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Q6ZQM8

- UD17C_MOUSE

UniProt

Q6ZQM8 - UD17C_MOUSE

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Protein

UDP-glucuronosyltransferase 1-7C

Gene

Ugt1a7c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. glucuronosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-7C (EC:2.4.1.17)
Short name:
UDPGT 1-7C
Short name:
UGT1*7C
Short name:
UGT1-07C
Short name:
UGT1.7C
Alternative name(s):
UDP-glucuronosyltransferase 1A7C
UGT1A10
Gene namesi
Name:Ugt1a7c
Synonyms:Ugt1a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:3032636. Ugt1a7c.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 531506UDP-glucuronosyltransferase 1-7CPRO_0000269994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6ZQM8.
PRIDEiQ6ZQM8.

PTM databases

PhosphoSiteiQ6ZQM8.

Expressioni

Tissue specificityi

Widely expressed with highest levels detected in colon and kidney.1 Publication

Gene expression databases

BgeeiQ6ZQM8.
ExpressionAtlasiQ6ZQM8. baseline.
GenevestigatoriQ6ZQM8.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQM8.
SMRiQ6ZQM8. Positions 281-442.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei489 – 50921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi55 – 595Poly-Val

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ6ZQM8.
KOiK00699.
OMAiCHYLEDA.
PhylomeDBiQ6ZQM8.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q6ZQM8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH
60 70 80 90 100
KGHEVVVVVP EVSWQLTKPL NFVVKTYAVS HTQEDLNREF KIFIDAQWKS
110 120 130 140 150
QQEGGILPLL DSPAKGFFEL LFSHCRSLFN DKKLVEYLKQ TSFDAVFLDP
160 170 180 190 200
FDVCGLTVAK YFSLPSVVFS RGIFCHYLED AAQCPSPPSY IPRMLLKFTD
210 220 230 240 250
TMTFKERTRN LLAYMGERAF CHKFFKSAAD IASEVLQTPV TMTDLFSPVS
260 270 280 290 300
IWLLRTDFVL EFPRPVMPNV IYIGGINCHQ GKPLSKEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):59,758
Last modified:July 5, 2004 - v1
Checksum:i1F89080BA0721E4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY227199 mRNA. Translation: AAP48598.1.
AK128918 mRNA. Translation: BAC87656.1.
AK144599 mRNA. Translation: BAE25958.1.
AK153157 mRNA. Translation: BAE31767.1.
AK165465 mRNA. Translation: BAE38202.1.
BC141205 mRNA. Translation: AAI41206.1.
BC141206 mRNA. Translation: AAI41207.1.
CCDSiCCDS15139.1. [Q6ZQM8-1]
RefSeqiNP_964004.1. NM_201642.4. [Q6ZQM8-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000058237; ENSMUSP00000058683; ENSMUSG00000090124. [Q6ZQM8-1]
GeneIDi394432.
KEGGimmu:394432.
UCSCiuc007byc.1. mouse. [Q6ZQM8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY227199 mRNA. Translation: AAP48598.1 .
AK128918 mRNA. Translation: BAC87656.1 .
AK144599 mRNA. Translation: BAE25958.1 .
AK153157 mRNA. Translation: BAE31767.1 .
AK165465 mRNA. Translation: BAE38202.1 .
BC141205 mRNA. Translation: AAI41206.1 .
BC141206 mRNA. Translation: AAI41207.1 .
CCDSi CCDS15139.1. [Q6ZQM8-1 ]
RefSeqi NP_964004.1. NM_201642.4. [Q6ZQM8-1 ]
UniGenei Mm.300095.

3D structure databases

ProteinModelPortali Q6ZQM8.
SMRi Q6ZQM8. Positions 281-442.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSitei Q6ZQM8.

Proteomic databases

MaxQBi Q6ZQM8.
PRIDEi Q6ZQM8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000058237 ; ENSMUSP00000058683 ; ENSMUSG00000090124 . [Q6ZQM8-1 ]
GeneIDi 394432.
KEGGi mmu:394432.
UCSCi uc007byc.1. mouse. [Q6ZQM8-1 ]

Organism-specific databases

CTDi 394432.
MGIi MGI:3032636. Ugt1a7c.

Phylogenomic databases

GeneTreei ENSGT00760000118949.
HOGENOMi HOG000220832.
HOVERGENi HBG004033.
InParanoidi Q6ZQM8.
KOi K00699.
OMAi CHYLEDA.
PhylomeDBi Q6ZQM8.
TreeFami TF315472.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.

Miscellaneous databases

ChiTaRSi UGT1A10. mouse.
NextBioi 405981.
PROi Q6ZQM8.
SOURCEi Search...

Gene expression databases

Bgeei Q6ZQM8.
ExpressionAtlasi Q6ZQM8. baseline.
Genevestigatori Q6ZQM8.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
    Zhang T., Haws P., Wu Q.
    Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Kidney and Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUD17C_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQM8
Secondary accession number(s): B2RUL6, Q6XL45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3