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Reviewed, UniProtKB/Swiss-Prot Q6ZQA6 (IGSF3_MOUSE)

Last modified November 25, 2008. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Immunoglobulin superfamily member 3
Gene names
Name: Igsf3
Synonyms: Kiaa0466
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1194 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subcellular location

Membrane; Single-pass type I membrane proteinPotential.

Sequence similarities

Contains 8 Ig-like C2-type (immunoglobulin-like) domains.

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Ontologies

Keywords

   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
   PTMGlycoprotein

Gene Ontology (GO)

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 11941175Immunoglobulin superfamily member 3
PRO_0000320135

Regions

Topological domain20 – 11241105Extracellular Potential
Transmembrane1125 – 114521 Potential
Topological domain1146 – 119449Cytoplasmic Potential
Domain20 – 138119Ig-like C2-type 1
Domain143 – 262120Ig-like C2-type 2
Domain276 – 386111Ig-like C2-type 3
Domain401 – 539139Ig-like C2-type 4
Domain545 – 661117Ig-like C2-type 5
Domain676 – 803128Ig-like C2-type 6
Domain813 – 945133Ig-like C2-type 7
Domain949 – 1097149Ig-like C2-type 8
Motif250 – 2523EWI motif

Amino acid modifications

Glycosylation431N-linked (GlcNAc...) Potential
Glycosylation4181N-linked (GlcNAc...) Potential
Glycosylation8421N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 120 By similarity
Disulfide bond167 ↔ 246 By similarity
Disulfide bond302 ↔ 376 By similarity
Disulfide bond432 ↔ 511 By similarity
Disulfide bond566 ↔ 645 By similarity
Disulfide bond701 ↔ 782 By similarity
Disulfide bond838 ↔ 918 By similarity
Disulfide bond974 ↔ 1080 By similarity

Experimental info

Sequence conflict5231E → G in AAH52892. Ref.2
Sequence conflict8001E → D in AAH52892. Ref.2

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Sequences

Sequence LengthMass (Da)Tools
Q6ZQA6-1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: 2A76F53A8B1FD3C3

FASTA1,194134,710
        10         20         30         40         50         60 
MKCFFPVLSC LAVLGVVSAQ RQVTVQEGPL YRTESSHITI WCNVSGYQGP SEQNFQWSIY 

        70         80         90        100        110        120 
LPSAPEREVQ IVSTVDSSFP YAIYTQRVRG GKIYVERIQG NSALLHITDL QARDAGEYEC 

       130        140        150        160        170        180 
HTPNTDERYF GSYSAKMNLV VIPDSLQTTA VPQTLHKVEQ DPLELSCEVA TETVQHTHLS 

       190        200        210        220        230        240 
VSWLRQKGGE NPVEVISLSR DFILHSSSEY AQRQSLGEVR LDKLGRSTFR LTIFHLQPSD 

       250        260        270        280        290        300 
QGEFYCEAAE WIQDPDGSWY AMTRKRSEGA VVNVQPTDKE FTVRLETDKR LHTVGEPVEF 

       310        320        330        340        350        360 
RCILEAQNIP DRYFAVSWAF NSSLIATMGP NAVPVLNSDF AHREAKGQLK VAKESDGVFV 

       370        380        390        400        410        420 
LKIYHLRQED SGKYNCRVTE REKTVTGEFI DKESKRPKNI PIVVLPLKSS ISVEVASNAS 

       430        440        450        460        470        480 
VVLEGEDLHF SCTVRTVGRL QARFSVIWQL VDRQNRRSNV MWLDRDGTLQ PGSAYWERSS 

       490        500        510        520        530        540 
YGGIQMEQVQ PNSFSLGIFN SRKEDEGQYE CHVTEWVRAV DGEWQIVGER RASTLVSITA 

       550        560        570        580        590        600 
LETGFAVTAI SRTPGVTYSD SFDLQCIIKP HYPARVPVSV TWRFQPVGTV EFHDLVTFTR 

       610        620        630        640        650        660 
DGGVQWGDKS STFRTRTAIE KAESSNNVRL SISRASDTEA GKYQCVAELW RRNYNNTWTR 

       670        680        690        700        710        720 
LAERTSNLLE IRVLQPVTKL QVSKSKRTLT LVENRAIQLN CSVKSQTSPN SHFAVLWYVH 

       730        740        750        760        770        780 
KPSDADGKLI LKTTHSSAFE YGTYAEEEGL RGRLQFERHV SGGLFSLTVQ RAEVSDSGSY 

       790        800        810        820        830        840 
YCHVEEWLLS PNYAWYKLAE EVSGRTEVTV KQPDSRLKLS QVQGSLSVLE TRQIQLECVV 

       850        860        870        880        890        900 
LNRTSVASQL LVEWFVWKPN HPEREVVAHL SRDATFHYGE QAAKNNLKGR LHAESPSSGV 

       910        920        930        940        950        960 
YRLFIQNVAV QDSGTYSCRV EEWLPSPSGV WYKRAEDTAG QTAVTVMRPD AALQVDTVVP 

       970        980        990       1000       1010       1020 
NATVTEKAAF QLDCSILSRS SQDSRFAVAW YSLRTKGGGK RGSLGIDEQE EEEEEEDISQ 

      1030       1040       1050       1060       1070       1080 
EEDSEDPTER TVLLSVGPDA VFGPEGSPWE GRLRFQRLSP LLYRLTVLEA SPQDTGNYSC 

      1090       1100       1110       1120       1130       1140 
HVEEWLPSPQ KEWYRLTEEE SAPIGIRVLD TSSTLQSLIC SNDALFYFVF FYPFPIFGIL 

      1150       1160       1170       1180       1190 
IITILLVRFK SRNSSKNSEG KNGVPLLWIK EPHLNYSPTC LEPPVLSIHP GAID

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References

[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryonic tail.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He.
Tissue: Osteoblast.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 717-1194.
Strain: C57BL/6J.
Tissue: Lung.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK129151 mRNA. Translation: BAC97961.1. Different initiation.
BC052892 mRNA. Translation: AAH52892.1.
AK052454 mRNA. Translation: BAC35000.1.
RefSeqNP_997088.2.
UniGeneMm.257997
Mm.396180
Mm.458336

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ6ZQA6.

Genome annotation databases

EnsemblENSMUSG00000042035. Mus musculus. [Contig view]
GeneID78908.
KEGGmmu:78908.

Organism-specific databases

MGIMGI:1926158. Igsf3.
RougeSearch...

Phylogenomic databases

HOGENOMQ6ZQA6.
HOVERGENQ6ZQA6.

Gene expression databases

ArrayExpressQ6ZQA6.
CleanExMM_IGSF3.

Family and domain databases

InterProIPR013151. Ig.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 7 hits.
PfamPF00047. ig. 3 hits.
PF07686. V-set. 3 hits.
[Graphical view]
SMARTSM00409. IG. 8 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 8 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio349722.
SOURCESearch...

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Entry information

Entry nameIGSF3_MOUSE
AccessionPrimary (citable) accession number: Q6ZQA6
Secondary accession number(s): A0A4X9, Q7TPV3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 25, 2008
This is version 27 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents