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Protein

Nucleoporin NUP188 homolog

Gene

Nup188

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a component of the nuclear pore complex (NPC).

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoporin NUP188 homolog
Gene namesi
Name:Nup188
Synonyms:Kiaa0169
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2446190. Nup188.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 17591758Nucleoporin NUP188 homologPRO_0000299173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei1719 – 17191PhosphoserineCombined sources
Modified residuei1727 – 17271PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6ZQH8.
MaxQBiQ6ZQH8.
PaxDbiQ6ZQH8.
PRIDEiQ6ZQH8.

PTM databases

iPTMnetiQ6ZQH8.
PhosphoSiteiQ6ZQH8.

Expressioni

Gene expression databases

BgeeiQ6ZQH8.
CleanExiMM_NUP188.
ExpressionAtlasiQ6ZQH8. baseline and differential.
GenevisibleiQ6ZQH8. MM.

Interactioni

Protein-protein interaction databases

BioGridi230667. 22 interactions.
IntActiQ6ZQH8. 23 interactions.
STRINGi10090.ENSMUSP00000065836.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4833. Eukaryota.
ENOG410Z045. LUCA.
GeneTreeiENSGT00390000005742.
HOGENOMiHOG000113876.
HOVERGENiHBG055598.
InParanoidiQ6ZQH8.
KOiK14311.
OMAiNCTASTA.
OrthoDBiEOG7W419V.
PhylomeDBiQ6ZQH8.
TreeFamiTF101106.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018864. Nucleoporin_Nup188.
[Graphical view]
PfamiPF10487. Nup188. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6ZQH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGGPCV RSSRELWTIL LGRSALRELN QIEAELNKYW QRLLEGLSYY
60 70 80 90 100
KPPSPSSAER VKANKDVASP LKELGLRVSK FLGLDEEQSV QLLQCYLQED
110 120 130 140 150
YRGTRDSLKT VLQDERQSQA LTLKIADYYY EERTCILRCV LHLLTYFQDE
160 170 180 190 200
RHPYRAEYAD CVDKLEKELV LKYRQQFEEL YRTEAPTWET HGNLMTERQV
210 220 230 240 250
SRWLVQCLRE QSMLLEIIFL YYAYFEMAPS DLLVLTKMFK EQGFGSRQTS
260 270 280 290 300
RHLVGGTMDP FVDRIGYFSA LILVEGMDIE SLHKYALDDR RELHQFAQDG
310 320 330 340 350
LICQDMDRAM LTLGDIPHHA PVLLAWALLR HTLSPEETSS VVRKIGGTAI
360 370 380 390 400
QLNVFQYLTR LLRSLASGGN DCTTSTACMC VYGLLSFALT SLELHTLGNQ
410 420 430 440 450
QDVIDTACEV LADPSLPELF WGTEPTSGLG IILDSVCGMF PHLLSPLLQL
460 470 480 490 500
LRALVSGKST AKKVYSFLDK MSFYNELHKH KPHDVLSHED GTLWRRQTPK
510 520 530 540 550
LLYPLGGQTN LRIPQGTVGQ VMLDDRAYLV RWEYSYSSWT LFTCEIEMLL
560 570 580 590 600
HVVSTADVIQ HCQRVKPIID LVHKVISTDL SIADCLLPIT SRIYMLLQRL
610 620 630 640 650
TTVISPPVNV IASCVNCLTV LAARNPAKVW TDLRHTGFLP FVAHPVSNMT
660 670 680 690 700
QMISAEGMNA GGYGSLLMNS EQPQGEYGVT IAFLRLVTTL VKGQLGSTQS
710 720 730 740 750
QGLVPCVMFV LKEMLPSYHK WRYNSHGVRE LIGCLILELI HAILNLCQET
760 770 780 790 800
ELHSSHTPSL PSLCICSLAY TEAGQTVISI MGIGVDTIDM VMAAQPRSDG
810 820 830 840 850
PEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LTQHGAHGNN
860 870 880 890 900
LIAVLAKYIY HRHDPALPRL AIQLLKRLAT VAPMSVYACL GSDAAAIRDA
910 920 930 940 950
FLTRLQSKIE DMRIKVMILE FLTVAVETQP GLIELFLNLE VKDGSNGSKE
960 970 980 990 1000
FSLGVWSCLH VVLELIDSQQ QDRYWCPPLL HRAAIAFLHA LWQDRRDSAM
1010 1020 1030 1040 1050
LVLRTKPKFW ENLTSPLFGT LSPPSETSEP SVLETCALIM KIICLEIYYV
1060 1070 1080 1090 1100
VKGSLDQSLK DTLKKFSSEK RFAYWSGYVK SLAVYMADTE GSSCTSLLEY
1110 1120 1130 1140 1150
QMLVSAWRIL LIIAASHADV MHLTDMAVRR QLFLDVLDGT KALLLVAASV
1160 1170 1180 1190 1200
NCLRLGSMMC TLLLILLRQW KRELGAVEKI LGPLTEILEG VLQADQQLME
1210 1220 1230 1240 1250
KTKAKVFSAF ITVLQMKELR VGDIPQYSQL VLNVCETLQE EVIALFDQTR
1260 1270 1280 1290 1300
HSLASDSAAE DKDSMETDDC PRPRHKDQRD GVCVLGLHLA KELCEVDEDG
1310 1320 1330 1340 1350
DSWLQVTRRL PILPTLLTTL EVSLRMKQNL HFTEAALHLL LTLARTQQGA
1360 1370 1380 1390 1400
TAVAGAGITQ SICLPLLSVY QLSSNGTGQT PSTSRKSLDA PSWPGVYRLS
1410 1420 1430 1440 1450
MSLMERLLKT LRYNFLTEAL DFVGVHQERT LQCLNAVKTV QSLACLEEAD
1460 1470 1480 1490 1500
HTVGFILQLS HFRKEWHFHL PQLMRDVQVN LGYLCQACTS LLHSRKMLQH
1510 1520 1530 1540 1550
YLQNKNGDGL PSAVTPRAQR PSTTTTTTTT TTALATPAGC SSKQPTADTE
1560 1570 1580 1590 1600
ASEQRALHTV QYGLLKILSR TLAALRHFTP DVCQILLDQS LDLAEYNFLF
1610 1620 1630 1640 1650
ALSFTTPTFD SEVAPSFGTL LATVNVALNM LGELDKKKES LTQAVGLSTQ
1660 1670 1680 1690 1700
AEGTRTLKSL LMFTMENCFY LLISQAVRYL RDPAVHPRDK QRMKQELSSE
1710 1720 1730 1740 1750
LSTLLSSLSR YFRRGAPSSP AAGVLPSPQG KATSLSKASP ESQEPLIQLV

QAFVRHVQR
Length:1,759
Mass (Da):196,696
Last modified:September 11, 2007 - v2
Checksum:i9067785281A0BF98
GO

Sequence cautioni

The sequence AAH25526.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC97883.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti798 – 7981S → R in BAC34911 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129073 mRNA. Translation: BAC97883.1. Different initiation.
AL954388 Genomic DNA. Translation: CAM23164.1.
BC025526 mRNA. Translation: AAH25526.1. Different initiation.
BC050199 mRNA. Translation: AAH50199.1.
BC096591 mRNA. Translation: AAH96591.1.
AK052272 mRNA. Translation: BAC34911.1.
CCDSiCCDS15878.1.
RefSeqiNP_938046.2. NM_198304.2.
UniGeneiMm.330119.

Genome annotation databases

EnsembliENSMUST00000064447; ENSMUSP00000065836; ENSMUSG00000052533.
GeneIDi227699.
KEGGimmu:227699.
UCSCiuc008jcb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129073 mRNA. Translation: BAC97883.1. Different initiation.
AL954388 Genomic DNA. Translation: CAM23164.1.
BC025526 mRNA. Translation: AAH25526.1. Different initiation.
BC050199 mRNA. Translation: AAH50199.1.
BC096591 mRNA. Translation: AAH96591.1.
AK052272 mRNA. Translation: BAC34911.1.
CCDSiCCDS15878.1.
RefSeqiNP_938046.2. NM_198304.2.
UniGeneiMm.330119.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230667. 22 interactions.
IntActiQ6ZQH8. 23 interactions.
STRINGi10090.ENSMUSP00000065836.

PTM databases

iPTMnetiQ6ZQH8.
PhosphoSiteiQ6ZQH8.

Proteomic databases

EPDiQ6ZQH8.
MaxQBiQ6ZQH8.
PaxDbiQ6ZQH8.
PRIDEiQ6ZQH8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064447; ENSMUSP00000065836; ENSMUSG00000052533.
GeneIDi227699.
KEGGimmu:227699.
UCSCiuc008jcb.1. mouse.

Organism-specific databases

CTDi23511.
MGIiMGI:2446190. Nup188.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4833. Eukaryota.
ENOG410Z045. LUCA.
GeneTreeiENSGT00390000005742.
HOGENOMiHOG000113876.
HOVERGENiHBG055598.
InParanoidiQ6ZQH8.
KOiK14311.
OMAiNCTASTA.
OrthoDBiEOG7W419V.
PhylomeDBiQ6ZQH8.
TreeFamiTF101106.

Enzyme and pathway databases

ReactomeiR-MMU-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-MMU-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-MMU-3371453. Regulation of HSF1-mediated heat shock response.
R-MMU-4570464. SUMOylation of RNA binding proteins.
R-MMU-4615885. SUMOylation of DNA replication proteins.
R-MMU-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

ChiTaRSiNup188. mouse.
PROiQ6ZQH8.
SOURCEiSearch...

Gene expression databases

BgeeiQ6ZQH8.
CleanExiMM_NUP188.
ExpressionAtlasiQ6ZQH8. baseline and differential.
GenevisibleiQ6ZQH8. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018864. Nucleoporin_Nup188.
[Graphical view]
PfamiPF10487. Nup188. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 7 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: B5/EGFP, FVB/N and NMRI.
    Tissue: Mammary tumor and Trophoblast stem cell.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-798.
    Strain: C57BL/6J.
    Tissue: Heart.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1061-1070, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1719 AND SER-1727, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNU188_MOUSE
AccessioniPrimary (citable) accession number: Q6ZQH8
Secondary accession number(s): Q4VA15
, Q80UL4, Q8C7A1, Q8R3F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 8, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.