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Protein

Forkhead box protein I2

Gene

FOXI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Possible transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi102 – 196Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I2
Gene namesi
Name:FOXI2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000186766.7.
HGNCiHGNC:32448. FOXI2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi399823.
OpenTargetsiENSG00000186766.
PharmGKBiPA162388813.

Polymorphism and mutation databases

BioMutaiFOXI2.
DMDMi182705226.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201181 – 318Forkhead box protein I2Add BLAST318

Proteomic databases

EPDiQ6ZQN5.
PaxDbiQ6ZQN5.
PeptideAtlasiQ6ZQN5.
PRIDEiQ6ZQN5.

PTM databases

iPTMnetiQ6ZQN5.
PhosphoSitePlusiQ6ZQN5.

Expressioni

Gene expression databases

BgeeiENSG00000186766.
CleanExiHS_FOXI2.

Interactioni

Protein-protein interaction databases

BioGridi134424. 51 interactors.
IntActiQ6ZQN5. 50 interactors.
STRINGi9606.ENSP00000373572.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQN5.
SMRiQ6ZQN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000236333.
HOVERGENiHBG067944.
InParanoidiQ6ZQN5.
KOiK09401.
OMAiYQYVAGN.
OrthoDBiEOG091G0ESH.
PhylomeDBiQ6ZQN5.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6ZQN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYCDDLGP SSAPPGQAQA TAHPPGYEPG DLGAVGGGPL LWVNAPALSP
60 70 80 90 100
KSYASGPGPA PPYAAPSYGA PGPLLGAPGG LAGADLAWLS LSGQQELLRL
110 120 130 140 150
VRPPYSYSAL IAMAIQSAPL RKLTLSQIYQ YVAGNFPFYK RSKAGWQNSI
160 170 180 190 200
RHNLSLNDCF KKVPRDEDDP GKGNYWTLDP NCEKMFDNGN FRRKRKRRAE
210 220 230 240 250
ASAAVRSGAR SVGGAEAPAL EPPSAACLDL QASPSPSAPE AATCFSGFAS
260 270 280 290 300
AMSALAGGLG TFPGGLAGDF SFGRRPPTVA THAPQTLNPS PGFAPGHQTA
310
AAGFRLSHLL YSREGTEV
Length:318
Mass (Da):32,979
Last modified:February 26, 2008 - v2
Checksum:i00226B44B9E018BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391005 Genomic DNA. No translation available.
AK128865 mRNA. Translation: BAC87649.1.
CCDSiCCDS7655.2.
RefSeqiNP_997309.2. NM_207426.2.
UniGeneiHs.449674.

Genome annotation databases

EnsembliENST00000388920; ENSP00000373572; ENSG00000186766.
GeneIDi399823.
KEGGihsa:399823.
UCSCiuc009yas.3. human.

Similar proteinsi

Entry informationi

Entry nameiFOXI2_HUMAN
AccessioniPrimary (citable) accession number: Q6ZQN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 27, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM