKPYECKQCG KVSRYWSGLQ 250 260 270 280 290 300 VHEVTHIGKK LYECKECGKS YYSSGSFLNH KRIHTREKSY ECKECGKAFG NPISFQKHEG 310 320 330 340 350 360 SHRKWKPYEC KECGKVFSFS SSLRRHERTH TEKLCECKQH GKGFFHRSCP RHMKIDTGEI 370 380 390 400 410 420 LHKRKIRGKV FHSPSSFQTC ERSHTREKRY KCKQCGKPFI YFNAFQRHQR SHTGENPYEC 430 440 450 460 470 480 KQCGKACISS TAFQCRELSH TGAKRYKCKQ CGKGFNLPSS IRYHEMTHTG EKPYECKQCG 490 500 510 520 530 540 RAFRSASHLR THERTHIGEK PYECKQCGKV YRYWSGLRIH GLTHIGKKPY EFNDRGKSFY 550 560 570 580 590 600 SSNFFLNHKR VHTRVKTYEC KECGKAFDNP TSFQKHEGSH RKGKSYECKE CGKVFSFSRS 610 FRRYERAHTG EKPCE

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thymus and Uterus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK128282 mRNA. Translation: BAC87366.1. Different initiation. AK128700 mRNA. Translation: BAC87578.1.
IPI	IPI00418724.
UniGene	Hs.127473.
3D structure databases
HSSP	HSSP built from PDB template 1XF7 based on UniProtKB P19544.
ProteinModelPortal	Q6ZQV5.
ModBase	Search...
PTM databases
PhosphoSite	Q6ZQV5.
Polymorphism databases
DMDM	152112418.
Proteomic databases
PaxDb	Q6ZQV5.
PRIDE	Q6ZQV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc002mtd.3. human.
Organism-specific databases
GeneCards	GC19P012203. GC19P012204.
HGNC	HGNC:33112. ZNF788.
HPA	HPA031128.
neXtProt	NX_Q6ZQV5.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG316972.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q6ZQV5.
OMA	ISFQKHE.
OrthoDB	EOG4B5P4P.
Gene expression databases
ArrayExpress	Q6ZQV5.
CleanEx	HS_ZNF788.
Genevestigator	Q6ZQV5.
Family and domain databases
Gene3D	3.30.160.60. 18 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 16 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 16 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF788. human.

Entry information

Entry name

ZN788_HUMAN

Accession

Primary (citable) accession number: Q6ZQV5
Secondary accession number(s): Q6ZRE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.