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Protein

Malectin

Gene

Mlec

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81CarbohydrateBy similarity1
Binding sitei103CarbohydrateBy similarity1
Binding sitei130CarbohydrateBy similarity1
Binding sitei131CarbohydrateBy similarity1
Binding sitei200CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-MMU-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

CAZyiCBM57. Carbohydrate-Binding Module Family 57.

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:Mlec
Synonyms:Kiaa0152
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924015. Mlec.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 268LumenalSequence analysisAdd BLAST238
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 291CytoplasmicSequence analysis2

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001398331 – 291MalectinAdd BLAST261

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6ZQI3.
MaxQBiQ6ZQI3.
PaxDbiQ6ZQI3.
PeptideAtlasiQ6ZQI3.
PRIDEiQ6ZQI3.

PTM databases

iPTMnetiQ6ZQI3.
PhosphoSitePlusiQ6ZQI3.
SwissPalmiQ6ZQI3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000048578.
CleanExiMM_2410014A08RIK.
ExpressionAtlasiQ6ZQI3. baseline and differential.
GenevisibleiQ6ZQI3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6ZQI3. 4 interactors.
MINTiMINT-4116267.
STRINGi10090.ENSMUSP00000055776.

Structurei

3D structure databases

ProteinModelPortaliQ6ZQI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi230 – 237Poly-Glu8

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ6ZQI3.
OMAiRTERYHT.
OrthoDBiEOG091G0J2K.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZQI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRPRGAEGT AVALLRLLLL LLLLGPKLRG PGLGVVGAAG AGLPESVIWA
60 70 80 90 100
VNAGGEAHVD VHGIHFRKDP LEGRVGRASD YGMKLPILRS TPEDQILYQT
110 120 130 140 150
ERYNEETFGY EVPVKEEGDY VLVLKFAEVY FAQSQQKVFD VRLNGHVVVK
160 170 180 190 200
DLDIFDRVGH STAHDEIIPM SIRKGKLSVR GEVSTFTGKL YIEFVKGYYD
210 220 230 240 250
NPKVCALYIL AGTVDDVPKL QPHPGLEKKE EEEEEEEYDE GSNLKRQTNK
260 270 280 290
NRVQSGPRTP NPYASDNSSL MFPILVAFGV FIPTLFCLCR L
Length:291
Mass (Da):32,342
Last modified:April 26, 2005 - v2
Checksum:i271EA5AA0F65214D
GO

Sequence cautioni

The sequence BAC97876 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69D → G in BAC27434 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129066 mRNA. Translation: BAC97876.1. Different initiation.
AK031525 mRNA. Translation: BAC27434.1.
AK075940 mRNA. Translation: BAC36070.1.
BC035300 mRNA. Translation: AAH35300.2.
BC058245 mRNA. Translation: AAH58245.1.
CCDSiCCDS19581.1.
RefSeqiNP_780612.2. NM_175403.3.
UniGeneiMm.153963.

Genome annotation databases

EnsembliENSMUST00000112121; ENSMUSP00000107749; ENSMUSG00000048578.
GeneIDi109154.
KEGGimmu:109154.
UCSCiuc008zdf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129066 mRNA. Translation: BAC97876.1. Different initiation.
AK031525 mRNA. Translation: BAC27434.1.
AK075940 mRNA. Translation: BAC36070.1.
BC035300 mRNA. Translation: AAH35300.2.
BC058245 mRNA. Translation: AAH58245.1.
CCDSiCCDS19581.1.
RefSeqiNP_780612.2. NM_175403.3.
UniGeneiMm.153963.

3D structure databases

ProteinModelPortaliQ6ZQI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6ZQI3. 4 interactors.
MINTiMINT-4116267.
STRINGi10090.ENSMUSP00000055776.

Protein family/group databases

CAZyiCBM57. Carbohydrate-Binding Module Family 57.

PTM databases

iPTMnetiQ6ZQI3.
PhosphoSitePlusiQ6ZQI3.
SwissPalmiQ6ZQI3.

Proteomic databases

EPDiQ6ZQI3.
MaxQBiQ6ZQI3.
PaxDbiQ6ZQI3.
PeptideAtlasiQ6ZQI3.
PRIDEiQ6ZQI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112121; ENSMUSP00000107749; ENSMUSG00000048578.
GeneIDi109154.
KEGGimmu:109154.
UCSCiuc008zdf.2. mouse.

Organism-specific databases

CTDi9761.
MGIiMGI:1924015. Mlec.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ6ZQI3.
OMAiRTERYHT.
OrthoDBiEOG091G0J2K.

Enzyme and pathway databases

ReactomeiR-MMU-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiMlec. mouse.
PROiQ6ZQI3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048578.
CleanExiMM_2410014A08RIK.
ExpressionAtlasiQ6ZQI3. baseline and differential.
GenevisibleiQ6ZQI3. MM.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLEC_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQI3
Secondary accession number(s): Q8C6C3, Q8CD40, Q8CI91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.