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Protein

Condensin-2 complex subunit D3

Gene

Ncapd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit D3
Alternative name(s):
Non-SMC condensin II complex subunit D3
Gene namesi
Name:Ncapd3
Synonyms:Kiaa0056
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2142989. Ncapd3.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome Source: MGI
  • condensed chromosome, centromeric region Source: GO_Central
  • germinal vesicle Source: MGI
  • membrane Source: MGI
  • nuclear condensin complex Source: UniProtKB
  • nuclear pericentric heterochromatin Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15061506Condensin-2 complex subunit D3PRO_0000050717Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei562 – 5621PhosphoserineBy similarity
Modified residuei1359 – 13591PhosphoserineBy similarity
Modified residuei1368 – 13681PhosphoserineBy similarity
Modified residuei1381 – 13811PhosphoserineBy similarity
Modified residuei1393 – 13931PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6ZQK0.
MaxQBiQ6ZQK0.
PaxDbiQ6ZQK0.
PRIDEiQ6ZQK0.

PTM databases

iPTMnetiQ6ZQK0.
PhosphoSiteiQ6ZQK0.

Expressioni

Gene expression databases

BgeeiQ6ZQK0.
CleanExiMM_NCAPD3.

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi219559. 1 interaction.
STRINGi10090.ENSMUSP00000072871.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQK0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati442 – 47635HEAT 1Add
BLAST
Repeati532 – 56736HEAT 2Add
BLAST
Repeati574 – 60532HEAT 3Add
BLAST
Repeati968 – 100437HEAT 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1213 – 127058Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 4 HEAT repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0413. Eukaryota.
ENOG410XSGK. LUCA.
HOGENOMiHOG000111840.
HOVERGENiHBG061537.
InParanoidiQ6ZQK0.
KOiK11491.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032682. Cnd1_C.
IPR012371. NCAPD3.
[Graphical view]
PfamiPF12717. Cnd1. 1 hit.
[Graphical view]
PIRSFiPIRSF036508. Condns_HCP-6. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6ZQK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQDLGENL QPWCPLGLSL EWVKTVWDLD FTEIEPLDPS IVGEILETGR
60 70 80 90 100
DAFTKLYGSL FPFATDESGS LESIWTFFTE NDISSNTLVA LFCHFVQEAH
110 120 130 140 150
KKSASAQYRE YGLHAAGLYF LLLEIPGIVV NQVFHPVMFD KCIQILKRSW
160 170 180 190 200
PQESNLTQKR KKDHSKSSKD NYRKSRKRGK PPRKEDYQVD ELSREEEEEE
210 220 230 240 250
EEIYFSGRDL CQIRDAIFNL LKNFLRLLPK FSLKEKPQSI QTCIEVFVAL
260 270 280 290 300
TSFEPIPHKF LISQARNLNE VKHISELAYY GLYLLCSPVH GEENKVIGSI
310 320 330 340 350
FHQMLNVILM LEVGEGSRCA PLAITSQVIN CRNQAVQFVS SLVDELQASV
360 370 380 390 400
YPVLGTLLQH ICAKVVDKAE YRTYAAQSLV QLLTKLPSEE YATFIAWLYK
410 420 430 440 450
YSRSSKIPHR VFTLDVALAL LTLPERELDD TVSLEHQKFL KHKFFVQEII
460 470 480 490 500
FDRCLDKAPT VRSKALSSFA HCLELSSSNT SESILEIFIN SNLVPGIQNL
510 520 530 540 550
SNTVLNPSPV LTSRNGYSAQ SRTHNNDEQT LPGERCFMTM LRKRIKDEKI
560 570 580 590 600
NVRKSALQVL MSILKHCDIL SMEQDLLILQ DHCRDPAISV RKQALQSLTE
610 620 630 640 650
LVMAQPTCVP VQKAWLMGVI PVVMDCESTV QEKALECLDQ LLLQNIKHHK
660 670 680 690 700
KFHSADRSQV LAWSLLALLT IENQDLRRYL NKAFHIWSKK DKFSSTFINS
710 720 730 740 750
VISHTDTERS APAWMLLSKI TCSSPKLDYT KIIESWERLS REQSPNSNTL
760 770 780 790 800
GYMLCVIGHI AKHLPKGTRD KITGVIKAKL NGFQWSPELI SSSVDALQKL
810 820 830 840 850
CRASAKTVLE EQGLLKQVCG DVLATCEQHL SNILLKEDGT GNMDEGLVVK
860 870 880 890 900
CIFTLGDIAQ LCPAIVEKRV FLLIQSILAS SAHSDHLPSS QGTTDALDSQ
910 920 930 940 950
PPFQPRSSAM PSVIRAHAII TLGKLCLQHE DLAKKSIPAL VRELEVSEDV
960 970 980 990 1000
AVRNNVIIVI CDLCIRYTVM VDNYIPNISV CLKDSDPFIR KQTLVLLTNL
1010 1020 1030 1040 1050
LQEEYVKWKG SLFFRFVSTL VDSHPDIASL GEFCLAHLLL KRNPTMFFQH
1060 1070 1080 1090 1100
FIECIFHFNS YEKHGQYNKF SQSERGKQLF LLKGKTNKEK RMRIYKFLLE
1110 1120 1130 1140 1150
HFTDEQRFNV TSKICLNILA CFTDGILPMD MEASELLSDT FDILNSKEIK
1160 1170 1180 1190 1200
LLAMRAQTSK DLLEEDDVAL ANVVMQEAQM KIISQVQKRN FIENIIPIII
1210 1220 1230 1240 1250
SLKTVLEKNK IPALRELMNY LREVMQDYRD EINDFFAVDK QLASELEYDM
1260 1270 1280 1290 1300
KKYNEQLAQE QALTEHANAT KGPEDSDRVP SAQVAPDLEA VPALAAAPMA
1310 1320 1330 1340 1350
AAAAAAPMAA AAAAAGQDNA DVPPTQSRPS APRSNFTPTL PPISENGPLK
1360 1370 1380 1390 1400
IMSSTRPMSL STIAILNSVK KAVASKNRTR SLGALPFNVE TGSPENPSSH
1410 1420 1430 1440 1450
ESSLSLEKES DRTVNHVTKR AISTPENSIS DVTFAAGVSY IGTPATFFTK
1460 1470 1480 1490 1500
EKHEAQEQGS DILCLSLLDK RPPQSPQWNV KSPARSHGST RSSRRSLRKA

PLKTAN
Length:1,506
Mass (Da):169,432
Last modified:July 27, 2011 - v3
Checksum:iD0DE95875214D3FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281I → S in BAB31654 (PubMed:16141072).Curated
Sequence conflicti128 – 1281I → S in BAC97856 (PubMed:14621295).Curated
Sequence conflicti422 – 4221T → E in BAC97856 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156163 Genomic DNA. No translation available.
CT025660 Genomic DNA. No translation available.
AK019297 mRNA. Translation: BAB31654.1.
AK129046 mRNA. Translation: BAC97856.1.
CCDSiCCDS57665.1.
RefSeqiNP_835214.2. NM_178113.3.
UniGeneiMm.251777.

Genome annotation databases

GeneIDi78658.
KEGGimmu:78658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC156163 Genomic DNA. No translation available.
CT025660 Genomic DNA. No translation available.
AK019297 mRNA. Translation: BAB31654.1.
AK129046 mRNA. Translation: BAC97856.1.
CCDSiCCDS57665.1.
RefSeqiNP_835214.2. NM_178113.3.
UniGeneiMm.251777.

3D structure databases

ProteinModelPortaliQ6ZQK0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219559. 1 interaction.
STRINGi10090.ENSMUSP00000072871.

PTM databases

iPTMnetiQ6ZQK0.
PhosphoSiteiQ6ZQK0.

Proteomic databases

EPDiQ6ZQK0.
MaxQBiQ6ZQK0.
PaxDbiQ6ZQK0.
PRIDEiQ6ZQK0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78658.
KEGGimmu:78658.

Organism-specific databases

CTDi23310.
MGIiMGI:2142989. Ncapd3.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0413. Eukaryota.
ENOG410XSGK. LUCA.
HOGENOMiHOG000111840.
HOVERGENiHBG061537.
InParanoidiQ6ZQK0.
KOiK11491.

Miscellaneous databases

ChiTaRSiNcapd3. mouse.
PROiQ6ZQK0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZQK0.
CleanExiMM_NCAPD3.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR032682. Cnd1_C.
IPR012371. NCAPD3.
[Graphical view]
PfamiPF12717. Cnd1. 1 hit.
[Graphical view]
PIRSFiPIRSF036508. Condns_HCP-6. 1 hit.
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-157.
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-1506.
    Tissue: Fetal brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1499-1506, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiCNDD3_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQK0
Secondary accession number(s): E9QPR0, Q9CS21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.