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Protein

UDP-glucuronosyltransferase 1-7C

Gene

Ugt1a7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-7C (EC:2.4.1.17)
Short name:
UDPGT 1-7C
Short name:
UGT1*7C
Short name:
UGT1-07C
Short name:
UGT1.7C
Alternative name(s):
UDP-glucuronosyltransferase 1A7C
UGT1A10
Gene namesi
Name:Ugt1a7c
Synonyms:Ugt1a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3032636. Ugt1a7c.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000026999426 – 531UDP-glucuronosyltransferase 1-7CAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZQM8.
PaxDbiQ6ZQM8.
PeptideAtlasiQ6ZQM8.
PRIDEiQ6ZQM8.

PTM databases

iPTMnetiQ6ZQM8.
PhosphoSitePlusiQ6ZQM8.
SwissPalmiQ6ZQM8.

Expressioni

Tissue specificityi

Widely expressed with highest levels detected in colon and kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000090124.
ExpressionAtlasiQ6ZQM8. baseline and differential.
GenevisibleiQ6ZQM8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058683.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi55 – 59Poly-Val5

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ6ZQM8.
KOiK00699.
OMAiCHYLEDA.
PhylomeDBiQ6ZQM8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q6ZQM8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH
60 70 80 90 100
KGHEVVVVVP EVSWQLTKPL NFVVKTYAVS HTQEDLNREF KIFIDAQWKS
110 120 130 140 150
QQEGGILPLL DSPAKGFFEL LFSHCRSLFN DKKLVEYLKQ TSFDAVFLDP
160 170 180 190 200
FDVCGLTVAK YFSLPSVVFS RGIFCHYLED AAQCPSPPSY IPRMLLKFTD
210 220 230 240 250
TMTFKERTRN LLAYMGERAF CHKFFKSAAD IASEVLQTPV TMTDLFSPVS
260 270 280 290 300
IWLLRTDFVL EFPRPVMPNV IYIGGINCHQ GKPLSKEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):59,758
Last modified:July 5, 2004 - v1
Checksum:i1F89080BA0721E4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227199 mRNA. Translation: AAP48598.1.
AK128918 mRNA. Translation: BAC87656.1.
AK144599 mRNA. Translation: BAE25958.1.
AK153157 mRNA. Translation: BAE31767.1.
AK165465 mRNA. Translation: BAE38202.1.
BC141205 mRNA. Translation: AAI41206.1.
BC141206 mRNA. Translation: AAI41207.1.
CCDSiCCDS15139.1. [Q6ZQM8-1]
RefSeqiNP_964004.1. NM_201642.4. [Q6ZQM8-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000058237; ENSMUSP00000058683; ENSMUSG00000090124. [Q6ZQM8-1]
GeneIDi394432.
KEGGimmu:394432.
UCSCiuc007byc.1. mouse. [Q6ZQM8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227199 mRNA. Translation: AAP48598.1.
AK128918 mRNA. Translation: BAC87656.1.
AK144599 mRNA. Translation: BAE25958.1.
AK153157 mRNA. Translation: BAE31767.1.
AK165465 mRNA. Translation: BAE38202.1.
BC141205 mRNA. Translation: AAI41206.1.
BC141206 mRNA. Translation: AAI41207.1.
CCDSiCCDS15139.1. [Q6ZQM8-1]
RefSeqiNP_964004.1. NM_201642.4. [Q6ZQM8-1]
UniGeneiMm.300095.

3D structure databases

ProteinModelPortaliQ6ZQM8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058683.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

iPTMnetiQ6ZQM8.
PhosphoSitePlusiQ6ZQM8.
SwissPalmiQ6ZQM8.

Proteomic databases

MaxQBiQ6ZQM8.
PaxDbiQ6ZQM8.
PeptideAtlasiQ6ZQM8.
PRIDEiQ6ZQM8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058237; ENSMUSP00000058683; ENSMUSG00000090124. [Q6ZQM8-1]
GeneIDi394432.
KEGGimmu:394432.
UCSCiuc007byc.1. mouse. [Q6ZQM8-1]

Organism-specific databases

CTDi394432.
MGIiMGI:3032636. Ugt1a7c.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ6ZQM8.
KOiK00699.
OMAiCHYLEDA.
PhylomeDBiQ6ZQM8.
TreeFamiTF315472.

Miscellaneous databases

PROiQ6ZQM8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090124.
ExpressionAtlasiQ6ZQM8. baseline and differential.
GenevisibleiQ6ZQM8. MM.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUD17C_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQM8
Secondary accession number(s): B2RUL6, Q6XL45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.