ID   WDR87_HUMAN             Reviewed;        2873 AA.
AC   Q6ZQQ6; E7ESW6; Q9BWV9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2024, sequence version 4.
DT   27-MAR-2024, entry version 145.
DE   RecName: Full=WD repeat-containing protein 87;
DE   AltName: Full=Testis development protein NYD-SP11;
GN   Name=WDR87;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1350 (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-1170 (ISOFORM 2).
RC   TISSUE=Testis;
RA   Sha J.H.;
RT   "Cloning of new testis gene (NYD-SP11) related to testis development from
RT   human testis cDNA library.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZQQ6-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZQQ6-2; Sequence=VSP_030380;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK20167.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAK20167.2; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AC016582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ABBA01040648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK128826; BAC87627.1; -; mRNA.
DR   EMBL; AY026504; AAK20167.2; ALT_SEQ; mRNA.
DR   CCDS; CCDS46063.1; -. [Q6ZQQ6-1]
DR   CCDS; CCDS74356.1; -. [Q6ZQQ6-2]
DR   RefSeq; NP_114157.4; NM_031951.4. [Q6ZQQ6-1]
DR   BioGRID; 123800; 12.
DR   IntAct; Q6ZQQ6; 6.
DR   STRING; 9606.ENSP00000405012; -.
DR   GlyGen; Q6ZQQ6; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6ZQQ6; -.
DR   PhosphoSitePlus; Q6ZQQ6; -.
DR   BioMuta; WDR87; -.
DR   EPD; Q6ZQQ6; -.
DR   jPOST; Q6ZQQ6; -.
DR   MassIVE; Q6ZQQ6; -.
DR   PaxDb; 9606-ENSP00000405012; -.
DR   PeptideAtlas; Q6ZQQ6; -.
DR   ProteomicsDB; 18075; -.
DR   ProteomicsDB; 68085; -. [Q6ZQQ6-1]
DR   ProteomicsDB; 68086; -. [Q6ZQQ6-2]
DR   Antibodypedia; 59216; 17 antibodies from 8 providers.
DR   Ensembl; ENST00000303868.5; ENSP00000368025.3; ENSG00000171804.11. [Q6ZQQ6-1]
DR   GeneID; 83889; -.
DR   KEGG; hsa:83889; -.
DR   UCSC; uc002ohj.3; human.
DR   UCSC; uc010efu.3; human. [Q6ZQQ6-1]
DR   AGR; HGNC:29934; -.
DR   CTD; 83889; -.
DR   DisGeNET; 83889; -.
DR   GeneCards; WDR87; -.
DR   HGNC; HGNC:29934; WDR87.
DR   HPA; ENSG00000171804; Tissue enriched (testis).
DR   MIM; 620274; gene.
DR   neXtProt; NX_Q6ZQQ6; -.
DR   OpenTargets; ENSG00000171804; -.
DR   PharmGKB; PA145147633; -.
DR   VEuPathDB; HostDB:ENSG00000171804; -.
DR   eggNOG; ENOG502QTCV; Eukaryota.
DR   GeneTree; ENSGT00530000063583; -.
DR   HOGENOM; CLU_000543_0_0_1; -.
DR   InParanoid; Q6ZQQ6; -.
DR   OMA; VVPLPWQ; -.
DR   OrthoDB; 1334606at2759; -.
DR   TreeFam; TF338139; -.
DR   PathwayCommons; Q6ZQQ6; -.
DR   SignaLink; Q6ZQQ6; -.
DR   BioGRID-ORCS; 83889; 21 hits in 1150 CRISPR screens.
DR   GenomeRNAi; 83889; -.
DR   Pharos; Q6ZQQ6; Tdark.
DR   PRO; PR:Q6ZQQ6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6ZQQ6; Protein.
DR   Bgee; ENSG00000171804; Expressed in tibialis anterior and 20 other cell types or tissues.
DR   ExpressionAtlas; Q6ZQQ6; baseline and differential.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR42968; WD REPEAT-CONTAINING; 1.
DR   PANTHER; PTHR42968:SF38; WD REPEAT-CONTAINING PROTEIN 87; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   Genevisible; Q6ZQQ6; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..2873
FT                   /note="WD repeat-containing protein 87"
FT                   /id="PRO_0000314821"
FT   REPEAT          108..146
FT                   /note="WD 1"
FT   REPEAT          199..239
FT                   /note="WD 2"
FT   REPEAT          242..283
FT                   /note="WD 3"
FT   REPEAT          368..407
FT                   /note="WD 4"
FT   REPEAT          415..460
FT                   /note="WD 5"
FT   REPEAT          516..553
FT                   /note="WD 6"
FT   REPEAT          565..604
FT                   /note="WD 7"
FT   REGION          1049..1124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1177..1199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1392..1413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1531..1607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2199..2338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1084..1099
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1100..1114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1183..1197
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1550..1572
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1585..1607
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2204..2221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2241..2280
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2281..2307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2308..2335
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         42
FT                   /note="S -> SQALFKESRYPQNMPCVCYYFSDAHFFASLSWVTSNTKEI (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.3"
FT                   /id="VSP_030380"
FT   VARIANT         496
FT                   /note="H -> Y (in dbSNP:rs12104280)"
FT                   /id="VAR_057638"
FT   VARIANT         1583
FT                   /note="R -> Q (in dbSNP:rs6508750)"
FT                   /id="VAR_057639"
FT   VARIANT         1885
FT                   /note="N -> K (in dbSNP:rs10422056)"
FT                   /id="VAR_057640"
FT   VARIANT         2570
FT                   /note="H -> L (in dbSNP:rs10408510)"
FT                   /id="VAR_057641"
FT   CONFLICT        135
FT                   /note="T -> S (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        177
FT                   /note="T -> A (in Ref. 2; BAC87627)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        226
FT                   /note="I -> T (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        529
FT                   /note="K -> Q (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        602
FT                   /note="G -> A (in Ref. 2; BAC87627 and 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        817..818
FT                   /note="DR -> NS (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        821
FT                   /note="E -> G (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        939
FT                   /note="E -> G (in Ref. 3; AAK20167)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2873 AA;  333215 MW;  10EBF9F9FFB8C1AE CRC64;
     MSSPRLIPLW KDLKLLLNDT INKSKQPSED PKNCLIVLSD RSQAVAWMKS KTEDMVEKRT
     FSMTERLPPI QSMVHAGSFH ILVVYCGDLI LRLFGDHFRA FKPLGKVPCR FNISCLCYDP
     EMKMLLSGIL GAVVTWVIEL GGTGLQIAHM VSMPGDELVQ DIVLNGPSGS LLALCETVVR
     VLMHQGKGQL GEVKRFTSTS SGSSITCCFT CFDQGFLYAG NQAGEIQVWS LQQGHPLHSF
     QAHQSGVICI RSRPEAHTLL TAGSDSLIKE WNLTSGSLLR RLELGEELYR LQFIDSITFF
     CQTAHSFSLH RLPCFYSLFN VCGSAPQQLR RVCCGNNWFR ILCTTEDGLL RFVSPVTGDL
     LVITWPFSIL DQAVDWAYDP GKEELFVATG SSEVLVFDTT RCPCPAKYLL GTSPNSQDFV
     QCLAYGHFNL GRGLEGLIFS GHQSGVIRVL SQHSCARLEK FMHFGAVLAL STLSGGIFGG
     QGNSLLCSYG MDDYVHLSEA VLDGVKVQLR PLASILSSCH LTHLILLPKS VGAITETNCL
     RLWKFHDFLS SGSQNGLKFI ETLPLHLCAI TSFDVCLSLS LFVTGSADGS VRIWDFHGRL
     IGILDSSLHF GPVCFANDRG DLLVTFNQSL YLVSCLKLLP PALLTRLSFM SISDEVLEVP
     KPFIPSFFFS FETMFVPKYI YPGQAQQKLV GLEKLVNNRA IAFDHSVPHV IEEDEEGSPV
     LLRSSMHYSL QDMEDWMQVS KRYQCHYVLP PQLQLTSWDG LNPYQILRYY FGHGREWLFA
     PDCYIPNSVI RARLWPEGTP IYLQCNLHAP QRELEWDRSQ EFFFWHSRVR AISNTEYPKN
     KEEDEHFLEM RLSKDVTYSV LTDGANRSWL GRKMSEITIN SMIETMLNIM VHASLLKYQC
     CVGALGQIFA SYQVSPALRS ETARRLLNDT TNSNPLIREL AWEGLKRLGM ITHLFAMPLA
     QGLMDKDERV RIKTLSLMAE IGIHSRTSLL QLTQKQETFR EMQQQMIGEE PLDHLLGMRA
     TDLQILSTQV EQRLNENLTL SHRDEKPAFS LDVSMPSELK SSLKPPTVSE ESEVAIKPSK
     GQRRGQAGVK KHSQKWLRGL KKTKERDSKQ MSTEPGLLED ESGTEAAPIE MEEASVYSQW
     SSSTSVIKLS KDVDSQEKDI SKDHIALTLK RLQKIRDKRD KKATAQKLKK KHKKKGKEAK
     VINEETTPPV MEQPVTKKVK IQGRGASGIS GRRSTAGDGS SWRDDLCRLM ALRISGSQTK
     MSENLNAELV TFAQEMLVDR HPSWELFQEI CPLLKKESKV LLEDLDWDVV PPEKKPIFIQ
     EGAIREDMIQ GVTQEVIRHK EVMPREEEQA QKKARDMLGL EETQVILKKG KKVIFLEPGN
     VTMGKEISKK EEKKTFQKSP KQGRKAVQKE RKVGKIKREM TKEERDMSEE VEEMATLEEK
     VVKQEGKLVM IERTPSWQDW KKAWDEWKQV HGETRKSWKA WKEEWEKRLL QEEEKLHQAG
     EKLSPEEEML QEDKKLKWEE WKQVWENMLS SKSKEQQYKD EEEVTLEEEV SREGEEKEQQ
     VTEEQRHIQE EHKWARIHRK RARAEKKRAQ EERKLAQEEE KLAQEERQLA QEERKLAQAY
     VKITQDDREM AQAEGKFAQK EETLAQRGEK LSQEAEKLAQ KRKKLAKKWE KVAREEEKLA
     KKGGKLAEVK NILAQKVEEL PQREQNLDWQ EKELAQELEE LEWDMEELSW KEEELNQEEG
     KLVEEKKKLA EEEEALAWQR EKLSEEETKL AQEEELLIQE KEKLAQHKEK MPEEEERLGR
     KREQLIEKKM KLAQKRERWI NSMEELTKNK MILYQKKNLA QEKKNLAQEK EKLAQRKENL
     LYNKERLTHS KKQLVQVKNK LGMFNKILAQ VEEKLTQEKE TVIKKKEKLA ETEKKLVQVE
     DSLAKKQEKL AQEKMKLALE KAMVQGKKRL RGELDIAKEE KALNLEMKRL AEEKMRLVEG
     KETLSKGETP ETSRQRKMTQ VEQELFERKL SLEEKILLHE DRILAMEESE IAKGKLEFTR
     GQRIFVQGQR KLAKASRKLI KKRESLSKEP AKLNKILKAL QKLTRDERKL TQEEIKMTKM
     KRALFVKERR LSIEQSKLDI KEWDFSEKRS ELTKDEKKLA RKQRKLANKM RRMINKEEKM
     TEEESKLARK HSEVILDDEE EGGIEEEEVI PFLKRRWRKR KEAKRGDKPK EKFSSQVDEV
     ESEEHFSEEM ESLLDELEKQ ESLSSEEEEE REEEEEREEE EEREEEEERK EEEEGEEKQV
     EKEEEEKKKK KKEKKKEEVQ EKEEVFEEKE EIMSEEETES LSDEEEEEES CSLEEEVDRE
     KEILKKEKQF KLQEQRRKSL RGRERVLSIL RGVPHGKGRA IRLGVLKSPL KKLMSTALEM
     KEKTPVPVPE KQISWEDKKA TVVEIPRKFL GTMDKEREVM GKYEPIPPHV LGTVLESQAQ
     DLKTPFMSHI LRRTVEAEEL QHKPLGAWWK WFLQHPPLMG QTEVQLPLSQ IPAKEQHADV
     SLSDVEWIRH VLERMEAGEQ LSRDGFHRLC QLLKDLASKG NLEWLHLAKH EAIVYRHRQA
     LESQDTRISS RQSMSPKYLK VIPPIKAKEK ESWPKPLAVP TQKSPLATKR IPDPRAKNWH
     LLGEPYRSER AQQISIAHKE MEMQYFYPAT RDIFPSAHAS VEKQTLALMF QKDFWDFKDK
     RRFPKLPKLE KKTQPISKKK EELPLWETFV ALYHVLRMLQ QRYPKDSTAW MEQFYQLMDL
     YQLKSPRIQK LLQELLMREE PQPQEIIYEE ALKATELVPG ERLFCCLFCG SSHTPRSPQE
     FQGAVPLPWQ NCVRTILPVG IARYGILELA WKSLPEADLH LTKALTHTVA PTL
//