Q6ZQM8 (UD17C_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 63.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: UDP-glucuronosyltransferase 1-7C Short name=UDPGT 1-7C Short name=UGT1*7C Short name=UGT1-07C Short name=UGT1.7C EC=2.4.1.17 Alternative name(s): UGT1A10 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 531 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. |
| Catalytic activity | UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. |
| Subcellular location | Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. |
| Sequence similarities | Belongs to the UDP-glycosyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Membrane Microsome |
| Coding sequence diversity | Alternative splicing |
| Domain | Signal Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW microsomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | glucuronosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues. | ||||||
| Isoform 1 (identifier: Q6ZQM8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 25 | 25 | Potential | ||||||
| Chain | 26 – 531 | 506 | UDP-glucuronosyltransferase 1-7C | PRO_0000269994 | |||||
Regions | |||||||||
| Transmembrane | 489 – 509 | 21 | Helical; Potential | ||||||
| Compositional bias | 55 – 59 | 5 | Poly-Val | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 293 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 431 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation." Zhang T., Haws P., Wu Q. Genome Res. 14:79-89(2004) [PubMed: 14672974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow, Kidney and Lung. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY227199 mRNA. Translation: AAP48598.1. AK128918 mRNA. Translation: BAC87656.1. AK144599 mRNA. Translation: BAE25958.1. AK153157 mRNA. Translation: BAE31767.1. AK165465 mRNA. Translation: BAE38202.1. BC141205 mRNA. Translation: AAI41206.1. BC141206 mRNA. Translation: AAI41207.1. |
| IPI | IPI00417181. |
| RefSeq | NP_964004.1. NM_201642.4. |
| UniGene | Mm.300095. |
3D structure databases | |
| ProteinModelPortal | Q6ZQM8. |
| SMR | Q6ZQM8. Positions 281-442. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q6ZQM8. |
Protein family/group databases | |
| CAZy | GT1. Glycosyltransferase Family 1. |
PTM databases | |
| PhosphoSite | Q6ZQM8. |
Proteomic databases | |
| PRIDE | Q6ZQM8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000058237; ENSMUSP00000058683; ENSMUSG00000090124. |
| GeneID | 394432. |
| KEGG | mmu:394432. |
| UCSC | uc007byd.2. mouse. |
Organism-specific databases | |
| CTD | 394432. |
| MGI | MGI:3032636. Ugt1a7c. |
Phylogenomic databases | |
| GeneTree | ENSGT00560000076681. |
| HOVERGEN | HBG004033. |
Gene expression databases | |
| ArrayExpress | Q6ZQM8. |
| Bgee | Q6ZQM8. |
| Genevestigator | Q6ZQM8. |
Family and domain databases | |
| InterPro | IPR002213. UDP_glucos_trans. [Graphical view] |
| KO | K00699. |
| PANTHER | PTHR11926. UDP_glucos_trans. 1 hit. |
| Pfam | PF00201. UDPGT. 1 hit. [Graphical view] |
| PROSITE | PS00375. UDPGT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 405981. |
| SOURCE | Search... |
Entry information
| Entry name | UD17C_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q6ZQM8 Secondary accession number(s): B2RUL6, Q6XL45 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with