Reviewed, UniProtKB/Swiss-Prot Q6ZQM8 (UD17C_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-7C
      Short name=UDPGT
      Short name=UGT1*7C
    EC=2.4.1.17
Alternative name(s):
    UGT1-07C
      Short name=UGT1.7C
    UGT1A7C
    UGT1A10

Gene names

Name:	Ugt1a7c
Synonyms:	Ugt1a10

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	531 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q6ZQM8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 531	506	UDP-glucuronosyltransferase 1-7C		PRO_0000269994
Regions
	Transmembrane	489 – 509	21	Potential
	Compositional bias	55 – 59	5	Poly-Val
Amino acid modifications
	Glycosylation	293	1	N-linked (GlcNAc...) Potential
	Glycosylation	431	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1F89080BA0721E4E	FASTA	531	59,758
	10 20 30 40 50 60 MAPADFPASL PLCVCLLLAS GLAQAGRLLV VPMDGSHWFT MQTVVEKLLH KGHEVVVVVP 70 80 90 100 110 120 EVSWQLTKPL NFVVKTYAVS HTQEDLNREF KIFIDAQWKS QQEGGILPLL DSPAKGFFEL 130 140 150 160 170 180 LFSHCRSLFN DKKLVEYLKQ TSFDAVFLDP FDVCGLTVAK YFSLPSVVFS RGIFCHYLED 190 200 210 220 230 240 AAQCPSPPSY IPRMLLKFTD TMTFKERTRN LLAYMGERAF CHKFFKSAAD IASEVLQTPV 250 260 270 280 290 300 TMTDLFSPVS IWLLRTDFVL EFPRPVMPNV IYIGGINCHQ GKPLSKEFEA YVNASGEHGI 310 320 330 340 350 360 VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV KWLPQNDLLG 370 380 390 400 410 420 HPKTRAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK RMETRGAGVT LNVLEMTADD 430 440 450 460 470 480 LENALKTVIN NKSYKENIMR LSSLHKDRPI EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT 490 500 510 520 530 WYQYHSLDVI GFLLAIVLTV VFIVFKCCAY GCRKCFGGKG RVKKSHKSKT H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation." Zhang T., Haws P., Wu Q. Genome Res. 14:79-89(2004) [PubMed: 14672974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Bone marrow, Kidney and Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY227199 mRNA. Translation: AAP48598.1. AK128918 mRNA. Translation: BAC87656.1. AK144599 mRNA. Translation: BAE25958.1. AK153157 mRNA. Translation: BAE31767.1. AK165465 mRNA. Translation: BAE38202.1.
IPI	IPI00417181.
RefSeq	NP_964004.1.
UniGene	Mm.300095
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q6ZQM8.
Genome annotation databases
Ensembl	ENSMUSG00000054545. Mus musculus. [Contig view]
GeneID	394432.
KEGG	mmu:394432.
Organism-specific databases
MGI	MGI:3032636. Ugt1a7c.
Phylogenomic databases
HOVERGEN	Q6ZQM8.
OMA	Q6ZQM8. IACHYLE.
Enzyme and pathway databases
BRENDA	2.4.1.17. 244.
Gene expression databases
ArrayExpress	Q6ZQM8.
Bgee	Q6ZQM8.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	405981.
SOURCE	Search...

Entry information

Entry name

UD17C_MOUSE

Accession

Primary (citable) accession number: Q6ZQM8
Secondary accession number(s): Q6XL45

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)