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Protein

UDP-glucuronosyltransferase 1-7C

Gene

Ugt1a7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-MMU-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-7C (EC:2.4.1.17)
Short name:
UDPGT 1-7C
Short name:
UGT1*7C
Short name:
UGT1-07C
Short name:
UGT1.7C
Alternative name(s):
UDP-glucuronosyltransferase 1A7C
UGT1A10
Gene namesi
Name:Ugt1a7c
Synonyms:Ugt1a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3032636 Ugt1a7c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000026999426 – 531UDP-glucuronosyltransferase 1-7CAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi293N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZQM8
PaxDbiQ6ZQM8
PeptideAtlasiQ6ZQM8
PRIDEiQ6ZQM8

PTM databases

iPTMnetiQ6ZQM8
PhosphoSitePlusiQ6ZQM8
SwissPalmiQ6ZQM8

Expressioni

Tissue specificityi

Widely expressed with highest levels detected in colon and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000090124
ExpressionAtlasiQ6ZQM8 baseline and differential
GenevisibleiQ6ZQM8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058683

Structurei

3D structure databases

ProteinModelPortaliQ6ZQM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 59Poly-Val5

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220832
HOVERGENiHBG004033
InParanoidiQ6ZQM8
KOiK00699
OMAiMPEVSWH
PhylomeDBiQ6ZQM8
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q6ZQM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH
60 70 80 90 100
KGHEVVVVVP EVSWQLTKPL NFVVKTYAVS HTQEDLNREF KIFIDAQWKS
110 120 130 140 150
QQEGGILPLL DSPAKGFFEL LFSHCRSLFN DKKLVEYLKQ TSFDAVFLDP
160 170 180 190 200
FDVCGLTVAK YFSLPSVVFS RGIFCHYLED AAQCPSPPSY IPRMLLKFTD
210 220 230 240 250
TMTFKERTRN LLAYMGERAF CHKFFKSAAD IASEVLQTPV TMTDLFSPVS
260 270 280 290 300
IWLLRTDFVL EFPRPVMPNV IYIGGINCHQ GKPLSKEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):59,758
Last modified:July 5, 2004 - v1
Checksum:i1F89080BA0721E4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227199 mRNA Translation: AAP48598.1
AK128918 mRNA Translation: BAC87656.1
AK144599 mRNA Translation: BAE25958.1
AK153157 mRNA Translation: BAE31767.1
AK165465 mRNA Translation: BAE38202.1
BC141205 mRNA Translation: AAI41206.1
BC141206 mRNA Translation: AAI41207.1
CCDSiCCDS15139.1 [Q6ZQM8-1]
RefSeqiNP_964004.1, NM_201642.4 [Q6ZQM8-1]
UniGeneiMm.300095

Genome annotation databases

EnsembliENSMUST00000058237; ENSMUSP00000058683; ENSMUSG00000090124 [Q6ZQM8-1]
GeneIDi394432
KEGGimmu:394432
UCSCiuc007byc.1 mouse [Q6ZQM8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiUD17C_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQM8
Secondary accession number(s): B2RUL6, Q6XL45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health