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Q6ZQN5

- FOXI2_HUMAN

UniProt

Q6ZQN5 - FOXI2_HUMAN

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Protein

Forkhead box protein I2

Gene
FOXI2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Possible transcriptional activator By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi102 – 19695Fork-headAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. double-stranded DNA binding Source: RefGenome
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding Source: InterPro
  5. transcription factor binding Source: RefGenome

GO - Biological processi

  1. anatomical structure morphogenesis Source: RefGenome
  2. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  3. organ development Source: RefGenome
  4. pattern specification process Source: RefGenome
  5. regulation of sequence-specific DNA binding transcription factor activity Source: RefGenome
  6. tissue development Source: RefGenome
  7. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I2
Gene namesi
Name:FOXI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:32448. FOXI2.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Forkhead box protein I2PRO_0000320118Add
BLAST

Proteomic databases

PaxDbiQ6ZQN5.
PRIDEiQ6ZQN5.

PTM databases

PhosphoSiteiQ6ZQN5.

Expressioni

Gene expression databases

BgeeiQ6ZQN5.
CleanExiHS_FOXI2.
GenevestigatoriQ6ZQN5.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000373572.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQN5.
SMRiQ6ZQN5. Positions 100-191.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000236333.
HOVERGENiHBG067944.
InParanoidiQ6ZQN5.
KOiK09401.
OMAiQSAPLRK.
OrthoDBiEOG7T4MKQ.
PhylomeDBiQ6ZQN5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6ZQN5-1 [UniParc]FASTAAdd to Basket

« Hide

MATYCDDLGP SSAPPGQAQA TAHPPGYEPG DLGAVGGGPL LWVNAPALSP    50
KSYASGPGPA PPYAAPSYGA PGPLLGAPGG LAGADLAWLS LSGQQELLRL 100
VRPPYSYSAL IAMAIQSAPL RKLTLSQIYQ YVAGNFPFYK RSKAGWQNSI 150
RHNLSLNDCF KKVPRDEDDP GKGNYWTLDP NCEKMFDNGN FRRKRKRRAE 200
ASAAVRSGAR SVGGAEAPAL EPPSAACLDL QASPSPSAPE AATCFSGFAS 250
AMSALAGGLG TFPGGLAGDF SFGRRPPTVA THAPQTLNPS PGFAPGHQTA 300
AAGFRLSHLL YSREGTEV 318
Length:318
Mass (Da):32,979
Last modified:February 26, 2008 - v2
Checksum:i00226B44B9E018BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391005 Genomic DNA. No translation available.
AK128865 mRNA. Translation: BAC87649.1.
CCDSiCCDS7655.2.
RefSeqiNP_997309.2. NM_207426.2.
UniGeneiHs.449674.

Genome annotation databases

EnsembliENST00000388920; ENSP00000373572; ENSG00000186766.
GeneIDi399823.
KEGGihsa:399823.
UCSCiuc009yas.2. human.

Polymorphism databases

DMDMi182705226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391005 Genomic DNA. No translation available.
AK128865 mRNA. Translation: BAC87649.1 .
CCDSi CCDS7655.2.
RefSeqi NP_997309.2. NM_207426.2.
UniGenei Hs.449674.

3D structure databases

ProteinModelPortali Q6ZQN5.
SMRi Q6ZQN5. Positions 100-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000373572.

PTM databases

PhosphoSitei Q6ZQN5.

Polymorphism databases

DMDMi 182705226.

Proteomic databases

PaxDbi Q6ZQN5.
PRIDEi Q6ZQN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388920 ; ENSP00000373572 ; ENSG00000186766 .
GeneIDi 399823.
KEGGi hsa:399823.
UCSCi uc009yas.2. human.

Organism-specific databases

CTDi 399823.
GeneCardsi GC10P129535.
HGNCi HGNC:32448. FOXI2.
neXtProti NX_Q6ZQN5.
PharmGKBi PA162388813.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000236333.
HOVERGENi HBG067944.
InParanoidi Q6ZQN5.
KOi K09401.
OMAi QSAPLRK.
OrthoDBi EOG7T4MKQ.
PhylomeDBi Q6ZQN5.
TreeFami TF316127.

Miscellaneous databases

GenomeRNAii 399823.
NextBioi 105603.
PROi Q6ZQN5.

Gene expression databases

Bgeei Q6ZQN5.
CleanExi HS_FOXI2.
Genevestigatori Q6ZQN5.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-318.
    Tissue: Uterus.

Entry informationi

Entry nameiFOXI2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZQN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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