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Protein

Malectin

Gene

Mlec

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81CarbohydrateBy similarity1
Binding sitei103CarbohydrateBy similarity1
Binding sitei130CarbohydrateBy similarity1
Binding sitei131CarbohydrateBy similarity1
Binding sitei200CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-MMU-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiCBM57 Carbohydrate-Binding Module Family 57

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:Mlec
Synonyms:Kiaa0152
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924015 Mlec

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 268LumenalSequence analysisAdd BLAST238
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 291CytoplasmicSequence analysis2

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001398331 – 291MalectinAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6ZQI3
MaxQBiQ6ZQI3
PaxDbiQ6ZQI3
PeptideAtlasiQ6ZQI3
PRIDEiQ6ZQI3

PTM databases

iPTMnetiQ6ZQI3
PhosphoSitePlusiQ6ZQI3
SwissPalmiQ6ZQI3

Expressioni

Gene expression databases

BgeeiENSMUSG00000048578
CleanExiMM_2410014A08RIK
GenevisibleiQ6ZQI3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi224576, 2 interactors
IntActiQ6ZQI3, 4 interactors
MINTiQ6ZQI3
STRINGi10090.ENSMUSP00000055776

Structurei

3D structure databases

ProteinModelPortaliQ6ZQI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 237Poly-Glu8

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593 Eukaryota
ENOG410XNU5 LUCA
GeneTreeiENSGT00390000016504
HOGENOMiHOG000290695
HOVERGENiHBG108138
InParanoidiQ6ZQI3
OMAiLYRTERY
OrthoDBiEOG091G0J2K

Family and domain databases

InterProiView protein in InterPro
IPR021720 Malectin
PfamiView protein in Pfam
PF11721 Malectin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZQI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRPRGAEGT AVALLRLLLL LLLLGPKLRG PGLGVVGAAG AGLPESVIWA
60 70 80 90 100
VNAGGEAHVD VHGIHFRKDP LEGRVGRASD YGMKLPILRS TPEDQILYQT
110 120 130 140 150
ERYNEETFGY EVPVKEEGDY VLVLKFAEVY FAQSQQKVFD VRLNGHVVVK
160 170 180 190 200
DLDIFDRVGH STAHDEIIPM SIRKGKLSVR GEVSTFTGKL YIEFVKGYYD
210 220 230 240 250
NPKVCALYIL AGTVDDVPKL QPHPGLEKKE EEEEEEEYDE GSNLKRQTNK
260 270 280 290
NRVQSGPRTP NPYASDNSSL MFPILVAFGV FIPTLFCLCR L
Length:291
Mass (Da):32,342
Last modified:April 26, 2005 - v2
Checksum:i271EA5AA0F65214D
GO

Sequence cautioni

The sequence BAC97876 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → G in BAC27434 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129066 mRNA Translation: BAC97876.1 Different initiation.
AK031525 mRNA Translation: BAC27434.1
AK075940 mRNA Translation: BAC36070.1
BC035300 mRNA Translation: AAH35300.2
BC058245 mRNA Translation: AAH58245.1
CCDSiCCDS19581.1
RefSeqiNP_780612.2, NM_175403.3
UniGeneiMm.153963

Genome annotation databases

EnsembliENSMUST00000112121; ENSMUSP00000107749; ENSMUSG00000048578
GeneIDi109154
KEGGimmu:109154
UCSCiuc008zdf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMLEC_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQI3
Secondary accession number(s): Q8C6C3, Q8CD40, Q8CI91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 28, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health